UA106445C2 - ГИДРАТ 1-{(2S)-2-АМИНО-4-[2,4-BIS(ТРИФТОРМЕТИЛ)-5,8-ДИГИДРОПИРИДО[3,4-d]ПИРИМИДИН-7(6H)-ИЛ]-4-ОКСОБУТИЛ}-5,5-ДИФТОРПИПЕРИДИН-2-ОНТАРТРАТА - Google Patents

ГИДРАТ 1-{(2S)-2-АМИНО-4-[2,4-BIS(ТРИФТОРМЕТИЛ)-5,8-ДИГИДРОПИРИДО[3,4-d]ПИРИМИДИН-7(6H)-ИЛ]-4-ОКСОБУТИЛ}-5,5-ДИФТОРПИПЕРИДИН-2-ОНТАРТРАТА

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Publication number
UA106445C2
UA106445C2 UAA201305462A UAA201305462A UA106445C2 UA 106445 C2 UA106445 C2 UA 106445C2 UA A201305462 A UAA201305462 A UA A201305462A UA A201305462 A UAA201305462 A UA A201305462A UA 106445 C2 UA106445 C2 UA 106445C2
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UA
Ukraine
Prior art keywords
oxobutyl
hydrate
trifluoromethyl
bis
amino
Prior art date
Application number
UAA201305462A
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English (en)
Ukrainian (uk)
Inventor
Кі Сук Парк
Цзюн Мінь Юнь
Бон Чан Кім
Кюу Юн Кім
Цзи Хє Лі
Original Assignee
Елджі Лайф Саєнсез Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45995015&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA106445(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Елджі Лайф Саєнсез Лтд. filed Critical Елджі Лайф Саєнсез Лтд.
Publication of UA106445C2 publication Critical patent/UA106445C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение касается 1.5 гидрата 1-{(2S)-2-амино-4-[2,4-бис(трифторметил)-5,8-дигидропиридо[3,4-d]пиримидин-7(6Н)-ил]-4-оксобутил}-5,5-дифторпиперидин-2-онтартрата, процесса его получения и фармацевтической композиции для угнетения дипептидилпептидазы-IV (DPP-IV), содержащей указанное соединение в качестве активного компонента.
UAA201305462A 2010-11-01 2011-10-31 ГИДРАТ 1-{(2S)-2-АМИНО-4-[2,4-BIS(ТРИФТОРМЕТИЛ)-5,8-ДИГИДРОПИРИДО[3,4-d]ПИРИМИДИН-7(6H)-ИЛ]-4-ОКСОБУТИЛ}-5,5-ДИФТОРПИПЕРИДИН-2-ОНТАРТРАТА UA106445C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20100107868 2010-11-01
PCT/KR2011/008186 WO2012060590A2 (en) 2010-11-01 2011-10-31 Hydrate of 1-{(2s)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di- hydropyrido[3,4-d]pyrimidin-7(6h)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate

Publications (1)

Publication Number Publication Date
UA106445C2 true UA106445C2 (ru) 2014-08-26

Family

ID=45995015

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201305462A UA106445C2 (ru) 2010-11-01 2011-10-31 ГИДРАТ 1-{(2S)-2-АМИНО-4-[2,4-BIS(ТРИФТОРМЕТИЛ)-5,8-ДИГИДРОПИРИДО[3,4-d]ПИРИМИДИН-7(6H)-ИЛ]-4-ОКСОБУТИЛ}-5,5-ДИФТОРПИПЕРИДИН-2-ОНТАРТРАТА

Country Status (29)

Country Link
US (1) US8859567B2 (ru)
EP (1) EP2635580B1 (ru)
JP (1) JP6193762B2 (ru)
KR (1) KR101446789B1 (ru)
CN (1) CN103189375B (ru)
AP (1) AP3287A (ru)
AR (1) AR083591A1 (ru)
AU (1) AU2011324253B2 (ru)
BR (1) BR112013010586A2 (ru)
CA (1) CA2814357C (ru)
CL (1) CL2013001137A1 (ru)
CO (1) CO6710945A2 (ru)
DO (1) DOP2013000090A (ru)
EA (1) EA024679B1 (ru)
EC (1) ECSP13012599A (ru)
GE (1) GEP20156218B (ru)
IL (1) IL225808A (ru)
MA (1) MA34625B1 (ru)
MX (1) MX341584B (ru)
MY (1) MY156428A (ru)
NZ (1) NZ609644A (ru)
PE (3) PE20140392A1 (ru)
PH (1) PH12013500685A1 (ru)
SG (1) SG189931A1 (ru)
TW (1) TWI519533B (ru)
UA (1) UA106445C2 (ru)
UY (1) UY33696A (ru)
WO (1) WO2012060590A2 (ru)
ZA (1) ZA201302646B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117399A2 (en) 2006-03-31 2007-10-18 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
PT2964229T (pt) 2013-03-06 2020-03-23 Janssen Pharmaceutica Nv Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina
PH12023550900A1 (en) * 2020-10-13 2024-03-04 Lg Chemical Ltd Oral combined formulation including gemigliptin and dapagliflozin and preparation method therefor
KR20250137744A (ko) 2024-03-11 2025-09-19 엠에프씨 주식회사 제미글립틴의 신규 결정형 및 이의 제조방법
KR20250147756A (ko) 2024-03-27 2025-10-14 엠에프씨 주식회사 신규한 형태의 제미글립틴 말산염 결정형 및 이의 제조방법
KR20250155700A (ko) 2024-04-24 2025-10-31 주식회사 다산제약 제미글립틴 산부가염 제조방법 및 이를 유효성분으로 포함하는 dpp-4 저해용 조성물
KR20260014098A (ko) 2024-07-23 2026-01-30 동방에프티엘(주) 피리도[3,4-d]피리미딘 치환된 피페리딘-2-온 유도체의 안정한 염 형태 및 이의 제조방법
CN119285630B (zh) * 2024-09-05 2025-05-27 安徽峆一药业股份有限公司 一种吉格列汀草酸盐及其晶型、制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208498B2 (en) * 2002-07-15 2007-04-24 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
WO2004069162A2 (en) * 2003-01-31 2004-08-19 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
TWI357902B (en) 2005-04-01 2012-02-11 Lg Life Science Ltd Dipeptidyl peptidase-iv inhibiting compounds, meth

Also Published As

Publication number Publication date
BR112013010586A2 (pt) 2016-08-09
ZA201302646B (en) 2014-01-29
AP2013006866A0 (en) 2013-05-31
JP2013540810A (ja) 2013-11-07
AP3287A (en) 2015-05-31
CA2814357C (en) 2015-07-07
PE20180464A1 (es) 2018-03-06
TW201245189A (en) 2012-11-16
US8859567B2 (en) 2014-10-14
TWI519533B (zh) 2016-02-01
EP2635580B1 (en) 2015-08-12
DOP2013000090A (es) 2018-06-30
MX2013004776A (es) 2013-11-04
MY156428A (en) 2016-02-26
SG189931A1 (en) 2013-06-28
CL2013001137A1 (es) 2013-09-06
PE20140392A1 (es) 2014-03-22
IL225808A0 (en) 2013-06-27
EP2635580A2 (en) 2013-09-11
EA024679B1 (ru) 2016-10-31
MA34625B1 (fr) 2013-10-02
CA2814357A1 (en) 2012-05-10
KR20120046069A (ko) 2012-05-09
WO2012060590A3 (en) 2012-06-28
AU2011324253A1 (en) 2013-05-02
KR101446789B1 (ko) 2014-10-01
JP6193762B2 (ja) 2017-09-06
CN103189375B (zh) 2016-08-10
AR083591A1 (es) 2013-03-06
AU2011324253B2 (en) 2015-10-29
EA201390644A1 (ru) 2014-11-28
MX341584B (es) 2016-08-25
US20130203787A1 (en) 2013-08-08
CO6710945A2 (es) 2013-07-15
IL225808A (en) 2016-08-31
UY33696A (es) 2012-04-30
PH12013500685A1 (en) 2015-10-02
PE20240220A1 (es) 2024-02-16
WO2012060590A2 (en) 2012-05-10
CN103189375A (zh) 2013-07-03
NZ609644A (en) 2016-02-26
GEP20156218B (en) 2015-01-12
EP2635580A4 (en) 2014-04-02
ECSP13012599A (es) 2013-07-31

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