UA81265C2 - Granulate formulation of the rapamycin ester cci-779 and process for the preparation thereof - Google Patents

Granulate formulation of the rapamycin ester cci-779 and process for the preparation thereof Download PDF

Info

Publication number: UA81265C2
Authority: UA; Ukraine
Prior art keywords: ssi; composition according; alcohol; surfactant; water
Prior art date: 2002-09-17

Application number

UAA200503586A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-17

Filing date

2003-09-15

Publication date

2007-12-25

2003-09-15 Application filed by Wyeth Corp filed Critical Wyeth Corp

2007-12-25 Publication of UA81265C2 publication Critical patent/UA81265C2/uk

Links

239000000203 mixture Substances 0.000 title claims abstract description 46
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QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract description 13
229960002930 sirolimus Drugs 0.000 title abstract description 13
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract description 12
CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title abstract description 4
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K9/1629—Organic macromolecular compounds
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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
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Public Health (AREA)
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Epidemiology (AREA)
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Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Oncology (AREA)
Hematology (AREA)
Transplantation (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cosmetics (AREA)

UAA200503586A 2002-09-17 2003-09-15 Granulate formulation of the rapamycin ester cci-779 and process for the preparation thereof UA81265C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41126402P	2002-09-17	2002-09-17
PCT/US2003/029228 WO2004026280A2 (en)	2002-09-17	2003-09-15	Granulate formulation of the rapamycin ester cci-779

Publications (1)

Publication Number	Publication Date
UA81265C2 true UA81265C2 (en)	2007-12-25

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ID=32030658

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Application Number	Title	Priority Date	Filing Date
UAA200503586A UA81265C2 (en)	2002-09-17	2003-09-15	Granulate formulation of the rapamycin ester cci-779 and process for the preparation thereof

Country Status (24)

Country	Link
US (1)	US20040077677A1 (de)
EP (1)	EP1635830B1 (de)
JP (1)	JP2006506353A (de)
KR (1)	KR20050084559A (de)
CN (1)	CN100415233C (de)
AT (1)	ATE413163T1 (de)
AU (1)	AU2003272489B2 (de)
BR (1)	BR0314397A (de)
CA (1)	CA2496332A1 (de)
CR (1)	CR7791A (de)
DE (1)	DE60324609D1 (de)
DK (1)	DK1635830T3 (de)
EC (1)	ECSP055731A (de)
ES (1)	ES2315530T3 (de)
IL (1)	IL166824A0 (de)
MX (1)	MXPA05002828A (de)
NO (1)	NO20050836L (de)
NZ (1)	NZ538781A (de)
PT (1)	PT1635830E (de)
RU (1)	RU2326654C2 (de)
SI (1)	SI1635830T1 (de)
UA (1)	UA81265C2 (de)
WO (1)	WO2004026280A2 (de)
ZA (1)	ZA200502220B (de)

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2003
- 2003-09-15 DE DE60324609T patent/DE60324609D1/de not_active Expired - Lifetime
- 2003-09-15 JP JP2004537911A patent/JP2006506353A/ja active Pending
- 2003-09-15 US US10/663,506 patent/US20040077677A1/en not_active Abandoned
- 2003-09-15 PT PT03754672T patent/PT1635830E/pt unknown
- 2003-09-15 MX MXPA05002828A patent/MXPA05002828A/es active IP Right Grant
- 2003-09-15 ES ES03754672T patent/ES2315530T3/es not_active Expired - Lifetime
- 2003-09-15 NZ NZ538781A patent/NZ538781A/en unknown
- 2003-09-15 AT AT03754672T patent/ATE413163T1/de not_active IP Right Cessation
- 2003-09-15 KR KR1020057004555A patent/KR20050084559A/ko not_active Ceased
- 2003-09-15 EP EP03754672A patent/EP1635830B1/de not_active Expired - Lifetime
- 2003-09-15 CA CA002496332A patent/CA2496332A1/en not_active Abandoned
- 2003-09-15 SI SI200331456T patent/SI1635830T1/sl unknown
- 2003-09-15 WO PCT/US2003/029228 patent/WO2004026280A2/en not_active Ceased
- 2003-09-15 RU RU2005111222/15A patent/RU2326654C2/ru not_active IP Right Cessation
- 2003-09-15 CN CNB03822013XA patent/CN100415233C/zh not_active Expired - Fee Related
- 2003-09-15 BR BR0314397-0A patent/BR0314397A/pt not_active IP Right Cessation
- 2003-09-15 UA UAA200503586A patent/UA81265C2/uk unknown
- 2003-09-15 DK DK03754672T patent/DK1635830T3/da active
- 2003-09-15 AU AU2003272489A patent/AU2003272489B2/en not_active Ceased
2005
- 2005-02-10 IL IL16682405A patent/IL166824A0/xx unknown
- 2005-02-16 NO NO20050836A patent/NO20050836L/no not_active Application Discontinuation
- 2005-03-16 ZA ZA200502220A patent/ZA200502220B/en unknown
- 2005-04-08 CR CR7791A patent/CR7791A/es not_active Application Discontinuation
- 2005-04-13 EC EC2005005731A patent/ECSP055731A/es unknown

Also Published As

Publication number	Publication date
PT1635830E (pt)	2008-12-31
WO2004026280A3 (en)	2005-12-01
EP1635830A2 (de)	2006-03-22
KR20050084559A (ko)	2005-08-26
EP1635830B1 (de)	2008-11-05
US20040077677A1 (en)	2004-04-22
WO2004026280A2 (en)	2004-04-01
DK1635830T3 (da)	2009-02-23
MXPA05002828A (es)	2005-05-27
NO20050836L (no)	2005-04-15
CN1764459A (zh)	2006-04-26
RU2326654C2 (ru)	2008-06-20
AU2003272489A1 (en)	2004-04-08
DE60324609D1 (de)	2008-12-18
ATE413163T1 (de)	2008-11-15
RU2005111222A (ru)	2005-09-20
NZ538781A (en)	2007-11-30
CA2496332A1 (en)	2004-04-01
ES2315530T3 (es)	2009-04-01
IL166824A0 (en)	2006-01-15
ZA200502220B (en)	2008-01-30
CR7791A (es)	2007-10-01
ECSP055731A (es)	2005-07-06
JP2006506353A (ja)	2006-02-23
SI1635830T1 (sl)	2009-02-28
HK1084050A1 (en)	2006-07-21
BR0314397A (pt)	2005-08-09
AU2003272489B2 (en)	2008-11-13
CN100415233C (zh)	2008-09-03

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DE602004004520T2 (de)	2007-11-08	Antineoplastische zusammensetzungen
US7060709B2 (en)	2006-06-13	Method of treating hepatic fibrosis
AU2004267910A1 (en)	2005-03-10	Solid dispersions comprising tacrolimus
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