UA19318A - СПОСІБ ОДЕРЖАHHЯ ЛЮДСЬКОЇ МnО2-ДИСМУТАЗИ - Google Patents

СПОСІБ ОДЕРЖАHHЯ ЛЮДСЬКОЇ МnО2-ДИСМУТАЗИ

Info

Publication number
UA19318A
UA19318A UA4355336A UA4355336A UA19318A UA 19318 A UA19318 A UA 19318A UA 4355336 A UA4355336 A UA 4355336A UA 4355336 A UA4355336 A UA 4355336A UA 19318 A UA19318 A UA 19318A
Authority
UA
Ukraine
Prior art keywords
dismutase
obtaining
human
mno2
kdna
Prior art date
Application number
UA4355336A
Other languages
English (en)
Russian (ru)
Inventor
Хекль Конрад
Спевак Вальтер
Остерманн Елінборг
Цефель Андреас
Кристек Едельтрауд
Маурер-Фогі Інгрід
Йозефа Віхе-Кастанон Марія
Стратова Крістіан
Гауптманн Рудольф
Original Assignee
Берінгер Інгельгейм Інтернаціональ Гмбх
Берингер Ингельгейм Интернациональ ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Берінгер Інгельгейм Інтернаціональ Гмбх, Берингер Ингельгейм Интернациональ ГмбХ filed Critical Берінгер Інгельгейм Інтернаціональ Гмбх
Publication of UA19318A publication Critical patent/UA19318A/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Винахід відноситься до біотехнології і генетичної інженерії, зокрема, до способів одержання людської MnO2-дисмутази для терапевтичних цілей, наприклад, як антизапальний засіб. Спосіб полягає у виділенні з плацентарної або печінкової тканини людини мРНК, отриманні полі (А)+РНК, синтезі двухланцюгової кДНК, конструюванні банку кДНК, виділенні послідовності ДНК і кодуванні Мn2О-дисмутази.
UA4355336A 1987-03-14 1988-03-14 СПОСІБ ОДЕРЖАHHЯ ЛЮДСЬКОЇ МnО2-ДИСМУТАЗИ UA19318A (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873708306 DE3708306A1 (de) 1987-03-14 1987-03-14 Humane mangan-superoxiddismutase (hmn-sod)

Publications (1)

Publication Number Publication Date
UA19318A true UA19318A (uk) 1997-12-25

Family

ID=6323067

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4355336A UA19318A (uk) 1987-03-14 1988-03-14 СПОСІБ ОДЕРЖАHHЯ ЛЮДСЬКОЇ МnО2-ДИСМУТАЗИ

Country Status (4)

Country Link
DE (1) DE3708306A1 (uk)
SU (1) SU1741610A3 (uk)
UA (1) UA19318A (uk)
ZA (1) ZA881743B (uk)

Also Published As

Publication number Publication date
DE3708306A1 (de) 1988-09-22
SU1741610A3 (ru) 1992-06-15
ZA881743B (en) 1989-11-29

Similar Documents

Publication Publication Date Title
ATE174599T1 (de) Bindungskompetente oligomere, die 2',5'-bindungen enthalten
PT910647E (pt) Variantes hiperactivas da dnase i humana
HU9501963D0 (en) 7-deazapurine modified oligonucleotides
AU637354B2 (en) Genetic units for inhibiting the function of rna
WO1999054461A3 (de) Menschliche nukleinsäuresequenzen aus endometriumtumorgewebe
PT1053313E (pt) Oligonucleotidos ''antisense'' optimizados complementares de sequencias de dna metiltransferase
MXPA03002413A (es) Moleculas tipo b7 y uso de las mismas.
MY134810A (en) Targeted gene expression of thrombopoietein, dnase i and b-interferon
WO1996034953A3 (en) Cd16-ii variants
EP0088195A3 (en) Messenger rna, production and use thereof
DK1175489T3 (da) Oligonukleotider indeholdende en antisense-sekvens stabiliseret af en sekundær struktur og farmaceutiske præparater indeholdende disse oligonukleotider
TW200640944A (en) VGF polypeptides and methods of treating VGF-related disorders
WO1998054313A3 (en) Dna methyltransferase genomic sequences and antisense oligonucleotides
DE69736276D1 (de) Menschliche dnase resistent gegen actininhibitoren
ATE371031T1 (de) Herpes-simplex virus, das das gen von interleukin-12 exprimiert, und dessen verwendung zur behandlung von krebs
WO1999054353A3 (de) Menschliche nukleinsäuresequenzen aus uterusnormalgewebe
WO1999054447A3 (de) Menschliche nukleinsäuresequenzen aus blasentumorgewebe
MXPA02000680A (es) Polipeptidos vgf y metodos para tratar desordenes relacionados con vgf.
EP1574507A3 (en) Furo- and pyrano-naphthoquinones and their use in the treatment of cancer
DE69730967D1 (en) Human dnase ii
WO1999054448A3 (de) Menschliche nukleinsäurefragmente, deren expression in uterusmyomgewebeerhoeht ist
DE69636737D1 (de) Neues immunoregulatorisches protein lst-1
HK1044568A1 (zh) 一种治疗剂的应激应答性诱导及其使用方法
WO1998006440A3 (en) Phenotypic conversion of cells mediated by external guide sequences
WO1996011562A3 (en) Human checkpoint gene and gene for antisense rna thereof