UA98962C2 - Аналоги тиреоидного гормона, фармацевтическая композиция, которая их содержит, способ лечения с их использованием, их применение и способ получения - Google Patents

Аналоги тиреоидного гормона, фармацевтическая композиция, которая их содержит, способ лечения с их использованием, их применение и способ получения

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UA98962C2
UA98962C2 UAA200913974A UAA200913974A UA98962C2 UA 98962 C2 UA98962 C2 UA 98962C2 UA A200913974 A UAA200913974 A UA A200913974A UA A200913974 A UAA200913974 A UA A200913974A UA 98962 C2 UA98962 C2 UA 98962C2
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preparation
compounds
treatment
pharmaceutical composition
formula
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UAA200913974A
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English (en)
Ukrainian (uk)
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Лаксмикант Чхипа
Шиталкумар Пукхарай Замбад
Рамеш Гупта
Давиндер Тули
Ашок Касундра
Сирали Мунши
М. Амир Сиддиквуй
Субрат Кумар Бхаттамисра
С. Дутт
Виджай Чаутайвале
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Торрент Фармасьютикалз Лтд.
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Publication of UA98962C2 publication Critical patent/UA98962C2/ru

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Данное изобретение описывает новые тиреоидоподобные соединения формулы (I), где R1, R2, R3, R4 и Z являются такими, как определено в описании, способ их получения, композицию, которая содержит такие соединения, и применение таких соединений и композиции как лекарственного средства.Соединения формулы (I) имеют очень низкую аффинность связывания с тиреоидными рецепторами и, таким образом, избегают тиреотоксического влияния.Изобретение также касается применения соединения формулы (I) для изготовления лекарственного средства для лечения различных болезней, таких как ожирение, дислипидемия, метаболический синдром и сопутствующие болезни, ассоциированные с метаболическим синдромом.
UAA200913974A 2007-06-06 2008-06-02 Аналоги тиреоидного гормона, фармацевтическая композиция, которая их содержит, способ лечения с их использованием, их применение и способ получения UA98962C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN857KO2007 2007-06-06

Publications (1)

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UA98962C2 true UA98962C2 (ru) 2012-07-10

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US (2) US8143424B2 (ru)
EP (1) EP2061766B1 (ru)
JP (1) JP5243537B2 (ru)
KR (1) KR101152965B1 (ru)
CN (1) CN101772487B (ru)
AR (1) AR066155A1 (ru)
AT (1) ATE478053T1 (ru)
AU (1) AU2008259314B2 (ru)
CA (1) CA2698704C (ru)
CY (1) CY1110925T1 (ru)
DE (1) DE602008002205D1 (ru)
DK (1) DK2061766T3 (ru)
EA (1) EA019084B1 (ru)
ES (1) ES2351274T3 (ru)
HR (1) HRP20100611T1 (ru)
IL (1) IL202515A (ru)
MX (1) MX2009013070A (ru)
NZ (1) NZ582273A (ru)
PL (1) PL2061766T3 (ru)
PT (1) PT2061766E (ru)
RS (1) RS51501B (ru)
SI (1) SI2061766T1 (ru)
TW (1) TWI360541B (ru)
UA (1) UA98962C2 (ru)
WO (1) WO2008149379A2 (ru)
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KR101152965B1 (ko) 2012-06-08
DK2061766T3 (da) 2010-12-13
EA019084B1 (ru) 2014-01-30
EA200901651A1 (ru) 2010-12-30
WO2008149379A3 (en) 2009-03-19
WO2008149379A2 (en) 2008-12-11
CN101772487B (zh) 2014-01-22
TW200911756A (en) 2009-03-16
SI2061766T1 (sl) 2010-12-31
HRP20100611T1 (hr) 2010-12-31
IL202515A0 (en) 2010-06-30
CN101772487A (zh) 2010-07-07
PT2061766E (pt) 2010-11-26
EP2061766B1 (en) 2010-08-18
ES2351274T3 (es) 2011-02-02
US20120202816A1 (en) 2012-08-09
NZ582273A (en) 2011-06-30
CY1110925T1 (el) 2015-06-10
US8143424B2 (en) 2012-03-27
IL202515A (en) 2013-07-31
US20100168110A1 (en) 2010-07-01
KR20100022104A (ko) 2010-02-26
US8378118B2 (en) 2013-02-19
TWI360541B (en) 2012-03-21
JP5243537B2 (ja) 2013-07-24
EP2061766A2 (en) 2009-05-27
AR066155A1 (es) 2009-07-29
MX2009013070A (es) 2010-01-29
ATE478053T1 (de) 2010-09-15
AU2008259314A1 (en) 2008-12-11
CA2698704A1 (en) 2008-12-11
ZA200908760B (en) 2010-08-25
JP2010529108A (ja) 2010-08-26
HK1129221A1 (en) 2009-11-20
CA2698704C (en) 2016-01-19
AU2008259314B2 (en) 2011-05-19
RS51501B (sr) 2011-04-30
PL2061766T3 (pl) 2011-02-28
DE602008002205D1 (de) 2010-09-30

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