UA90878C2 - Конденсированные производные пиразола и способы лечения с их помощью заболеваний, вызванных нарушением обмена веществ - Google Patents

Конденсированные производные пиразола и способы лечения с их помощью заболеваний, вызванных нарушением обмена веществ

Info

Publication number: UA90878C2
Authority: UA; Ukraine
Prior art keywords: inhibitors; present; compounds; metabolic; treatment
Prior art date: 2004-12-23

Application number

UAA200708375A

Other languages

English (en)

Russian (ru)

Ukrainian (uk)

Inventor

Дуглас П. Боутмат

Томас О. Шрадер

Греем Семпл

Филипп Дж. Скиннер

Дзае-Киу Дзунг

Original Assignee

Арена Фармасьютикалз, Инк.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-23

Filing date

2005-12-22

Publication date

2010-06-10

2005-12-22 Application filed by Арена Фармасьютикалз, Инк. filed Critical Арена Фармасьютикалз, Инк.

2010-06-10 Publication of UA90878C2 publication Critical patent/UA90878C2/ru

Links

230000002503 metabolic effect Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
150000003217 pyrazoles Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 2
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 2
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 2
239000003623 enhancer Substances 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 abstract 1
229940077274 Alpha glucosidase inhibitor Drugs 0.000 abstract 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
229940123208 Biguanide Drugs 0.000 abstract 1
208000032928 Dyslipidaemia Diseases 0.000 abstract 1
229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
206010022489 Insulin Resistance Diseases 0.000 abstract 1
208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
239000003888 alpha glucosidase inhibitor Substances 0.000 abstract 1
150000004283 biguanides Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
208000029078 coronary artery disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 1
229940125753 fibrate Drugs 0.000 abstract 1
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
230000003914 insulin secretion Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940031439 squalene Drugs 0.000 abstract 1
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

UAA200708375A 2004-12-23 2005-12-22 Конденсированные производные пиразола и способы лечения с их помощью заболеваний, вызванных нарушением обмена веществ UA90878C2 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63866804P	2004-12-23	2004-12-23

Publications (1)

Publication Number	Publication Date
UA90878C2 true UA90878C2 (ru)	2010-06-10

Family

ID=38938221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200708375A UA90878C2 (ru)	2004-12-23	2005-12-22	Конденсированные производные пиразола и способы лечения с их помощью заболеваний, вызванных нарушением обмена веществ

Country Status (4)

Country	Link
CN (1)	CN101087765A (es)
CR (1)	CR9178A (es)
UA (1)	UA90878C2 (es)
ZA (1)	ZA200705147B (es)

2005
- 2005-12-22 UA UAA200708375A patent/UA90878C2/ru unknown
- 2005-12-22 CN CN 200580044454 patent/CN101087765A/zh active Pending
2007
- 2007-06-12 CR CR9178A patent/CR9178A/es not_active Application Discontinuation
- 2007-06-21 ZA ZA200705147A patent/ZA200705147B/xx unknown

Also Published As

Publication number	Publication date
ZA200705147B (en)	2008-10-29
CN101087765A (zh)	2007-12-12
CR9178A (es)	2007-10-23

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