UA35547C2 - 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organism - Google Patents
1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organismInfo
- Publication number
- UA35547C2 UA35547C2 UA5001786A UA5001786A UA35547C2 UA 35547 C2 UA35547 C2 UA 35547C2 UA 5001786 A UA5001786 A UA 5001786A UA 5001786 A UA5001786 A UA 5001786A UA 35547 C2 UA35547 C2 UA 35547C2
- Authority
- UA
- Ukraine
- Prior art keywords
- diazacyclooctadecane
- tetraoxa
- metal
- group
- hydrogen
- Prior art date
Links
- NLMDJJTUQPXZFG-UHFFFAOYSA-N 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane Chemical class C1COCCOCCNCCOCCOCCN1 NLMDJJTUQPXZFG-UHFFFAOYSA-N 0.000 title abstract 2
- 229910021645 metal ion Inorganic materials 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 title 1
- 229910052791 calcium Inorganic materials 0.000 title 1
- 239000011575 calcium Substances 0.000 title 1
- 230000008030 elimination Effects 0.000 title 1
- 238000003379 elimination reaction Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052751 metal Inorganic materials 0.000 abstract 3
- 239000002184 metal Substances 0.000 abstract 3
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002285 radioactive effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 229910052684 Cerium Inorganic materials 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- ZMIGMASIKSOYAM-UHFFFAOYSA-N cerium Chemical compound [Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce] ZMIGMASIKSOYAM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052712 strontium Inorganic materials 0.000 abstract 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910001428 transition metal ion Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention relates to partially novel metal complexes, salts and double salts of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane compounds of formula (I) (I) wherein Q1 and Q2 mean hydrogen or a group of formula (III), (III) in the groups of formula (III) the R substituents independently represent hydrogen, a C1-5 straight or branched chain alkyl group, a C2-5 straight or branched chain alkenyl group, phenyl or phenyl-C1-5alkyl group, the two latter ones optionally being substituted on their aromatic part by one or more halogen(s), C1-5alkyl, C1-5alkoxy, cyano or nitro group(s), with the proviso that at least one of Q1 and Q2 is other than hydrogen; Me stands for an alkaline metal or alkaline earth metal or transition metal ion; q is 0 or 1; M and N, independently from each other, stand for hydrogen or an alkaline metal, alkaline earth metal or optionally substituted ammonium ion; m, n and p are integers each being equal to the charge of M, N or Me, respectively; s and r are, independently from each other, 0, 1, 2, 3 or 4, with the proviso that (i) r, s and q cannot simultaneously be 0; and (ii) the number of hydrogens in the meaning of M or N may be 0, 1 or 2, as well as pharmaceutical compositions containing these compounds. The compounds and compositions according to the invention can be used for decorporation of metal ions, mainly radioactive isotopes such as radioactive strontium or cerium being harmful to the living organism. The active agents according to the invention exert their effects either in intravenous or local, transdermal or rectal route of administration.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU90145A HU210667B (en) | 1990-01-16 | 1990-01-16 | Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them |
| PCT/HU1990/000070 WO1991010655A1 (en) | 1990-01-16 | 1990-11-07 | 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA35547C2 true UA35547C2 (en) | 2001-04-16 |
Family
ID=10948158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA5001786A UA35547C2 (en) | 1990-01-16 | 1990-11-07 | 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organism |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0463123A1 (en) |
| JP (1) | JPH04505626A (en) |
| KR (1) | KR970009042B1 (en) |
| AU (1) | AU645507B2 (en) |
| CA (1) | CA2048627A1 (en) |
| HU (2) | HU210667B (en) |
| IN (1) | IN171733B (en) |
| RU (1) | RU2060256C1 (en) |
| UA (1) | UA35547C2 (en) |
| WO (1) | WO1991010655A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0554358A4 (en) * | 1990-09-27 | 1995-09-06 | Brunswick Corp | Chelating agents |
| IL117302A (en) * | 1995-03-07 | 2005-03-20 | Univ Hawaii | Cryptophycin derivatives, methods for the production thereof and pharmaceutical compositions containing the same |
| HUP1100731A2 (en) * | 2011-12-30 | 2013-06-28 | Stratoxer S Kft | Complex forming compounds |
| EA019079B1 (en) * | 2012-06-19 | 2013-12-30 | Елена Владимировна ОРЛОВА | BIOSAFETY NANOCOMPOSITE POLYMER SORBENT FOR SELECTIVE BINDING OF Sr AND Cs ISOTOPES FROM LIQUID MEDIUMS AND RAW MIX FOR PRODUCING SAME |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4190462A (en) * | 1978-07-04 | 1980-02-26 | Shell Oil Company | Dissolving barium sulfate scale with aqueous solutions of salts of carboxymethyl monocyclic macrocyclic polyamines |
| US4597903A (en) * | 1984-08-21 | 1986-07-01 | University Of Maryland | Process for the direct preparation of N,N-disubstituted derivatives for 4,13-diaza-18-crown-6 |
| JPS61263964A (en) * | 1985-05-17 | 1986-11-21 | Terumo Corp | Novel crown (thio)ether and production thereof |
-
1990
- 1990-01-16 HU HU90145A patent/HU210667B/en not_active IP Right Cessation
- 1990-01-16 HU HU9502769A patent/HUT73493A/en unknown
- 1990-11-07 EP EP90916523A patent/EP0463123A1/en not_active Withdrawn
- 1990-11-07 UA UA5001786A patent/UA35547C2/en unknown
- 1990-11-07 KR KR1019910701044A patent/KR970009042B1/en not_active Expired - Lifetime
- 1990-11-07 CA CA002048627A patent/CA2048627A1/en not_active Abandoned
- 1990-11-07 RU SU905001786A patent/RU2060256C1/en active
- 1990-11-07 AU AU67116/90A patent/AU645507B2/en not_active Ceased
- 1990-11-07 WO PCT/HU1990/000070 patent/WO1991010655A1/en not_active Ceased
- 1990-11-07 JP JP2515439A patent/JPH04505626A/en active Pending
- 1990-11-22 IN IN943/MAS/90A patent/IN171733B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9502769D0 (en) | 1995-11-28 |
| HU900145D0 (en) | 1990-03-28 |
| AU6711690A (en) | 1991-08-05 |
| AU645507B2 (en) | 1994-01-20 |
| RU2060256C1 (en) | 1996-05-20 |
| IN171733B (en) | 1992-12-26 |
| WO1991010655A1 (en) | 1991-07-25 |
| JPH04505626A (en) | 1992-10-01 |
| HU210667B (en) | 1998-03-30 |
| HUT73493A (en) | 1996-08-28 |
| CA2048627A1 (en) | 1991-07-17 |
| EP0463123A1 (en) | 1992-01-02 |
| KR920701184A (en) | 1992-08-11 |
| KR970009042B1 (en) | 1997-06-03 |
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