UA65321A - Composition for treating viral lesions of oral mucosa - Google Patents

Abstract

The composition for treating the viral lesions of the oral mucosa comprises ethanol, diethyl ether, propolis, Epigen, Vibrocil and the essential oils from the following plants: St. John's wort, myrrh, pelargonium, rose-wood, lavender, cinnamon, and thyme.

Description

The invention belongs in general to medicine, namely, specifically to the section of therapeutic dentistry, dedicated to the clinic, diagnosis and treatment of diseases of the mucous membrane and can be used for the therapy of lesions of the mucous membrane of the oral cavity of a viral nature.

A well-known remedy for the treatment of viral lesions of the mucous membrane of the oral cavity (1. Marchenko A.I.,

Kononovych EF, Solntseva TA. Pharmacotherapy in dentistry. - K.: Zdorovya, 1986. - P.147-1481|, which includes gossypol in the form of 0.195 solution or 395 liniment, which are produced from cotton.

The disadvantage of the known remedy is that gossypol, against the background of viral colonization, changes the properties of other microorganisms involved in the development of the inflammatory process of the mucous membrane of the oral cavity, and the antimicrobial properties of the indicated drug are insufficient in relation to gram-positive bacteria and pathogenic protozoa (they are activated on integumentary tissues) . In addition, over the years, the therapeutic effectiveness of this drug decreases, or its medicinal effect is not observed at all, even against viruses.

The closest in terms of technical essence of the remedy that appears is a remedy for the treatment of viral lesions of the mucous membrane (2. Kh. Kuriyan in the book by A.P. Groholsky, N.A. Kodola, V.G. Burgonsky, Y.B. Tchaikovsky .

Non-traditional methods of treatment in stomatology. - K.: Health, 1995. - P.173-174|, which includes stomapin, obtained by replacing the antibiotic rondomycin with methylene blue.

In addition to cotton, this composition also includes propolis, ethyl alcohol, diethyl ether, royal jelly, bee honey, and fish oil.

The disadvantage of this remedy is that it is used to treat viral lesions of the oral mucosa, but it lacks both pronounced antimicrobial and antiviral effects. In the process of using this method, patients may develop an allergic reaction to beekeeping components: bee honey and royal jelly; and fish oil, which can be obtained from the fresh liver of cod fish, has been completely discontinued.

The invention is based on the task of creating a remedy for the treatment of viral lesions of the mucous membrane of the oral cavity of a viral nature, which includes ethyl alcohol, diethyl ether, propolis, additionally contains epigen, vibrocil and several essential oils: with St. John's wort, myrrh, geranium, rose tree, cinnamon, lavender, thyme, which makes it possible to simultaneously eliminate pain for a long time, restrain the reproduction of viral and bacterial flora, which complicates the clinical picture of the disease, accelerate reparative processes, reduce the risk of allergic reactions.

The components of the product in this ratio, mass. 9b.:

Ethyl alcohol 30.0-32.0

Diethyl ether 20.0-23.0

Propolis 33.0-35.0

Epigene 2.5-2.0

Vibrocil 2.5-2.0

St. John's wort essential oil 2.0-1.0

Myrrh essential oil 2.0-1.0

Geranium essential oil 2.0-1.0

Rosewood essential oil 1.0-0.5

Cinnamon essential oil 2.0-1.0

Lavender essential oil 1.0-0.5

Thyme essential oil 2.0-1.0

The composition is prepared in two stages.

First, propolis in the amount of 33.0-35.0 mass. 96, previously crushed, pour hot 7095 ethyl alcohol 30.0-32, Omas. 95 and add 20.0-23, Omas. 95 diethyl ether (rgo pagsozi). The container in which this mixture is placed should have a tight-fitting lid. It takes 7-10 days to dissolve and infuse propolis.

However, the mixture is not simply infused for several days, repeatedly shaking. Then the obtained substrate is filtered either through a sheet of paper or through several layers of gauze. Epigen 2.5-2.Omas is added to the resulting filtrate. 9o, enter vibrocil 2.5-2, Omas. 95, essential oils with St. John's wort 2.0-1, Omas. 95, myrrh 2.0-1, Omas. 95, geraniums 2.0-1, wt. 95, rosewood 1.0-0.5 mass. 9o, cinnamon 2.0-1, Omas. 95, lavender 1.0-0.5 mass. 95, thyme 2.0-1.0 mass. 905.

The resulting final product is thoroughly mixed until completely dissolved and stored in a cool place (up to two years) in a container with a tight-fitting lid.

Indications for the use of this medicinal composition are acute herpetic stomatitis, chronic recurrent aphthous stomatitis, shingles, etc.

The medicinal composition in the proposed composition affects the quantitatively increased viral flora and the qualitatively changed mucous membrane of the oral cavity (hyperemia, blisters, erosions, aphthae), in addition to ethyl alcohol 30.0-32, Omas. 95, diethyl ether 20.0-23.0 wt. 95 and propolis 33.0-35.0 mass. 95, according to the original prescription, additionally contains an antiviral agent - the drug epigen - 2.5-2.0 mass. 95, endowed with a wide spectrum of antiviral activity (it is active against different strains of viruses: Negrez zitrieh (NBU) and Magiseia 2o5ieg (NAM)). We use vibrocil 2.0-2.5 mass as a means that blocks histamine No-receptors, as well as as a sympathomimetic. 95 (this drug attracts our attention as an anti-allergic agent with a vasoconstrictor effect). Several components of herbal preparations were used - essential oil with St. John's wort 2.0-1.0 mass. 95, which enhances anti-inflammatory properties, accelerates the healing processes of the mucous membrane of the oral cavity, myrrh essential oil 2.0-1.0 mass. 95, which in the specified concentration is too strong an antiseptic, is used not only for the treatment of erosions and ulcers on the mucous membrane of the oral cavity, but also as a means to strengthen the gums (with gingivitis, the gums are loose, etc., that is, as a drug, it is used to combat secondary phenomena - symptomatic therapy). Selection of geranium essential oil 2.0-1.0 wt. 95 is due to the fact that it is known not only as an antiviral agent, but also a drug, the use of which eliminates the pain syndrome. The geranium preparation we used is a good antiseptic with a pronounced anti-edematous effect. Enhancement of the antiviral effect of the above-mentioned medicinal substances is achieved by introducing 1.0-0.5 mass of rosewood essential oil into the composition. 90. In addition to the indicated viricidal action, rosewood essential oil also has antibacterial and deodorizing properties, normalizes metabolic processes, and this, in turn, accelerates the healing of the integumentary tissue. We also added 2.0-1.0 mass of cinnamon essential oil to the medicinal composition. 96, which is characterized not only as an antiviral agent, but also as an antiseptic agent. Among other things, cinnamon reduces bleeding and is used as a detoxifier. Lavender essential oil 1.0-0.5 mass supplements this rather representative prescription. 9о, the spectrum of action of which is quite diverse and wide: it is used as an analgesic, antiseptic, anti-inflammatory agent that stops the symptoms of an allergic reaction, and also as a deodorizer for wasps. Attention should be focused on a very significant fact - the healing properties of lavender are realized quite quickly. Thyme essential oil 2.0-1.0 mass completes the bouquet of the composition. 95, which actively eliminates tissue hyperemia, which in itself certainly affects the "resolution" of the inflammatory reaction due to the state of blood vessel tone.

The remedy proposed by us for the treatment of lesions of the mucous membrane of the oral cavity of a viral nature is more effective in comparison with the existing one due to the fact that epigen and a number of phytopreparations are used as a viral preparation. Epigen is characterized by a wide spectrum of action, quite active against various strains of viruses. It is of great importance that the phenomenon of habituation is not observed, that is, the viral flora, seeding the covering tissue of the oral cavity, is quite sensitive to the action of the author's medicinal composition. We have not noticed any allergic reactions, which, according to the developers, is due to the inclusion of vibrocil in the composition. St. John's wort essential oil is used in several guises: as a hypoallergenic drug, also endowed with an analgesic and anti-inflammatory effect, it promotes accelerated healing of skin defects - erosions and ulcers. Myrrh essential oil - one of the strongest antiseptics - helps to eliminate looseness of treated tissues, isolating the latter.

Geranium essential oil has a pronounced antiviral effect, which is combined with analgesic, anti-edematous effects, as it affects local blood and lymph circulation, accelerates the healing of covering tissues due to the intensification of metabolic processes.

Geranium oil extract is also a good antiseptic, has a viricidal effect, and relieves pain. Rosewood essential oil is an antibacterial and antiviral agent that helps improve the "ecology" of the oral cavity (deodorant) and normalize tissue metabolism.

Cinnamon essential oil, in addition to antiviral and antiseptic properties, also has the ability to reduce bleeding. Lavender essential oil has a multi-vector effect: as a pain reliever, as an antiseptic, as a drug for interrupting some mechanisms of the development of inflammatory diseases and allergic reactions. Deodorizes the oral cavity.

Thyme essential oil helps to normalize the permeability of blood vessels and, as a result, reduces the hydration of these tissues, eliminates their hyperemia.

We give specific examples.

Example 1

Patient D., 17 years old, turned to a dentist with complaints of pain and burning in the oral cavity, which worsens when eating. Body temperature is 37.97C. I've been sick since days.

About: on the hyperemic mucous membrane of the lips and cheeks, numerous aphthae were found, covered with a thick coating, surrounded by a hyperemic corolla, sharply painful when touched. The submandibular lymph nodes are enlarged, somewhat painful, mobile.

According to the development of the clinical picture, a diagnosis was made: acute herpetic aphthous stomatitis.

During the first visit, all pathological elements were thoroughly treated with a tested medicinal composition, which included ethyl alcohol - 30, Omas. 95, diethyl ether - 20, Omas. 95, propolis - 33, Omas. oh, epigen - 2.5 mass. 95, vibrocil - 2.5 mass. 95, essential oils of St. John's wort 2, Omas. 95, myrrh - 2, Omas. 95, geraniums - 2, Omas. 90, rosewood - 1.O0 mass. 95, cinnamon - 2, Omas. 95, lavender - 1, Omas. 95 and thyme - 2.00 mass. 95. After the first application, the intensity of the pain immediately decreased, the burning sensation disappeared, the hyperemic areas turned slightly pale, and the swelling was "stuck". On the second day, the plaques disappeared. On the fourth day, the canker sores as such disappeared.

Drug therapy carried out in the polyclinic was reinforced by the prescription of drugs (antihistamines) to be taken at home. On the second day, the body temperature was 37.2"C, after a day it normalized. After 4 days (4 sessions), the condition of the mucous membrane of the oral cavity changed significantly. The pain and burning sensation disappeared, the mucous membrane, hyperemia and plaques disappeared, the aphthae epithelialized. It is recommended to complete prescribed treatment in 2 days.

Example 2

Patient V., 28 years old, turned to a periodontologist with complaints of pain, blistering rashes on the red border of the lips, an increase in body temperature to 37.4°C. She suffers from gout. Over the course of several years, similar rashes appear periodically, especially after hypothermia

About: there are several crusted erosions on the red border of the lips. A hyperemic border surrounds the erosions.

Touching the affected elements causes pain. Submandibular lymph nodes are enlarged, painless, mobile.

A diagnosis was made: chronic recurrent herpes.

During the first visit - irrigation and application of a prepared and tested medicinal composition, the composition of which is represented by ethyl alcohol - 32, Omas. 95, with diethyl ether - 23, Omas. 95, propolis - 35, Omas. oh, epigenome - 2.0 mass. 95, vibrotsilom - 2.0 mass. 95, St. John's wort essential oils - 1.0 mass. 95, myrrh - 1, Omabs. 90, geraniums - 1, Omas. 95 rosewood - 0.5 mass. 905, cinnamon - 1, Omas. 9o, lavender - 0.5 mass. 95, thyme - 1 Omas. 95.

After the first visit, the pain disappeared, the swelling decreased a little, the mucous membrane became pale. Repeated, it is the last, irrigation and application of the proposed means. The home assignment did not include measures of general exposure.

Example C

Patient S., 24 years old, was treated by a therapist for SARS. At the height of the viral infection, pain in the gums appeared, which increased during eating, brushing teeth, and bad breath.

About: body temperature is 38.4"C. The patient is pale, the gingival mucosa is bright red, swollen. The gingival papillae are cut through ulcers, covered with a dirty-gray plaque, painful and bleed when touched. Regional lymph nodes are enlarged, painful when palpated. , mobile

Diagnosis: acute ulcerative-necrotic gingivitis (as a result of SARS).

Treatment: necrotic plaque was removed under application anesthesia, treatment was carried out with the author's medicinal composition of Iosyv Togbi, which includes: ethyl alcohol - 30, Omas. 95, diethyl ether - 20, Omabs. 90, propolis - 33, Omas. 95, epigen - 2.5 mass. 95, vibrocil - 2.5 mass. 9o, St. John's wort essential oil 2, Omas. 9o, myrrh - 2, Omas. oh, geraniums - 2.0 mass. 95, rosewood - 1.0 mass. 905, cinnamon - 2.0 mass. 9 o, lavender - 1.0 mass. 95 and thyme - 2.00 mass. 95.

The subjective picture underwent significant changes, losing its characteristic sharpness: the pain subsided after the initial treatment, the bleeding decreased significantly. Oral care recommendations are provided. Active therapy was completed after 3 days.

The treatment was tested on 24 volunteer patients. Normalization of the process occurred after 1-3 sessions. When diagnosing more severe cases, when the mucous membrane of the oral cavity was affected at the same time or severe immunodepression was detected, the treatment period was slightly extended. The scheme of therapeutic effects was complicated by the prescription of antipyretics, antihistamines reg o5, general strengthening therapy, etc. But in any case, despite the different degrees of severity of the disease, the patients immediately noted relief, and we, doctors, noted the subsidence of pain, the disappearance of erosions, aphthae, etc., the reduction of inflammatory phenomena, etc.

Thus, the use of the claimed agent for the treatment of viral lesions allows: first, to simplify the medical treatment of aphthae and erosions, due to 2-3 times lubrication with a medicinal composition, which at the same time performs the role of a therapeutic bandage (the formed thin film is preserved a few hours); secondly, to reduce the risk of allergic reactions (this quality of the medicinal composition is associated with the introduction of drugs that deactivate a number of biologically active substances (vibrocil, lavender essential oil); thirdly, to avoid not only overdose during external use (compared to those medicinal forms that are prepared immediately before use); as well as getting used to the components of the medicinal composition; fourthly, the proposed medicinal composition does not require strict storage conditions; therefore, the shelf life reaches 2 years; fifthly, reliably reduce the number of visits, as well as the duration of treatment up to 4-7 days;

Literary sources: 1. Marchenko A.I., Kononovych E.F., Solntseva T.A. Pharmacotherapy in dentistry. - K.: Health, 1986. - p. 147-148. 2. H. Kuriyan in the book by A.P. Grokholsky, N.A. Kodola, V.G. Burgonsky, and Y.B. Tchaikovsky. Non-traditional method of treatment in stomatology. - K.: Health, 1995. - P.173-174.

Claims (1)

Means for the treatment of lesions of the mucous membrane of the oral cavity of a viral nature, which includes ethyl alcohol, diethyl ether, propolis, which is distinguished by the fact that it additionally includes epigen, vibrocil, essential oils of St. John's wort, myrrh, geranium, rosewood, lavender, cinnamon and thyme in such a ratios of components, mass 90: ethyl alcohol 30.0-32.0 diethyl ether 20.0-23.0 propolis 33.0-35.0 epigen 2.5-2.0 vibrocil 2.5-2.0 St. John's wort essential oil 2.0-1 ,0 myrrh essential oil 2.0-1.0 geranium essential oil 2.0-1.0 rosewood essential oil 1.0-0.5 cinnamon essential oil 2.0-1.0 lavender essential oil 1.0- 0.5 essential oil of thyme 2.0-1.0.