UA62924C2 - Silanzetron-containing dosage forms - Google Patents

Silanzetron-containing dosage forms Download PDF

Info

Publication number: UA62924C2
Authority: UA; Ukraine
Prior art keywords: dosage form; acid; cilanzetron; pharmaceutical dosage; fact
Prior art date: 1997-08-01

Application number

UA98074202A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Solway Pharmaceuticals Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-01

Filing date

1998-07-31

Publication date

2004-01-15

1998-07-31 Application filed by Solway Pharmaceuticals Gmbh filed Critical Solway Pharmaceuticals Gmbh

2004-01-15 Publication of UA62924C2 publication Critical patent/UA62924C2/uk

Links

239000002552 dosage form Substances 0.000 title claims description 63
239000000654 additive Substances 0.000 claims abstract description 78
239000002253 acid Substances 0.000 claims abstract description 53
150000003839 salts Chemical class 0.000 claims abstract description 46
230000000996 additive effect Effects 0.000 claims abstract description 40
230000006340 racemization Effects 0.000 claims abstract description 31
239000008297 liquid dosage form Substances 0.000 claims abstract description 18
150000007524 organic acids Chemical class 0.000 claims abstract description 17
235000005985 organic acids Nutrition 0.000 claims abstract description 17
239000007909 solid dosage form Substances 0.000 claims abstract description 16
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 6
230000000087 stabilizing effect Effects 0.000 claims abstract description 5
230000002378 acidificating effect Effects 0.000 claims description 59
239000007787 solid Substances 0.000 claims description 29
239000000203 mixture Substances 0.000 claims description 27
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
239000013543 active substance Substances 0.000 claims description 22
150000007513 acids Chemical class 0.000 claims description 19
239000007788 liquid Substances 0.000 claims description 17
229940093915 gynecological organic acid Drugs 0.000 claims description 15
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
230000006641 stabilisation Effects 0.000 claims description 12
238000011105 stabilization Methods 0.000 claims description 12
239000000126 substance Substances 0.000 claims description 12
239000000243 solution Substances 0.000 claims description 11
239000000969 carrier Substances 0.000 claims description 9
239000008187 granular material Substances 0.000 claims description 8
238000000034 method Methods 0.000 claims description 8
239000011668 ascorbic acid Substances 0.000 claims description 7
235000010323 ascorbic acid Nutrition 0.000 claims description 7
229960005070 ascorbic acid Drugs 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 7
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 6
239000007853 buffer solution Substances 0.000 claims description 6
229960004106 citric acid Drugs 0.000 claims description 6
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
239000007979 citrate buffer Substances 0.000 claims description 4
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
229940124531 pharmaceutical excipient Drugs 0.000 claims description 3
239000000843 powder Substances 0.000 claims description 3
QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims description 2
UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims description 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
239000008351 acetate buffer Substances 0.000 claims description 2
239000001530 fumaric acid Substances 0.000 claims description 2
229960002598 fumaric acid Drugs 0.000 claims description 2
239000004310 lactic acid Substances 0.000 claims description 2
235000014655 lactic acid Nutrition 0.000 claims description 2
229940099563 lactobionic acid Drugs 0.000 claims description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
239000011976 maleic acid Substances 0.000 claims description 2
229940098895 maleic acid Drugs 0.000 claims description 2
229960002510 mandelic acid Drugs 0.000 claims description 2
235000006408 oxalic acid Nutrition 0.000 claims description 2
150000007519 polyprotic acids Polymers 0.000 claims description 2
239000011975 tartaric acid Substances 0.000 claims description 2
235000002906 tartaric acid Nutrition 0.000 claims description 2
229910052500 inorganic mineral Inorganic materials 0.000 claims 3
239000011707 mineral Substances 0.000 claims 3
239000003937 drug carrier Substances 0.000 claims 1
239000008363 phosphate buffer Substances 0.000 claims 1
239000000725 suspension Substances 0.000 claims 1
150000007522 mineralic acids Chemical class 0.000 abstract description 4
239000003826 tablet Substances 0.000 description 24
238000003860 storage Methods 0.000 description 14
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
239000002585 base Substances 0.000 description 7
229920002261 Corn starch Polymers 0.000 description 6
230000015572 biosynthetic process Effects 0.000 description 6
239000008120 corn starch Substances 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
239000001267 polyvinylpyrrolidone Chemical class 0.000 description 6
229920000036 polyvinylpyrrolidone Chemical class 0.000 description 6
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
239000002775 capsule Substances 0.000 description 5
230000000052 comparative effect Effects 0.000 description 5
150000001875 compounds Chemical class 0.000 description 5
238000012360 testing method Methods 0.000 description 5
238000005303 weighing Methods 0.000 description 5
-1 2-methyl-imidazol-2-yl Chemical group 0.000 description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
239000007900 aqueous suspension Substances 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
239000008101 lactose Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
229930195725 Mannitol Natural products 0.000 description 3
235000021355 Stearic acid Nutrition 0.000 description 3
239000003637 basic solution Substances 0.000 description 3
238000005469 granulation Methods 0.000 description 3
230000003179 granulation Effects 0.000 description 3
239000000594 mannitol Substances 0.000 description 3
235000010355 mannitol Nutrition 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
239000008194 pharmaceutical composition Substances 0.000 description 3
239000012488 sample solution Substances 0.000 description 3
239000008117 stearic acid Substances 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
229920000881 Modified starch Polymers 0.000 description 2
229910052784 alkaline earth metal Inorganic materials 0.000 description 2
229910000147 aluminium phosphate Inorganic materials 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
229960002303 citric acid monohydrate Drugs 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
239000000945 filler Substances 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
239000008108 microcrystalline cellulose Substances 0.000 description 2
235000019813 microcrystalline cellulose Nutrition 0.000 description 2
229940016286 microcrystalline cellulose Drugs 0.000 description 2
235000019426 modified starch Nutrition 0.000 description 2
239000008055 phosphate buffer solution Substances 0.000 description 2
239000000377 silicon dioxide Substances 0.000 description 2
235000012239 silicon dioxide Nutrition 0.000 description 2
239000007921 spray Substances 0.000 description 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241000158728 Meliaceae Species 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical class [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
150000008043 acidic salts Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000008044 alkali metal hydroxides Chemical class 0.000 description 1
150000001447 alkali salts Chemical class 0.000 description 1
150000001342 alkaline earth metals Chemical class 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
239000003708 ampul Substances 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
239000000872 buffer Substances 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000008298 dragée Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 1
239000011256 inorganic filler Substances 0.000 description 1
229910003475 inorganic filler Inorganic materials 0.000 description 1
229960000448 lactic acid Drugs 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
238000002156 mixing Methods 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000003921 oil Substances 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
229940116315 oxalic acid Drugs 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000008213 purified water Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000011973 solid acid Substances 0.000 description 1
SETMGIIITGNLAS-UHFFFAOYSA-N spizofurone Chemical compound O=C1C2=CC(C(=O)C)=CC=C2OC21CC2 SETMGIIITGNLAS-UHFFFAOYSA-N 0.000 description 1
229950001870 spizofurone Drugs 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
235000021092 sugar substitutes Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
229960001367 tartaric acid Drugs 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

UA98074202A 1997-08-01 1998-07-31 Silanzetron-containing dosage forms UA62924C2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19733271		1997-08-01

Publications (1)

Publication Number	Publication Date
UA62924C2 true UA62924C2 (en)	2004-01-15

Family

ID=7837672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA98074202A UA62924C2 (en)	1997-08-01	1998-07-31	Silanzetron-containing dosage forms

Country Status (28)

Country	Link
US (1)	US5977127A (fr)
EP (1)	EP0895782B1 (fr)
JP (1)	JP4324260B2 (fr)
KR (1)	KR100515201B1 (fr)
CN (1)	CN1117565C (fr)
AR (1)	AR010178A1 (fr)
AT (1)	ATE283706T1 (fr)
AU (1)	AU743043B2 (fr)
BR (1)	BR9803730A (fr)
CA (1)	CA2244389C (fr)
CZ (1)	CZ295072B6 (fr)
DE (2)	DE19813661A1 (fr)
DK (1)	DK0895782T3 (fr)
DZ (1)	DZ2560A1 (fr)
ES (1)	ES2234051T3 (fr)
HU (1)	HUP9801712A3 (fr)
ID (1)	ID20685A (fr)
IL (1)	IL125403A (fr)
NO (1)	NO323229B1 (fr)
NZ (1)	NZ331083A (fr)
PL (1)	PL191767B1 (fr)
PT (1)	PT895782E (fr)
RU (1)	RU2199318C2 (fr)
SK (1)	SK284916B6 (fr)
TR (1)	TR199801432A3 (fr)
TW (1)	TW509570B (fr)
UA (1)	UA62924C2 (fr)
ZA (1)	ZA986715B (fr)

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US7452545B2 (en) *	2001-11-13	2008-11-18	Yu Ruey J	Oligosaccharide aldonic acids and their topical use
WO2002076432A2 (fr) *	2001-03-26	2002-10-03	Novartis Ag	Compositions pharmaceutiques
GB0216027D0 (en) *	2002-07-10	2002-08-21	Arachnova Therapeutics Ltd	New therapeutic use
US20040048874A1 (en) *	2001-05-22	2004-03-11	Bardsley Hazel Judith	New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
KR20050111318A (ko) *	2003-01-13	2005-11-24	다이노젠 파마세우티컬스, 인코포레이티드	기능성 장 질환을 치료하는 방법
ES2285407T3 (es) *	2003-01-13	2007-11-16	Dynogen Pharmaceuticals Inc.	Metodo para el tratamiento de nauseas, vomitos, arcadas o cualquiera de sus combinaciones.
CA2519379A1 (fr) *	2003-04-04	2004-10-21	Dynogen Pharmaceuticals, Inc.	Methode de traitement de troubles des voies urinaires inferieures
US7820690B2 (en) *	2004-03-19	2010-10-26	Solvay Pharmaceuticals Gmbh	Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist
WO2006105117A2 (fr) *	2005-03-28	2006-10-05	Dynogen Pharmaceuticals, Inc.	Procede destine a traiter des troubles et des conditions au moyen d'inhibiteurs et d'antagonistes a peripherie restreinte
US20110152342A1 (en) *	2008-08-14	2011-06-23	Hiroshi Uchida	Stabilized pharmaceutical composition
WO2021100728A1 (fr)	2019-11-20	2021-05-27	塩野義製薬株式会社	Formulation solide contenant un dérivé de morphinane 6,7-insaturé du 7-carbamoyl

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DE3885357T2 (de) *	1987-06-29	1994-03-24	Duphar Int Res	Anellierte Indolderivate.
DE4238553A1 (de) *	1992-11-14	1994-05-19	Kali Chemie Pharma Gmbh	Neue Imidazol-1-yl-Verbindungen enthaltende Arzneimittel
AU702594B2 (en) *	1995-10-13	1999-02-25	Duphar International Research B.V.	Process for the preparation of enantiomerically pure imidazolyl compounds

1998
- 1998-03-27 DE DE19813661A patent/DE19813661A1/de not_active Withdrawn
- 1998-06-05 CN CN98109652A patent/CN1117565C/zh not_active Expired - Fee Related
- 1998-06-17 TW TW087109651A patent/TW509570B/zh not_active IP Right Cessation
- 1998-06-18 AR ARP980102904A patent/AR010178A1/es active IP Right Grant
- 1998-07-11 KR KR10-1998-0028014A patent/KR100515201B1/ko not_active Expired - Fee Related
- 1998-07-15 DZ DZ980170A patent/DZ2560A1/fr active
- 1998-07-20 IL IL12540398A patent/IL125403A/en not_active IP Right Cessation
- 1998-07-22 DE DE59812317T patent/DE59812317D1/de not_active Expired - Lifetime
- 1998-07-22 AT AT98113643T patent/ATE283706T1/de active
- 1998-07-22 PT PT98113643T patent/PT895782E/pt unknown
- 1998-07-22 EP EP98113643A patent/EP0895782B1/fr not_active Expired - Lifetime
- 1998-07-22 DK DK98113643T patent/DK0895782T3/da active
- 1998-07-22 ES ES98113643T patent/ES2234051T3/es not_active Expired - Lifetime
- 1998-07-23 TR TR1998/01432A patent/TR199801432A3/tr unknown
- 1998-07-24 SK SK1009-98A patent/SK284916B6/sk not_active IP Right Cessation
- 1998-07-24 NZ NZ331083A patent/NZ331083A/xx not_active IP Right Cessation
- 1998-07-27 CZ CZ19982367A patent/CZ295072B6/cs not_active IP Right Cessation
- 1998-07-28 ZA ZA986715A patent/ZA986715B/xx unknown
- 1998-07-29 HU HU9801712A patent/HUP9801712A3/hu unknown
- 1998-07-29 RU RU98114668/14A patent/RU2199318C2/ru not_active IP Right Cessation
- 1998-07-31 US US09/126,751 patent/US5977127A/en not_active Expired - Lifetime
- 1998-07-31 JP JP21707598A patent/JP4324260B2/ja not_active Expired - Fee Related
- 1998-07-31 NO NO19983540A patent/NO323229B1/no not_active IP Right Cessation
- 1998-07-31 CA CA002244389A patent/CA2244389C/fr not_active Expired - Fee Related
- 1998-07-31 UA UA98074202A patent/UA62924C2/uk unknown
- 1998-07-31 PL PL327786A patent/PL191767B1/pl not_active IP Right Cessation
- 1998-07-31 BR BR9803730-7A patent/BR9803730A/pt not_active Application Discontinuation
- 1998-07-31 AU AU78630/98A patent/AU743043B2/en not_active Ceased
- 1998-08-03 ID IDP981075A patent/ID20685A/id unknown

Also Published As

Publication number	Publication date
ID20685A (id)	1999-02-18
CZ236798A3 (cs)	1999-02-17
HUP9801712A2 (hu)	1999-04-28
TR199801432A2 (xx)	1999-02-22
KR19990023194A (ko)	1999-03-25
DK0895782T3 (da)	2005-01-03
CA2244389C (fr)	2008-01-15
NZ331083A (en)	2000-01-28
DE59812317D1 (de)	2005-01-05
CN1207292A (zh)	1999-02-10
TR199801432A3 (tr)	1999-02-22
HUP9801712A3 (en)	2001-08-28
HK1017611A1 (en)	1999-11-26
ZA986715B (en)	1999-02-04
IL125403A (en)	2001-11-25
TW509570B (en)	2002-11-11
CZ295072B6 (cs)	2005-05-18
EP0895782A2 (fr)	1999-02-10
US5977127A (en)	1999-11-02
CN1117565C (zh)	2003-08-13
AR010178A1 (es)	2000-05-17
BR9803730A (pt)	2000-03-28
EP0895782B1 (fr)	2004-12-01
JP4324260B2 (ja)	2009-09-02
DE19813661A1 (de)	1999-02-04
JPH1192369A (ja)	1999-04-06
AU7863098A (en)	1999-02-11
NO983540D0 (no)	1998-07-31
SK100998A3 (en)	1999-02-11
KR100515201B1 (ko)	2005-12-09
NO983540L (no)	1999-02-02
RU2199318C2 (ru)	2003-02-27
PT895782E (pt)	2005-02-28
PL327786A1 (en)	1999-02-15
DZ2560A1 (fr)	2003-02-15
NO323229B1 (no)	2007-02-05
HU9801712D0 (en)	1998-09-28
IL125403A0 (en)	1999-03-12
ES2234051T3 (es)	2005-06-16
CA2244389A1 (fr)	1999-02-01
ATE283706T1 (de)	2004-12-15
AU743043B2 (en)	2002-01-17
PL191767B1 (pl)	2006-06-30
SK284916B6 (sk)	2006-02-02
EP0895782A3 (fr)	2001-01-31

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