UA124331C2 - Пептид, здатний зв'язуватися з молекулою головного комплексу гістосумісності (mhc) людини i класу - Google Patents

Пептид, здатний зв'язуватися з молекулою головного комплексу гістосумісності (mhc) людини i класу

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Publication number
UA124331C2
UA124331C2 UAA201702214A UAA201702214A UA124331C2 UA 124331 C2 UA124331 C2 UA 124331C2 UA A201702214 A UAA201702214 A UA A201702214A UA A201702214 A UAA201702214 A UA A201702214A UA 124331 C2 UA124331 C2 UA 124331C2
Authority
UA
Ukraine
Prior art keywords
peptide
mhc
bind
molecule
tcr
Prior art date
Application number
UAA201702214A
Other languages
English (en)
Inventor
Тоні Вайншенк
Тони Вайншенк
Андреа Мар
Йенс Фрітше
Йенс Фритше
Філіп Мюллер
Филип МЮЛЛЕР
Аніта Вібе
Анита Вибэ
Сара Кучер
Original Assignee
Імматікс Біотекнолоджіс Гмбх
Имматикс Биотекнолоджис Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1501017.6A external-priority patent/GB201501017D0/en
Application filed by Імматікс Біотекнолоджіс Гмбх, Имматикс Биотекнолоджис Гмбх filed Critical Імматікс Біотекнолоджіс Гмбх
Publication of UA124331C2 publication Critical patent/UA124331C2/uk

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    • C07—ORGANIC CHEMISTRY
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Abstract

Винахід стосується пептиду, що складається з амінокислотної послідовності SEQ ID NO: 6, або його фармацевтично прийнятної солі, причому згаданий пептид здатний зв'язуватися з молекулою головного комплексу гістосумісності (MHC) людини I класу і згаданий пептид, якщо він зв'язаний з MHC, здатний розпізнаватися CD8 T-клітинами. Також винахід стосується антитіла, Т-клітинного рецептору (ТКР), нуклеїнової кислоти, вектору експресії, клітини-хазяїна, способу отримання пептиду, антитіла або ТКР, способу продукування активованих Т-лімфоцитів in vitro, активованої Т-клітини, фармацевтичної композиції, застосування активованого пептиду, антитіла, ТКР для виробництва лікарського засобу для лікування раку, що виявляє надмірну експресію AXIN2, та терапевтичного комплекту.
UAA201702214A 2014-12-23 2015-12-16 Пептид, здатний зв'язуватися з молекулою головного комплексу гістосумісності (mhc) людини i класу UA124331C2 (uk)

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PCT/EP2015/080018 WO2016102272A1 (en) 2014-12-23 2015-12-16 Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (hcc) and other cancers

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