UA123781C2 - Малеатна сіль агоніста tlr7, її кристалічні форми c, d і e, способи одержання і застосування малеатної солі і кристалічних форм - Google Patents

Малеатна сіль агоніста tlr7, її кристалічні форми c, d і e, способи одержання і застосування малеатної солі і кристалічних форм Download PDF

Info

Publication number: UA123781C2
Authority: UA; Ukraine
Prior art keywords: crystalline form; crystalline; formula; compound; ray powder
Prior art date: 2016-02-05

Application number

UAA201809085A

Other languages

English (en)

Ukrainian (uk)

Inventor

Чжаочжун Дін

Чжаочжун ДИН

Фей СУНЬ

Інху Ху

Инху Ху

Ілун Чжоу

Илун Чжоу

Чжен Ван

Лін Ян

Лин Ян

Original Assignee

Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд.

Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-02-05

Filing date

2017-02-04

Publication date

2021-06-02

2017-02-04 Application filed by Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд., Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. filed Critical Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд.

2021-06-02 Publication of UA123781C2 publication Critical patent/UA123781C2/uk

Links

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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
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Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
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Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
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Communicable Diseases (AREA)
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Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

UAA201809085A 2016-02-05 2017-02-04 Малеатна сіль агоніста tlr7, її кристалічні форми c, d і e, способи одержання і застосування малеатної солі і кристалічних форм UA123781C2 (uk)

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CN201610082030.0A CN107043380A (zh)	2016-02-05	2016-02-05	一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
PCT/CN2017/072890 WO2017133683A1 (zh)	2016-02-05	2017-02-04	一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e及其制备方法和用途

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US (2)	US10780091B2 (2)
EP (1)	EP3412671B1 (2)
JP (1)	JP6898336B2 (2)
KR (1)	KR102393279B1 (2)
CN (2)	CN107043380A (2)
AR (1)	AR107547A1 (2)
AU (1)	AU2017215800B2 (2)
CA (1)	CA3013682C (2)
CL (1)	CL2018002089A1 (2)
DK (1)	DK3412671T3 (2)
EA (1)	EA038794B1 (2)
ES (1)	ES2834303T3 (2)
HU (1)	HUE052211T2 (2)
IL (1)	IL260965B (2)
MX (1)	MX374295B (2)
MY (1)	MY196762A (2)
NZ (1)	NZ745231A (2)
PH (1)	PH12018501644B1 (2)
SG (1)	SG11201806682TA (2)
TW (1)	TWI778951B (2)
UA (1)	UA123781C2 (2)
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ZA (1)	ZA201805185B (2)

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UA121345C2 (uk)	2015-11-05	2020-05-12	Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд.	7-(тіазол-5-іл)піролопіримідин як агоніст рецептора tlr7
TWI714661B (zh)	2015-11-05	2021-01-01	法商賽諾菲公司	新穎念珠藻素化合物及接合物、其製備與其治療用途
CN107043380A (zh)	2016-02-05	2017-08-15	正大天晴药业集团股份有限公司	一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043379A (zh)	2016-02-05	2017-08-15	正大天晴药业集团股份有限公司	一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043377A (zh)	2016-02-05	2017-08-15	正大天晴药业集团股份有限公司	一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途
CN107043378A (zh) *	2016-02-05	2017-08-15	正大天晴药业集团股份有限公司	一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

2016
- 2016-02-05 CN CN201610082030.0A patent/CN107043380A/zh active Pending
2017
- 2017-02-03 TW TW106103694A patent/TWI778951B/zh active
- 2017-02-04 KR KR1020187024626A patent/KR102393279B1/ko active Active
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- 2017-02-04 WO PCT/CN2017/072890 patent/WO2017133683A1/zh not_active Ceased
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HK1259175A1 (zh)	2019-11-29
AU2017215800B2 (en)	2020-08-20
CA3013682A1 (en)	2017-08-10
AU2017215800A1 (en)	2018-08-30
ZA201805185B (en)	2024-08-28
NZ745231A (en)	2022-07-29
SG11201806682TA (en)	2018-09-27
EP3412671A1 (en)	2018-12-12
MX2018009500A (es)	2018-12-11
JP2019505532A (ja)	2019-02-28
CA3013682C (en)	2022-06-21
US20200368241A1 (en)	2020-11-26
ES2834303T3 (es)	2021-06-17
US10780091B2 (en)	2020-09-22
CL2018002089A1 (es)	2018-12-07
PH12018501644A1 (en)	2019-06-03
CN108602830A (zh)	2018-09-28
JP6898336B2 (ja)	2021-07-07
TWI778951B (zh)	2022-10-01
EA038794B1 (ru)	2021-10-20
DK3412671T3 (da)	2020-11-09
MY196762A (en)	2023-05-03
MX374295B (es)	2025-03-06
EA201891770A1 (ru)	2019-01-31
US20190070179A1 (en)	2019-03-07
PH12018501644B1 (en)	2022-09-07
BR112018015881A2 (pt)	2018-12-26
AR107547A1 (es)	2018-05-09
IL260965B (en)	2022-02-01
CN107043380A (zh)	2017-08-15
KR20180104116A (ko)	2018-09-19
HUE052211T2 (hu)	2021-04-28
KR102393279B1 (ko)	2022-05-02
TW201728588A (zh)	2017-08-16
WO2017133683A1 (zh)	2017-08-10
CN108602830B (zh)	2020-07-28
EP3412671A4 (en)	2019-07-24
EP3412671B1 (en)	2020-09-16

Publication	Publication Date	Title
UA123781C2 (uk)	2021-06-02	Малеатна сіль агоніста tlr7, її кристалічні форми c, d і e, способи одержання і застосування малеатної солі і кристалічних форм
UA121161C2 (uk)	2020-04-10	Кристалічна форма a агоніста tlr7, її спосіб одержання і використання
CA3013521C (en)	2022-07-12	Trifluoroacetate salt of a pyrrolo[3,2-d]pyrimidin compound as tlr7 agonist and crystalline form b thereof
HK1259175B (zh)	2021-02-19	一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e及其制备方法和用途
HK1259170B (zh)	2021-06-11	一种tlr7激动剂的晶型a、其制备方法和用途
HK1259182B (zh)	2021-02-19	一种tlr7激动剂的三氟乙酸盐、晶型b、制备方法和用途