UA93552C2 - Fermentative production of lipstatin - Google Patents

Fermentative production of lipstatin

Info

Publication number
UA93552C2
UA93552C2 UAA200814663A UAA200814663A UA93552C2 UA 93552 C2 UA93552 C2 UA 93552C2 UA A200814663 A UAA200814663 A UA A200814663A UA A200814663 A UAA200814663 A UA A200814663A UA 93552 C2 UA93552 C2 UA 93552C2
Authority
UA
Ukraine
Prior art keywords
lipstatin
production
fermentative production
present
inhibitor
Prior art date
Application number
UAA200814663A
Other languages
English (en)
Ukrainian (uk)
Inventor
Алес Гаспарик
Гордан Сладик
Сважель Неда Бениски
Митья Пелко
Петер Распор
Грвое Петкович
Штефан Фюйс
Original Assignee
Kpka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kpka filed Critical Kpka
Publication of UA93552C2 publication Critical patent/UA93552C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Способ получения липстатина, который включает стадии создания среды, которая содержит не менее 0,3 масс.% линолевой кислоты или ее эфира(ов), или соли(ей) и более 1 масс.% масла, после чего проводят процесс инокуляции среды зерна культуры, которая включает микроорганизм, продуцирующий липстатин, культивирование, и, возможно, выделение липстатина. Липстатин является сильным ингибитором липазы поджелудочной железы и имеет полезное действие при лечении и/или профилактике ожирения и ассоциированных с ним заболеваниях.
UAA200814663A 2006-05-22 2007-05-22 Fermentative production of lipstatin UA93552C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06010470A EP1860194A1 (en) 2006-05-22 2006-05-22 Fermentative production of lipstatin

Publications (1)

Publication Number Publication Date
UA93552C2 true UA93552C2 (en) 2011-02-25

Family

ID=37037452

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200814663A UA93552C2 (en) 2006-05-22 2007-05-22 Fermentative production of lipstatin

Country Status (9)

Country Link
EP (2) EP1860194A1 (ru)
AT (1) ATE500339T1 (ru)
DE (1) DE602007012862D1 (ru)
EA (1) EA014192B1 (ru)
NO (1) NO20085062L (ru)
PL (1) PL2019869T3 (ru)
SI (1) SI2019869T1 (ru)
UA (1) UA93552C2 (ru)
WO (1) WO2007134836A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2755736T3 (es) * 2008-03-26 2020-04-23 Biocon Ltd Proceso de fermentación mejorado para un coeficiente de rendimiento más alto de inhibidor de lipasa respecto al ácido graso consumido
EP2141236A1 (en) 2008-07-03 2010-01-06 KRKA, D.D., Novo Mesto Process for production of lipstatin and microorganisms therefore
CN102268466B (zh) * 2011-07-23 2013-06-12 鲁南新时代生物技术有限公司 一种发酵生产利普司他汀的方法及其培养基组份
CN102827892A (zh) * 2012-09-05 2012-12-19 李海霞 一种尼泊司他汀生产工艺
CN103468603B (zh) * 2013-07-17 2015-02-11 杭州华东医药集团新药研究院有限公司 一种毒三素链霉菌及其在制备利普司他汀中的应用
CN105063118A (zh) * 2015-07-19 2015-11-18 聊城大学 一种添加亚油酸缓释微囊提高利普斯他汀发酵单位的方法
CN105061365A (zh) * 2015-07-20 2015-11-18 聊城大学 一锅法从发酵液中提取利普司他汀的方法
CN106868070A (zh) * 2017-04-14 2017-06-20 孟怡杉 一种微生物发酵生产利普司他汀的培养基
CN108753861B (zh) * 2018-06-08 2022-02-01 福建省微生物研究所 一种毒三素链霉菌发酵产利普司他汀的培养基及方法
CN115851553B (zh) * 2022-12-30 2024-04-26 西南大学 一种可防治根肿病的弗吉尼亚链霉菌及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY116591A (en) * 1996-04-26 2004-02-28 Hoffmann La Roche Process for the production of lipstatin and tetrahydrolipstatin
AU2002359601A1 (en) * 2001-12-04 2003-06-17 Biogal Gyogyszergyar Rt A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth

Also Published As

Publication number Publication date
EA014192B1 (ru) 2010-10-29
DE602007012862D1 (de) 2011-04-14
NO20085062L (no) 2009-02-16
PL2019869T3 (pl) 2011-07-29
EP2019869B1 (en) 2011-03-02
WO2007134836A1 (en) 2007-11-29
SI2019869T1 (sl) 2011-07-29
EP1860194A1 (en) 2007-11-28
EA200802175A1 (ru) 2009-04-28
ATE500339T1 (de) 2011-03-15
EP2019869A1 (en) 2009-02-04

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