UA96445C2 - 2-(замещенные амино)бензотиазолсульфонамидные ингибиторы вич-протеазы - Google Patents

2-(замещенные амино)бензотиазолсульфонамидные ингибиторы вич-протеазы

Info

Publication number
UA96445C2
UA96445C2 UAA200813950A UAA200813950A UA96445C2 UA 96445 C2 UA96445 C2 UA 96445C2 UA A200813950 A UAA200813950 A UA A200813950A UA A200813950 A UAA200813950 A UA A200813950A UA 96445 C2 UA96445 C2 UA 96445C2
Authority
UA
Ukraine
Prior art keywords
protease inhibitors
amino
substituted
benzothiazole sulfonamide
hiv protease
Prior art date
Application number
UAA200813950A
Other languages
English (en)
Ukrainian (uk)
Inventor
Кок Херман Августинус Де
Тим Хуго Мария Джонкерс
Пауль Джозеф Габриэль Мария Боонантс
Стефаан Джулиен Ласт
Инге Диеринк
Джудит Ева Баумистер
'Т Клоостер Гербен Алберт Элеузериус ван
Original Assignee
Тиботек Фармасьютикелз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тиботек Фармасьютикелз Лтд. filed Critical Тиботек Фармасьютикелз Лтд.
Publication of UA96445C2 publication Critical patent/UA96445C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение касается 2-(замещенных амино)бензотиазолсульфонамидных соединений формулыи производных, их применение как ингибиторов протеазы, особенно как ингибиторов протеазы ВИЧ, которые имеют широкий спектр, способов их получения, а также фармацевтических композиций и диагностических наборов, которые содержат их.Данное изобретение также касается комбинаций представленных 2-(замещенных амино)бензотиазолсульфонамидных соединений и производных с другим антиретровирусным агентом. Изобретение, кроме того, касается применения соединений в анализах как эталонных соединений или как реагентов.
UAA200813950A 2006-06-23 2007-06-22 2-(замещенные амино)бензотиазолсульфонамидные ингибиторы вич-протеазы UA96445C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06116003 2006-06-23

Publications (1)

Publication Number Publication Date
UA96445C2 true UA96445C2 (ru) 2011-11-10

Family

ID=37596252

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200813950A UA96445C2 (ru) 2006-06-23 2007-06-22 2-(замещенные амино)бензотиазолсульфонамидные ингибиторы вич-протеазы

Country Status (30)

Country Link
US (1) US8202887B2 (ru)
EP (1) EP2035432B1 (ru)
JP (1) JP5232776B2 (ru)
KR (1) KR101419320B1 (ru)
CN (1) CN101479275B (ru)
AP (1) AP2069A (ru)
AR (1) AR061619A1 (ru)
AT (1) ATE544769T1 (ru)
AU (1) AU2007262943B2 (ru)
BR (1) BRPI0713487B1 (ru)
CA (1) CA2653233C (ru)
CL (1) CL2007001826A1 (ru)
CY (1) CY1112971T1 (ru)
DK (1) DK2035432T3 (ru)
EA (1) EA016387B1 (ru)
ES (1) ES2381129T3 (ru)
IL (1) IL195381A (ru)
JO (1) JO2841B1 (ru)
MX (1) MX2009000160A (ru)
MY (1) MY146805A (ru)
NZ (1) NZ573286A (ru)
PE (1) PE20080342A1 (ru)
PL (1) PL2035432T3 (ru)
PT (1) PT2035432E (ru)
SI (1) SI2035432T1 (ru)
TW (1) TWI415851B (ru)
UA (1) UA96445C2 (ru)
UY (1) UY30416A1 (ru)
WO (1) WO2007147884A1 (ru)
ZA (1) ZA200810350B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3090B1 (ar) * 2009-12-11 2017-03-15 Janssen Sciences Ireland Uc 5- امينو-4- هيدروكسي-بنتويل اميدات
AP2013006706A0 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc Napht-2-ylacetic acid derivatives to treat AIDS
KR20130124291A (ko) 2010-07-02 2013-11-13 길리애드 사이언시즈, 인코포레이티드 Ｈｉｖ 항바이러스 화합물로서의 2-퀴놀리닐-아세트산 유도체
US9024038B2 (en) * 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
BR112013027096A2 (pt) * 2011-04-21 2016-12-27 Gilead Sciences Inc compostos de benzotiazol e seu uso farmacêutico
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
ES2571479T3 (es) 2012-04-20 2016-05-25 Gilead Sciences Inc Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2275866T3 (es) * 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
PL374948A1 (en) * 2002-08-02 2005-11-14 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
US20080234288A1 (en) * 2003-09-30 2008-09-25 Kenneth Alan Simmen Hcv Inhibiting Sulfonamides

Also Published As

Publication number Publication date
UY30416A1 (es) 2008-01-31
CN101479275A (zh) 2009-07-08
CY1112971T1 (el) 2016-04-13
JP2009541272A (ja) 2009-11-26
NZ573286A (en) 2011-09-30
EA200970052A1 (ru) 2009-04-28
PT2035432E (pt) 2012-04-24
JP5232776B2 (ja) 2013-07-10
TWI415851B (zh) 2013-11-21
IL195381A (en) 2013-01-31
SI2035432T1 (sl) 2012-06-29
ATE544769T1 (de) 2012-02-15
EA016387B1 (ru) 2012-04-30
KR20090024257A (ko) 2009-03-06
WO2007147884A1 (en) 2007-12-27
ES2381129T3 (es) 2012-05-23
AP2069A (en) 2009-12-08
MY146805A (en) 2012-09-28
AU2007262943A1 (en) 2007-12-27
KR101419320B1 (ko) 2014-07-14
DK2035432T3 (da) 2012-05-14
JO2841B1 (en) 2014-09-15
TW200817416A (en) 2008-04-16
HK1125633A1 (en) 2009-08-14
US20090209583A1 (en) 2009-08-20
PL2035432T3 (pl) 2012-07-31
BRPI0713487B1 (pt) 2022-07-26
CL2007001826A1 (es) 2008-01-18
ZA200810350B (en) 2010-05-26
IL195381A0 (en) 2009-08-03
BRPI0713487A8 (pt) 2018-01-02
EP2035432B1 (en) 2012-02-08
AP2008004679A0 (en) 2008-12-31
MX2009000160A (es) 2009-01-23
CA2653233A1 (en) 2007-12-27
AU2007262943B2 (en) 2012-04-12
CA2653233C (en) 2015-09-29
BRPI0713487A2 (ru) 2012-11-13
PE20080342A1 (es) 2008-04-25
CN101479275B (zh) 2012-03-07
US8202887B2 (en) 2012-06-19
EP2035432A1 (en) 2009-03-18
AR061619A1 (es) 2008-09-10

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