UA108740C2 - Замещенные производные триазола и имидазола в качестве модулятора гамма-секретазы - Google Patents

Замещенные производные триазола и имидазола в качестве модулятора гамма-секретазы

Info

Publication number
UA108740C2
UA108740C2 UAA201115452A UAA201115452A UA108740C2 UA 108740 C2 UA108740 C2 UA 108740C2 UA A201115452 A UAA201115452 A UA A201115452A UA A201115452 A UAA201115452 A UA A201115452A UA 108740 C2 UA108740 C2 UA 108740C2
Authority
UA
Ukraine
Prior art keywords
imidazole derivatives
gamma
substituted triazole
compounds
secretase modulator
Prior art date
Application number
UAA201115452A
Other languages
English (en)
Ukrainian (uk)
Inventor
Тонгфей Ву
Хенрікус Якобус Марія Гійсен
Фредерік Ян Ріта Ромбутс
Франсуа Пол Бішофф
Дідьє Жан-Клод Бертело
Даніель Ульріх
Клейн Мішель Анна Жозеф де
Серж Марія Алоізіус Пітерс
Гарретт Берлонд Мінне
Адріана Інгрід Велтер
Брандт Свен Францискус Анна Ван
Мішель Суркін
Original Assignee
Янссен Фармасьютікелз, Інк
Селлзом Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармасьютікелз, Інк, Селлзом Лімітед filed Critical Янссен Фармасьютікелз, Інк
Priority claimed from PCT/EP2010/060083 external-priority patent/WO2011006903A1/en
Publication of UA108740C2 publication Critical patent/UA108740C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым замещенным производным триазола и имидазола формулы (I), где R1, R2, А1, А2, А3, А4, и Het1 имеют значения, определенные в формуле изобретения. Соединения по изобретению пригодны как модуляторы гамма-секретазы. Кроме того, изобретение касается способов получения таких новых соединений, фармацевтических композиций, содержащих указанные соединения в качестве активного ингредиента, а также применения указанных соединений в качестве лекарственного средства. EMBED ISISServer (I)
UAA201115452A 2009-07-15 2010-07-13 Замещенные производные триазола и имидазола в качестве модулятора гамма-секретазы UA108740C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09165585 2009-07-15
PCT/EP2010/060083 WO2011006903A1 (en) 2009-07-15 2010-07-13 Substituted triazole and imidazole derivatives as gamma secretase modulators

Publications (1)

Publication Number Publication Date
UA108740C2 true UA108740C2 (ru) 2015-06-10

Family

ID=40886740

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201115452A UA108740C2 (ru) 2009-07-15 2010-07-13 Замещенные производные триазола и имидазола в качестве модулятора гамма-секретазы

Country Status (2)

Country Link
AR (1) AR077570A1 (ru)
UA (1) UA108740C2 (ru)

Also Published As

Publication number Publication date
AR077570A1 (es) 2011-09-07

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