UA105397C2 - Терапевтичний dll4-зв'язувальний білок - Google Patents

Info

Publication number

UA105397C2

UA105397C2 UAA201203804A UAA201203804A UA105397C2 UA 105397 C2 UA105397 C2 UA 105397C2 UA A201203804 A UAA201203804 A UA A201203804A UA A201203804 A UAA201203804 A UA A201203804A UA 105397 C2 UA105397 C2 UA 105397C2

Authority

UA

Ukraine

Prior art keywords

sok

soc

residues

iyu

zeo

Prior art date

2009-08-29

Links

• Espacenet
• Global Dossier
• Discuss

• 230000027455 binding Effects 0.000 title claims abstract description 195
• 108090000623 proteins and genes Proteins 0.000 title claims description 137
• 102000004169 proteins and genes Human genes 0.000 title claims description 113
• 230000001225 therapeutic effect Effects 0.000 title claims description 30
• 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 title abstract 2
• 102100033553 Delta-like protein 4 Human genes 0.000 title 1
• 108091008324 binding proteins Proteins 0.000 claims abstract description 268
• 239000000427 antigen Substances 0.000 claims abstract description 180
• 108091007433 antigens Proteins 0.000 claims abstract description 179
• 102000036639 antigens Human genes 0.000 claims abstract description 179
• 241000282414 Homo sapiens Species 0.000 claims description 282
• 238000000034 method Methods 0.000 claims description 201
• 210000004027 cell Anatomy 0.000 claims description 173
• 239000012634 fragment Substances 0.000 claims description 94
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 91
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 79
• 230000000694 effects Effects 0.000 claims description 75
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 70
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 60
• 229920001184 polypeptide Polymers 0.000 claims description 59
• 239000003814 drug Substances 0.000 claims description 54
• 108060003951 Immunoglobulin Proteins 0.000 claims description 51
• 206010028980 Neoplasm Diseases 0.000 claims description 51
• 102000018358 immunoglobulin Human genes 0.000 claims description 51
• 208000035475 disorder Diseases 0.000 claims description 49
• 239000003795 chemical substances by application Substances 0.000 claims description 47
• 229940124597 therapeutic agent Drugs 0.000 claims description 47
• 238000010494 dissociation reaction Methods 0.000 claims description 32
• 230000005593 dissociations Effects 0.000 claims description 32
• 101100257262 Caenorhabditis elegans soc-1 gene Proteins 0.000 claims description 31
• 239000008194 pharmaceutical composition Substances 0.000 claims description 27
• 239000013598 vector Substances 0.000 claims description 27
• 150000007523 nucleic acids Chemical class 0.000 claims description 26
• 108010076504 Protein Sorting Signals Proteins 0.000 claims description 25
• 230000013595 glycosylation Effects 0.000 claims description 24
• 102000039446 nucleic acids Human genes 0.000 claims description 23
• 108020004707 nucleic acids Proteins 0.000 claims description 23
• 102000005962 receptors Human genes 0.000 claims description 22
• 201000010099 disease Diseases 0.000 claims description 21
• 238000006206 glycosylation reaction Methods 0.000 claims description 21
• 230000035772 mutation Effects 0.000 claims description 21
• 229910052700 potassium Inorganic materials 0.000 claims description 21
• 238000011282 treatment Methods 0.000 claims description 21
• 238000006467 substitution reaction Methods 0.000 claims description 19
• 102000004127 Cytokines Human genes 0.000 claims description 18
• 108090000695 Cytokines Proteins 0.000 claims description 18
• 230000003993 interaction Effects 0.000 claims description 18
• 201000011510 cancer Diseases 0.000 claims description 17
• 229910052740 iodine Inorganic materials 0.000 claims description 16
• 229910052760 oxygen Inorganic materials 0.000 claims description 16
• 239000013078 crystal Substances 0.000 claims description 15
• 230000003472 neutralizing effect Effects 0.000 claims description 15
• 230000033115 angiogenesis Effects 0.000 claims description 13
• 238000010276 construction Methods 0.000 claims description 13
• 230000007423 decrease Effects 0.000 claims description 12
• 239000007788 liquid Substances 0.000 claims description 12
• 230000008859 change Effects 0.000 claims description 11
• 229940127121 immunoconjugate Drugs 0.000 claims description 11
• 241000282553 Macaca Species 0.000 claims description 10
• 229910052739 hydrogen Inorganic materials 0.000 claims description 10
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 9
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 9
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 9
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 9
• 239000003246 corticosteroid Substances 0.000 claims description 9
• 210000003527 eukaryotic cell Anatomy 0.000 claims description 9
• 229960000485 methotrexate Drugs 0.000 claims description 9
• 229910052727 yttrium Inorganic materials 0.000 claims description 9
• 108010036949 Cyclosporine Proteins 0.000 claims description 8
• 229960001265 ciclosporin Drugs 0.000 claims description 8
• 229930182912 cyclosporin Natural products 0.000 claims description 8
• 229940127089 cytotoxic agent Drugs 0.000 claims description 8
• 239000003937 drug carrier Substances 0.000 claims description 8
• 239000001963 growth medium Substances 0.000 claims description 8
• 229960001334 corticosteroids Drugs 0.000 claims description 7
• 239000002254 cytotoxic agent Substances 0.000 claims description 7
• 231100000599 cytotoxic agent Toxicity 0.000 claims description 7
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 7
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 6
• 229940043355 kinase inhibitor Drugs 0.000 claims description 6
• 210000004962 mammalian cell Anatomy 0.000 claims description 6
• 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 6
• 239000004037 angiogenesis inhibitor Substances 0.000 claims description 5
• 210000004102 animal cell Anatomy 0.000 claims description 5
• 229940045799 anthracyclines and related substance Drugs 0.000 claims description 5
• 229910052799 carbon Inorganic materials 0.000 claims description 5
• 238000012258 culturing Methods 0.000 claims description 5
• 239000003102 growth factor Substances 0.000 claims description 5
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 5
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 5
• 229960002930 sirolimus Drugs 0.000 claims description 5
• 241000238631 Hexapoda Species 0.000 claims description 4
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 4
• 239000003242 anti bacterial agent Substances 0.000 claims description 4
• 230000008827 biological function Effects 0.000 claims description 4
• 230000002538 fungal effect Effects 0.000 claims description 4
• 201000010065 polycystic ovary syndrome Diseases 0.000 claims description 4
• 210000002307 prostate Anatomy 0.000 claims description 4
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
• VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims description 3
• 206010003445 Ascites Diseases 0.000 claims description 3
• 241000271566 Aves Species 0.000 claims description 3
• 206010029113 Neovascularisation Diseases 0.000 claims description 3
• 206010036049 Polycystic ovaries Diseases 0.000 claims description 3
• 206010039491 Sarcoma Diseases 0.000 claims description 3
• 229940121369 angiogenesis inhibitor Drugs 0.000 claims description 3
• 230000003115 biocidal effect Effects 0.000 claims description 3
• 230000000139 costimulatory effect Effects 0.000 claims description 3
• 201000006417 multiple sclerosis Diseases 0.000 claims description 3
• 206010003210 Arteriosclerosis Diseases 0.000 claims description 2
• 208000037260 Atherosclerotic Plaque Diseases 0.000 claims description 2
• 208000011231 Crohn disease Diseases 0.000 claims description 2
• 201000009273 Endometriosis Diseases 0.000 claims description 2
• 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 2
• 101500024558 Homo sapiens Pancreatic icosapeptide Proteins 0.000 claims description 2
• 206010020880 Hypertrophy Diseases 0.000 claims description 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
• 206010027476 Metastases Diseases 0.000 claims description 2
• 206010030113 Oedema Diseases 0.000 claims description 2
• 206010033645 Pancreatitis Diseases 0.000 claims description 2
• 208000008469 Peptic Ulcer Diseases 0.000 claims description 2
• 201000004681 Psoriasis Diseases 0.000 claims description 2
• 206010040047 Sepsis Diseases 0.000 claims description 2
• 206010046798 Uterine leiomyoma Diseases 0.000 claims description 2
• 230000001594 aberrant effect Effects 0.000 claims description 2
• 239000000853 adhesive Substances 0.000 claims description 2
• 230000001070 adhesive effect Effects 0.000 claims description 2
• 239000002168 alkylating agent Substances 0.000 claims description 2
• 229940100198 alkylating agent Drugs 0.000 claims description 2
• 230000000340 anti-metabolite Effects 0.000 claims description 2
• 229940100197 antimetabolite Drugs 0.000 claims description 2
• 239000002256 antimetabolite Substances 0.000 claims description 2
• 239000003080 antimitotic agent Substances 0.000 claims description 2
• 230000001640 apoptogenic effect Effects 0.000 claims description 2
• 208000011775 arteriosclerosis disease Diseases 0.000 claims description 2
• 201000011066 hemangioma Diseases 0.000 claims description 2
• 230000009033 hematopoietic malignancy Effects 0.000 claims description 2
• 201000010260 leiomyoma Diseases 0.000 claims description 2
• 230000003211 malignant effect Effects 0.000 claims description 2
• 201000001441 melanoma Diseases 0.000 claims description 2
• 201000000306 sarcoidosis Diseases 0.000 claims description 2
• 210000005253 yeast cell Anatomy 0.000 claims description 2
• 102000023732 binding proteins Human genes 0.000 claims 69
• 102100026737 Serine/threonine-protein kinase 25 Human genes 0.000 claims 12
• 101710183953 Serine/threonine-protein kinase 25 Proteins 0.000 claims 12
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 3
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 3
• 101001023095 Anemonia sulcata Delta-actitoxin-Avd1a Proteins 0.000 claims 1
• 101000641989 Araneus ventricosus Kunitz-type U1-aranetoxin-Av1a Proteins 0.000 claims 1
• 206010004593 Bile duct cancer Diseases 0.000 claims 1
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 101001028691 Carybdea rastonii Toxin CrTX-A Proteins 0.000 claims 1
• 101000685083 Centruroides infamatus Beta-toxin Cii1 Proteins 0.000 claims 1
• 101000685085 Centruroides noxius Toxin Cn1 Proteins 0.000 claims 1
• 101001028688 Chironex fleckeri Toxin CfTX-1 Proteins 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 101000644407 Cyriopagopus schmidti U6-theraphotoxin-Hs1a Proteins 0.000 claims 1
• 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
• 206010023825 Laryngeal cancer Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 208000015021 Meningeal Neoplasms Diseases 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 206010031096 Oropharyngeal cancer Diseases 0.000 claims 1
• 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 101000679608 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) Cysteine rich necrotrophic effector Tox1 Proteins 0.000 claims 1
• 241001377010 Pila Species 0.000 claims 1
• 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
• 208000000453 Skin Neoplasms Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
• 208000026900 bile duct neoplasm Diseases 0.000 claims 1
• 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 201000011523 endocrine gland cancer Diseases 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 208000024519 eye neoplasm Diseases 0.000 claims 1
• 201000010175 gallbladder cancer Diseases 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 210000004392 genitalia Anatomy 0.000 claims 1
• 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
• 201000004962 larynx cancer Diseases 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 201000005831 male reproductive organ cancer Diseases 0.000 claims 1
• 208000029559 malignant endocrine neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 208000022006 malignant tumor of meninges Diseases 0.000 claims 1
• 210000000944 nerve tissue Anatomy 0.000 claims 1
• 201000008106 ocular cancer Diseases 0.000 claims 1
• 201000006958 oropharynx cancer Diseases 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 206010038038 rectal cancer Diseases 0.000 claims 1
• 201000001275 rectum cancer Diseases 0.000 claims 1
• 201000000849 skin cancer Diseases 0.000 claims 1
• 201000002314 small intestine cancer Diseases 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 102000014914 Carrier Proteins Human genes 0.000 abstract description 199
• 102000044457 human DLL4 Human genes 0.000 abstract 1
• 235000018102 proteins Nutrition 0.000 description 110
• 239000000203 mixture Substances 0.000 description 86
• 235000001014 amino acid Nutrition 0.000 description 70
• 150000001413 amino acids Chemical class 0.000 description 48
• 239000000243 solution Substances 0.000 description 47
• 239000000872 buffer Substances 0.000 description 33
• 241000699666 Mus <mouse, genus> Species 0.000 description 31
• 238000004458 analytical method Methods 0.000 description 31
• 230000006870 function Effects 0.000 description 30
• 241001465754 Metazoa Species 0.000 description 29
• 230000014509 gene expression Effects 0.000 description 29
• 230000000069 prophylactic effect Effects 0.000 description 29
• -1 polydepsipeptides Polymers 0.000 description 27
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 26
• 125000000539 amino acid group Chemical group 0.000 description 26
• 239000000126 substance Substances 0.000 description 25
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
• 210000004408 hybridoma Anatomy 0.000 description 24
• 230000000903 blocking effect Effects 0.000 description 23
• 239000000523 sample Substances 0.000 description 23
• 239000002202 Polyethylene glycol Substances 0.000 description 22
• 229920001223 polyethylene glycol Polymers 0.000 description 22
• 150000001875 compounds Chemical class 0.000 description 21
• 108020003175 receptors Proteins 0.000 description 21
• 108020004414 DNA Proteins 0.000 description 20
• 241000699670 Mus sp. Species 0.000 description 20
• 238000005516 engineering process Methods 0.000 description 20
• 239000003112 inhibitor Substances 0.000 description 20
• 241000894007 species Species 0.000 description 20
• 230000005764 inhibitory process Effects 0.000 description 19
• 102000004190 Enzymes Human genes 0.000 description 18
• 108090000790 Enzymes Proteins 0.000 description 18
• 229940088598 enzyme Drugs 0.000 description 18
• 210000004602 germ cell Anatomy 0.000 description 18
• 230000004071 biological effect Effects 0.000 description 17
• 238000002347 injection Methods 0.000 description 16
• 239000007924 injection Substances 0.000 description 16
• 238000004519 manufacturing process Methods 0.000 description 16
• 210000002966 serum Anatomy 0.000 description 16
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 15
• 238000001556 precipitation Methods 0.000 description 15
• 235000002639 sodium chloride Nutrition 0.000 description 15
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 15
• 210000001519 tissue Anatomy 0.000 description 15
• 241000282412 Homo Species 0.000 description 14
• 229960002685 biotin Drugs 0.000 description 14
• 239000011616 biotin Substances 0.000 description 14
• 235000020958 biotin Nutrition 0.000 description 13
• 239000002299 complementary DNA Substances 0.000 description 13
• 239000002552 dosage form Substances 0.000 description 13
• 239000013604 expression vector Substances 0.000 description 13
• 238000012216 screening Methods 0.000 description 13
• 230000009870 specific binding Effects 0.000 description 13
• 238000010561 standard procedure Methods 0.000 description 13
• 230000015572 biosynthetic process Effects 0.000 description 12
• 238000006243 chemical reaction Methods 0.000 description 12
• 238000011161 development Methods 0.000 description 12
• 230000018109 developmental process Effects 0.000 description 12
• 239000002773 nucleotide Substances 0.000 description 12
• 238000003752 polymerase chain reaction Methods 0.000 description 12
• 241001529936 Murinae Species 0.000 description 11
• 241000700159 Rattus Species 0.000 description 11
• 230000009824 affinity maturation Effects 0.000 description 11
• 239000005557 antagonist Substances 0.000 description 11
• 239000012636 effector Substances 0.000 description 11
• 238000004949 mass spectrometry Methods 0.000 description 11
• 125000003729 nucleotide group Chemical group 0.000 description 11
• 230000001105 regulatory effect Effects 0.000 description 11
• 230000009471 action Effects 0.000 description 10
• 230000000295 complement effect Effects 0.000 description 10
• 238000000113 differential scanning calorimetry Methods 0.000 description 10
• 239000004615 ingredient Substances 0.000 description 10
• 108091033319 polynucleotide Proteins 0.000 description 10
• 102000040430 polynucleotide Human genes 0.000 description 10
• 239000002157 polynucleotide Substances 0.000 description 10
• 238000003259 recombinant expression Methods 0.000 description 10
• 150000003839 salts Chemical class 0.000 description 10
• 239000007787 solid Substances 0.000 description 10
• 208000024891 symptom Diseases 0.000 description 10
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 9
• 240000004270 Colocasia esculenta var. antiquorum Species 0.000 description 9
• 229920002560 Polyethylene Glycol 3000 Polymers 0.000 description 9
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 9
• 108010090804 Streptavidin Proteins 0.000 description 9
• 230000004913 activation Effects 0.000 description 9
• 238000001802 infusion Methods 0.000 description 9
• 230000002401 inhibitory effect Effects 0.000 description 9
• 239000000463 material Substances 0.000 description 9
• 239000013612 plasmid Substances 0.000 description 9
• 230000019491 signal transduction Effects 0.000 description 9
• 239000003826 tablet Substances 0.000 description 9
• 108091035707 Consensus sequence Proteins 0.000 description 8
• 244000019459 Cynara cardunculus Species 0.000 description 8
• 235000019106 Cynara scolymus Nutrition 0.000 description 8
• 102100034546 E3 ubiquitin-protein ligase FANCL Human genes 0.000 description 8
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 8
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 8
• 239000004698 Polyethylene Substances 0.000 description 8
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
• 238000010521 absorption reaction Methods 0.000 description 8
• 239000000443 aerosol Substances 0.000 description 8
• 235000016520 artichoke thistle Nutrition 0.000 description 8
• 238000003556 assay Methods 0.000 description 8
• 239000012472 biological sample Substances 0.000 description 8
• 210000004369 blood Anatomy 0.000 description 8
• 239000008280 blood Substances 0.000 description 8
• 238000001514 detection method Methods 0.000 description 8
• 238000010790 dilution Methods 0.000 description 8
• 239000012895 dilution Substances 0.000 description 8
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 8
• 235000013305 food Nutrition 0.000 description 8
• 238000001990 intravenous administration Methods 0.000 description 8
• 238000005259 measurement Methods 0.000 description 8
• 108020004999 messenger RNA Proteins 0.000 description 8
• 239000002953 phosphate buffered saline Substances 0.000 description 8
• 230000008569 process Effects 0.000 description 8
• 210000004243 sweat Anatomy 0.000 description 8
• 230000009261 transgenic effect Effects 0.000 description 8
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 7
• 241000282472 Canis lupus familiaris Species 0.000 description 7
• 241000124008 Mammalia Species 0.000 description 7
• 229960002964 adalimumab Drugs 0.000 description 7
• 230000033228 biological regulation Effects 0.000 description 7
• 238000012512 characterization method Methods 0.000 description 7
• 238000004590 computer program Methods 0.000 description 7
• 238000006471 dimerization reaction Methods 0.000 description 7
• 238000011156 evaluation Methods 0.000 description 7
• 210000001508 eye Anatomy 0.000 description 7
• 238000009472 formulation Methods 0.000 description 7
• 235000011389 fruit/vegetable juice Nutrition 0.000 description 7
• 239000000499 gel Substances 0.000 description 7
• 230000003053 immunization Effects 0.000 description 7
• XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 7
• 239000000178 monomer Substances 0.000 description 7
• 238000006386 neutralization reaction Methods 0.000 description 7
• 238000007911 parenteral administration Methods 0.000 description 7
• 239000011148 porous material Substances 0.000 description 7
• 238000002360 preparation method Methods 0.000 description 7
• 239000011734 sodium Substances 0.000 description 7
• 239000000758 substrate Substances 0.000 description 7
• 241000283707 Capra Species 0.000 description 6
• 238000002965 ELISA Methods 0.000 description 6
• UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 6
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 6
• 229930012538 Paclitaxel Natural products 0.000 description 6
• 206010035226 Plasma cell myeloma Diseases 0.000 description 6
• 229920001213 Polysorbate 20 Polymers 0.000 description 6
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 6
• 235000004279 alanine Nutrition 0.000 description 6
• 239000012491 analyte Substances 0.000 description 6
• 229960002170 azathioprine Drugs 0.000 description 6
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 6
• 239000002775 capsule Substances 0.000 description 6
• 238000003776 cleavage reaction Methods 0.000 description 6
• 238000013270 controlled release Methods 0.000 description 6
• 230000004069 differentiation Effects 0.000 description 6
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 6
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 6
• 229940072221 immunoglobulins Drugs 0.000 description 6
• 150000002500 ions Chemical class 0.000 description 6
• 210000004072 lung Anatomy 0.000 description 6
• 238000002703 mutagenesis Methods 0.000 description 6
• 231100000350 mutagenesis Toxicity 0.000 description 6
• 229960001592 paclitaxel Drugs 0.000 description 6
• 210000002381 plasma Anatomy 0.000 description 6
• 229920000642 polymer Polymers 0.000 description 6
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 6
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 6
• 239000000843 powder Substances 0.000 description 6
• 230000000770 proinflammatory effect Effects 0.000 description 6
• 238000003127 radioimmunoassay Methods 0.000 description 6
• 230000002441 reversible effect Effects 0.000 description 6
• 230000007017 scission Effects 0.000 description 6
• 230000003248 secreting effect Effects 0.000 description 6
• 230000035939 shock Effects 0.000 description 6
• 239000011780 sodium chloride Substances 0.000 description 6
• 229960001940 sulfasalazine Drugs 0.000 description 6
• NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 6
• NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 6
• 239000000725 suspension Substances 0.000 description 6
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 6
• 238000012360 testing method Methods 0.000 description 6
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 5
• 108020004511 Recombinant DNA Proteins 0.000 description 5
• 239000013543 active substance Substances 0.000 description 5
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 5
• 150000001720 carbohydrates Chemical class 0.000 description 5
• RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 5
• 229960000590 celecoxib Drugs 0.000 description 5
• 230000001413 cellular effect Effects 0.000 description 5
• 239000006185 dispersion Substances 0.000 description 5
• 229940079593 drug Drugs 0.000 description 5
• 238000007710 freezing Methods 0.000 description 5
• 230000004927 fusion Effects 0.000 description 5
• 238000001415 gene therapy Methods 0.000 description 5
• 125000003147 glycosyl group Chemical group 0.000 description 5
• 238000002744 homologous recombination Methods 0.000 description 5
• 230000006801 homologous recombination Effects 0.000 description 5
• 238000002649 immunization Methods 0.000 description 5
• 238000007912 intraperitoneal administration Methods 0.000 description 5
• 238000002955 isolation Methods 0.000 description 5
• 239000003446 ligand Substances 0.000 description 5
• 210000004698 lymphocyte Anatomy 0.000 description 5
• 239000003550 marker Substances 0.000 description 5
• 230000004048 modification Effects 0.000 description 5
• 238000012986 modification Methods 0.000 description 5
• 201000000050 myeloid neoplasm Diseases 0.000 description 5
• 239000003921 oil Substances 0.000 description 5
• 235000019198 oils Nutrition 0.000 description 5
• 230000003287 optical effect Effects 0.000 description 5
• 210000001236 prokaryotic cell Anatomy 0.000 description 5
• 229920005989 resin Polymers 0.000 description 5
• 239000011347 resin Substances 0.000 description 5
• 239000007921 spray Substances 0.000 description 5
• 238000007920 subcutaneous administration Methods 0.000 description 5
• 238000013268 sustained release Methods 0.000 description 5
• 239000012730 sustained-release form Substances 0.000 description 5
• 238000001890 transfection Methods 0.000 description 5
• 230000004614 tumor growth Effects 0.000 description 5
• 210000002700 urine Anatomy 0.000 description 5
• UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 4
• IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 4
• 108090001008 Avidin Proteins 0.000 description 4
• 241000894006 Bacteria Species 0.000 description 4
• 206010010356 Congenital anomaly Diseases 0.000 description 4
• 241001327708 Coriaria sarmentosa Species 0.000 description 4
• 108010010803 Gelatin Proteins 0.000 description 4
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 4
• 241000282567 Macaca fascicularis Species 0.000 description 4
• 108091028043 Nucleic acid sequence Proteins 0.000 description 4
• 239000004365 Protease Substances 0.000 description 4
• 108700019146 Transgenes Proteins 0.000 description 4
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 4
• CCAZWUJBLXKBAY-ULZPOIKGSA-N Tutin Chemical compound C([C@]12[C@@H]3O[C@@H]3[C@@]3(O)[C@H]4C(=O)O[C@@H]([C@H]([C@]32C)O)[C@H]4C(=C)C)O1 CCAZWUJBLXKBAY-ULZPOIKGSA-N 0.000 description 4
• 239000002671 adjuvant Substances 0.000 description 4
• 239000000556 agonist Substances 0.000 description 4
• 239000003708 ampul Substances 0.000 description 4
• 239000002246 antineoplastic agent Substances 0.000 description 4
• 230000001580 bacterial effect Effects 0.000 description 4
• 230000008901 benefit Effects 0.000 description 4
• 235000014633 carbohydrates Nutrition 0.000 description 4
• 239000000969 carrier Substances 0.000 description 4
• 238000004113 cell culture Methods 0.000 description 4
• 238000001142 circular dichroism spectrum Methods 0.000 description 4
• 239000011248 coating agent Substances 0.000 description 4
• 238000000576 coating method Methods 0.000 description 4
• 239000012141 concentrate Substances 0.000 description 4
• 229920001577 copolymer Polymers 0.000 description 4
• RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 4
• 235000018417 cysteine Nutrition 0.000 description 4
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
• 230000003247 decreasing effect Effects 0.000 description 4
• 230000003111 delayed effect Effects 0.000 description 4
• 238000004925 denaturation Methods 0.000 description 4
• 230000036425 denaturation Effects 0.000 description 4
• 238000006073 displacement reaction Methods 0.000 description 4
• 229960004679 doxorubicin Drugs 0.000 description 4
• 239000000839 emulsion Substances 0.000 description 4
• 210000002889 endothelial cell Anatomy 0.000 description 4
• 238000002270 exclusion chromatography Methods 0.000 description 4
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 4
• 235000019152 folic acid Nutrition 0.000 description 4
• 239000011724 folic acid Substances 0.000 description 4
• 238000013467 fragmentation Methods 0.000 description 4
• 238000006062 fragmentation reaction Methods 0.000 description 4
• 230000008014 freezing Effects 0.000 description 4
• 229920000159 gelatin Polymers 0.000 description 4
• 239000008273 gelatin Substances 0.000 description 4
• 229940014259 gelatin Drugs 0.000 description 4
• 235000019322 gelatine Nutrition 0.000 description 4
• 235000011852 gelatine desserts Nutrition 0.000 description 4
• 230000001279 glycosylating effect Effects 0.000 description 4
• 230000012010 growth Effects 0.000 description 4
• 230000005847 immunogenicity Effects 0.000 description 4
• 238000011534 incubation Methods 0.000 description 4
• 238000007918 intramuscular administration Methods 0.000 description 4
• 239000008176 lyophilized powder Substances 0.000 description 4
• 230000001404 mediated effect Effects 0.000 description 4
• 239000012528 membrane Substances 0.000 description 4
• KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 4
• 229960004963 mesalazine Drugs 0.000 description 4
• 210000000822 natural killer cell Anatomy 0.000 description 4
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 4
• 239000002674 ointment Substances 0.000 description 4
• 239000000546 pharmaceutical excipient Substances 0.000 description 4
• 239000012071 phase Substances 0.000 description 4
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
• 229960004618 prednisone Drugs 0.000 description 4
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 4
• 238000004321 preservation Methods 0.000 description 4
• 239000003755 preservative agent Substances 0.000 description 4
• 230000002265 prevention Effects 0.000 description 4
• 238000012545 processing Methods 0.000 description 4
• 239000000047 product Substances 0.000 description 4
• 230000006920 protein precipitation Effects 0.000 description 4
• RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 4
• 238000010188 recombinant method Methods 0.000 description 4
• 230000002829 reductive effect Effects 0.000 description 4
• 230000028327 secretion Effects 0.000 description 4
• 239000002904 solvent Substances 0.000 description 4
• 210000000952 spleen Anatomy 0.000 description 4
• 150000003431 steroids Chemical class 0.000 description 4
• 235000000346 sugar Nutrition 0.000 description 4
• 239000006228 supernatant Substances 0.000 description 4
• 238000010257 thawing Methods 0.000 description 4
• 238000002560 therapeutic procedure Methods 0.000 description 4
• 230000009466 transformation Effects 0.000 description 4
• 239000000080 wetting agent Substances 0.000 description 4
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
• VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 3
• 239000005541 ACE inhibitor Substances 0.000 description 3
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
• 206010003402 Arthropod sting Diseases 0.000 description 3
• 241000282693 Cercopithecidae Species 0.000 description 3
• 102000008186 Collagen Human genes 0.000 description 3
• 108010035532 Collagen Proteins 0.000 description 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 3
• 239000012624 DNA alkylating agent Substances 0.000 description 3
• 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 description 3
• 101100234002 Drosophila melanogaster Shal gene Proteins 0.000 description 3
• 241000196324 Embryophyta Species 0.000 description 3
• 235000002757 Erythrina edulis Nutrition 0.000 description 3
• 240000008187 Erythrina edulis Species 0.000 description 3
• 241000282326 Felis catus Species 0.000 description 3
• 102000009123 Fibrin Human genes 0.000 description 3
• 108010073385 Fibrin Proteins 0.000 description 3
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
• 235000008730 Ficus carica Nutrition 0.000 description 3
• 244000025361 Ficus carica Species 0.000 description 3
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 3
• 108090000288 Glycoproteins Proteins 0.000 description 3
• 102000003886 Glycoproteins Human genes 0.000 description 3
• 101001022170 Homo sapiens FYN-binding protein 2 Proteins 0.000 description 3
• 101000990990 Homo sapiens Midkine Proteins 0.000 description 3
• 108700005091 Immunoglobulin Genes Proteins 0.000 description 3
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
• 239000005411 L01XE02 - Gefitinib Substances 0.000 description 3
• 239000005551 L01XE03 - Erlotinib Substances 0.000 description 3
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
• 108060001084 Luciferase Proteins 0.000 description 3
• 239000005089 Luciferase Substances 0.000 description 3
• FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 3
• 102100030335 Midkine Human genes 0.000 description 3
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 3
• 241000283973 Oryctolagus cuniculus Species 0.000 description 3
• 108090000526 Papain Proteins 0.000 description 3
• 229920002732 Polyanhydride Polymers 0.000 description 3
• 229920000954 Polyglycolide Polymers 0.000 description 3
• 241000288906 Primates Species 0.000 description 3
• 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 description 3
• 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 description 3
• 241000283984 Rodentia Species 0.000 description 3
• 229920002684 Sepharose Polymers 0.000 description 3
• 235000015076 Shorea robusta Nutrition 0.000 description 3
• 244000166071 Shorea robusta Species 0.000 description 3
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
• 229930006000 Sucrose Natural products 0.000 description 3
• 210000001744 T-lymphocyte Anatomy 0.000 description 3
• 239000000317 Topoisomerase II Inhibitor Substances 0.000 description 3
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
• 239000004480 active ingredient Substances 0.000 description 3
• 229940009456 adriamycin Drugs 0.000 description 3
• 210000000628 antibody-producing cell Anatomy 0.000 description 3
• 230000000890 antigenic effect Effects 0.000 description 3
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 3
• 230000009286 beneficial effect Effects 0.000 description 3
• 210000004204 blood vessel Anatomy 0.000 description 3
• 210000004556 brain Anatomy 0.000 description 3
• 210000004899 c-terminal region Anatomy 0.000 description 3
• 229960004562 carboplatin Drugs 0.000 description 3
• 230000004663 cell proliferation Effects 0.000 description 3
• 239000001913 cellulose Chemical class 0.000 description 3
• 235000010980 cellulose Nutrition 0.000 description 3
• 229920002678 cellulose Chemical class 0.000 description 3
• 239000003153 chemical reaction reagent Substances 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 238000002983 circular dichroism Methods 0.000 description 3
• 238000000978 circular dichroism spectroscopy Methods 0.000 description 3
• 229960004316 cisplatin Drugs 0.000 description 3
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 3
• 229920001436 collagen Polymers 0.000 description 3
• 238000002648 combination therapy Methods 0.000 description 3
• 230000009137 competitive binding Effects 0.000 description 3
• 230000002860 competitive effect Effects 0.000 description 3
• 229940111134 coxibs Drugs 0.000 description 3
• 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 3
• 239000003085 diluting agent Substances 0.000 description 3
• 229960003668 docetaxel Drugs 0.000 description 3
• 235000001159 dosh Nutrition 0.000 description 3
• 244000245171 dosh Species 0.000 description 3
• 230000009977 dual effect Effects 0.000 description 3
• 238000004520 electroporation Methods 0.000 description 3
• 230000002255 enzymatic effect Effects 0.000 description 3
• 229960001433 erlotinib Drugs 0.000 description 3
• AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 description 3
• 229950003499 fibrin Drugs 0.000 description 3
• 239000000945 filler Substances 0.000 description 3
• 238000000684 flow cytometry Methods 0.000 description 3
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 3
• 229960002949 fluorouracil Drugs 0.000 description 3
• 235000008191 folinic acid Nutrition 0.000 description 3
• 239000011672 folinic acid Substances 0.000 description 3
• VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 3
• XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 3
• 229960002584 gefitinib Drugs 0.000 description 3
• 229960005277 gemcitabine Drugs 0.000 description 3
• 229940020967 gemzar Drugs 0.000 description 3
• 230000002068 genetic effect Effects 0.000 description 3
• 150000004676 glycans Chemical class 0.000 description 3
• 108091005608 glycosylated proteins Proteins 0.000 description 3
• 102000035122 glycosylated proteins Human genes 0.000 description 3
• 210000005260 human cell Anatomy 0.000 description 3
• 230000036571 hydration Effects 0.000 description 3
• 238000006703 hydration reaction Methods 0.000 description 3
• 239000012216 imaging agent Substances 0.000 description 3
• 230000001900 immune effect Effects 0.000 description 3
• 230000028993 immune response Effects 0.000 description 3
• 239000007943 implant Substances 0.000 description 3
• 238000003780 insertion Methods 0.000 description 3
• 230000037431 insertion Effects 0.000 description 3
• 229960004768 irinotecan Drugs 0.000 description 3
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 3
• 239000008101 lactose Substances 0.000 description 3
• 229960001691 leucovorin Drugs 0.000 description 3
• 230000000670 limiting effect Effects 0.000 description 3
• 239000002502 liposome Substances 0.000 description 3
• 239000012669 liquid formulation Substances 0.000 description 3
• 239000003589 local anesthetic agent Substances 0.000 description 3
• 210000001165 lymph node Anatomy 0.000 description 3
• 229920002521 macromolecule Polymers 0.000 description 3
• 239000011159 matrix material Substances 0.000 description 3
• 230000008018 melting Effects 0.000 description 3
• 238000002844 melting Methods 0.000 description 3
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 3
• 229960001428 mercaptopurine Drugs 0.000 description 3
• 229960004110 olsalazine Drugs 0.000 description 3
• QQBDLJCYGRGAKP-FOCLMDBBSA-N olsalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=C(C(O)=CC=2)C(O)=O)=C1 QQBDLJCYGRGAKP-FOCLMDBBSA-N 0.000 description 3
• 238000012856 packing Methods 0.000 description 3
• 229940055729 papain Drugs 0.000 description 3
• 235000019834 papain Nutrition 0.000 description 3
• 229960005489 paracetamol Drugs 0.000 description 3
• 239000002245 particle Substances 0.000 description 3
• 230000037361 pathway Effects 0.000 description 3
• 238000002823 phage display Methods 0.000 description 3
• 229920000747 poly(lactic acid) Polymers 0.000 description 3
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
• 230000035755 proliferation Effects 0.000 description 3
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 3
• 238000001742 protein purification Methods 0.000 description 3
• 239000012460 protein solution Substances 0.000 description 3
• 230000009257 reactivity Effects 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 238000006722 reduction reaction Methods 0.000 description 3
• 238000011160 research Methods 0.000 description 3
• 230000004044 response Effects 0.000 description 3
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 3
• 230000035945 sensitivity Effects 0.000 description 3
• 238000013207 serial dilution Methods 0.000 description 3
• 230000011664 signaling Effects 0.000 description 3
• 230000007781 signaling event Effects 0.000 description 3
• 150000003384 small molecules Chemical class 0.000 description 3
• 235000014347 soups Nutrition 0.000 description 3
• 210000004988 splenocyte Anatomy 0.000 description 3
• 239000003381 stabilizer Substances 0.000 description 3
• 230000000087 stabilizing effect Effects 0.000 description 3
• 238000003860 storage Methods 0.000 description 3
• 239000005720 sucrose Substances 0.000 description 3
• 210000001179 synovial fluid Anatomy 0.000 description 3
• 238000003786 synthesis reaction Methods 0.000 description 3
• 230000005030 transcription termination Effects 0.000 description 3
• 238000011830 transgenic mouse model Methods 0.000 description 3
• 238000013519 translation Methods 0.000 description 3
• 239000011534 wash buffer Substances 0.000 description 3
• 238000005406 washing Methods 0.000 description 3
• 235000014101 wine Nutrition 0.000 description 3
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
• VDPLLINNMXFNQX-UHFFFAOYSA-N (1-aminocyclohexyl)methanol Chemical compound OCC1(N)CCCCC1 VDPLLINNMXFNQX-UHFFFAOYSA-N 0.000 description 2
• 229930182837 (R)-adrenaline Natural products 0.000 description 2
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
• IJJWOSAXNHWBPR-HUBLWGQQSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-(6-hydrazinyl-6-oxohexyl)pentanamide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)NCCCCCC(=O)NN)SC[C@@H]21 IJJWOSAXNHWBPR-HUBLWGQQSA-N 0.000 description 2
• 102100027211 Albumin Human genes 0.000 description 2
• 108010088751 Albumins Chemical class 0.000 description 2
• 241001279686 Allium moly Species 0.000 description 2
• 241000272517 Anseriformes Species 0.000 description 2
• 239000004475 Arginine Substances 0.000 description 2
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
• 241000283690 Bos taurus Species 0.000 description 2
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
• OWNRRUFOJXFKCU-UHFFFAOYSA-N Bromadiolone Chemical compound C=1C=C(C=2C=CC(Br)=CC=2)C=CC=1C(O)CC(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=CC=C1 OWNRRUFOJXFKCU-UHFFFAOYSA-N 0.000 description 2
• VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 2
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
• 241000283153 Cetacea Species 0.000 description 2
• 108091026890 Coding region Proteins 0.000 description 2
• 206010010071 Coma Diseases 0.000 description 2
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
• 229920002261 Corn starch Polymers 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
• 102000053602 DNA Human genes 0.000 description 2
• 229940126161 DNA alkylating agent Drugs 0.000 description 2
• 229920002307 Dextran Polymers 0.000 description 2
• 241000283086 Equidae Species 0.000 description 2
• 102000003951 Erythropoietin Human genes 0.000 description 2
• 108090000394 Erythropoietin Proteins 0.000 description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
• 241000206602 Eukaryota Species 0.000 description 2
• 108091029865 Exogenous DNA Proteins 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 235000010469 Glycine max Nutrition 0.000 description 2
• 108010051696 Growth Hormone Proteins 0.000 description 2
• 101000939500 Homo sapiens UBX domain-containing protein 11 Proteins 0.000 description 2
• 101000935117 Homo sapiens Voltage-dependent P/Q-type calcium channel subunit alpha-1A Proteins 0.000 description 2
• 108090000144 Human Proteins Proteins 0.000 description 2
• 102000003839 Human Proteins Human genes 0.000 description 2
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
• 101150087317 IDE gene Proteins 0.000 description 2
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
• 229930195725 Mannitol Natural products 0.000 description 2
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
• 241001494479 Pecora Species 0.000 description 2
• 102000057297 Pepsin A Human genes 0.000 description 2
• 108090000284 Pepsin A Proteins 0.000 description 2
• 241001442654 Percnon planissimum Species 0.000 description 2
• 206010057249 Phagocytosis Diseases 0.000 description 2
• 108010004729 Phycoerythrin Proteins 0.000 description 2
• 229920001710 Polyorthoester Polymers 0.000 description 2
• 239000004372 Polyvinyl alcohol Substances 0.000 description 2
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
• 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 description 2
• 240000005481 Salvia hispanica Species 0.000 description 2
• 235000001498 Salvia hispanica Nutrition 0.000 description 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• 229920002125 Sokalan® Polymers 0.000 description 2
• 102100038803 Somatotropin Human genes 0.000 description 2
• 240000006394 Sorghum bicolor Species 0.000 description 2
• 235000011684 Sorghum saccharatum Nutrition 0.000 description 2
• 241000282887 Suidae Species 0.000 description 2
• 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 description 2
• 235000009430 Thespesia populnea Nutrition 0.000 description 2
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
• 102100029645 UBX domain-containing protein 11 Human genes 0.000 description 2
• 229910052770 Uranium Inorganic materials 0.000 description 2
• 229960001138 acetylsalicylic acid Drugs 0.000 description 2
• 230000002411 adverse Effects 0.000 description 2
• 239000011543 agarose gel Substances 0.000 description 2
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
• 239000003263 anabolic agent Substances 0.000 description 2
• 230000003444 anaesthetic effect Effects 0.000 description 2
• 230000000202 analgesic effect Effects 0.000 description 2
• 150000001450 anions Chemical class 0.000 description 2
• 230000001088 anti-asthma Effects 0.000 description 2
• 230000003092 anti-cytokine Effects 0.000 description 2
• 230000001430 anti-depressive effect Effects 0.000 description 2
• 230000003110 anti-inflammatory effect Effects 0.000 description 2
• 230000000845 anti-microbial effect Effects 0.000 description 2
• 230000000561 anti-psychotic effect Effects 0.000 description 2
• 230000000259 anti-tumor effect Effects 0.000 description 2
• 239000000924 antiasthmatic agent Substances 0.000 description 2
• 239000000935 antidepressant agent Substances 0.000 description 2
• 229940005513 antidepressants Drugs 0.000 description 2
• 229940030999 antipsoriatics Drugs 0.000 description 2
• 239000003435 antirheumatic agent Substances 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
• 238000002820 assay format Methods 0.000 description 2
• 208000027697 autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency Diseases 0.000 description 2
• 235000013405 beer Nutrition 0.000 description 2
• 229940125388 beta agonist Drugs 0.000 description 2
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
• 239000013060 biological fluid Substances 0.000 description 2
• 230000031018 biological processes and functions Effects 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 210000000988 bone and bone Anatomy 0.000 description 2
• 229940098773 bovine serum albumin Drugs 0.000 description 2
• 210000000481 breast Anatomy 0.000 description 2
• 229960004436 budesonide Drugs 0.000 description 2
• 239000007853 buffer solution Substances 0.000 description 2
• 239000004067 bulking agent Substances 0.000 description 2
• 239000001506 calcium phosphate Substances 0.000 description 2
• 229910000389 calcium phosphate Inorganic materials 0.000 description 2
• 235000011010 calcium phosphates Nutrition 0.000 description 2
• 150000001768 cations Chemical class 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 239000007795 chemical reaction product Substances 0.000 description 2
• 239000012829 chemotherapy agent Substances 0.000 description 2
• 235000014167 chia Nutrition 0.000 description 2
• 101150116749 chuk gene Proteins 0.000 description 2
• MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
• 238000010367 cloning Methods 0.000 description 2
• 229960001338 colchicine Drugs 0.000 description 2
• 238000002967 competitive immunoassay Methods 0.000 description 2
• 230000004540 complement-dependent cytotoxicity Effects 0.000 description 2
• 238000002591 computed tomography Methods 0.000 description 2
• 235000008504 concentrate Nutrition 0.000 description 2
• 239000003636 conditioned culture medium Substances 0.000 description 2
• 229910052802 copper Inorganic materials 0.000 description 2
• 239000010949 copper Substances 0.000 description 2
• 239000008120 corn starch Substances 0.000 description 2
• 239000006071 cream Substances 0.000 description 2
• 230000009260 cross reactivity Effects 0.000 description 2
• 239000002577 cryoprotective agent Substances 0.000 description 2
• 238000002425 crystallisation Methods 0.000 description 2
• 230000008025 crystallization Effects 0.000 description 2
• 229960002104 cyanocobalamin Drugs 0.000 description 2
• 235000000639 cyanocobalamin Nutrition 0.000 description 2
• 239000011666 cyanocobalamin Substances 0.000 description 2
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
• 239000000409 cytokine receptor agonist Substances 0.000 description 2
• 239000000430 cytokine receptor antagonist Substances 0.000 description 2
• 108010057085 cytokine receptors Proteins 0.000 description 2
• 102000003675 cytokine receptors Human genes 0.000 description 2
• 231100000135 cytotoxicity Toxicity 0.000 description 2
• 230000003013 cytotoxicity Effects 0.000 description 2
• 230000007123 defense Effects 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• CFCUWKMKBJTWLW-UHFFFAOYSA-N deoliosyl-3C-alpha-L-digitoxosyl-MTM Natural products CC=1C(O)=C2C(O)=C3C(=O)C(OC4OC(C)C(O)C(OC5OC(C)C(O)C(OC6OC(C)C(O)C(C)(O)C6)C5)C4)C(C(OC)C(=O)C(O)C(C)O)CC3=CC2=CC=1OC(OC(C)C1O)CC1OC1CC(O)C(O)C(C)O1 CFCUWKMKBJTWLW-UHFFFAOYSA-N 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 229960004193 dextropropoxyphene Drugs 0.000 description 2
• XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 description 2
• 229960001193 diclofenac sodium Drugs 0.000 description 2
• 230000008034 disappearance Effects 0.000 description 2
• 235000021186 dishes Nutrition 0.000 description 2
• 239000002612 dispersion medium Substances 0.000 description 2
• 239000003534 dna topoisomerase inhibitor Substances 0.000 description 2
• 238000012377 drug delivery Methods 0.000 description 2
• 239000000428 dust Substances 0.000 description 2
• 210000005069 ears Anatomy 0.000 description 2
• 230000008030 elimination Effects 0.000 description 2
• 238000003379 elimination reaction Methods 0.000 description 2
• 239000003995 emulsifying agent Substances 0.000 description 2
• 238000006911 enzymatic reaction Methods 0.000 description 2
• 229960005139 epinephrine Drugs 0.000 description 2
• 229940105423 erythropoietin Drugs 0.000 description 2
• 235000019441 ethanol Nutrition 0.000 description 2
• 239000005038 ethylene vinyl acetate Substances 0.000 description 2
• 239000003925 fat Substances 0.000 description 2
• 239000007850 fluorescent dye Substances 0.000 description 2
• 229940014144 folate Drugs 0.000 description 2
• 229960000304 folic acid Drugs 0.000 description 2
• 101150077246 gas5 gene Proteins 0.000 description 2
• 239000011521 glass Substances 0.000 description 2
• 239000000122 growth hormone Substances 0.000 description 2
• 238000003306 harvesting Methods 0.000 description 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
• 230000013632 homeostatic process Effects 0.000 description 2
• 235000012907 honey Nutrition 0.000 description 2
• 238000002657 hormone replacement therapy Methods 0.000 description 2
• 229960002764 hydrocodone bitartrate Drugs 0.000 description 2
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 229960001680 ibuprofen Drugs 0.000 description 2
• 239000005457 ice water Substances 0.000 description 2
• 238000003384 imaging method Methods 0.000 description 2
• 210000000987 immune system Anatomy 0.000 description 2
• 238000003018 immunoassay Methods 0.000 description 2
• 229960003444 immunosuppressant agent Drugs 0.000 description 2
• 230000001861 immunosuppressant effect Effects 0.000 description 2
• 239000003018 immunosuppressive agent Substances 0.000 description 2
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 229960000598 infliximab Drugs 0.000 description 2
• 238000010255 intramuscular injection Methods 0.000 description 2
• 239000007927 intramuscular injection Substances 0.000 description 2
• 238000010253 intravenous injection Methods 0.000 description 2
• 239000007951 isotonicity adjuster Substances 0.000 description 2
• 238000002372 labelling Methods 0.000 description 2
• 239000000787 lecithin Substances 0.000 description 2
• 235000010445 lecithin Nutrition 0.000 description 2
• 229940067606 lecithin Drugs 0.000 description 2
• 229960000681 leflunomide Drugs 0.000 description 2
• VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 2
• 229960004194 lidocaine Drugs 0.000 description 2
• 238000001638 lipofection Methods 0.000 description 2
• 239000008297 liquid dosage form Substances 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 238000002595 magnetic resonance imaging Methods 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 235000010355 mannitol Nutrition 0.000 description 2
• 230000007246 mechanism Effects 0.000 description 2
• 239000003475 metalloproteinase inhibitor Substances 0.000 description 2
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
• OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 description 2
• 229960004584 methylprednisolone Drugs 0.000 description 2
• 229960000282 metronidazole Drugs 0.000 description 2
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
• 239000011859 microparticle Substances 0.000 description 2
• 229960005249 misoprostol Drugs 0.000 description 2
• 238000012544 monitoring process Methods 0.000 description 2
• 210000000214 mouth Anatomy 0.000 description 2
• 210000004877 mucosa Anatomy 0.000 description 2
• 239000003158 myorelaxant agent Substances 0.000 description 2
• 230000003533 narcotic effect Effects 0.000 description 2
• 239000000842 neuromuscular blocking agent Substances 0.000 description 2
• 150000002482 oligosaccharides Chemical class 0.000 description 2
• 229960000381 omeprazole Drugs 0.000 description 2
• SBQLYHNEIUGQKH-UHFFFAOYSA-N omeprazole Chemical compound N1=C2[CH]C(OC)=CC=C2N=C1S(=O)CC1=NC=C(C)C(OC)=C1C SBQLYHNEIUGQKH-UHFFFAOYSA-N 0.000 description 2
• 238000011275 oncology therapy Methods 0.000 description 2
• 210000000056 organ Anatomy 0.000 description 2
• 210000000496 pancreas Anatomy 0.000 description 2
• 229940111202 pepsin Drugs 0.000 description 2
• 230000008782 phagocytosis Effects 0.000 description 2
• 235000013550 pizza Nutrition 0.000 description 2
• 231100000614 poison Toxicity 0.000 description 2
• 239000002574 poison Substances 0.000 description 2
• 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
• 229920002401 polyacrylamide Polymers 0.000 description 2
• 239000004584 polyacrylic acid Substances 0.000 description 2
• 239000004626 polylactic acid Substances 0.000 description 2
• 229920002451 polyvinyl alcohol Polymers 0.000 description 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
• 230000004481 post-translational protein modification Effects 0.000 description 2
• 229960004919 procaine Drugs 0.000 description 2
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 2
• 239000003380 propellant Substances 0.000 description 2
• 230000006432 protein unfolding Effects 0.000 description 2
• 229950010131 puromycin Drugs 0.000 description 2
• LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
• 230000005855 radiation Effects 0.000 description 2
• 230000002285 radioactive effect Effects 0.000 description 2
• 239000000941 radioactive substance Substances 0.000 description 2
• 239000012217 radiopharmaceutical Substances 0.000 description 2
• 229940121896 radiopharmaceutical Drugs 0.000 description 2
• 230000002799 radiopharmaceutical effect Effects 0.000 description 2
• 238000001959 radiotherapy Methods 0.000 description 2
• 210000000664 rectum Anatomy 0.000 description 2
• 230000000717 retained effect Effects 0.000 description 2
• 239000012465 retentate Substances 0.000 description 2
• 230000001177 retroviral effect Effects 0.000 description 2
• 101150006257 rig-4 gene Proteins 0.000 description 2
• 210000003296 saliva Anatomy 0.000 description 2
• WVYADZUPLLSGPU-UHFFFAOYSA-N salsalate Chemical compound OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O WVYADZUPLLSGPU-UHFFFAOYSA-N 0.000 description 2
• 238000007790 scraping Methods 0.000 description 2
• 239000000932 sedative agent Substances 0.000 description 2
• 230000001624 sedative effect Effects 0.000 description 2
• 230000008054 signal transmission Effects 0.000 description 2
• 238000001542 size-exclusion chromatography Methods 0.000 description 2
• 230000007958 sleep Effects 0.000 description 2
• 210000000813 small intestine Anatomy 0.000 description 2
• 239000000779 smoke Substances 0.000 description 2
• 239000001488 sodium phosphate Substances 0.000 description 2
• 229910000162 sodium phosphate Inorganic materials 0.000 description 2
• JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 2
• 239000007790 solid phase Substances 0.000 description 2
• 235000010356 sorbitol Nutrition 0.000 description 2
• 239000000600 sorbitol Substances 0.000 description 2
• 238000001228 spectrum Methods 0.000 description 2
• 210000002784 stomach Anatomy 0.000 description 2
• 238000010254 subcutaneous injection Methods 0.000 description 2
• 239000007929 subcutaneous injection Substances 0.000 description 2
• 239000000375 suspending agent Substances 0.000 description 2
• 239000006188 syrup Substances 0.000 description 2
• 235000020357 syrup Nutrition 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
• 238000011200 topical administration Methods 0.000 description 2
• 229940044693 topoisomerase inhibitor Drugs 0.000 description 2
• 231100000331 toxic Toxicity 0.000 description 2
• 230000002588 toxic effect Effects 0.000 description 2
• 230000007704 transition Effects 0.000 description 2
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
• 230000005747 tumor angiogenesis Effects 0.000 description 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
• 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 2
• 210000005166 vasculature Anatomy 0.000 description 2
• 239000013603 viral vector Substances 0.000 description 2
• XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
• BFNXYSZBURSNHS-UVJOBNTFSA-N (2s)-1-[(2s)-6-amino-2-[[(1s)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;6-chloro-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O.C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 BFNXYSZBURSNHS-UVJOBNTFSA-N 0.000 description 1
• OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 description 1
• LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
• OTHYPAMNTUGKDK-UHFFFAOYSA-N (3-acetylphenyl) acetate Chemical compound CC(=O)OC1=CC=CC(C(C)=O)=C1 OTHYPAMNTUGKDK-UHFFFAOYSA-N 0.000 description 1
• DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 description 1
• MTDHILKWIRSIHB-UHFFFAOYSA-N (5-azaniumyl-3,4,6-trihydroxyoxan-2-yl)methyl sulfate Chemical compound NC1C(O)OC(COS(O)(=O)=O)C(O)C1O MTDHILKWIRSIHB-UHFFFAOYSA-N 0.000 description 1
• PQMFVUNERGGBPG-UHFFFAOYSA-N (6-bromopyridin-2-yl)hydrazine Chemical compound NNC1=CC=CC(Br)=N1 PQMFVUNERGGBPG-UHFFFAOYSA-N 0.000 description 1
• HMLGSIZOMSVISS-ONJSNURVSA-N (7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N([C@@H]1C(N2C(=C(C=C)CSC21)C(O)=O)=O)C(=O)\C(=N/OCOC(=O)C(C)(C)C)C1=CSC(N)=N1 HMLGSIZOMSVISS-ONJSNURVSA-N 0.000 description 1
• METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 1
• RZPZLFIUFMNCLY-WLHGVMLRSA-N (e)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol Chemical compound OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1 RZPZLFIUFMNCLY-WLHGVMLRSA-N 0.000 description 1
• DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
• RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
• UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 1
• PRPINYUDVPFIRX-UHFFFAOYSA-N 1-naphthaleneacetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CC=CC2=C1 PRPINYUDVPFIRX-UHFFFAOYSA-N 0.000 description 1
• PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
• BKUSIKGSPSFQAC-RRKCRQDMSA-N 2'-deoxyinosine-5'-diphosphate Chemical compound O1[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(NC=NC2=O)=C2N=C1 BKUSIKGSPSFQAC-RRKCRQDMSA-N 0.000 description 1
• SZXUTTGMFUSMCE-UHFFFAOYSA-N 2-(1h-imidazol-2-yl)pyridine Chemical class C1=CNC(C=2N=CC=CC=2)=N1 SZXUTTGMFUSMCE-UHFFFAOYSA-N 0.000 description 1
• ZAVJTSLIGAGALR-UHFFFAOYSA-N 2-(2,2,2-trifluoroacetyl)cyclooctan-1-one Chemical compound FC(F)(F)C(=O)C1CCCCCCC1=O ZAVJTSLIGAGALR-UHFFFAOYSA-N 0.000 description 1
• MIJDSYMOBYNHOT-UHFFFAOYSA-N 2-(ethylamino)ethanol Chemical compound CCNCCO MIJDSYMOBYNHOT-UHFFFAOYSA-N 0.000 description 1
• FEDJGPQLLNQAIY-UHFFFAOYSA-N 2-[(6-oxo-1h-pyridazin-3-yl)oxy]acetic acid Chemical compound OC(=O)COC=1C=CC(=O)NN=1 FEDJGPQLLNQAIY-UHFFFAOYSA-N 0.000 description 1
• NBGAYCYFNGPNPV-UHFFFAOYSA-N 2-aminooxybenzoic acid Chemical class NOC1=CC=CC=C1C(O)=O NBGAYCYFNGPNPV-UHFFFAOYSA-N 0.000 description 1
• RGHMISIYKIHAJW-UHFFFAOYSA-N 3,4-dihydroxymandelic acid Chemical compound OC(=O)C(O)C1=CC=C(O)C(O)=C1 RGHMISIYKIHAJW-UHFFFAOYSA-N 0.000 description 1
• MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 description 1
• NBUHTTJGQKIBMR-UHFFFAOYSA-N 4,6-dimethylpyrimidin-5-amine Chemical compound CC1=NC=NC(C)=C1N NBUHTTJGQKIBMR-UHFFFAOYSA-N 0.000 description 1
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
• WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 1
• RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 description 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
• CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 1
• NVOYVOBDTVTBDX-AGUVMIOSSA-N 8g15t83e6i Chemical compound C1([C@@H](CO)C(=O)OC2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)CC)=CC=CC=C1 NVOYVOBDTVTBDX-AGUVMIOSSA-N 0.000 description 1
• LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 1
• 241000218642 Abies Species 0.000 description 1
• 244000215068 Acacia senegal Species 0.000 description 1
• 102000012440 Acetylcholinesterase Human genes 0.000 description 1
• 108010022752 Acetylcholinesterase Proteins 0.000 description 1
• 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
• 208000002874 Acne Vulgaris Diseases 0.000 description 1
• 206010069754 Acquired gene mutation Diseases 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 102000007469 Actins Human genes 0.000 description 1
• 240000006054 Agastache cana Species 0.000 description 1
• 244000005894 Albizia lebbeck Species 0.000 description 1
• OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 description 1
• 235000019489 Almond oil Nutrition 0.000 description 1
• 241001116389 Aloe Species 0.000 description 1
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
• 102100030988 Angiotensin-converting enzyme Human genes 0.000 description 1
• 235000002198 Annona diversifolia Nutrition 0.000 description 1
• 101150104773 Apoh gene Proteins 0.000 description 1
• 108010039627 Aprotinin Proteins 0.000 description 1
• 200000000007 Arterial disease Diseases 0.000 description 1
• 206010003571 Astrocytoma Diseases 0.000 description 1
• 208000023275 Autoimmune disease Diseases 0.000 description 1
• 206010061692 Benign muscle neoplasm Diseases 0.000 description 1
• 102100026189 Beta-galactosidase Human genes 0.000 description 1
• 241000566113 Branta sandvicensis Species 0.000 description 1
• 235000014698 Brassica juncea var multisecta Nutrition 0.000 description 1
• 239000002083 C09CA01 - Losartan Substances 0.000 description 1
• 239000004072 C09CA03 - Valsartan Substances 0.000 description 1
• 101100024000 Caenorhabditis elegans mom-5 gene Proteins 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 241000282832 Camelidae Species 0.000 description 1
• 201000009030 Carcinoma Diseases 0.000 description 1
• 241000700198 Cavia Species 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 1
• 229920001268 Cholestyramine Polymers 0.000 description 1
• 241000251730 Chondrichthyes Species 0.000 description 1
• 229920002567 Chondroitin Polymers 0.000 description 1
• 208000006332 Choriocarcinoma Diseases 0.000 description 1
• 244000035851 Chrysanthemum leucanthemum Species 0.000 description 1
• 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
• 241000132536 Cirsium Species 0.000 description 1
• 108020004635 Complementary DNA Chemical group 0.000 description 1
• 241000699800 Cricetinae Species 0.000 description 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 description 1
• 108010092160 Dactinomycin Proteins 0.000 description 1
• 101000616562 Danio rerio Sonic hedgehog protein A Proteins 0.000 description 1
• XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
• 241000632511 Daviesia arborea Species 0.000 description 1
• 206010012177 Deja vu Diseases 0.000 description 1
• 101150105088 Dele1 gene Proteins 0.000 description 1
• 241000702421 Dependoparvovirus Species 0.000 description 1
• 206010012646 Diabetic blindness Diseases 0.000 description 1
• 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
• LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
• 241001397104 Dima Species 0.000 description 1
• 241001649081 Dina Species 0.000 description 1
• 235000008597 Diospyros kaki Nutrition 0.000 description 1
• 244000236655 Diospyros kaki Species 0.000 description 1
• 235000008247 Echinochloa frumentacea Nutrition 0.000 description 1
• 241000168022 Elaphurus davidianus Species 0.000 description 1
• MBYXEBXZARTUSS-QLWBXOBMSA-N Emetamine Natural products O(C)c1c(OC)cc2c(c(C[C@@H]3[C@H](CC)CN4[C@H](c5c(cc(OC)c(OC)c5)CC4)C3)ncc2)c1 MBYXEBXZARTUSS-QLWBXOBMSA-N 0.000 description 1
• 108010061435 Enalapril Proteins 0.000 description 1
• 102400001368 Epidermal growth factor Human genes 0.000 description 1
• 101800003838 Epidermal growth factor Proteins 0.000 description 1
• 241000283074 Equus asinus Species 0.000 description 1
• 206010015150 Erythema Diseases 0.000 description 1
• 241001524679 Escherichia virus M13 Species 0.000 description 1
• 108010008165 Etanercept Proteins 0.000 description 1
• 235000014066 European mistletoe Nutrition 0.000 description 1
• 208000023281 Fallot tetralogy Diseases 0.000 description 1
• 108010049003 Fibrinogen Proteins 0.000 description 1
• 102000008946 Fibrinogen Human genes 0.000 description 1
• 241000724791 Filamentous phage Species 0.000 description 1
• WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 description 1
• PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 230000005526 G1 to G0 transition Effects 0.000 description 1
• 229910052688 Gadolinium Inorganic materials 0.000 description 1
• 241000755093 Gaidropsarus vulgaris Species 0.000 description 1
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
• 235000008100 Ginkgo biloba Nutrition 0.000 description 1
• 244000194101 Ginkgo biloba Species 0.000 description 1
• 206010018338 Glioma Diseases 0.000 description 1
• 239000004366 Glucose oxidase Substances 0.000 description 1
• 108010015776 Glucose oxidase Proteins 0.000 description 1
• 244000068988 Glycine max Species 0.000 description 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
• 102000005744 Glycoside Hydrolases Human genes 0.000 description 1
• 108010031186 Glycoside Hydrolases Proteins 0.000 description 1
• 108700023372 Glycosyltransferases Proteins 0.000 description 1
• 108010026389 Gramicidin Proteins 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 208000017604 Hodgkin disease Diseases 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 101100508103 Homo sapiens IDE gene Proteins 0.000 description 1
• 101000901659 Homo sapiens Myotonin-protein kinase Proteins 0.000 description 1
• 101000693728 Homo sapiens S-acyl fatty acid synthase thioesterase, medium chain Proteins 0.000 description 1
• 101000633680 Homo sapiens Tetratricopeptide repeat protein 37 Proteins 0.000 description 1
• 241000257303 Hymenoptera Species 0.000 description 1
• 206010062767 Hypophysitis Diseases 0.000 description 1
• 235000010650 Hyssopus officinalis Nutrition 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
• 206010061216 Infarction Diseases 0.000 description 1
• 102000008070 Interferon-gamma Human genes 0.000 description 1
• 108010074328 Interferon-gamma Proteins 0.000 description 1
• 102000014150 Interferons Human genes 0.000 description 1
• 108010050904 Interferons Proteins 0.000 description 1
• 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
• 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 description 1
• 241000347881 Kadua laxiflora Species 0.000 description 1
• 208000007766 Kaposi sarcoma Diseases 0.000 description 1
• 108091071243 Kappa family Proteins 0.000 description 1
• 102000040712 Kappa family Human genes 0.000 description 1
• ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 description 1
• 241000087799 Koma Species 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• 241000282838 Lama Species 0.000 description 1
• 235000019687 Lamb Nutrition 0.000 description 1
• 108091071262 Lambda family Proteins 0.000 description 1
• 108090001090 Lectins Chemical group 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 208000034800 Leukoencephalopathies Diseases 0.000 description 1
• GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 description 1
• 239000000867 Lipoxygenase Inhibitor Substances 0.000 description 1
• 108010007859 Lisinopril Proteins 0.000 description 1
• 241000406668 Loxodonta cyclotis Species 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• 241000294754 Macroptilium atropurpureum Species 0.000 description 1
• 241001446467 Mama Species 0.000 description 1
• ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 description 1
• RGHAZVBIOOEVQX-UHFFFAOYSA-N Metoprolol succinate Chemical compound OC(=O)CCC(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 RGHAZVBIOOEVQX-UHFFFAOYSA-N 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 229930192392 Mitomycin Natural products 0.000 description 1
• 239000004909 Moisturizer Substances 0.000 description 1
• 241000840267 Moma Species 0.000 description 1
• 241001206439 Motya Species 0.000 description 1
• 241000699660 Mus musculus Species 0.000 description 1
• 101100269376 Mus musculus Agfg2 gene Proteins 0.000 description 1
• 101100459301 Mus musculus Myl4 gene Proteins 0.000 description 1
• 101000935118 Mus musculus Voltage-dependent P/Q-type calcium channel subunit alpha-1A Proteins 0.000 description 1
• 201000004458 Myoma Diseases 0.000 description 1
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
• PYUSHNKNPOHWEZ-YFKPBYRVSA-N N-formyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC=O PYUSHNKNPOHWEZ-YFKPBYRVSA-N 0.000 description 1
• 229940125652 NAMI Drugs 0.000 description 1
• BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 description 1
• CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
• 241001611408 Nebo Species 0.000 description 1
• 206010029260 Neuroblastoma Diseases 0.000 description 1
• 208000005890 Neuroma Diseases 0.000 description 1
• 239000000020 Nitrocellulose Substances 0.000 description 1
• SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
• 239000000006 Nitroglycerin Substances 0.000 description 1
• 102000010410 Nogo Proteins Human genes 0.000 description 1
• 108010077641 Nogo Proteins Proteins 0.000 description 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
• 230000004989 O-glycosylation Effects 0.000 description 1
• 240000008881 Oenanthe javanica Species 0.000 description 1
• 101100491259 Oryza sativa subsp. japonica AP2-2 gene Proteins 0.000 description 1
• 208000001132 Osteoporosis Diseases 0.000 description 1
• 241000697033 Ostracion meleagris Species 0.000 description 1
• BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 1
• 208000025174 PANDAS Diseases 0.000 description 1
• 102100035591 POU domain, class 2, transcription factor 2 Human genes 0.000 description 1
• 101710084411 POU domain, class 2, transcription factor 2 Proteins 0.000 description 1
• 239000002033 PVDF binder Substances 0.000 description 1
• 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 description 1
• 241000282579 Pan Species 0.000 description 1
• 240000000220 Panda oleosa Species 0.000 description 1
• 235000016496 Panda oleosa Nutrition 0.000 description 1
• 240000004072 Panicum sumatrense Species 0.000 description 1
• 241001659863 Panna Species 0.000 description 1
• 241000282320 Panthera leo Species 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 1
• 241001387976 Pera Species 0.000 description 1
• 108010081690 Pertussis Toxin Proteins 0.000 description 1
• 108091000080 Phosphotransferase Proteins 0.000 description 1
• 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
• 229920000331 Polyhydroxybutyrate Polymers 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
• 241001252410 Pteronia incana Species 0.000 description 1
• 208000017442 Retinal disease Diseases 0.000 description 1
• 201000000582 Retinoblastoma Diseases 0.000 description 1
• 206010038923 Retinopathy Diseases 0.000 description 1
• 244000152640 Rhipsalis cassutha Species 0.000 description 1
• 235000012300 Rhipsalis cassutha Nutrition 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 102100025541 S-acyl fatty acid synthase thioesterase, medium chain Human genes 0.000 description 1
• 102100028029 SCL-interrupting locus protein Human genes 0.000 description 1
• AUVVAXYIELKVAI-UHFFFAOYSA-N SJ000285215 Natural products N1CCC2=CC(OC)=C(OC)C=C2C1CC1CC2C3=CC(OC)=C(OC)C=C3CCN2CC1CC AUVVAXYIELKVAI-UHFFFAOYSA-N 0.000 description 1
• RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
• 235000008026 Santalum lanceolatum Nutrition 0.000 description 1
• 241000555745 Sciuridae Species 0.000 description 1
• 102000005686 Serum Globulins Human genes 0.000 description 1
• 108010045362 Serum Globulins Proteins 0.000 description 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
• 235000018650 Solanum gilo Nutrition 0.000 description 1
• 244000258044 Solanum gilo Species 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 241001415849 Strigiformes Species 0.000 description 1
• 241000272534 Struthio camelus Species 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 241001424341 Tara spinosa Species 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 201000003005 Tetralogy of Fallot Diseases 0.000 description 1
• 102100029210 Tetratricopeptide repeat protein 37 Human genes 0.000 description 1
• 244000299461 Theobroma cacao Species 0.000 description 1
• 235000009470 Theobroma cacao Nutrition 0.000 description 1
• 241000767684 Thoe Species 0.000 description 1
• 108090000190 Thrombin Proteins 0.000 description 1
• 241000218636 Thuja Species 0.000 description 1
• 241000656145 Thyrsites atun Species 0.000 description 1
• 241000613130 Tima Species 0.000 description 1
• ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
• 239000000365 Topoisomerase I Inhibitor Substances 0.000 description 1
• 235000006732 Torreya nucifera Nutrition 0.000 description 1
• 244000111306 Torreya nucifera Species 0.000 description 1
• GBOGMAARMMDZGR-UHFFFAOYSA-N UNPD149280 Natural products N1C(=O)C23OC(=O)C=CC(O)CCCC(C)CC=CC3C(O)C(=C)C(C)C2C1CC1=CC=CC=C1 GBOGMAARMMDZGR-UHFFFAOYSA-N 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
• 108020000999 Viral RNA Proteins 0.000 description 1
• 241000289690 Xenarthra Species 0.000 description 1
• 241000212695 Zesius Species 0.000 description 1
• HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 description 1
• SXEHKFHPFVVDIR-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1C1=CC=C(NN)C=C1 SXEHKFHPFVVDIR-UHFFFAOYSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 239000003070 absorption delaying agent Substances 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• 229940022698 acetylcholinesterase Drugs 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 206010000496 acne Diseases 0.000 description 1
• DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
• 229930183665 actinomycin Natural products 0.000 description 1
• 230000006978 adaptation Effects 0.000 description 1
• 230000002730 additional effect Effects 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 210000004404 adrenal cortex Anatomy 0.000 description 1
• 239000000464 adrenergic agent Substances 0.000 description 1
• 206010064930 age-related macular degeneration Diseases 0.000 description 1
• NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
• 229960004343 alendronic acid Drugs 0.000 description 1
• 229940072056 alginate Drugs 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 229920000615 alginic acid Chemical class 0.000 description 1
• 239000008168 almond oil Substances 0.000 description 1
• 235000011399 aloe vera Nutrition 0.000 description 1
• WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
• 229960003556 aminophylline Drugs 0.000 description 1
• FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 description 1
• QXAITBQSYVNQDR-UHFFFAOYSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1N=CN(C)C=NC1=CC=C(C)C=C1C QXAITBQSYVNQDR-UHFFFAOYSA-N 0.000 description 1
• ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 description 1
• 229960004005 amlodipine besylate Drugs 0.000 description 1
• 210000004381 amniotic fluid Anatomy 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• 229960004238 anakinra Drugs 0.000 description 1
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 230000001093 anti-cancer Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 239000003146 anticoagulant agent Substances 0.000 description 1
• 239000003429 antifungal agent Substances 0.000 description 1
• 229940121375 antifungal agent Drugs 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 229960004676 antithrombotic agent Drugs 0.000 description 1
• 229960004405 aprotinin Drugs 0.000 description 1
• 239000012062 aqueous buffer Substances 0.000 description 1
• 229960002274 atenolol Drugs 0.000 description 1
• 125000004429 atom Chemical group 0.000 description 1
• 229960001770 atorvastatin calcium Drugs 0.000 description 1
• 229960002028 atropine sulfate Drugs 0.000 description 1
• 229940009100 aurothiomalate Drugs 0.000 description 1
• XJHSMFDIQHVMCY-UHFFFAOYSA-M aurothiomalic acid Chemical compound OC(=O)CC(S[Au])C(O)=O XJHSMFDIQHVMCY-UHFFFAOYSA-M 0.000 description 1
• 239000012752 auxiliary agent Substances 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 229960004168 balsalazide Drugs 0.000 description 1
• IPOKCKJONYRRHP-FMQUCBEESA-N balsalazide Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1\N=N\C1=CC=C(O)C(C(O)=O)=C1 IPOKCKJONYRRHP-FMQUCBEESA-N 0.000 description 1
• 229960000560 balsalazide disodium Drugs 0.000 description 1
• 108010005774 beta-Galactosidase Proteins 0.000 description 1
• 102000014974 beta2-adrenergic receptor activity proteins Human genes 0.000 description 1
• 108040006828 beta2-adrenergic receptor activity proteins Proteins 0.000 description 1
• 230000001588 bifunctional effect Effects 0.000 description 1
• 210000000013 bile duct Anatomy 0.000 description 1
• 239000003809 bile pigment Substances 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 229920000249 biocompatible polymer Polymers 0.000 description 1
• 239000012620 biological material Substances 0.000 description 1
• 230000005540 biological transmission Effects 0.000 description 1
• 238000010352 biotechnological method Methods 0.000 description 1
• 125000004057 biotinyl group Chemical group [H]N1C(=O)N([H])[C@]2([H])[C@@]([H])(SC([H])([H])[C@]12[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 description 1
• 229960005400 bisoprolol fumarate Drugs 0.000 description 1
• 230000017531 blood circulation Effects 0.000 description 1
• RSIHSRDYCUFFLA-DYKIIFRCSA-N boldenone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 RSIHSRDYCUFFLA-DYKIIFRCSA-N 0.000 description 1
• 230000014461 bone development Effects 0.000 description 1
• 206010006007 bone sarcoma Diseases 0.000 description 1
• 239000004327 boric acid Substances 0.000 description 1
• 244000275904 brauner Senf Species 0.000 description 1
• 235000008429 bread Nutrition 0.000 description 1
• 235000021152 breakfast Nutrition 0.000 description 1
• 239000006189 buccal tablet Substances 0.000 description 1
• 235000019846 buffering salt Nutrition 0.000 description 1
• MAEIEVLCKWDQJH-UHFFFAOYSA-N bumetanide Chemical compound CCCCNC1=CC(C(O)=O)=CC(S(N)(=O)=O)=C1OC1=CC=CC=C1 MAEIEVLCKWDQJH-UHFFFAOYSA-N 0.000 description 1
• 229960004064 bumetanide Drugs 0.000 description 1
• DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 1
• 229960000830 captopril Drugs 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 229910002092 carbon dioxide Inorganic materials 0.000 description 1
• 229960004424 carbon dioxide Drugs 0.000 description 1
• 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 description 1
• 210000000748 cardiovascular system Anatomy 0.000 description 1
• NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 description 1
• 229960004195 carvedilol Drugs 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 238000001516 cell proliferation assay Methods 0.000 description 1
• 230000008614 cellular interaction Effects 0.000 description 1
• 210000003710 cerebral cortex Anatomy 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• CKMOQBVBEGCJGW-UHFFFAOYSA-L chembl1200760 Chemical compound [Na+].[Na+].C1=C(C([O-])=O)C(O)=CC=C1N=NC1=CC=C(C(=O)NCCC([O-])=O)C=C1 CKMOQBVBEGCJGW-UHFFFAOYSA-L 0.000 description 1
• XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 description 1
• 238000010382 chemical cross-linking Methods 0.000 description 1
• 230000035605 chemotaxis Effects 0.000 description 1
• 235000015111 chews Nutrition 0.000 description 1
• DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
• 210000000349 chromosome Anatomy 0.000 description 1
• 229960003405 ciprofloxacin Drugs 0.000 description 1
• DIOIOSKKIYDRIQ-UHFFFAOYSA-N ciprofloxacin hydrochloride Chemical compound Cl.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 DIOIOSKKIYDRIQ-UHFFFAOYSA-N 0.000 description 1
• 229960001229 ciprofloxacin hydrochloride Drugs 0.000 description 1
• 230000004087 circulation Effects 0.000 description 1
• 238000004140 cleaning Methods 0.000 description 1
• GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 description 1
• 229960003958 clopidogrel bisulfate Drugs 0.000 description 1
• 238000003501 co-culture Methods 0.000 description 1
• 229940047766 co-trimoxazole Drugs 0.000 description 1
• 229960004415 codeine phosphate Drugs 0.000 description 1
• 229960005188 collagen Drugs 0.000 description 1
• 210000001072 colon Anatomy 0.000 description 1
• 230000000112 colonic effect Effects 0.000 description 1
• 238000004737 colorimetric analysis Methods 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 230000006957 competitive inhibition Effects 0.000 description 1
• 239000004074 complement inhibitor Substances 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 238000010411 cooking Methods 0.000 description 1
• 229960000265 cromoglicic acid Drugs 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 235000021438 curry Nutrition 0.000 description 1
• 229960004397 cyclophosphamide Drugs 0.000 description 1
• GBOGMAARMMDZGR-JREHFAHYSA-N cytochalasin B Natural products C[C@H]1CCC[C@@H](O)C=CC(=O)O[C@@]23[C@H](C=CC1)[C@H](O)C(=C)[C@@H](C)[C@@H]2[C@H](Cc4ccccc4)NC3=O GBOGMAARMMDZGR-JREHFAHYSA-N 0.000 description 1
• GBOGMAARMMDZGR-TYHYBEHESA-N cytochalasin B Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@@H]3/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(=O)O[C@@]23C(=O)N1)=C)C)C1=CC=CC=C1 GBOGMAARMMDZGR-TYHYBEHESA-N 0.000 description 1
• 210000004292 cytoskeleton Anatomy 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
• 229960000975 daunorubicin Drugs 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• RSIHSRDYCUFFLA-UHFFFAOYSA-N dehydrotestosterone Natural products O=C1C=CC2(C)C3CCC(C)(C(CC4)O)C4C3CCC2=C1 RSIHSRDYCUFFLA-UHFFFAOYSA-N 0.000 description 1
• 239000008367 deionised water Substances 0.000 description 1
• 229910021641 deionized water Inorganic materials 0.000 description 1
• 108700041286 delta Proteins 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 230000006866 deterioration Effects 0.000 description 1
• 229960003957 dexamethasone Drugs 0.000 description 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
• 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
• 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
• 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
• 229960001259 diclofenac Drugs 0.000 description 1
• DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 description 1
• 229960005156 digoxin Drugs 0.000 description 1
• LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
• LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
• 229960005316 diltiazem hydrochloride Drugs 0.000 description 1
• 239000012470 diluted sample Substances 0.000 description 1
• 229960004192 diphenoxylate Drugs 0.000 description 1
• HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 1
• 239000007884 disintegrant Substances 0.000 description 1
• VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 1
• CDMADVZSLOHIFP-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane;decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 CDMADVZSLOHIFP-UHFFFAOYSA-N 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 239000008298 dragée Substances 0.000 description 1
• 230000035622 drinking Effects 0.000 description 1
• 239000003602 elastase inhibitor Substances 0.000 description 1
• 238000010828 elution Methods 0.000 description 1
• 230000013020 embryo development Effects 0.000 description 1
• AUVVAXYIELKVAI-CKBKHPSWSA-N emetine Chemical compound N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC AUVVAXYIELKVAI-CKBKHPSWSA-N 0.000 description 1
• 229960002694 emetine Drugs 0.000 description 1
• AUVVAXYIELKVAI-UWBTVBNJSA-N emetine Natural products N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC AUVVAXYIELKVAI-UWBTVBNJSA-N 0.000 description 1
• 229960000309 enalapril maleate Drugs 0.000 description 1
• OYFJQPXVCSSHAI-QFPUQLAESA-N enalapril maleate Chemical compound OC(=O)\C=C/C(O)=O.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 OYFJQPXVCSSHAI-QFPUQLAESA-N 0.000 description 1
• 238000005538 encapsulation Methods 0.000 description 1
• 210000001174 endocardium Anatomy 0.000 description 1
• 230000002124 endocrine Effects 0.000 description 1
• 210000003372 endocrine gland Anatomy 0.000 description 1
• 230000003511 endothelial effect Effects 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 229960005153 enoxaparin sodium Drugs 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 239000002532 enzyme inhibitor Substances 0.000 description 1
• 229940116977 epidermal growth factor Drugs 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 210000003238 esophagus Anatomy 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 229960000403 etanercept Drugs 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
• 150000002170 ethers Chemical class 0.000 description 1
• MAUQAXOHCVNUMX-BUHFOSPRSA-N ethyl (e)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate Chemical compound CCOC(=O)CC(O)CC(O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 MAUQAXOHCVNUMX-BUHFOSPRSA-N 0.000 description 1
• 229960005293 etodolac Drugs 0.000 description 1
• XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 description 1
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
• 229960005420 etoposide Drugs 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 239000000284 extract Substances 0.000 description 1
• OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 description 1
• 229960000815 ezetimibe Drugs 0.000 description 1
• 210000000887 face Anatomy 0.000 description 1
• 201000003373 familial cold autoinflammatory syndrome 3 Diseases 0.000 description 1
• 210000003746 feather Anatomy 0.000 description 1
• 210000003608 fece Anatomy 0.000 description 1
• 229960003580 felodipine Drugs 0.000 description 1
• 210000001752 female genitalia Anatomy 0.000 description 1
• YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 description 1
• 229960002297 fenofibrate Drugs 0.000 description 1
• PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
• 229960002428 fentanyl Drugs 0.000 description 1
• 229940012952 fibrinogen Drugs 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 238000011049 filling Methods 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 238000010304 firing Methods 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 229960000785 fluocinonide Drugs 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 235000019253 formic acid Nutrition 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 230000005714 functional activity Effects 0.000 description 1
• 238000002825 functional assay Methods 0.000 description 1
• ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
• 229960003883 furosemide Drugs 0.000 description 1
• UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
• 229930182830 galactose Natural products 0.000 description 1
• 210000000232 gallbladder Anatomy 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 208000005017 glioblastoma Diseases 0.000 description 1
• 239000003862 glucocorticoid Substances 0.000 description 1
• 229960002849 glucosamine sulfate Drugs 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 229940116332 glucose oxidase Drugs 0.000 description 1
• 235000019420 glucose oxidase Nutrition 0.000 description 1
• 229960003711 glyceryl trinitrate Drugs 0.000 description 1
• 108700014210 glycosyltransferase activity proteins Proteins 0.000 description 1
• 102000045442 glycosyltransferase activity proteins Human genes 0.000 description 1
• 229960004905 gramicidin Drugs 0.000 description 1
• ZWCXYZRRTRDGQE-SORVKSEFSA-N gramicidina Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-SORVKSEFSA-N 0.000 description 1
• 210000004013 groin Anatomy 0.000 description 1
• 125000005843 halogen group Chemical group 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 210000003709 heart valve Anatomy 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 230000002949 hemolytic effect Effects 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
• 230000002440 hepatic effect Effects 0.000 description 1
• 102000048595 human DMPK Human genes 0.000 description 1
• 229920002674 hyaluronan Polymers 0.000 description 1
• 229960003160 hyaluronic acid Drugs 0.000 description 1
• 229960002003 hydrochlorothiazide Drugs 0.000 description 1
• 229960000890 hydrocortisone Drugs 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 230000003301 hydrolyzing effect Effects 0.000 description 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
• 229960004171 hydroxychloroquine Drugs 0.000 description 1
• XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
• 229960002927 hydroxychloroquine sulfate Drugs 0.000 description 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
• 229960001550 hyoscyamine sulfate Drugs 0.000 description 1
• 229940124452 immunizing agent Drugs 0.000 description 1
• 238000003119 immunoblot Methods 0.000 description 1
• 230000002163 immunogen Effects 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 238000002991 immunohistochemical analysis Methods 0.000 description 1
• 238000001114 immunoprecipitation Methods 0.000 description 1
• 230000003308 immunostimulating effect Effects 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 230000008676 import Effects 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 229960000905 indomethacin Drugs 0.000 description 1
• 239000003701 inert diluent Substances 0.000 description 1
• 230000007574 infarction Effects 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
• 208000014674 injury Diseases 0.000 description 1
• 230000008611 intercellular interaction Effects 0.000 description 1
• 229960003130 interferon gamma Drugs 0.000 description 1
• 229940047124 interferons Drugs 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 238000000185 intracerebroventricular administration Methods 0.000 description 1
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• 229960001888 ipratropium Drugs 0.000 description 1
• OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 description 1
• 235000014413 iron hydroxide Nutrition 0.000 description 1
• JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
• MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 1
• 229960000201 isosorbide dinitrate Drugs 0.000 description 1
• YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
• 229960003827 isosorbide mononitrate Drugs 0.000 description 1
• 229960004958 ketotifen Drugs 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
• 239000000832 lactitol Substances 0.000 description 1
• VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
• 235000010448 lactitol Nutrition 0.000 description 1
• 229960003451 lactitol Drugs 0.000 description 1
• 229910052747 lanthanoid Inorganic materials 0.000 description 1
• 150000002602 lanthanoids Chemical group 0.000 description 1
• 210000000867 larynx Anatomy 0.000 description 1
• 239000012633 leachable Substances 0.000 description 1
• 239000002523 lectin Chemical group 0.000 description 1
• 229950007278 lenercept Drugs 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 229960003376 levofloxacin Drugs 0.000 description 1
• 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
• YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
• 239000006193 liquid solution Substances 0.000 description 1
• 229960002394 lisinopril Drugs 0.000 description 1
• RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 229960002983 loperamide hydrochloride Drugs 0.000 description 1
• PGYPOBZJRVSMDS-UHFFFAOYSA-N loperamide hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 PGYPOBZJRVSMDS-UHFFFAOYSA-N 0.000 description 1
• 229960000519 losartan potassium Drugs 0.000 description 1
• 239000006210 lotion Substances 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical group O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• 208000002780 macular degeneration Diseases 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 210000000260 male genitalia Anatomy 0.000 description 1
• 210000005075 mammary gland Anatomy 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• 229940126601 medicinal product Drugs 0.000 description 1
• 239000002609 medium Substances 0.000 description 1
• 229960001929 meloxicam Drugs 0.000 description 1
• 206010027191 meningioma Diseases 0.000 description 1
• 229940051129 meperidine hydrochloride Drugs 0.000 description 1
• QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
• 229910052753 mercury Inorganic materials 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 208000037819 metastatic cancer Diseases 0.000 description 1
• 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
• FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
• 229930182817 methionine Natural products 0.000 description 1
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
• 229960001293 methylprednisolone acetate Drugs 0.000 description 1
• PLBHSZGDDKCEHR-LFYFAGGJSA-N methylprednisolone acetate Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(C)=O)CC[C@H]21 PLBHSZGDDKCEHR-LFYFAGGJSA-N 0.000 description 1
• 229960000334 methylprednisolone sodium succinate Drugs 0.000 description 1
• 229960000939 metoprolol succinate Drugs 0.000 description 1
• 229960001300 metoprolol tartrate Drugs 0.000 description 1
• 239000004530 micro-emulsion Substances 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 239000003094 microcapsule Substances 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• PLYSCVSCYOQVRP-UHFFFAOYSA-N midazolam hydrochloride Chemical compound Cl.C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F PLYSCVSCYOQVRP-UHFFFAOYSA-N 0.000 description 1
• 229960002853 midazolam hydrochloride Drugs 0.000 description 1
• CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 1
• 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 description 1
• 229960004857 mitomycin Drugs 0.000 description 1
• 229960001156 mitoxantrone Drugs 0.000 description 1
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
• 230000001333 moisturizer Effects 0.000 description 1
• 230000004879 molecular function Effects 0.000 description 1
• 238000013365 molecular weight analysis method Methods 0.000 description 1
• ODLHGICHYURWBS-FOSILIAISA-N molport-023-220-444 Chemical compound CC(O)COC[C@@H]([C@@H]([C@H]([C@@H]1O)O)O[C@@H]2O[C@H]([C@H](O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O3)[C@@H](O)[C@@H]2O)COCC(O)C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O)[C@H]3O[C@H]1COCC(C)O ODLHGICHYURWBS-FOSILIAISA-N 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 229960004715 morphine sulfate Drugs 0.000 description 1
• GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 description 1
• 229960004866 mycophenolate mofetil Drugs 0.000 description 1
• RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 description 1
• 230000002107 myocardial effect Effects 0.000 description 1
• 210000004165 myocardium Anatomy 0.000 description 1
• ZTLGJPIZUOVDMT-UHFFFAOYSA-N n,n-dichlorotriazin-4-amine Chemical compound ClN(Cl)C1=CC=NN=N1 ZTLGJPIZUOVDMT-UHFFFAOYSA-N 0.000 description 1
• 229950006780 n-acetylglucosamine Drugs 0.000 description 1
• 229960004270 nabumetone Drugs 0.000 description 1
• VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 description 1
• 229960004255 nadolol Drugs 0.000 description 1
• 229960002009 naproxen Drugs 0.000 description 1
• CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
• 229960003940 naproxen sodium Drugs 0.000 description 1
• CDBRNDSHEYLDJV-FVGYRXGTSA-M naproxen sodium Chemical compound [Na+].C1=C([C@H](C)C([O-])=O)C=CC2=CC(OC)=CC=C21 CDBRNDSHEYLDJV-FVGYRXGTSA-M 0.000 description 1
• 229960005027 natalizumab Drugs 0.000 description 1
• RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
• 229960004398 nedocromil Drugs 0.000 description 1
• 230000011234 negative regulation of signal transduction Effects 0.000 description 1
• 210000000653 nervous system Anatomy 0.000 description 1
• 208000007538 neurilemmoma Diseases 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
• 229960001597 nifedipine Drugs 0.000 description 1
• 210000002445 nipple Anatomy 0.000 description 1
• 229920001220 nitrocellulos Polymers 0.000 description 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
• 230000001254 nonsecretory effect Effects 0.000 description 1
• 230000006911 nucleation Effects 0.000 description 1
• 238000010899 nucleation Methods 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 238000007899 nucleic acid hybridization Methods 0.000 description 1
• 210000004940 nucleus Anatomy 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 229920001542 oligosaccharide Polymers 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 239000007935 oral tablet Substances 0.000 description 1
• 210000003300 oropharynx Anatomy 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 210000000963 osteoblast Anatomy 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 229960002739 oxaprozin Drugs 0.000 description 1
• OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 description 1
• 235000010603 pastilles Nutrition 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 230000007310 pathophysiology Effects 0.000 description 1
• 230000035515 penetration Effects 0.000 description 1
• 229960001639 penicillamine Drugs 0.000 description 1
• 125000001151 peptidyl group Chemical group 0.000 description 1
• 230000002085 persistent effect Effects 0.000 description 1
• 108700010839 phage proteins Proteins 0.000 description 1
• 239000008177 pharmaceutical agent Substances 0.000 description 1
• 230000003285 pharmacodynamic effect Effects 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
• LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 102000020233 phosphotransferase Human genes 0.000 description 1
• 229960002702 piroxicam Drugs 0.000 description 1
• QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
• 210000003635 pituitary gland Anatomy 0.000 description 1
• 229910052697 platinum Inorganic materials 0.000 description 1
• 229960003171 plicamycin Drugs 0.000 description 1
• 238000001874 polarisation spectroscopy Methods 0.000 description 1
• 230000010287 polarization Effects 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920001308 poly(aminoacid) Polymers 0.000 description 1
• 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
• 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 1
• 230000008488 polyadenylation Effects 0.000 description 1
• 229920001610 polycaprolactone Polymers 0.000 description 1
• 239000004632 polycaprolactone Substances 0.000 description 1
• 229920002721 polycyanoacrylate Polymers 0.000 description 1
• 239000000622 polydioxanone Substances 0.000 description 1
• 229920000728 polyester Polymers 0.000 description 1
• 239000004633 polyglycolic acid Substances 0.000 description 1
• 229920002704 polyhistidine Polymers 0.000 description 1
• 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
• 239000004926 polymethyl methacrylate Substances 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 229940068977 polysorbate 20 Drugs 0.000 description 1
• 229940068968 polysorbate 80 Drugs 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
• 238000002600 positron emission tomography Methods 0.000 description 1
• 231100000683 possible toxicity Toxicity 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 239000001103 potassium chloride Substances 0.000 description 1
• 235000011164 potassium chloride Nutrition 0.000 description 1
• 229960002816 potassium chloride Drugs 0.000 description 1
• 229910000160 potassium phosphate Inorganic materials 0.000 description 1
• 235000011009 potassium phosphates Nutrition 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 230000001376 precipitating effect Effects 0.000 description 1
• 229940071643 prefilled syringe Drugs 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 230000001023 pro-angiogenic effect Effects 0.000 description 1
• XXPDBLUZJRXNNZ-UHFFFAOYSA-N promethazine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 XXPDBLUZJRXNNZ-UHFFFAOYSA-N 0.000 description 1
• 229960002244 promethazine hydrochloride Drugs 0.000 description 1
• 230000000644 propagated effect Effects 0.000 description 1
• 229960003712 propranolol Drugs 0.000 description 1
• 229960004604 propranolol hydrochloride Drugs 0.000 description 1
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
• QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical class CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 229940076372 protein antagonist Drugs 0.000 description 1
• 238000002818 protein evolution Methods 0.000 description 1
• 230000012846 protein folding Effects 0.000 description 1
• 230000004853 protein function Effects 0.000 description 1
• 230000004850 protein–protein interaction Effects 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 230000006337 proteolytic cleavage Effects 0.000 description 1
• 239000008262 pumice Substances 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• 239000003379 purinergic P1 receptor agonist Substances 0.000 description 1
• 235000008160 pyridoxine Nutrition 0.000 description 1
• 239000011677 pyridoxine Substances 0.000 description 1
• 239000002510 pyrogen Substances 0.000 description 1
• 238000010791 quenching Methods 0.000 description 1
• 230000000171 quenching effect Effects 0.000 description 1
• 229960003401 ramipril Drugs 0.000 description 1
• HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 230000008707 rearrangement Effects 0.000 description 1
• 239000002464 receptor antagonist Substances 0.000 description 1
• 229940044551 receptor antagonist Drugs 0.000 description 1
• 238000001525 receptor binding assay Methods 0.000 description 1
• 230000010837 receptor-mediated endocytosis Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 230000010076 replication Effects 0.000 description 1
• 238000012340 reverse transcriptase PCR Methods 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 230000005070 ripening Effects 0.000 description 1
• 229960004641 rituximab Drugs 0.000 description 1
• 229960000371 rofecoxib Drugs 0.000 description 1
• RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
• 229960002052 salbutamol Drugs 0.000 description 1
• 229960000953 salsalate Drugs 0.000 description 1
• 239000004576 sand Substances 0.000 description 1
• 210000002955 secretory cell Anatomy 0.000 description 1
• 238000004062 sedimentation Methods 0.000 description 1
• 210000001625 seminal vesicle Anatomy 0.000 description 1
• 239000008299 semisolid dosage form Substances 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 238000002864 sequence alignment Methods 0.000 description 1
• 239000002453 shampoo Substances 0.000 description 1
• 125000005629 sialic acid group Chemical group 0.000 description 1
• 230000009450 sialylation Effects 0.000 description 1
• 229910052710 silicon Inorganic materials 0.000 description 1
• 239000010703 silicon Substances 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 235000012239 silicon dioxide Nutrition 0.000 description 1
• RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
• 229960002855 simvastatin Drugs 0.000 description 1
• 238000009097 single-agent therapy Methods 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 239000000344 soap Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
• 229960003339 sodium phosphate Drugs 0.000 description 1
• 229940079832 sodium starch glycolate Drugs 0.000 description 1
• 239000008109 sodium starch glycolate Substances 0.000 description 1
• 229920003109 sodium starch glycolate Polymers 0.000 description 1
• 229940074404 sodium succinate Drugs 0.000 description 1
• ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
• PEVNIEPIRVCPAW-UHFFFAOYSA-J sodium;1h-imidazole;methylsulfinylmethane;ruthenium(3+);tetrachloride Chemical compound [Na+].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3].CS(C)=O.C1=CNC=N1 PEVNIEPIRVCPAW-UHFFFAOYSA-J 0.000 description 1
• AGHLUVOCTHWMJV-UHFFFAOYSA-J sodium;gold(3+);2-sulfanylbutanedioate Chemical compound [Na+].[Au+3].[O-]C(=O)CC(S)C([O-])=O.[O-]C(=O)CC(S)C([O-])=O AGHLUVOCTHWMJV-UHFFFAOYSA-J 0.000 description 1
• 239000007909 solid dosage form Substances 0.000 description 1
• 230000000392 somatic effect Effects 0.000 description 1
• 230000037439 somatic mutation Effects 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 229960003579 sotalol hydrochloride Drugs 0.000 description 1
• VIDRYROWYFWGSY-UHFFFAOYSA-N sotalol hydrochloride Chemical compound Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 VIDRYROWYFWGSY-UHFFFAOYSA-N 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
• 229960002256 spironolactone Drugs 0.000 description 1
• 230000003393 splenic effect Effects 0.000 description 1
• 238000001694 spray drying Methods 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000013112 stability test Methods 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 229940032147 starch Drugs 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000008174 sterile solution Substances 0.000 description 1
• 239000008223 sterile water Substances 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 238000013517 stratification Methods 0.000 description 1
• 239000010902 straw Substances 0.000 description 1
• 230000002739 subcortical effect Effects 0.000 description 1
• 229960004793 sucrose Drugs 0.000 description 1
• 150000005846 sugar alcohols Polymers 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 229960004306 sulfadiazine Drugs 0.000 description 1
• SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
• 229960000894 sulindac Drugs 0.000 description 1
• MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 239000004094 surface-active agent Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 230000002194 synthesizing effect Effects 0.000 description 1
• 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
• 229940037128 systemic glucocorticoids Drugs 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 235000012976 tarts Nutrition 0.000 description 1
• NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
• 229960001278 teniposide Drugs 0.000 description 1
• 229960000195 terbutaline Drugs 0.000 description 1
• WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 description 1
• 210000001550 testis Anatomy 0.000 description 1
• 229960002372 tetracaine Drugs 0.000 description 1
• GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
• 229960004989 tetracycline hydrochloride Drugs 0.000 description 1
• CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
• 229910052716 thallium Inorganic materials 0.000 description 1
• 229960000278 theophylline Drugs 0.000 description 1
• 238000001757 thermogravimetry curve Methods 0.000 description 1
• AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229960004072 thrombin Drugs 0.000 description 1
• RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 238000003325 tomography Methods 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 230000005026 transcription initiation Effects 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
• 229960002117 triamcinolone acetonide Drugs 0.000 description 1
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
• 229940029284 trichlorofluoromethane Drugs 0.000 description 1
• 208000007004 trichohepatoenteric syndrome Diseases 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
• 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
• 238000005199 ultracentrifugation Methods 0.000 description 1
• 238000002211 ultraviolet spectrum Methods 0.000 description 1
• ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
• HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
• 241000701161 unidentified adenovirus Species 0.000 description 1
• 241001430294 unidentified retrovirus Species 0.000 description 1
• 210000003932 urinary bladder Anatomy 0.000 description 1
• 210000001635 urinary tract Anatomy 0.000 description 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
• 210000003741 urothelium Anatomy 0.000 description 1
• 210000004291 uterus Anatomy 0.000 description 1
• 238000001291 vacuum drying Methods 0.000 description 1
• LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
• 229960002004 valdecoxib Drugs 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 229960004699 valsartan Drugs 0.000 description 1
• SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
• 229910052720 vanadium Inorganic materials 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 239000003981 vehicle Substances 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• 201000010653 vesiculitis Diseases 0.000 description 1
• 108700026220 vif Genes Proteins 0.000 description 1
• 229960003048 vinblastine Drugs 0.000 description 1
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
• 229960004528 vincristine Drugs 0.000 description 1
• 230000009385 viral infection Effects 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1
• 229940011671 vitamin b6 Drugs 0.000 description 1
• 239000003039 volatile agent Substances 0.000 description 1
• 235000012431 wafers Nutrition 0.000 description 1
• 238000001262 western blot Methods 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 239000002023 wood Substances 0.000 description 1