UA123716U - OBTECHOLIC ACID - Google Patents
OBTECHOLIC ACIDInfo
- Publication number
- UA123716U UA123716U UAU201707853U UAU201707853U UA123716U UA 123716 U UA123716 U UA 123716U UA U201707853 U UAU201707853 U UA U201707853U UA U201707853 U UAU201707853 U UA U201707853U UA 123716 U UA123716 U UA 123716U
- Authority
- UA
- Ukraine
- Prior art keywords
- acid
- formula
- obethicholic
- obtecholic
- cholan
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- ZXERDUOLZKYMJM-ZWECCWDJSA-N obeticholic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)CCC(O)=O)CC[C@H]21 ZXERDUOLZKYMJM-ZWECCWDJSA-N 0.000 abstract 1
- 229960001601 obeticholic acid Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Обетіхолева кислота, отримана способом, при якому як вихідну речовину використовують (E)-3(-гідроксі-6-етиліден-7-кето-5(-холан-24-оік кислоту формули І EMBED ISISServer , Формула І причому спосіб одержання здійснюють у три стадії: а) за рахунок реакції з Pd/C і гідрогеном утворюють форму (Е)-3(-гідроксі-6-етил-7-кето-5(-холан-24-оік кислоту Формули II: EMBED ISISServer , Формула ІІ b) реакції сполуки Формули II з NaBH4 з утворенням кристалів обетіхолевої кислоти форми С; c) перекристалізації обетіхолевої кислоти, одержаної на стадії b) до утворення обетіхолевої кислоти форми 1.Obeticholic acid, obtained by the method in which (E) -3 (-hydroxy-6-ethylidene-7-keto-5 (-cholan-24-oic acid of formula I EMBED ISISServer, Formula I is used as the starting material, and the method of preparation is carried out in three steps: a) by reaction with Pd / C and hydrogen to form (E) -3 (-hydroxy-6-ethyl-7-keto-5 (-cholan-24-oic acid) Formula II: EMBED ISISServer, Formula II b) reaction of the compound of Formula II with NaBH4 to form crystals of obethicholic acid of form C; c) recrystallization of obethicholic acid obtained in step b) to form obethicholic acid of form 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAU201707853U UA123716U (en) | 2017-07-26 | 2017-07-26 | OBTECHOLIC ACID |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAU201707853U UA123716U (en) | 2017-07-26 | 2017-07-26 | OBTECHOLIC ACID |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA123716U true UA123716U (en) | 2018-03-12 |
Family
ID=61615864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAU201707853U UA123716U (en) | 2017-07-26 | 2017-07-26 | OBTECHOLIC ACID |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA123716U (en) |
-
2017
- 2017-07-26 UA UAU201707853U patent/UA123716U/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2015002616A (en) | Synthesis of bis(fluorosulfonyl)imide. | |
| NZ705827A (en) | Method of synthesizing thyroid hormone analogs and polymorphs thereof | |
| AR076974A1 (en) | METHOD FOR SYNTHETIZING PYRFENIDONE | |
| PE20142359A1 (en) | PROCEDURE FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLOPYRIDINES SUBSTITUTED | |
| AR076027A1 (en) | METHODS AND INTERMEDIARIES FOR THE PREPARATION OF PHARMACEUTICAL AGENTS | |
| AU2016237099B2 (en) | Method for producing novel nitrogen-containing compound or salt thereof, and production intermediate of same | |
| AR117002A2 (en) | PROCESS FOR THE PREPARATION OF KINASE C-FMS INHIBITORS | |
| EA201690755A1 (en) | SALT AND CRYSTAL FORMS OF PLK-4 INHIBITOR | |
| MX2017001459A (en) | Synthesis of phosphoramidates. | |
| MX378594B (en) | Process and intermediates for the 6,7-alpha-epoxidation of steroid 4,6-dienes | |
| MX384710B (en) | PROCESS FOR PREPARING 3-METHYLCYCLOPENTADECANE-1,5-DIONE. | |
| JOP20190264A1 (en) | Method for preparing an intermediate compound from 4-methoxypyrrole derivative | |
| EA201391721A1 (en) | METHOD OF OBTAINING POLYMORPHIC FORM I ETHORIKOXIB | |
| JOP20180126A1 (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| EA201990237A1 (en) | NEW METHODS FOR PRODUCING STIMULANTS OF SOLUBLE GUANILATICYCLASE | |
| PH12013500609A1 (en) | Novel method of preparing benzoimidazole derivatives | |
| EA200971019A1 (en) | METHODS OF OBTAINING (R) -2-METHILPYRROLIDINE AND (S) -2-METHILPYRROLIDINE AND THEIR SALTS OF WINE ACID | |
| EA201592167A1 (en) | METHOD FOR OBTAINING DERIVATIVES OF PYRROLIDIN-2-CARBONIC ACID | |
| EA201491463A1 (en) | METHOD OF OBTAINING A COMPOUND ON A NEW REACTION OF THE MICHAEL ACCESSION WITH THE APPLICATION OF WATER OR DIFFERENT ACIDS AS ADDITIVE | |
| UA123716U (en) | OBTECHOLIC ACID | |
| MX2015003237A (en) | Methods of producing molindone and its salts. | |
| MD4443B1 (en) | Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | |
| CO6280533A2 (en) | PROCESS TO PREPARE AN INTERMEDIATE COMPOUND TO SYNTHEIZE AN ANTI-GLOSSY | |
| EA202092114A1 (en) | NEW METHOD FOR PRODUCING SPRINGEN | |
| EA201400269A1 (en) | METHOD OF SYNTHESIS OF 7,8-DIMETOXY -1,3-DIHYDRO-2H-3-BENZAZEPIN-2-SHE COMPOUNDS AND IVABRADIN |