UA88604C2 - Use of antibody binding to alfa-4-integrin for treatment of demyelinating diseases - Google Patents
Use of antibody binding to alfa-4-integrin for treatment of demyelinating diseasesInfo
- Publication number
- UA88604C2 UA88604C2 UAA200508278A UA2005008278A UA88604C2 UA 88604 C2 UA88604 C2 UA 88604C2 UA A200508278 A UAA200508278 A UA A200508278A UA 2005008278 A UA2005008278 A UA 2005008278A UA 88604 C2 UA88604 C2 UA 88604C2
- Authority
- UA
- Ukraine
- Prior art keywords
- demyelination
- compositions
- alfa
- integrin
- treatment
- Prior art date
Links
- 208000016192 Demyelinating disease Diseases 0.000 title abstract 4
- 206010012305 Demyelination Diseases 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 206010033799 Paralysis Diseases 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- -1 antibodies Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44217103P | 2003-01-24 | 2003-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA88604C2 true UA88604C2 (en) | 2009-11-10 |
Family
ID=37959752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200508278A UA88604C2 (en) | 2003-01-24 | 2004-01-26 | Use of antibody binding to alfa-4-integrin for treatment of demyelinating diseases |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1942161B (en) |
| UA (1) | UA88604C2 (en) |
| ZA (1) | ZA200505869B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2509573C2 (en) * | 2010-07-27 | 2014-03-20 | Олег Ильич Эпштейн | Drug for treating multiple sclerosis and method of treating multiple sclerosis |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015534564A (en) * | 2012-10-09 | 2015-12-03 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | Combination therapy and use for the treatment of demyelinating disorders |
| CN106316982B (en) * | 2015-06-30 | 2020-08-14 | 中国人民解放军军事医学科学院毒物药物研究所 | Thiazinamide derivatives and their uses |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060501A (en) * | 1994-06-02 | 2000-05-09 | Schering Aktiengesellschaft | Combined treatment of multiple sclerosis |
-
2004
- 2004-01-26 ZA ZA200505869A patent/ZA200505869B/en unknown
- 2004-01-26 CN CN2004800080890A patent/CN1942161B/en not_active Expired - Lifetime
- 2004-01-26 UA UAA200508278A patent/UA88604C2/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2509573C2 (en) * | 2010-07-27 | 2014-03-20 | Олег Ильич Эпштейн | Drug for treating multiple sclerosis and method of treating multiple sclerosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1942161B (en) | 2012-05-30 |
| ZA200505869B (en) | 2006-11-29 |
| CN1942161A (en) | 2007-04-04 |
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