UA33033A - Method of making bezilate amlodipine - Google Patents
Method of making bezilate amlodipineInfo
- Publication number
- UA33033A UA33033A UA98105446A UA98105446A UA33033A UA 33033 A UA33033 A UA 33033A UA 98105446 A UA98105446 A UA 98105446A UA 98105446 A UA98105446 A UA 98105446A UA 33033 A UA33033 A UA 33033A
- Authority
- UA
- Ukraine
- Prior art keywords
- bezilate
- amlodipine
- making
- benzenesulfonic acid
- acid before
- Prior art date
Links
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title 1
- 229960000528 amlodipine Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 2
- 229940092714 benzenesulfonic acid Drugs 0.000 abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process is realized by means of interaction with benzenesulfonic acid before inert solvent. It is linked together a 2-[2-(N-tritylamino)-etoxymethyl]-4-(2-chlorophenyl)-3- ethoxycarbonyl -5- methoxycarbonyl-6-methyl-1,4- dihydropyridine with benzenesulfonic acid before methanol.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA98105446A UA33033A (en) | 1998-10-16 | 1998-10-16 | Method of making bezilate amlodipine |
| RU99121192/04A RU2173685C2 (en) | 1998-10-16 | 1999-10-05 | Method of preparing amlodipine bezylate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA98105446A UA33033A (en) | 1998-10-16 | 1998-10-16 | Method of making bezilate amlodipine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA33033A true UA33033A (en) | 2001-02-15 |
Family
ID=35863216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA98105446A UA33033A (en) | 1998-10-16 | 1998-10-16 | Method of making bezilate amlodipine |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2173685C2 (en) |
| UA (1) | UA33033A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100841409B1 (en) * | 2003-12-16 | 2008-06-25 | 에스케이케미칼주식회사 | Amlodipine gentisate salt and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| SI9200344B (en) * | 1992-11-26 | 1998-06-30 | Lek, | A process for the preparation of amlodipine benzenesulfonate |
-
1998
- 1998-10-16 UA UA98105446A patent/UA33033A/en unknown
-
1999
- 1999-10-05 RU RU99121192/04A patent/RU2173685C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2173685C2 (en) | 2001-09-20 |
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