UA111147C2 - Способи та композиції для лікування або профілактики зовнішнього отиту - Google Patents
Способи та композиції для лікування або профілактики зовнішнього отитуInfo
- Publication number
- UA111147C2 UA111147C2 UAA201207023A UAA201207023A UA111147C2 UA 111147 C2 UA111147 C2 UA 111147C2 UA A201207023 A UAA201207023 A UA A201207023A UA A201207023 A UAA201207023 A UA A201207023A UA 111147 C2 UA111147 C2 UA 111147C2
- Authority
- UA
- Ukraine
- Prior art keywords
- agents
- composition
- enhancing
- auditory canal
- viscosity
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 206010033072 otitis externa Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 210000000613 ear canal Anatomy 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 abstract 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- -1 90H phospholipon Chemical compound 0.000 abstract 1
- 241000220479 Acacia Species 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 239000000783 alginic acid Substances 0.000 abstract 1
- 229960001126 alginic acid Drugs 0.000 abstract 1
- 150000004781 alginic acids Chemical class 0.000 abstract 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- 229940125687 antiparasitic agent Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229960001631 carbomer Drugs 0.000 abstract 1
- 235000010980 cellulose Nutrition 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 229940106189 ceramide Drugs 0.000 abstract 1
- 150000001783 ceramides Chemical class 0.000 abstract 1
- 229930183167 cerebroside Natural products 0.000 abstract 1
- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 abstract 1
- 229940082500 cetostearyl alcohol Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000002270 gangliosides Chemical class 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000003193 general anesthetic agent Substances 0.000 abstract 1
- 150000002321 glycerophosphoglycerophosphoglycerols Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 239000002960 lipid emulsion Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 abstract 1
- 125000001095 phosphatidyl group Chemical group 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 1
- 150000003905 phosphatidylinositols Chemical class 0.000 abstract 1
- 150000003408 sphingolipids Chemical class 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Винахід належать до способу лікування або профілактики інфікування зовнішнього отиту та його наслідків шляхом місцевого введення фармацевтично прийнятної композиції в зовнішній слуховий прохід, де зазначена композиція не містить целюлоз, що підвищують в’язкість, або засобів, що підвищують в’язкість, вибраних з альгінової кислоти, желатину, карбомеру акації та цетостеарилового спирту, або адгезивних компонентів, і не є у формі гелю, і де зазначена композиція містить ліпідний носій, і принаймні два активні засоби, вибрані із групи, що складається з антибіотиків, протигрибкових засобів, антипаразитарних засобів, противірусних засобів, нестероїдних протизапальних засобів, знеболювальних засобів, анестетичних засобів і стероїдів, де ліпідний носій є ліпідною емульсією типу «масло у воді», ліпідною мікроемульсією або ліпідною везикулою, та де ліпіди вибирають з фосфоліпідів, які вибирають зі сполук фосфатидилу, що вибираються з фосфатидилгліцерину, фосфатидилінозитолу, фосфатидилхоліну, фосфоліпону 90Н, фосфатидилсерину, фосфатидилетаноламіну, сфінголіпідів, цереброзидів, гангліозидів, кардіоліпінів, трилінолеїнів, лецетину та церамідів, при цьому зазначений спосіб включає введення зазначеної композиції в зовнішній слуховий прохід однією дозою, достатньою для клінічного покращення або повного виліковування даного хворого стану.Також винахід належить до застосування заявленої композиції.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26030909P | 2009-11-11 | 2009-11-11 | |
| PCT/US2010/056255 WO2011060083A1 (en) | 2009-11-11 | 2010-11-10 | Methods and compositions for rapid treatment of otitis externa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA111147C2 true UA111147C2 (uk) | 2016-04-11 |
Family
ID=43992011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201207023A UA111147C2 (uk) | 2009-11-11 | 2010-10-11 | Способи та композиції для лікування або профілактики зовнішнього отиту |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8927006B2 (uk) |
| EP (1) | EP2498792B1 (uk) |
| JP (2) | JP2013510861A (uk) |
| KR (2) | KR20120116398A (uk) |
| CN (1) | CN102612372B (uk) |
| AU (1) | AU2010319538B2 (uk) |
| BR (1) | BR112012011017A2 (uk) |
| CA (1) | CA2780160C (uk) |
| CL (1) | CL2012001227A1 (uk) |
| CO (1) | CO6540004A2 (uk) |
| DK (1) | DK2498792T3 (uk) |
| EC (1) | ECSP12011967A (uk) |
| ES (1) | ES2645200T3 (uk) |
| HR (1) | HRP20171520T1 (uk) |
| HU (1) | HUE034617T2 (uk) |
| IL (1) | IL219483A (uk) |
| LT (1) | LT2498792T (uk) |
| MX (1) | MX2012005521A (uk) |
| MY (1) | MY162687A (uk) |
| NO (1) | NO2498792T3 (uk) |
| NZ (1) | NZ599559A (uk) |
| PH (1) | PH12012500913A1 (uk) |
| PL (1) | PL2498792T3 (uk) |
| PT (1) | PT2498792T (uk) |
| RU (1) | RU2680137C2 (uk) |
| SI (1) | SI2498792T1 (uk) |
| UA (1) | UA111147C2 (uk) |
| WO (1) | WO2011060083A1 (uk) |
| ZA (1) | ZA201203239B (uk) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014036165A1 (en) * | 2012-08-29 | 2014-03-06 | Bayer Healthcare, Llc | Aqueous based compositions for treating otitis externa |
| CN104337952A (zh) * | 2013-08-10 | 2015-02-11 | 李谊 | 一种中西医结合治疗爆震性耳聋的组合药物 |
| CN104739768A (zh) * | 2013-12-27 | 2015-07-01 | 河南惠通天下生物工程有限公司 | 一种甲砜霉素纳米脂质体及其制备方法 |
| EP3482744A1 (de) * | 2017-11-14 | 2019-05-15 | ProFem GmbH | Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen |
| PL3709968T3 (pl) | 2017-11-14 | 2024-02-19 | Profem Gmbh | Emulsje do leczenia infekcji pochwy |
| KR20220070246A (ko) | 2019-09-23 | 2022-05-30 | 디디에스 리서치 인크. | 침투 증진제를 갖는 지질 소포 조성물 |
| JP7680653B2 (ja) * | 2019-10-11 | 2025-05-21 | デクラ ベテリナリー プロダクツ リミテッド ライアビリティー カンパニー | 耳用製剤、方法およびデバイス |
| MX2023011157A (es) | 2021-03-24 | 2024-01-25 | Glo Pharma Inc | Peptidos y metodos para reducir la pigmentacion de la piel. |
| CN113876658B (zh) * | 2021-11-01 | 2023-10-20 | 仙乐健康科技股份有限公司 | 水包油型乳液组合物及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL178438B1 (pl) * | 1994-02-04 | 2000-04-28 | Scotia Lipidteknik Ab | Preparat dwuwarstwy lipidowej, środek farmaceutyczny zawierający preparat dwuwarstwy lipidowej i sposób wytwarzania środka farmaceutycznego |
| WO1996011003A1 (en) * | 1994-10-10 | 1996-04-18 | Novartis Ag | Ophthalmic and aural compositions containing diclofenac potassium |
| ES2173287T3 (es) * | 1995-06-06 | 2002-10-16 | Bayer Ag | Composiciones oticas antibacterianas no irritantes, no sensibilizantes y no ototoxicas. |
| IT1295369B1 (it) | 1997-10-21 | 1999-05-12 | Fatro Spa | Composizione a base di tiamfenicolo e diclofenac |
| US6433024B1 (en) * | 2000-05-08 | 2002-08-13 | Karl F. Popp | Topical anti-acne composition |
| AUPR798901A0 (en) * | 2001-09-28 | 2001-10-25 | Medvet Science Pty. Ltd. | Spheroidal hdl particles with a defined phospholipid composition |
| US20080206161A1 (en) * | 2002-10-25 | 2008-08-28 | Dov Tamarkin | Quiescent foamable compositions, steroids, kits and uses thereof |
| EP1624858B1 (en) * | 2003-04-09 | 2018-06-06 | Rutgers, the State University of New Jersey | Novel encochleation methods |
| CA2533101A1 (en) * | 2003-07-31 | 2005-02-03 | Pharmacia & Upjohn Company Llc | Dispersible formulation of an anti-inflammatory agent |
| US20070054844A1 (en) | 2003-08-20 | 2007-03-08 | Fairfield Clinical Trials, Llc | Method for treating otitis externa |
| US20050159369A1 (en) | 2003-08-20 | 2005-07-21 | Qtm Llc | Method of treatment of otitis externa |
| US20070078116A1 (en) * | 2003-08-20 | 2007-04-05 | Fairfield Clinical Trials, Llc | Method of treatment of otitis externa |
| MX2007002462A (es) | 2004-09-03 | 2007-10-10 | Piedmont Pharmaceuticals Llc | Metodo para el tratamiento de transmembrana y prevencion de la otitis media. |
| JP2008533048A (ja) * | 2005-03-10 | 2008-08-21 | スリーエム イノベイティブ プロパティズ カンパニー | 耳の感染症の治療方法 |
| US20090082337A1 (en) * | 2007-09-21 | 2009-03-26 | Srini Venkastesh | Compositions Comprising Quinolone and Methods for Treating or Controlling Infections |
| US20090111780A1 (en) * | 2007-10-31 | 2009-04-30 | Everett Laboratories, Inc. | Compositions and methods for treatment of ear canal infection and inflammation |
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2010
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- 2010-11-10 KR KR1020127013348A patent/KR20120116398A/ko not_active Ceased
- 2010-11-10 JP JP2012538954A patent/JP2013510861A/ja active Pending
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- 2010-11-10 MX MX2012005521A patent/MX2012005521A/es active IP Right Grant
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