UA76960C2 - Method of analgesia - Google Patents

Method of analgesia Download PDF

Info

Publication number: UA76960C2
Authority: UA; Ukraine
Prior art keywords: pain; tetrodotoxin; cancer; ttx; dose
Prior art date: 2000-09-18

Application number

UA2003032528A

Other languages

English (en)

Ukrainian (uk)

Inventor

Frank Haykong Shum

Original Assignee

Wex Medical Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-18

Filing date

2001-11-09

Publication date

2006-10-16

2001-11-09 Application filed by Wex Medical Ltd filed Critical Wex Medical Ltd

2006-10-16 Publication of UA76960C2 publication Critical patent/UA76960C2/uk

Links

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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
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Medicinal Chemistry (AREA)
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Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Electrotherapy Devices (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Laser Surgery Devices (AREA)

UA2003032528A 2000-09-18 2001-11-09 Method of analgesia UA76960C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CNB001245171A CN1284536C (zh)	2000-09-18	2000-09-18	河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用
PCT/CN2001/001391 WO2002022129A1 (en)	2000-09-18	2001-09-11	A method of analgesia

Publications (1)

Publication Number	Publication Date
UA76960C2 true UA76960C2 (en)	2006-10-16

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Application Number	Title	Priority Date	Filing Date
UA2003032528A UA76960C2 (en)	2000-09-18	2001-11-09	Method of analgesia

Country Status (26)

Country	Link
US (1)	US6407088B1 (is)
EP (3)	EP1563839B1 (is)
JP (1)	JP2004508404A (is)
KR (2)	KR100891568B1 (is)
CN (1)	CN1284536C (is)
AT (2)	ATE447959T1 (is)
AU (1)	AU2002213785A1 (is)
BG (1)	BG107690A (is)
BR (1)	BR0113961A (is)
CA (1)	CA2421562C (is)
DE (1)	DE60140466D1 (is)
EA (1)	EA004870B1 (is)
EE (1)	EE200300106A (is)
ES (1)	ES2435463T3 (is)
HR (1)	HRP20030202A2 (is)
HU (1)	HUP0302677A3 (is)
IL (1)	IL154342A0 (is)
IS (1)	IS6719A (is)
MX (1)	MXPA03002389A (is)
NO (1)	NO323960B1 (is)
PL (1)	PL360616A1 (is)
SK (1)	SK3732003A3 (is)
UA (1)	UA76960C2 (is)
WO (1)	WO2002022129A1 (is)
YU (1)	YU17103A (is)
ZA (1)	ZA200301852B (is)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2778455C2 (ru) *	2017-03-29	2022-08-19	Сайтван Терапевтикс, Инк.	11,13-модифицированные сакситоксины для лечения боли

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998047869A1 (en)	1997-04-22	1998-10-29	Cocensys, Inc.	Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof
CN1236773C (zh) *	2000-11-22	2006-01-18	南宁枫叶药业有限公司	用于镇痛、麻醉或治疗药物依赖性的制剂
US7119062B1 (en)	2001-02-23	2006-10-10	Neucoll, Inc.	Methods and compositions for improved articular surgery using collagen
CN1269482C (zh) *	2001-05-18	2006-08-16	威克斯医药有限公司	钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用
CN1203860C (zh) *	2001-06-22	2005-06-01	威克斯医药有限公司	钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用
EA006739B1 (ru) *	2001-11-15	2006-04-28	Майкроу Элджи Корпорейшн	Фармацевтические композиции, содержащие 3,4-пропинопергидропурины, и их применение для блокирования нейронной передачи
WO2004013637A1 (en) *	2002-08-01	2004-02-12	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 37 (gpr37)
US20040209960A1 (en) *	2003-01-30	2004-10-21	Dynogen Pharmaceuticals, Inc.	Methods of treating lower urinary tract disorders using sodium channell modulators
CN1568999A (zh) *	2003-07-14	2005-01-26	南宁枫叶药业有限公司	稳定的医药用河豚毒素冷冻干燥制剂
JP2005154368A (ja) *	2003-11-27	2005-06-16	Teikoku Seiyaku Co Ltd	ジソピラミド含有神経因性疼痛の鎮痛剤
CN101123967A (zh) *	2004-05-07	2008-02-13	菲特托克斯有限公司	藻毒素的经皮给药
WO2005110275A1 (en) *	2004-05-07	2005-11-24	Phytotox Limited	Methods of treating wounds with gonyautoxins
US20050282836A1 (en) *	2004-06-22	2005-12-22	Weiyang Lin	Solid orally ingestible formulations of tetrodotoxin
US20060034823A1 (en) *	2004-08-13	2006-02-16	Paul Reid	Method of production and use of crotoxin as an analgesic
CN100363006C (zh) *	2004-08-20	2008-01-23	厦门朝阳生物工程有限公司	一种戒毒制剂及其制备方法
EP1799219A1 (en) *	2004-09-21	2007-06-27	Laboratorios del Dr. Esteve S.A.	Tetrodotoxin and its derivatives for the treatment of central-nervously derived neuropathic pain
WO2006032459A1 (en) *	2004-09-22	2006-03-30	Laboratorios Del Dr. Esteve S.A.	Tetrodotoxin and its derivatives for the treatment of peripheral-nervously derived neuropathic pain
EP1690541A1 (en) *	2005-02-11	2006-08-16	Laboratorios Del Dr. Esteve, S.A.	Use of a sodium channel blocker and their analogues for the treatment of nicotine dependency
EP1714655A1 (en) *	2005-04-22	2006-10-25	Laboratorios Del Dr. Esteve, S.A.	Use of sodium channel blockers and their analogues for the treatment of nicotine dependency
TW200640463A (en) *	2005-02-11	2006-12-01	Esteve Labor Dr	Use of sodium channel blockers and their analogues for the treatment of nicotine dependency
EP1702627A1 (en) *	2005-03-18	2006-09-20	Laboratorios Del Dr. Esteve, S.A.	Analgesic combination of sodium channel blockers with opioid antagonists
WO2007025213A2 (en) *	2005-08-25	2007-03-01	Wex Pharmaceuticals, Inc.	Use of sodium channel blockers for the management of musculoskeletal pain
CA2619856A1 (en) *	2005-08-25	2007-03-01	Wex Pharmaceuticals Inc.	Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment
US20070148159A1 (en) *	2005-12-22	2007-06-28	Reid Paul F	Use of crotoxin as an analgesic - CIP
GB0603008D0 (en) *	2006-02-14	2006-03-29	Portela & Ca Sa	Method
EP1844781A1 (en)	2006-02-22	2007-10-17	Wex Pharmaceuticals Inc.	Use of sodium channel blockers for the treatment of preterm labor
EP1844782A1 (en) *	2006-03-27	2007-10-17	Wex Pharmaceuticals, Inc	Use of 4,9-anhydro-tetrodotoxin for the treatment of diseases related to the voltage-gated sodium channel subunit Nav1.6
WO2007110220A1 (en) *	2006-03-27	2007-10-04	Wex Pharmaceuticals Inc.	USE OF 4,9-ANHYDRO-TETRODOTOXIN FOR THE TREATMENT OF DISEASES RELATED TO THE VOLTAGE-GATED SODIUM CHANNEL α SUBUNIT NAV 1.6
EP1844783A1 (en) *	2006-03-27	2007-10-17	Wex Pharmaceuticals, Inc	Use of 4,9-anhydro-tetrodotoxin for the treatment of diseases related to the voltage-gated sodium channel - subunit Nav1.6
US9018222B2 (en)	2006-03-27	2015-04-28	Wex Medical Limited	Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
CN100438873C (zh) *	2006-06-26	2008-12-03	黄致强	将河鲀毒素作为镇痛药的耐受抑制剂在制备复方镇痛制剂中的应用
EP1882692A1 (en) *	2006-07-28	2008-01-30	Wex Pharmaceuticals Inc.	Dimethano-[1,3]dioxocino[6,5-D]pyrimidine-spiro derivatives of tetrodotoxin, process for their synthesis and uses thereof in the treatment of pain
AU2008275752A1 (en) *	2007-07-06	2009-01-15	Nuon Therapeutics, Inc.	Treatment of neuropathic pain
CN101352422B (zh) *	2008-09-17	2011-04-20	厦门朝阳生物工程有限公司	河豚毒素冻干粉针制剂及其制备方法
US8957207B2 (en)	2009-03-24	2015-02-17	Proteus S.A.	Methods for producing phycotoxins
US20120034296A1 (en) *	2009-04-08	2012-02-09	Massachusetts Institute Of Technology	Prolonged duration local anesthesia with minimal toxicity
WO2011098539A1 (en) *	2010-02-10	2011-08-18	Phytotox Limited	Treatment of loss of sense of touch with saxitoxin derivatives
WO2012075337A2 (en)	2010-12-01	2012-06-07	Spinal Modulation, Inc.	Directed delivery of agents to neural anatomy
EA201591754A1 (ru)	2013-03-14	2016-01-29	Ридженерон Фармасьютикалз, Инк.	Человеческие антитела к na1.7
RS58750B1 (sr) *	2013-03-15	2019-06-28	Childrens Medical Ct Corp	Kombinovane formulacije neosaksitoksina za produženu lokalnu anesteziju
US8986694B1 (en)	2014-07-15	2015-03-24	Kymab Limited	Targeting human nav1.7 variants for treatment of pain
US8992927B1 (en)	2014-07-15	2015-03-31	Kymab Limited	Targeting human NAV1.7 variants for treatment of pain
GB201403775D0 (en)	2014-03-04	2014-04-16	Kymab Ltd	Antibodies, uses & methods
US9139653B1 (en)	2015-04-30	2015-09-22	Kymab Limited	Anti-human OX40L antibodies and methods of treatment
JP7461741B2 (ja)	2016-06-20	2024-04-04	カイマブ・リミテッド	抗ｐｄ－ｌ１およびｉｌ－２サイトカイン
US11779604B2 (en)	2016-11-03	2023-10-10	Kymab Limited	Antibodies, combinations comprising antibodies, biomarkers, uses and methods
CN107198689A (zh) *	2017-07-11	2017-09-26	东新皓特（北京）生化科技有限公司	用于治疗疼痛病症的河豚毒素药物组合物及外用药
US20240226105A1 (en)	2021-04-23	2024-07-11	Wex Pharmaceuticals Inc.	Tetrodotoxin liquid formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4029793A (en)	1973-06-12	1977-06-14	Astra Pharmaceutical Products, Inc.	Synergistic local anesthetic compositions
US4022899A (en)	1973-06-12	1977-05-10	Astra Pharmaceutical Products, Inc.	Synergistic local anesthetic compositions
US5846975A (en) *	1994-03-17	1998-12-08	Nanning Maple Leaf Pharmaceutical Co., Ltd.	Use of amino hydrogenated quinazoline compounds and derivatives thereof for abstaining from drug dependence
CN1072486C (zh) *	1996-09-24	2001-10-10	王维国	用于戒毒、镇痛的药剂及其制法
WO1998043619A2 (en) *	1997-04-02	1998-10-08	The Regents Of The University Of California	Method of local anesthesia
AU7389098A (en) *	1997-05-16	1998-12-08	Brigham And Women's Hospital	Local anesthetic formulations
CN1236773C (zh) *	2000-11-22	2006-01-18	南宁枫叶药业有限公司	用于镇痛、麻醉或治疗药物依赖性的制剂
CN1269482C (zh) *	2001-05-18	2006-08-16	威克斯医药有限公司	钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用

2000
- 2000-09-18 CN CNB001245171A patent/CN1284536C/zh not_active Expired - Lifetime
- 2000-10-25 US US09/695,053 patent/US6407088B1/en not_active Expired - Lifetime
2001
- 2001-09-11 AU AU2002213785A patent/AU2002213785A1/en not_active Abandoned
- 2001-09-11 CA CA2421562A patent/CA2421562C/en not_active Expired - Lifetime
- 2001-09-11 AT AT01982091T patent/ATE447959T1/de not_active IP Right Cessation
- 2001-09-11 EP EP04022073A patent/EP1563839B1/en not_active Expired - Lifetime
- 2001-09-11 PL PL36061601A patent/PL360616A1/xx unknown
- 2001-09-11 WO PCT/CN2001/001391 patent/WO2002022129A1/en not_active Ceased
- 2001-09-11 EP EP01982091A patent/EP1320369B1/en not_active Expired - Lifetime
- 2001-09-11 HR HR20030202A patent/HRP20030202A2/hr not_active Application Discontinuation
- 2001-09-11 DE DE60140466T patent/DE60140466D1/de not_active Expired - Lifetime
- 2001-09-11 EA EA200300172A patent/EA004870B1/ru unknown
- 2001-09-11 IL IL15434201A patent/IL154342A0/xx unknown
- 2001-09-11 YU YU17103A patent/YU17103A/sh unknown
- 2001-09-11 KR KR1020037003723A patent/KR100891568B1/ko not_active Expired - Lifetime
- 2001-09-11 EE EEP200300106A patent/EE200300106A/xx unknown
- 2001-09-11 AT AT04022073T patent/ATE542534T1/de active
- 2001-09-11 HU HU0302677A patent/HUP0302677A3/hu unknown
- 2001-09-11 EP EP10180006.8A patent/EP2298306B1/en not_active Expired - Lifetime
- 2001-09-11 BR BR0113961-4A patent/BR0113961A/pt not_active IP Right Cessation
- 2001-09-11 JP JP2002526380A patent/JP2004508404A/ja not_active Abandoned
- 2001-09-11 MX MXPA03002389A patent/MXPA03002389A/es active IP Right Grant
- 2001-09-11 KR KR1020077023825A patent/KR20070112864A/ko not_active Withdrawn
- 2001-09-11 SK SK373-2003A patent/SK3732003A3/sk unknown
- 2001-09-11 ES ES10180006T patent/ES2435463T3/es not_active Expired - Lifetime
- 2001-11-09 UA UA2003032528A patent/UA76960C2/uk unknown
2003
- 2003-02-14 IS IS6719A patent/IS6719A/is unknown
- 2003-02-27 NO NO20030915A patent/NO323960B1/no unknown
- 2003-03-06 ZA ZA200301852A patent/ZA200301852B/en unknown
- 2003-03-31 BG BG107690A patent/BG107690A/bg unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2778455C2 (ru) *	2017-03-29	2022-08-19	Сайтван Терапевтикс, Инк.	11,13-модифицированные сакситоксины для лечения боли

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Publication number	Publication date
EA200300172A1 (ru)	2003-12-25
SK3732003A3 (sk)	2005-05-05
HRP20030202A2 (en)	2005-02-28
HUP0302677A2 (hu)	2003-11-28
ATE542534T1 (de)	2012-02-15
KR20070112864A (ko)	2007-11-27
CA2421562C (en)	2011-05-24
US6407088B1 (en)	2002-06-18
EP1320369A4 (en)	2003-07-02
DE60140466D1 (de)	2009-12-24
BR0113961A (pt)	2004-01-13
EP2298306B1 (en)	2013-09-11
MXPA03002389A (es)	2004-03-12
AU2002213785A1 (en)	2002-03-26
ZA200301852B (en)	2004-06-21
WO2002022129A1 (en)	2002-03-21
EP1563839B1 (en)	2012-01-25
BG107690A (bg)	2004-01-30
EP1320369B1 (en)	2009-11-11
IL154342A0 (en)	2003-09-17
EP1563839A1 (en)	2005-08-17
YU17103A (sh)	2006-03-03
ATE447959T1 (de)	2009-11-15
CA2421562A1 (en)	2002-03-21
EP2298306A1 (en)	2011-03-23
EA004870B1 (ru)	2004-08-26
ES2435463T3 (es)	2013-12-19
NO20030915D0 (no)	2003-02-27
HUP0302677A3 (en)	2005-01-28
CN1356104A (zh)	2002-07-03
NO20030915L (no)	2003-04-25
KR20030034181A (ko)	2003-05-01
JP2004508404A (ja)	2004-03-18
NO323960B1 (no)	2007-07-23
EP1320369A1 (en)	2003-06-25
IS6719A (is)	2003-02-14
PL360616A1 (en)	2004-09-20
CN1284536C (zh)	2006-11-15
EE200300106A (et)	2005-04-15
KR100891568B1 (ko)	2009-04-03

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UA76960C2 - Method of analgesia - Google Patents

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