UA94100C2 - Способ получения индазолилмочевин, которые угнетают ванилоидные рецепторы подтипа 1 (vr1) - Google Patents

Способ получения индазолилмочевин, которые угнетают ванилоидные рецепторы подтипа 1 (vr1)

Info

Publication number
UA94100C2
UA94100C2 UAA200813189A UAA200813189A UA94100C2 UA 94100 C2 UA94100 C2 UA 94100C2 UA A200813189 A UAA200813189 A UA A200813189A UA A200813189 A UAA200813189 A UA A200813189A UA 94100 C2 UA94100 C2 UA 94100C2
Authority
UA
Ukraine
Prior art keywords
receptors
preparation
ureas
inhibit vanilloid
indazolyl
Prior art date
Application number
UAA200813189A
Other languages
English (en)
Ukrainian (uk)
Inventor
Кирилл А. Лукин
Су Маргарет Чи-Пин
Дилини П. Фернандо
Брайан Дж. Котеки
Марвин Р. Линна
Original Assignee
Эбботт Леборетриз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эбботт Леборетриз filed Critical Эбботт Леборетриз
Publication of UA94100C2 publication Critical patent/UA94100C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Данное изобретение касается способа получения индазолилмочевин, которые пригодны как ингибиторы ванилоидных рецепторов подтипа 1 (VR1).
UAA200813189A 2006-04-14 2007-04-13 Способ получения индазолилмочевин, которые угнетают ванилоидные рецепторы подтипа 1 (vr1) UA94100C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79209906P 2006-04-14 2006-04-14

Publications (1)

Publication Number Publication Date
UA94100C2 true UA94100C2 (ru) 2011-04-11

Family

ID=38610399

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200813189A UA94100C2 (ru) 2006-04-14 2007-04-13 Способ получения индазолилмочевин, которые угнетают ванилоидные рецепторы подтипа 1 (vr1)

Country Status (20)

Country Link
US (2) US7847104B2 (ru)
EP (1) EP2012779B1 (ru)
JP (1) JP2009533474A (ru)
KR (2) KR20110017464A (ru)
CN (4) CN101466374B (ru)
AU (1) AU2007238019B2 (ru)
BR (1) BRPI0709963A2 (ru)
CA (1) CA2647261A1 (ru)
CR (1) CR10357A (ru)
EC (1) ECSP088878A (ru)
ES (1) ES2385404T3 (ru)
MX (1) MX2008013205A (ru)
MY (1) MY145334A (ru)
NO (1) NO20084698L (ru)
NZ (1) NZ571705A (ru)
RU (1) RU2446161C2 (ru)
TW (1) TW200815362A (ru)
UA (1) UA94100C2 (ru)
WO (1) WO2007121339A2 (ru)
ZA (1) ZA200808596B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009055730A1 (en) * 2007-10-25 2009-04-30 Genentech, Inc. Process for making thienopyrimidine compounds
US8232411B2 (en) 2008-03-20 2012-07-31 Abbott Laboratories Methods for making central nervous system agents that are TRPV1 antagonists
CN102070420B (zh) * 2011-01-04 2013-12-18 常州大学 一种2-溴-6-氟苯甲醛的制备方法
WO2014158640A1 (en) * 2013-03-13 2014-10-02 Dow Agrosciences Llc Improved process for the preparation of certain triaryl rhamnose carbamates
AU2017295745A1 (en) 2016-07-12 2019-01-31 Bayer Cropscience Aktiengesellschaft Bicyclic compounds as pest control agents
CN106977535A (zh) * 2017-04-28 2017-07-25 大连联化化学有限公司 一种合成2‑氰基3‑氟苯硼酸工艺

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054833A (ru) * 1963-08-09
DE2458965C3 (de) * 1974-12-13 1979-10-11 Bayer Ag, 5090 Leverkusen 3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel
US5905080A (en) * 1993-08-20 1999-05-18 Smithkline Beecham, P.L.C. Amide and urea derivatives as 5HT1D receptor antagonists
IL161576A0 (en) * 2001-10-26 2004-09-27 Aventis Pharma Inc Benzimidazoles and analogues and their use as protein kinases inhibitors
BR0309551A (pt) 2002-04-26 2005-02-09 Upjohn Co Derivados substituìdos de pirazina
KR100976076B1 (ko) * 2003-05-22 2010-08-17 아보트 러보러터리즈 인다졸, 벤즈이속사졸 및 벤즈이소티아졸 키나제 억제제
US7015233B2 (en) * 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
US7375126B2 (en) * 2003-06-12 2008-05-20 Abbott Laboratories Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
JP4499721B2 (ja) * 2003-06-30 2010-07-07 ヒフ バイオ，インク． 化合物、組成物および方法
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20070021450A1 (en) * 2004-07-16 2007-01-25 Benjamin Sklarz Indanylamino uracils and their use as antioxidants and neuroprotectants
WO2006020070A2 (en) * 2004-07-16 2006-02-23 Teva Pharmaceutical Industries, Ltd. Indanylamino uracils and their use as antioxidants and neuroprotectants
EP1940843A4 (en) * 2005-08-11 2010-09-15 Ariad Pharma Inc UNSATURATED HETEROCYCLIC DERIVATIVES
GB0520657D0 (en) * 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
US20070149508A1 (en) * 2005-11-02 2007-06-28 Targegen, Inc. Six membered heteroaromatic inhibitors targeting resistant kinase mutations
BRPI0619263A2 (pt) * 2005-11-30 2011-09-27 Hoffmann La Roche indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis

Also Published As

Publication number Publication date
EP2012779A4 (en) 2010-11-24
KR20090003335A (ko) 2009-01-09
US20070244178A1 (en) 2007-10-18
US7847104B2 (en) 2010-12-07
AU2007238019A1 (en) 2007-10-25
TW200815362A (en) 2008-04-01
US20110040102A1 (en) 2011-02-17
CN102140081A (zh) 2011-08-03
RU2008144961A (ru) 2010-05-20
RU2446161C2 (ru) 2012-03-27
ZA200808596B (en) 2010-03-31
BRPI0709963A2 (pt) 2011-08-02
US8519186B2 (en) 2013-08-27
CN101466374B (zh) 2012-03-21
KR20110017464A (ko) 2011-02-21
JP2009533474A (ja) 2009-09-17
NZ571705A (en) 2012-03-30
CR10357A (es) 2008-12-11
CN101466374A (zh) 2009-06-24
EP2012779A2 (en) 2009-01-14
WO2007121339A2 (en) 2007-10-25
CN102321025A (zh) 2012-01-18
KR101118932B1 (ko) 2012-02-27
ES2385404T3 (es) 2012-07-24
CA2647261A1 (en) 2007-10-25
ECSP088878A (es) 2008-12-30
NO20084698L (no) 2008-11-07
MX2008013205A (es) 2008-10-22
CN102775350A (zh) 2012-11-14
WO2007121339A3 (en) 2008-10-02
MY145334A (en) 2012-01-31
HK1123725A1 (en) 2009-06-26
EP2012779B1 (en) 2012-05-16
AU2007238019B2 (en) 2013-03-14

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