UA71605C2 - Composition for treatment of psoriasis based on ethanol extract from human placenta - Google Patents
Composition for treatment of psoriasis based on ethanol extract from human placenta Download PDFInfo
- Publication number
- UA71605C2 UA71605C2 UA2001096494A UA2001096494A UA71605C2 UA 71605 C2 UA71605 C2 UA 71605C2 UA 2001096494 A UA2001096494 A UA 2001096494A UA 2001096494 A UA2001096494 A UA 2001096494A UA 71605 C2 UA71605 C2 UA 71605C2
- Authority
- UA
- Ukraine
- Prior art keywords
- treatment
- psoriasis
- composition
- water
- patients
- Prior art date
Links
- 201000004681 Psoriasis Diseases 0.000 title claims abstract description 35
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 210000002826 placenta Anatomy 0.000 title claims abstract description 27
- 239000000469 ethanolic extract Substances 0.000 title 1
- 239000004520 water soluble gel Substances 0.000 claims abstract description 13
- 239000000284 extract Substances 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 3
- 235000021313 oleic acid Nutrition 0.000 claims description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 2
- 239000012675 alcoholic extract Substances 0.000 claims 2
- 235000021319 Palmitoleic acid Nutrition 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 150000002889 oleic acids Chemical class 0.000 claims 1
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid group Chemical group C(CCCCCCC\C=C/CCCCCC)(=O)O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000012876 topography Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 20
- 210000002615 epidermis Anatomy 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 9
- 238000012360 testing method Methods 0.000 abstract description 9
- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000008929 regeneration Effects 0.000 abstract description 2
- 238000011069 regeneration method Methods 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 230000036560 skin regeneration Effects 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 231100000024 genotoxic Toxicity 0.000 abstract 1
- 230000001738 genotoxic effect Effects 0.000 abstract 1
- 230000002110 toxicologic effect Effects 0.000 abstract 1
- 231100000027 toxicology Toxicity 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 16
- 238000000034 method Methods 0.000 description 13
- 230000002682 anti-psoriatic effect Effects 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 239000000126 substance Substances 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 9
- 239000002674 ointment Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000005059 placental tissue Anatomy 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- 239000011719 vitamin A Substances 0.000 description 3
- 229940045997 vitamin a Drugs 0.000 description 3
- 241000700159 Rattus Species 0.000 description 2
- 210000001691 amnion Anatomy 0.000 description 2
- 229960002537 betamethasone Drugs 0.000 description 2
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229960003662 desonide Drugs 0.000 description 2
- WBGKWQHBNHJJPZ-LECWWXJVSA-N desonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O WBGKWQHBNHJJPZ-LECWWXJVSA-N 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000036732 histological change Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002803 maceration Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
- 229960003415 propylparaben Drugs 0.000 description 2
- 230000001185 psoriatic effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 206010040882 skin lesion Diseases 0.000 description 2
- 231100000444 skin lesion Toxicity 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000003954 umbilical cord Anatomy 0.000 description 2
- WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 1
- 240000006487 Aciphylla squarrosa Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000028782 Hereditary disease Diseases 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 208000024556 Mendelian disease Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000145297 Vanni Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000012137 double-staining Methods 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003041 laboratory chemical Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 238000010517 secondary reaction Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000130 skin irritation / corrosion testing Toxicity 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229960003087 tioguanine Drugs 0.000 description 1
- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU1999016A CU22693A1 (es) | 1999-02-22 | 1999-02-22 | Composición para el tratamiento de la psoriasis y método para su obtención |
| PCT/CU2000/000001 WO2000050047A2 (es) | 1999-02-22 | 2000-02-22 | Composicion para el tratamiento de la psoriasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA71605C2 true UA71605C2 (en) | 2004-12-15 |
Family
ID=5459199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2001096494A UA71605C2 (en) | 1999-02-22 | 2000-02-22 | Composition for treatment of psoriasis based on ethanol extract from human placenta |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1159966B1 (de) |
| JP (1) | JP2002537342A (de) |
| CN (1) | CN1165299C (de) |
| AR (1) | AR022704A1 (de) |
| AT (1) | ATE226440T1 (de) |
| BG (1) | BG105924A (de) |
| BR (1) | BR0008394A (de) |
| CA (1) | CA2363036A1 (de) |
| CU (1) | CU22693A1 (de) |
| DE (1) | DE60000658T2 (de) |
| ES (1) | ES2187446T3 (de) |
| HU (1) | HUP0200005A3 (de) |
| RU (1) | RU2225717C2 (de) |
| UA (1) | UA71605C2 (de) |
| WO (1) | WO2000050047A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20040423A1 (it) * | 2004-03-04 | 2004-06-04 | Pier Mario Biava | Uso di un estratto di embrioni di ovipari e di mucosa di utero gravido o di placenta di mammiferi non umani per la preparazione di un prodotto di attivita' antipsoriasica |
| CN102688483B (zh) * | 2011-03-22 | 2015-02-18 | 王成德 | 一种治疗皮肤病的组合物、含有该组合物的制剂及其制备方法 |
| RU2599038C1 (ru) * | 2015-10-22 | 2016-10-10 | Общество с ограниченной ответственностью Медицинская Корпорация "РАНА" | Применение препарата лаеннек для лечения заболевания, связанного с нарушением иммунитета, представляющего собой хронический рецидивирующий герпес, атопический дерматит или псориаз |
| CN112168812B (zh) * | 2019-07-02 | 2022-07-08 | 瑞微（深圳）生物科技有限公司 | 棕榈油酸用于制备预防或治疗炎症性疾病的组合物的用途 |
| CN114544783B (zh) * | 2020-11-20 | 2024-01-30 | 上海交通大学医学院附属瑞金医院 | 一种预防银屑病复发的内源性代谢物组合 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4190669A (en) * | 1976-03-08 | 1980-02-26 | The Regents Of The University Of Michigan | Method for treating psoriasis |
| SU1061818A1 (ru) * | 1982-07-19 | 1983-12-23 | Центральный научно-исследовательский кожно-венерологический институт | Способ лечени пустулезного псориаза |
| HU205860B (en) * | 1990-08-24 | 1992-07-28 | Biogal Gyogyszergyar | Process for producing pharmaceutical compositiojns for topical treating psoriasis |
| CN1052883C (zh) * | 1994-02-02 | 2000-05-31 | 李庆和 | 一种治疗牛皮癣的中药制剂 |
| RU94022543A (ru) * | 1994-06-10 | 1996-05-20 | АОЗТ "Научно-практический центр медикобиологических проблем" | Основа лекарственного средства и способ ее изготовления |
| AU7003096A (en) * | 1996-06-21 | 1998-01-07 | Jury Evgenievich Belyaev | Semi-finished product for producing drug bases, bases obtained using the same and variants, and drugs obtained using these bases and variants |
| RU2123334C1 (ru) * | 1997-03-05 | 1998-12-20 | Тихоокеанский научно-исследовательский рыбохозяйственный центр | Способ лечения псориаза |
-
1999
- 1999-02-22 CU CU1999016A patent/CU22693A1/es unknown
-
2000
- 2000-02-21 AR ARP000100724A patent/AR022704A1/es unknown
- 2000-02-22 ES ES00907415T patent/ES2187446T3/es not_active Expired - Lifetime
- 2000-02-22 CN CNB008054363A patent/CN1165299C/zh not_active Expired - Fee Related
- 2000-02-22 JP JP2000600658A patent/JP2002537342A/ja active Pending
- 2000-02-22 UA UA2001096494A patent/UA71605C2/uk unknown
- 2000-02-22 EP EP00907415A patent/EP1159966B1/de not_active Expired - Lifetime
- 2000-02-22 RU RU2001125918/15A patent/RU2225717C2/ru not_active IP Right Cessation
- 2000-02-22 AT AT00907415T patent/ATE226440T1/de not_active IP Right Cessation
- 2000-02-22 DE DE60000658T patent/DE60000658T2/de not_active Expired - Fee Related
- 2000-02-22 BR BR0008394-1A patent/BR0008394A/pt not_active IP Right Cessation
- 2000-02-22 HU HU0200005A patent/HUP0200005A3/hu unknown
- 2000-02-22 WO PCT/CU2000/000001 patent/WO2000050047A2/es not_active Ceased
- 2000-02-22 CA CA002363036A patent/CA2363036A1/en not_active Abandoned
-
2001
- 2001-09-20 BG BG105924A patent/BG105924A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1165299C (zh) | 2004-09-08 |
| BR0008394A (pt) | 2002-11-19 |
| HUP0200005A3 (en) | 2003-03-28 |
| ATE226440T1 (de) | 2002-11-15 |
| EP1159966B1 (de) | 2002-10-23 |
| ES2187446T3 (es) | 2003-06-16 |
| DE60000658D1 (de) | 2002-11-28 |
| BG105924A (en) | 2002-04-30 |
| CN1347324A (zh) | 2002-05-01 |
| EP1159966A2 (de) | 2001-12-05 |
| DE60000658T2 (de) | 2003-06-26 |
| HUP0200005A2 (hu) | 2002-05-29 |
| JP2002537342A (ja) | 2002-11-05 |
| RU2225717C2 (ru) | 2004-03-20 |
| AR022704A1 (es) | 2002-09-04 |
| CU22693A1 (es) | 2001-07-31 |
| WO2000050047A3 (es) | 2000-12-21 |
| HK1043938A1 (en) | 2002-10-04 |
| CA2363036A1 (en) | 2000-08-31 |
| WO2000050047A2 (es) | 2000-08-31 |
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