UA62849A - Method for producing carbon enterosorbents - Google Patents

Abstract

The method for producing the carbon enterosorbent consists in grinding and wetting the activated material. The end product with the residual moisture of 30-70 mass % relative the dry mass of the sorbent is then granulated.

Description

Description of the invention

The invention relates to the medical industry, in particular, to the production of carbon sorption materials 2 (enterosorbents), which are used orally in acute and chronic poisoning, endogenous intoxications, acute intestinal and some immune-dependent diseases.

The method of obtaining tableted carbon enterosorbent (patent of Ukraine 21318

IPC A 61 K 33/44). In accordance with this method, activated carbon materials are crushed, moistened and pressed without a binder into tablets (boluses) with a diameter of 5-15 mm with a residual pressing moisture of 20-8Omas.9o relative to the dry weight of the tablet, followed by packaging in a hermetic container.

The disadvantage of the prototype is the low strength of the tablets (boluses) obtained, which is associated with small forces of interaction between water and the sorption material itself. At the same time, the forces that arise during packaging, transportation and use of tablets, applied to points relatively far apart from each other, cause the destruction of the tablets, the shedding of the edges, the formation of small fragments. 19 The task of the invention is to improve the method of production of carbon enterosorbent, which consists of the sorbent itself and water, by optimizing its mechanical properties, which allows obtaining a stable dosage form of the drug, which does not change under mechanical loads accompanying its packaging, transportation and use.

The task is solved by the fact that in the method of obtaining a carbon enterosorbent, which includes grinding activated materials, their hydration, the finished preparation with a residual moisture of 30-7Omas.9o relative to the dry mass of the sorbent is formed in the form of granules obtained by mixing, sieving or rubbing through a perforated plate , or a punching sieve, or a special granulator.

Granules are packed in a hermetic container and are easily dosed with a regular lozenge. Under mechanical influences, vibration, transport shaking, etc., the granulometric composition of the resulting mixture practically does not change, because along with the destruction of individual granules, their formation de pomo (rolling) is observed. In addition, "small (2-Zmm) granules are much worse subject to destruction than large tablets, due to the lack of torques sufficient for this.

The proposed wet granules fully preserve the advantages of water-carbon mixtures, which consist in the absence of the effect of screening the pores with a binder, as well as in the improvement of the kinetics of sorption due to the preliminary filling of the transport pores with water, and in the high organoleptic properties of the drug, which enable "I swallow it with a minimum amount of water in the form of an indifferent mushy substance.

The method is carried out as follows: a given amount of activated carbon material is crushed by an extrusion method or in a layer mill to obtain particles with sizes from 7 to 150 μm, moistened with water, granulated by mixing in a special container, sieving or rubbing through

From a perforated plate or punch sieve, or using a special granulator. at

The quality of the granules is assessed by the criteria of the absence of their sticking together into large conglomerates, which are formed when there is an excess of water as a binder, or their crumbling into a powder when there is not enough water. Table 1 shows the limit values of water content for different types of activated carbon, which allow obtaining complete granules. With c su ' 2

f name)

These data make it possible to determine the moisture range of the granules, within which their shape is preserved. Table 2 shows the results of testing the strength of wet tablets and granules after a standard cycle of 20 vibration loads for AUT-M fibrous carbon sorbent. When carrying out this test, tablets with a diameter of 15 mm and granules with a diameter of 2-3 mm were used, which are subject to careful

Me, sieving through sieves with a diameter of 6 and 2 mm holes, respectively. z" 60 tre 0.001 "p" 0.1

Table 2 shows that after the same mechanical load, wet tablets with a diameter of 15 mm are almost completely destroyed and 5795 carbon material passes through a sieve with holes with a diameter of mm, that is, the amount of sifted material before and after mechanical load changes reliably by 16 times. At 65, at the same time, the sifted granule fraction does not reliably change after mechanical loading. This result demonstrates a much higher mechanical stability of natural enterosorbents in the form of wet granules compared to that of wet tablets (boluses).

Claims (1)

The formula of the invention The method of obtaining a carbon enterosorbent, in which the activated materials are crushed and then moistened, which is distinguished by the fact that the finished preparation has a residual moisture of 30-70 wt. 95 relative to the dry mass of the sorbent is formed in the form of granules, obtained by mixing, sieving or rubbing )o0 through a perforated plate or punching sieve, or by using a special granulator. Official bulletin "Industrial Property". Book 1 "Inventions, useful models, topographies of integrated microcircuits", 2003, M 12, 15.12.2003. State Department of Intellectual Property of the Ministry of Education and Science of Ukraine. « (o) « (ee) s (Se) - with . and? (o) ime) (ee) sh» 3e) 60 b5