UA112855C2 - Композиції бензімідазолів з модифікованим вивільненням - Google Patents

Композиції бензімідазолів з модифікованим вивільненням Download PDF

Info

Publication number: UA112855C2
Authority: UA; Ukraine
Prior art keywords: coating; pellets; omeprazole; stage; release
Prior art date: 2010-12-29

Application number

UAA201309355A

Other languages

English (en)

Ukrainian (uk)

Inventor

Лінгам Мека

Срініваса Алмаредді Редді

Вагіша Сінха

Хітеш Джоджия

Срінівас Арутла

Равірадж Піллаі

Рахул Судхакар Гаванде

Прасад Вуре

Венкатесварлу Вобалабоіна

Original Assignee

Др. Редді'С Лабораторіс Лтд.

Др. Редді'С Лабораторіс, Інк.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-12-29

Filing date

2011-12-29

Publication date

2016-11-10

2011-12-29 Application filed by Др. Редді'С Лабораторіс Лтд., Др. Редді'С Лабораторіс, Інк. filed Critical Др. Редді'С Лабораторіс Лтд.

2016-11-10 Publication of UA112855C2 publication Critical patent/UA112855C2/uk

Links

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238000000576 coating method Methods 0.000 claims abstract description 123
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229960000381 omeprazole Drugs 0.000 claims abstract description 101
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235000003441 saturated fatty acids Nutrition 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229960001153 serine Drugs 0.000 description 1
239000000344 soap Substances 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229940080350 sodium stearate Drugs 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
229910052979 sodium sulfide Inorganic materials 0.000 description 1
GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
239000012453 solvate Substances 0.000 description 1
229960002920 sorbitol Drugs 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
238000005563 spheronization Methods 0.000 description 1
150000003408 sphingolipids Chemical class 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
238000013112 stability test Methods 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000003457 sulfones Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
238000010998 test method Methods 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229960002898 threonine Drugs 0.000 description 1
UIERETOOQGIECD-ONEGZZNKSA-N tiglic acid Chemical compound C\C=C(/C)C(O)=O UIERETOOQGIECD-ONEGZZNKSA-N 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
229940029614 triethanolamine stearate Drugs 0.000 description 1
229960004418 trolamine Drugs 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
229960004441 tyrosine Drugs 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
238000009461 vacuum packaging Methods 0.000 description 1
239000002966 varnish Substances 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
229920003176 water-insoluble polymer Polymers 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
229920001221 xylan Polymers 0.000 description 1
150000004823 xylans Chemical class 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
235000014692 zinc oxide Nutrition 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
239000002888 zwitterionic surfactant Substances 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

UAA201309355A 2010-12-29 2011-12-29 Композиції бензімідазолів з модифікованим вивільненням UA112855C2 (uk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN4013CH2010		2010-12-29
PCT/US2011/067868 WO2012092486A2 (fr)	2010-12-29	2011-12-29	Formulations de benzimidazole à libération modifiée

Publications (1)

Publication Number	Publication Date
UA112855C2 true UA112855C2 (uk)	2016-11-10

Family

ID=46383862

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA201309355A UA112855C2 (uk)	2010-12-29	2011-12-29	Композиції бензімідазолів з модифікованим вивільненням

Country Status (7)

Country	Link
EP (1)	EP2661260A4 (fr)
CN (1)	CN103402501A (fr)
AU (1)	AU2011352037A1 (fr)
EA (1)	EA201390979A1 (fr)
NZ (1)	NZ613090A (fr)
UA (1)	UA112855C2 (fr)
WO (1)	WO2012092486A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HK1201477A1 (en) *	2011-11-02	2015-09-04	Laboratorios Del. Dr. Esteve, S.A.	Pharmaceutical composition of omeprazole
MX2015010041A (es)	2013-02-05	2015-10-30	Purdue Pharma Lp	Formulacion farmaceuticas resistentes a la alteracion.
WO2014142938A1 (fr) *	2013-03-15	2014-09-18	Aihol Corporation	Formulation pharmaceutique contenant un glycosaminoglycane
US9539265B2 (en)	2013-03-15	2017-01-10	Aihol Corporation	Pharmaceutical formulation containing glycosaminoglycan
US20170042806A1 (en)	2015-04-29	2017-02-16	Dexcel Pharma Technologies Ltd.	Orally disintegrating compositions
US10076494B2 (en)	2016-06-16	2018-09-18	Dexcel Pharma Technologies Ltd.	Stable orally disintegrating pharmaceutical compositions
CN112336696B (zh) *	2020-12-01	2022-08-05	苏州中化药品工业有限公司	一种长效脉冲制剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050244497A1 (en) *	1997-11-05	2005-11-03	Wockhardt Limited	Delayed delivery system for acid-sensitive drugs
MY148805A (en) *	2002-10-16	2013-05-31	Takeda Pharmaceutical	Controlled release preparation
JP4541807B2 (ja) *	2004-09-03	2010-09-08	Ｏｋｉセミコンダクタ株式会社	半導体素子保持装置および半導体素子の搬送方法
AR051654A1 (es) *	2004-11-04	2007-01-31	Astrazeneca Ab	Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones
FR2891459B1 (fr) *	2005-09-30	2007-12-28	Flamel Technologies Sa	Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
AU2008282900B2 (en) *	2007-07-27	2014-05-22	Depomed, Inc.	Pulsatile gastric retentive dosage forms
US20090214599A1 (en) *	2008-02-21	2009-08-27	Agi Therapeutics Plc	Proton pump inhibitor formulations, and methods of preparing and using such formulations

2011
- 2011-12-29 WO PCT/US2011/067868 patent/WO2012092486A2/fr not_active Ceased
- 2011-12-29 NZ NZ613090A patent/NZ613090A/en not_active IP Right Cessation
- 2011-12-29 AU AU2011352037A patent/AU2011352037A1/en not_active Abandoned
- 2011-12-29 UA UAA201309355A patent/UA112855C2/uk unknown
- 2011-12-29 EP EP11853533.5A patent/EP2661260A4/fr not_active Withdrawn
- 2011-12-29 EA EA201390979A patent/EA201390979A1/ru unknown
- 2011-12-29 CN CN201180068674XA patent/CN103402501A/zh active Pending

Also Published As

Publication number	Publication date
WO2012092486A2 (fr)	2012-07-05
NZ613090A (en)	2015-11-27
EP2661260A4 (fr)	2014-05-14
AU2011352037A1 (en)	2013-08-01
EA201390979A1 (ru)	2013-12-30
CN103402501A (zh)	2013-11-20
EP2661260A2 (fr)	2013-11-13
WO2012092486A3 (fr)	2012-11-01

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US20120058194A1 (en)	2012-03-08	Pharmaceutical formulations comprising substituted benzimidazole derivatives
CA2346988C (fr)	2009-02-10	Formulation pharmaceutique contenant de l'omeprazole
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US20110189271A1 (en)	2011-08-04	Pharmaceutical formulations of acid-labile drugs
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US12433842B2 (en)	2025-10-07	Pediatric dosage forms, methods of making and using
RS20070365A (sr)	2009-01-22	Gastrorezistentne farmaceutske formulacije koje sadrže rifaksimin
KR20100126465A (ko)	2010-12-01	미코페놀레이트를 포함하는 변형 방출 제약 조성물 및 그것의 방법
SA99191077B1 (ar)	2006-07-11	صورة لجرعة صيدلانية طويلة المفعول تعطى عن طريق الفم
MX2011003562A (es)	2011-05-02	Tableta resistente al alcohol.
CZ20002709A3 (cs)	2000-12-13	Mikrogranule omeprazolu s vnější vrstvou chránící před žaludečním prostředím, způsob přípravy mikrogranulí
RU2647472C2 (ru)	2018-03-15	Фармацевтическая композиция омепразола
JP2015522653A (ja)	2015-08-06	プロトンポンプ阻害剤の医薬組成物
JP7541617B2 (ja)	2024-08-28	腸溶性ペレット及びその製造方法並びにそれを含む製剤
TW201815383A (zh)	2018-05-01	用於藥學用途之多層珠粒
EP3117824A1 (fr)	2017-01-18	Microparticules multicouche à libération de composé pharmaceutiquement actif sous forme posologique liquide
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WO2010117756A2 (fr)	2010-10-14	Formulations pharmaceutiques de benzimidazole substitué
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