UA90654C2 - Polymer conjugates of interferon-beta with enhanced biological potency - Google Patents

Polymer conjugates of interferon-beta with enhanced biological potency

Info

Publication number
UA90654C2
UA90654C2 UAA200507467A UA2005007467A UA90654C2 UA 90654 C2 UA90654 C2 UA 90654C2 UA A200507467 A UAA200507467 A UA A200507467A UA 2005007467 A UA2005007467 A UA 2005007467A UA 90654 C2 UA90654 C2 UA 90654C2
Authority
UA
Ukraine
Prior art keywords
beta
interferon
biological potency
polymer conjugates
enhanced biological
Prior art date
Application number
UAA200507467A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Марк Г.П. Саифер
Алекса Л. Мартинес
Девид Л. Уиллиамс
Мерри Р. Шерман
Original Assignee
Маунтин Вью Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Маунтин Вью Фармасьютикалз, Инк. filed Critical Маунтин Вью Фармасьютикалз, Инк.
Publication of UA90654C2 publication Critical patent/UA90654C2/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method for increasing the biological potency of a non-glycosylated interferon-beta, comprising selectively coupling one or more synthetic water-soluble polymers to the amino-terminal amino acid of said interferon-beta, wherein said amino-terminal amino acid is located remotely from the receptor-binding domain(s) of said interferon-beta, a pharmaceutical composition comprising one or more of the conjugates. The invention further relates to a method of preventing, diagnosing, or treating an interferon-beta-responsive physical disorder.
UAA200507467A 2002-12-26 2003-12-23 Polymer conjugates of interferon-beta with enhanced biological potency UA90654C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43602002P 2002-12-26 2002-12-26

Publications (1)

Publication Number Publication Date
UA90654C2 true UA90654C2 (en) 2010-05-25

Family

ID=37134126

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200507467A UA90654C2 (en) 2002-12-26 2003-12-23 Polymer conjugates of interferon-beta with enhanced biological potency
UAA200507468A UA91325C2 (en) 2002-12-26 2003-12-23 Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA200507468A UA91325C2 (en) 2002-12-26 2003-12-23 Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity

Country Status (3)

Country Link
CN (2) CN1852732A (en)
UA (2) UA90654C2 (en)
ZA (2) ZA200505394B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114630B2 (en) * 2007-05-02 2012-02-14 Ambrx, Inc. Modified interferon beta polypeptides and their uses
WO2010024557A2 (en) * 2008-08-25 2010-03-04 Viromed Co., Ltd. Biopolymer conjugates comprising an interleukin-11 analog
WO2012065086A1 (en) * 2010-11-12 2012-05-18 Nektar Therapeutics Conjugates of an il-2 moiety and a polymer
AR096890A1 (en) * 2013-07-12 2016-02-03 Hanmi Pharm Ind Co Ltd CONJUGATING FC OF IMMUNOGLOBULINA, THAT MAINTAINS THE UNION AFFINITY OF THE FC FRAGMENT OF THE IMMUNOGLOBULIN TO FCRN
KR102762243B1 (en) * 2014-06-30 2025-02-05 알토 바이오사이언스 엘엘씨 Il-15-based molecules and methods of use thereof
CN104725482A (en) * 2015-04-06 2015-06-24 苏州普罗达生物科技有限公司 Platelet-derived growth factor antagonistic polypeptide and applications thereof
EP3595699A4 (en) * 2017-03-16 2020-12-23 Blaze Bioscience, Inc. CARTILLE HOMING PEPTIDE CONJUGATES AND METHOD OF USING THEREOF
WO2019222296A1 (en) * 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable interleukin 12 polypeptides and methods of use thereof
CN113797318B (en) * 2021-10-26 2023-06-30 深圳科兴药业有限公司 Interferon composition and preparation method and application thereof
CN117711525B (en) * 2024-02-05 2024-05-10 北京悦康科创医药科技股份有限公司 Activity prediction model training and activity prediction related products

Also Published As

Publication number Publication date
ZA200505394B (en) 2007-03-28
ZA200505393B (en) 2007-03-28
UA91325C2 (en) 2010-07-26
CN1852732A (en) 2006-10-25
CN1859925A (en) 2006-11-08

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