UA86782C2 - Применение галоидного производного гидроксамовой кислоты в лечении нейродегенеративных заболеваний центральной нервной системы - Google Patents

Применение галоидного производного гидроксамовой кислоты в лечении нейродегенеративных заболеваний центральной нервной системы

Info

Publication number
UA86782C2
UA86782C2 UAA200605899A UAA200605899A UA86782C2 UA 86782 C2 UA86782 C2 UA 86782C2 UA A200605899 A UAA200605899 A UA A200605899A UA A200605899 A UAA200605899 A UA A200605899A UA 86782 C2 UA86782 C2 UA 86782C2
Authority
UA
Ukraine
Prior art keywords
treatment
neurodegenerative diseases
acid halide
hydroximic acid
halide derivative
Prior art date
Application number
UAA200605899A
Other languages
English (en)
Ukrainian (uk)
Inventor
Линда Гринсмит
Джефри Бьёрнстокк
Рудольф Урбаникс
Original Assignee
Ситарекс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ситарекс Корпорейшн filed Critical Ситарекс Корпорейшн
Publication of UA86782C2 publication Critical patent/UA86782C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Изобретение относится к области медицины и касается применения химического вещества, выбранного из N-[2-гидрокси-3-(1-пиперидинил)пропокси]пиридин-1-оксид-3-карбоксимидоилхлорида, его оптически активных энантиомеров или смесей энантиомеров и фармацевтически приемлемой соли оптически активного энантиомера или смеси ее энантиомеров для получения фармацевтической композиции для лечения или профилактики нейродегенеративных заболеваний центральной нервной системы.
UAA200605899A 2003-10-30 2004-10-25 Применение галоидного производного гидроксамовой кислоты в лечении нейродегенеративных заболеваний центральной нервной системы UA86782C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0303584A HUP0303584A3 (en) 2003-10-30 2003-10-30 Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
UA86782C2 true UA86782C2 (ru) 2009-05-25

Family

ID=89981738

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200605899A UA86782C2 (ru) 2003-10-30 2004-10-25 Применение галоидного производного гидроксамовой кислоты в лечении нейродегенеративных заболеваний центральной нервной системы

Country Status (26)

Country Link
US (3) US20080039497A1 (ru)
EP (2) EP1696922B1 (ru)
JP (1) JP5077997B2 (ru)
KR (1) KR20060103323A (ru)
CN (1) CN1901913A (ru)
AT (1) ATE409038T1 (ru)
AU (1) AU2004285343B2 (ru)
BR (1) BRPI0415625A (ru)
CA (1) CA2544332C (ru)
CY (1) CY1110450T1 (ru)
CZ (1) CZ2006347A3 (ru)
DE (1) DE602004016770D1 (ru)
DK (1) DK1696922T3 (ru)
EA (1) EA011301B1 (ru)
ES (1) ES2314458T3 (ru)
HR (1) HRP20080660T3 (ru)
HU (1) HUP0303584A3 (ru)
IL (1) IL175334A (ru)
NO (1) NO20062401L (ru)
NZ (1) NZ547216A (ru)
PL (1) PL1696922T3 (ru)
PT (1) PT1696922E (ru)
SI (1) SI1696922T1 (ru)
UA (1) UA86782C2 (ru)
WO (1) WO2005041965A1 (ru)
ZA (1) ZA200604376B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057664A1 (en) 2002-01-11 2003-07-17 Biorex Kutató És Fejlesztö Rt. Carboxamidine derivatives and their use in the treatment of vascular diseases
WO2008039514A1 (en) * 2006-09-26 2008-04-03 Cytrx Corporation Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration
AU2009262670B2 (en) 2008-06-26 2013-06-20 Zevra Denmark A/S Use of Hsp70 as a regulator of enzymatic activity
US20110224200A1 (en) 2008-11-18 2011-09-15 Shin-Ichiro Hirai Therapeutic agent for chorioretinal degenerative disease containing pyridine-3-carbaldehyde 0-(piperidin-1-yl-propyl)-oxime derivative as active ingredient
CA2817773A1 (en) 2010-11-30 2012-06-07 Orphazyme Aps Methods for increasing intracellular activity of hsp70
HUP1100534A2 (en) * 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
CN103804309B (zh) * 2012-11-09 2019-08-02 广州喜鹊医药有限公司 一种氯肟类化合物及其制备方法和在制药中的应用
AU2015317447B2 (en) * 2014-09-15 2021-02-25 Zevra Denmark A/S Arimoclomol formulation
US10898476B2 (en) 2016-04-13 2021-01-26 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
DK3782624T3 (da) * 2016-04-29 2025-12-15 Zevra Denmark As Arimoclomol til behandling af glucocerebrosidase-associerede lidelser
MX2019013835A (es) 2017-05-24 2020-07-14 Orphazyme As Inductores de proteinas de choque termico y trastornos frontotemporales.
HUP1800298A1 (hu) 2018-08-30 2020-05-28 N Gene Res Laboratories Inc Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU177578B (en) 1976-08-27 1981-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives
DE2651083A1 (de) 1976-11-09 1978-05-18 Hoechst Ag Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HUT54347A (en) * 1989-01-10 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoximes
US5334600A (en) * 1991-07-30 1994-08-02 Ciba-Geigy Corporation Isoquinolyl substituted hydroxylamine derivatives
EP0758315B1 (en) 1994-05-06 1998-08-26 Biorex Kutato Es Fejlesztö Rt. Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same
HU9502843D0 (en) * 1995-09-29 1995-11-28 Livigene Ltd Pharmaceutical composition
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
UA64716C2 (en) 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
HU220971B1 (hu) 1997-04-03 2002-07-29 BIOREX Kutató és Fejlesztő Rt. Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
UA65635C2 (ru) * 1998-09-03 2004-04-15 Н-Гене Кутато Кфт. НЕНАСЫЧЕННЫЕ ПРОИЗВОДНЫЕ ГИДРОКСИМОВОЙ КИСЛОТЫ, ИМЕЮЩИЕ СВОЙСТВА ИНГИБИТОРОВ NAD<sup>+-ADP-РИБОЗИЛТРАНСФЕРАЗЫ
HUP9900475D0 (en) * 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HUP0001583A2 (hu) 2000-04-18 2002-11-28 BIOREX Kutató és Fejlesztő Rt. Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
HU0103939D0 (en) 2001-09-27 2001-11-28 Biorex Kutato Fejlesztoe Kft Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
ITMI20012573A1 (it) 2001-12-06 2003-06-06 D B P Dev Biotechonologica L P Gli acilsalicilati:una nuova classe di induttori di risposta heat shock

Also Published As

Publication number Publication date
IL175334A0 (en) 2008-04-13
US20080039497A1 (en) 2008-02-14
WO2005041965A1 (en) 2005-05-12
AU2004285343A1 (en) 2005-05-12
DE602004016770D1 (de) 2008-11-06
EA200600866A1 (ru) 2006-10-27
US20150126551A1 (en) 2015-05-07
PT1696922E (pt) 2008-10-17
ZA200604376B (en) 2009-04-29
IL175334A (en) 2010-12-30
US8962604B2 (en) 2015-02-24
EP1696922A1 (en) 2006-09-06
JP5077997B2 (ja) 2012-11-21
CA2544332A1 (en) 2005-05-12
AU2004285343B2 (en) 2010-05-13
SI1696922T1 (sl) 2008-12-31
EP1696922B1 (en) 2008-09-24
DK1696922T3 (da) 2008-12-01
HK1097438A1 (en) 2007-06-29
HUP0303584A3 (en) 2009-12-28
JP2007509920A (ja) 2007-04-19
BRPI0415625A (pt) 2006-12-12
ES2314458T3 (es) 2009-03-16
NO20062401L (no) 2006-07-27
CA2544332C (en) 2014-09-23
CY1110450T1 (el) 2015-04-29
HRP20080660T3 (hr) 2009-01-31
CN1901913A (zh) 2007-01-24
CZ2006347A3 (cs) 2006-10-11
HU0303584D0 (en) 2003-12-29
PL1696922T3 (pl) 2009-03-31
EP2020233A3 (en) 2009-09-30
US20120115908A1 (en) 2012-05-10
EA011301B1 (ru) 2009-02-27
KR20060103323A (ko) 2006-09-28
ATE409038T1 (de) 2008-10-15
HUP0303584A2 (hu) 2005-12-28
EP2020233A2 (en) 2009-02-04
NZ547216A (en) 2009-03-31

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