UA84462C2 - Полиморфные модификации кислотно-аддитивных солей иматиниба с метансульфоновой кислотой - Google Patents

Полиморфные модификации кислотно-аддитивных солей иматиниба с метансульфоновой кислотой

Info

Publication number
UA84462C2
UA84462C2 UAA200611573A UAA200611573A UA84462C2 UA 84462 C2 UA84462 C2 UA 84462C2 UA A200611573 A UAA200611573 A UA A200611573A UA A200611573 A UAA200611573 A UA A200611573A UA 84462 C2 UA84462 C2 UA 84462C2
Authority
UA
Ukraine
Prior art keywords
imatinib
acid addition
methanesulfonic acid
addition salts
crystalline polymorphs
Prior art date
Application number
UAA200611573A
Other languages
English (en)
Ukrainian (uk)
Inventor
Войцех Щепек
Дорота Самсон-Лазинска
Богдан Загродзки
Магдалена Глице
Виолета Марушак
Катаржина Корчак
Ришард Модзелевски
Марта Лавецка
Лукаш Качмарек
Веслав Шелеевски
Уршула Фрачек
Петр Цмох
Original Assignee
Институт Фармацевтични
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL366885A external-priority patent/PL216883B1/pl
Application filed by Институт Фармацевтични filed Critical Институт Фармацевтични
Priority claimed from PL374074A external-priority patent/PL374074A1/pl
Publication of UA84462C2 publication Critical patent/UA84462C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
UAA200611573A 2004-04-02 2005-02-04 Полиморфные модификации кислотно-аддитивных солей иматиниба с метансульфоновой кислотой UA84462C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL366885A PL216883B1 (pl) 2004-04-02 2004-04-02 Sposób wytwarzania krystalicznej formy a soli addycyjnej kwasu metanosulfonowego i 4-(4-metylopiperazyn-1-ylometylo)-N-[4-metylo-3-[(4-pirydyn-3-ylo)pirymidyn-2- -yloamino)fenylo]benzamidu
PL374074A PL374074A1 (pl) 2005-04-01 2005-04-01 Sposób wytwarzania krystalicznej formy Ó monomesylanu 4-(4-metylopiperazyn-1-ylometylo)-N-[4-metylo-3-[(4-pirydyn-3-ylo)pirymidyn-2-yloamino]fenylo]benzamidu
PCT/PL2005/000024 WO2005095379A2 (en) 2004-04-02 2005-04-02 Crystalline methanesulfonic acid addition salts of imatinib

Publications (1)

Publication Number Publication Date
UA84462C2 true UA84462C2 (ru) 2008-10-27

Family

ID=34981470

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200611573A UA84462C2 (ru) 2004-04-02 2005-02-04 Полиморфные модификации кислотно-аддитивных солей иматиниба с метансульфоновой кислотой

Country Status (5)

Country Link
US (1) US7732601B2 (ru)
EP (1) EP1742933A2 (ru)
IL (1) IL178097A (ru)
UA (1) UA84462C2 (ru)
WO (1) WO2005095379A2 (ru)

Families Citing this family (45)

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USRE43932E1 (en) 1997-07-18 2013-01-15 Novartis Ag Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use
US8269003B2 (en) 2004-09-02 2012-09-18 Cipla Limited Stable crystal form of imatinib mesylate and process for the preparation thereof
WO2006048890A1 (en) * 2004-11-04 2006-05-11 Sun Pharmaceutical Industries Limited Imatinib mesylate crystal form and process for preparation thereof
WO2006054314A1 (en) * 2004-11-17 2006-05-26 Natco Pharma Limited Polymorphic forms of imatinib mesylate
AR055613A1 (es) * 2005-08-26 2007-08-29 Novartis Ag Formas cristalinas delta y epsilon de mesilato de imatinib
KR20130137721A (ko) * 2005-11-25 2013-12-17 노파르티스 아게 이마티니브 메실레이트의 ｆ, ｇ, ｈ, ｉ 및 ｋ 결정형
US8067421B2 (en) 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
EP1919893A2 (en) 2006-04-27 2008-05-14 Sicor, Inc. Polymorphic forms of imatinib mesylate and processes for their preparation as well as of amorphous imatinib mesylate and form alpha
US7977348B2 (en) 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US20060223816A1 (en) * 2006-05-08 2006-10-05 Chemagis Ltd. Imatinib mesylate alpha form and production process therefor
EP2009008A1 (en) 2006-10-26 2008-12-31 Sicor, Inc. Imatinib base, and imatinib mesylate and processes for preparation thereof
US7550591B2 (en) 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process
WO2008150481A2 (en) * 2007-05-29 2008-12-11 Sicor Inc. Processes for the preparation of crystalline form beta of imatinib mesylate
EP2081556A1 (en) * 2007-09-25 2009-07-29 Teva Pharmaceutical Industries Ltd. Stable imatinib compositions
US7947699B2 (en) 2008-01-10 2011-05-24 Actavis Group Ptc Ehf Anhydrous amorphous imatinib mesylate
US20100330130A1 (en) 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
CZ2009570A3 (cs) 2009-08-26 2011-03-09 Zentiva, K. S. Príprava, stabilizace a využití polymorfu imatinib mesylátu pro vývoj lékových forem
PL389357A1 (pl) 2009-10-22 2011-04-26 Tomasz Koźluk Sole imatinibu z pochodnymi kwasów winowych i sposób ich wytwarzania
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
WO2011100282A2 (en) * 2010-02-09 2011-08-18 Dr. Reddy's Laboratories Ltd. Imatinib mesylate polymorphs
CA2789989A1 (en) 2010-02-15 2011-08-18 Reliance Life Sciences Pvt. Ltd. Process for the preparation of alpha form of imatinib mesylate
PL390611A1 (pl) 2010-03-04 2011-09-12 Tomasz Koźluk Sposób otrzymywania polimorficznej formy alfa i nowa forma polimorficzna mesylanu imatinibu
US20130060030A1 (en) 2010-03-15 2013-03-07 Natco Pharma Limited Process for the preparation of highly pure crystalline imatinib base
WO2011130918A1 (zh) 2010-04-23 2011-10-27 上海百灵医药科技有限公司 一种伊马替尼的合成方法
WO2011158255A1 (en) * 2010-06-16 2011-12-22 Aptuit Laurus Private Limited Process for preparation of stable imatintb mesylate alpha form
EA024088B1 (ru) * 2010-06-18 2016-08-31 КРКА, д.д., НОВО МЕСТО α-ФОРМА МЕЗИЛАТА ИМАТИНИБА, СПОСОБЫ ЕЕ ПОЛУЧЕНИЯ И СОДЕРЖАЩАЯ ЕЁ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
WO2012014000A1 (en) * 2010-07-30 2012-02-02 Ramesh Babu Potluri STABLE α-CRYSTAL FORM OF IMATINIB MESYLATE AND PREPARING PROCESS THEREOF
CN102146073A (zh) * 2011-02-23 2011-08-10 江苏先声药物研究有限公司 一种伊玛替尼甲烷磺酸盐α晶型新的制备方法
PL394169A1 (pl) 2011-03-09 2012-09-10 Adamed Spółka Z Ograniczoną Odpowiedzialnością Kompozycja farmaceutyczna metanosulfonianu imatinibu do napełniania jednostkowych postaci dawkowania oraz sposób jej wytwarzania
WO2012131711A1 (en) * 2011-03-31 2012-10-04 Ind-Swift Laboratories Limited Improved process for preparation of imatinib and its mesylate salt
CN102321070B (zh) * 2011-07-27 2013-05-22 江苏先声药物研究有限公司 反溶剂重结晶法制备伊玛替尼甲烷磺酸盐α晶型
IN2012DE00728A (ru) * 2012-03-13 2015-08-21 Fresenius Kabi Oncology Ltd
CN102633775B (zh) * 2012-04-06 2013-07-17 江南大学 一种甲磺酸伊马替尼α晶型的制备方法
CN102617552A (zh) * 2012-04-06 2012-08-01 江南大学 一种制备α晶型甲磺酸伊马替尼的结晶方法
CN103467446A (zh) * 2012-06-05 2013-12-25 广东东阳光药业有限公司 一种甲磺酸伊马替尼α晶型的制备方法
KR101242955B1 (ko) * 2012-06-25 2013-03-12 제일약품주식회사 이마티닙 메실레이트 결정형 α의 제조 방법
CN103570677B (zh) * 2012-08-02 2017-03-01 广东东阳光药业有限公司 一种α晶型甲磺酸伊马替尼的制备方法
CN103570674A (zh) * 2012-08-04 2014-02-12 浙江九洲药业股份有限公司 一种甲磺酸伊马替尼α晶型的制备方法
CN103058991A (zh) * 2012-12-28 2013-04-24 南京艾德凯腾生物医药有限责任公司 一种α晶型甲磺酸伊马替尼的制备方法
EP2749557A1 (en) 2012-12-31 2014-07-02 Deva Holding Anonim Sirketi Process for preparation of alpha polymorph of imatinib mesylate from IPA and THF solvate forms of imatinib mesylate
EP2803353B1 (en) 2013-05-14 2018-05-23 Hetero Research Foundation Compositions of Imatinib
EP3007699A4 (en) * 2013-06-12 2017-01-18 Shilpa Medicare Limited Crystalline imatinib mesylate process
CN103483314B (zh) * 2013-09-16 2015-02-18 南京优科生物医药研究有限公司 一种便捷的制备甲磺酸伊马替尼α晶型的方法
WO2017078647A1 (en) 2015-11-05 2017-05-11 Koçak Farma Ilaç Ve Kimya Sanayi Anonim Şirketi Pharmaceutical compositions of imatinib
CN113260667B (zh) * 2018-12-21 2023-06-30 倍耐力轮胎股份公司 含硫化促进剂的胶囊，制备方法和在轮胎用弹性体胶料硫化中的用途

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CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
WO2004026930A2 (en) 2002-06-26 2004-04-01 The Ohio State University Research Foundation The method for reducing inflammation using sti-571 or its salt

Also Published As

Publication number Publication date
WO2005095379A3 (en) 2006-05-18
IL178097A (en) 2013-03-24
WO2005095379B1 (en) 2006-07-13
US7732601B2 (en) 2010-06-08
IL178097A0 (en) 2006-12-31
EP1742933A2 (en) 2007-01-17
WO2005095379A2 (en) 2005-10-13
US20070197545A1 (en) 2007-08-23

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