US10575967B2 - Implantable nuclear prosthesis - Google Patents

Implantable nuclear prosthesis Download PDF

Info

Publication number
US10575967B2
US10575967B2 US15/254,282 US201615254282A US10575967B2 US 10575967 B2 US10575967 B2 US 10575967B2 US 201615254282 A US201615254282 A US 201615254282A US 10575967 B2 US10575967 B2 US 10575967B2
Authority
US
United States
Prior art keywords
proximal
implant device
spinal implant
enclosure
plug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US15/254,282
Other languages
English (en)
Other versions
US20170056195A1 (en
Inventor
James D. Lutz
W. Loren FRANCIS
Mark Novotny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spinal Stabilization Technologies LLC
Original Assignee
Spinal Stabilization Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spinal Stabilization Technologies LLC filed Critical Spinal Stabilization Technologies LLC
Priority to US15/254,282 priority Critical patent/US10575967B2/en
Publication of US20170056195A1 publication Critical patent/US20170056195A1/en
Assigned to SPINAL STABILIZATION TECHNOLOGIES LLC reassignment SPINAL STABILIZATION TECHNOLOGIES LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FRANCIS, W. LOREN
Assigned to SPINAL STABILIZATION TECHNOLOGIES LLC reassignment SPINAL STABILIZATION TECHNOLOGIES LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NOVOTNY, MARK
Priority to US16/806,580 priority patent/US11576793B2/en
Application granted granted Critical
Publication of US10575967B2 publication Critical patent/US10575967B2/en
Priority to US18/168,475 priority patent/US12533245B2/en
Active legal-status Critical Current
Adjusted expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4603—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2/4611—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30069—Properties of materials and coating materials elastomeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30462—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
    • A61F2002/30586—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid having two or more inflatable pockets or chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/4435—Support means or repair of the natural disc wall, i.e. annulus, e.g. using plates, membranes or meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A61F2002/4475—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2002/4635—Special tools for implanting artificial joints using minimally invasive surgery

Definitions

  • This application relates generally to methods and devices for replacing an intervertebral disc. More specifically, the application relates to an implantable disc replacement which may be implanted using minimally invasive surgical techniques or percutaneously, and methods for manufacturing such a disc replacement/prosthesis.
  • a common medical issue is back pain due to spinal disc injuries caused by trauma, the aging process or other disorders.
  • One method of treatment that has been proposed is to remove the existing nucleus pulposus and replace it with a nuclear prosthesis formed in situ using open surgery or minimally invasive surgical techniques.
  • One proposed method comprises the steps of (i) providing a mold, such as a balloon, to contain a flowable curable material that can cure in situ within the disc space, (ii) providing a conduit to connect the mold cavity to a source of flowable curable material, (iii) delivering the flowable curable material into the mold to fill the cavity, and (iv) permitting the curable material to cure.
  • the existing techniques for forming a nuclear prosthesis in situ have not achieved convincing clinical acceptance or commercial success.
  • One problem identified by the present inventors is the substantial difference in the modulus of elasticity between the vertebral bony elements, including the vertebral end plates, and the annulus fibrosus on the one hand, and the implanted elements on the other.
  • the high modulus of elasticity of the implanted material is disadvantageous since it does not dampen impacts or sudden increases in intradiscal pressure during extreme bending or torsion, especially during high loading peaks.
  • the large difference in the modulus of elasticity between implanted disc materials and adjacent tissues can also lead to softening of the vertebral end plates and adjacent bone (spongeosus), resulting in subsidence of the nuclear implant. Migration and expulsion of the implant can also occur.
  • a kit for implanting a nucleus replacement device comprises a spinal implant device and an inflation stylus.
  • the inner fillable enclosure has a proximal end with a proximal opening and a distal end with a distal opening.
  • the outer fillable enclosure has a proximal end and a distal end, and the proximal and distal ends of the inner and outer fillable enclosures are coupled together so that the outer fillable enclosure encapsulates the inner fillable enclosure.
  • a distal plug seals the distal opening in the distal end of the inner fillable enclosure and a proximal plug seals the proximal opening in the proximal end of the inner fillable enclosure.
  • the proximal plug has a first lumen for providing access to the inner enclosure and a second lumen for providing access to the outer enclosure.
  • the inflation stylus is adapted to mate with the proximal plug, and the inflation stylus comprises a first lumen for delivering fluid to the inner enclosure and a second lumen for delivering fluid to the outer enclosure.
  • a reinforcing band surrounds a perimeter of the outer fillable enclosure.
  • the reinforcing band may comprise a textile.
  • a control element may be coupled to a central zone of the annular reinforcement band.
  • At least one pull string may be coupled to an edge of the annular reinforcing band.
  • a delivery sheath surrounds the inflation stylus, wherein the delivery sheath is movable from a delivery position to a deployed position.
  • the control element and at least one pull string are positioned between the delivery sheath and the inflation stylus.
  • a spinal implant device comprises an inner fillable enclosure and an outer fillable enclosure.
  • the inner fillable enclosure has a proximal end with a proximal opening and a distal end with a distal opening.
  • the outer fillable enclosure has a proximal end and a distal end, and the proximal and distal ends of the inner and outer fillable enclosures are coupled together so that the outer fillable enclosure substantially encapsulates the inner fillable enclosure.
  • a distal plug seals the distal opening in the distal end of the inner fillable enclosure and a proximal plug seals the proximal opening in the proximal end of the inner fillable enclosure.
  • a proximal plug seals the proximal opening in the proximal end of the inner fillable enclosure.
  • the proximal plug has a first lumen for providing access to the inner enclosure and a second lumen for providing access to the outer enclosure.
  • the first lumen for providing access to the inner enclosure remains open after implantation.
  • the inner and outer fillable enclosures comprises a unitary piece of material.
  • the proximal plug is adapted to receive an inflation stylus comprising first and second lumens for delivering fluid to the inner and outer enclosures, respectively.
  • a reinforcing band surrounds a perimeter of the outer fillable enclosure.
  • the reinforcing band may comprise a textile.
  • a control element may be coupled to a central zone of the annular reinforcement band.
  • At least one pull string may be coupled to an edge of the annular reinforcing band.
  • the outer enclosure is filled with a curable silicone material.
  • a method of implanting a prosthetic device into an intervertebral space having a nucleus pulposus surrounded by an annulus fibrosus comprises penetrating the annulus fibrosus; removing the nucleus pulposus to create a enucleated disc cavity; inserting a fillable disc implant device into the enucleated disc cavity, the fillable disc implant device having an inner fillable enclosure forming an inner enclosure and an outer fillable enclosure coupled to the inner fillable enclosure so that the outer fillable enclosure substantially completely surrounds the inner fillable enclosure; inflating the inner fillable enclosure with a fluidic medium; inflating the outer fillable enclosure with a curable medium; allowing the curable medium to cure; removing the fluidic medium from the inner fillable enclosure; and leaving the inner fillable enclosure vented so that fluids may enter and exit the inner fillable enclosure.
  • the fluidic medium comprises a substantially incompressible fluid, such as a contrast medium.
  • a reinforcing band for reinforcing the perimeter of the fillable disc implant is provided.
  • the reinforcing band is inserted into the enucleated disc cavity and manipulated to create a pocket for receiving the fillable disc implant.
  • the reinforcing band may be manipulated by pulling an inferior edge of the reinforcing band and a superior edge of the reinforcing band to pull the edges toward the interior of the enucleated disc cavity; and activating a control element in a central portion of the reinforcing band to press the annular reinforcing band outward in the central portion toward the annulus fibrosus of the enucleated disc cavity.
  • the inferior and superior edges of the reinforcing band may be pulled by using inferior and superior pull strings disposed at the inferior and superior edges of the reinforcing band.
  • the control element may be activated by using a flexible ribbon to press the annular reinforcing band outward towards the annulus fibrosus.
  • the pull strings and flexible ribbons may be removed after the outer fillable enclosure is filled.
  • a reinforcing band for a spinal disc implant comprises a textile band having a superior edge, an inferior edge, and a central zone between the superior and inferior edges.
  • a superior drawstring is disposed at the superior edge of the textile band for tightening the superior edge of the textile band when pulled and an inferior drawstring disposed at the inferior edge of the textile band for tightening the superior edge of the textile band when pulled.
  • a control element is disposed in the central zone for expanding the central zone.
  • the control element may comprise a metal ribbon.
  • Coupled is defined as connected, although not necessarily directly.
  • the terms “a” and “an” are defined as one or more unless this disclosure explicitly requires otherwise.
  • the terms “substantially,” “approximately,” and “about” are defined as largely but not necessarily wholly what is specified (and includes what is specified; e.g., substantially 90 degrees includes 90 degrees and substantially parallel includes parallel), as understood by a person of ordinary skill in the art.
  • the terms “substantially,” “approximately,” and “about” may be substituted with “within [a percentage] of” what is specified, where the percentage includes 0.1, 1, 5, and 10 percent.
  • a method that “comprises,” “has,” “includes” or “contains” one or more steps possesses those one or more steps, but is not limited to possessing only those one or more steps.
  • terms such as “first” and “second” are used only to differentiate structures or features, and not to limit the different structures or features to a particular order.
  • a device, system, or component of either that is configured in a certain way is configured in at least that way, but it can also be configured in other ways than those specifically described.
  • any embodiment of any of the systems and methods can consist of or consist essentially of—rather than comprise/include/contain/have—any of the described elements, features, and/or steps.
  • the term “consisting of” or “consisting essentially of” can be substituted for any of the open-ended linking verbs recited above, in order to change the scope of a given claim from what it would otherwise be using the open-ended linking verb.
  • FIG. 1 is a top plan view of an implant in accordance with an embodiment of the present disclosure
  • FIG. 2 is a left plan view of the implant of FIG. 1 ;
  • FIG. 3 is a right plan view of the implant of FIG. 1 ;
  • FIG. 4 is a side plan view of the implant of FIG. 1 ;
  • FIG. 5 is a sectional view taken along line 5 - 5 in FIG. 4 ;
  • FIG. 6 is an enlarged view of a distal plug of the implant of FIG. 1 ;
  • FIG. 7 is an enlarged view of a proximal plug of the implant of FIG. 1 ;
  • FIG. 8 is a perspective view of an implant blank for forming the implant of FIG. 1 ;
  • FIG. 9 is a cut-away perspective view of the implant blank of FIG. 8 after the implant blank has been partially inverted;
  • FIG. 10 is an inflation stylus inserted into the distal plug of the implant of FIG. 1 ;
  • FIG. 11 is a plan view of the distal end of the inflation stylus of FIG. 10 ;
  • FIG. 12 is a plan view of the proximal end of the inflation stylus of FIG. 10 ;
  • FIG. 13 is a sectional view of the distal end of another inflation stylus
  • FIG. 14 illustrates an annular reinforcing band for use with the implant of FIG. 1 , with a deflated implant located in the interior of the band;
  • FIG. 15 illustrates the annular reinforcing band of FIG. 14 , with a filled implant
  • FIG. 16 illustrates the annular reinforcing band of FIG. 14 during deployment
  • FIG. 17 is a sectional view of the textile band of FIG. 13 ;
  • FIG. 18 illustrates a first step in implanting the implant assembly of FIG. 1 ;
  • FIG. 19 illustrates a second step in implanting the implant assembly of FIG. 1 ;
  • FIG. 20 illustrates a third step in implanting the implant assembly of FIG. 1 ;
  • FIG. 21 illustrates a fourth step in implanting the implant assembly of FIG. 1 ;
  • FIG. 22 illustrates a fifth step in implanting the implant assembly of FIG. 1 ;
  • FIG. 23 illustrates a sixth step in implanting the implant assembly of FIG. 1 .
  • an embodiment of a minimally invasive or percutaneously deliverable spinal implant 100 includes an outer fillable enclosure 102 and an inner fillable enclosure 104 .
  • Outer fillable enclosure 102 forms an outer enclosure 106
  • inner fillable enclosure 104 forms a inner chamber 108 .
  • Inner chamber 108 is encapsulated within outer chamber 102 .
  • encapsulated means that inner chamber 108 is substantially contained within outer chamber 106 such that inner chamber 108 is substantially surrounded on all sides by outer chamber 106 .
  • Outer and inner fillable enclosures 102 , 104 may be formed as a seamless, unitary piece of an elastomeric material, such as silicone rubber.
  • compliant enclosures 102 , 104 The use of an elastomeric material produces compliant outer and inner enclosures 102 , 104 . That is, the outer and inner enclosures 102 , 104 expand as the internal pressure increases when filled with a curable material.
  • compliant enclosures provide certain advantages. Compliant enclosures accommodate the irregular, flat or discoid configuration of the nuclear space. Furthermore, compliant enclosures can help maintain an appropriate modulus of elasticity of the nuclear implant following elastomeric curing, and help preserve bio-mechanical mobility of the vertebral segment, and help allow unhindered deformation of the cured silicone component into the central void.
  • the physical characteristics of inner and outer fillable enclosures 102 , 104 may be tailored to provide desired physical outcomes.
  • enclosures 102 , 104 preferentially expand in a transverse plane.
  • inner and outer fillable enclosures 102 , 104 may be completely or partially semi-compliant or non-compliant (i.e., the do not expand or minimally expand as the internal pressure is increased).
  • different parts of inner and outer fillable enclosures 102 , 104 may be formed of different materials to provide different characteristics to enclosures 102 , 104 .
  • Implant 100 is preferably sized so that it can be inserted percutaneously or using minimally invasive surgery into a enucleated intervertebral disc cavity while deflated and then filled to fill the enucleated cavity.
  • the exterior of filled implant 100 is approximately 30 mm in length, 20 mm in width, and 10 mm in height, and the exterior of inner fillable enclosure 104 is approximately 9 mm long, 6 mm wide, and 6 mm thick.
  • the enclosure does not expand significantly when it is filled (i.e., it is non-compliant or semi-compliant).
  • the implant is filled so that the implant expands by approximately 100% (i.e., doubles in size) when implanted.
  • the implant is filled so that the implant expands by more than 100% when implanted.
  • Outer fillable enclosure 102 has a first (or proximal) end 110 and a second (or distal) end 112 .
  • Inner fillable enclosure 104 has a first (or proximal) end 114 coupled to a proximal neck 116 .
  • a second (or distal) end 118 of inner fillable enclosure 104 is coupled to a distal neck 120 .
  • An end portion 122 of distal neck portion 120 is coupled to distal end 112 of outer fillable enclosure 102
  • an end portion 124 of proximal neck 116 is coupled to proximal end 110 of outer fillable enclosure 102 .
  • end portion 124 of proximal neck 124 is coupled to proximal end 110 of outer fillable enclosure 102 by forming them together as a unitary piece, as will be described in more detail below.
  • Distal end 112 of outer fillable enclosure 102 is inverted and bonded to end portion 122 of distal neck portion to form a substantially fluid tight seal. Coupling the enclosures together in this manner forms a substantially fluid tight outer chamber 106 .
  • a proximal plug 126 is located in the opening formed by proximal neck 116 .
  • Proximal neck 116 may have features, such as grooves 148 , for mating with matching features on proximal plug 126 to assist in locating proximal plug 126 .
  • Proximal plug 126 may be inserted into and bonded with proximal neck 116 .
  • Proximal plug 126 is adapted to mate with an inflation tip 192 of an inflation stylus 130 .
  • a receptacle 132 receives a first lumen 186 of inflation tip 192 to deliver material through aperture 134 into outer chamber 106 .
  • Aperture 134 may be a bottleneck in delivering material to outer chamber 106 , and may be formed as a skived hole to maximum the size of aperture 134 .
  • Proximal plug 126 may be made of silicone or another material which is compatible with enclosures 102 , 104 , and may be manufactured using conventional manufacturing techniques, such as injection molding.
  • a locking feature to help prevent inadvertent dislodgment of inflation stylus 130 from proximal plug 126 is provided.
  • a recess 136 may be provided in proximal plug 126 and a mating feature (e.g., bead 152 , FIG. 13 ) may be provided on inflation tip 192 .
  • An access lumen 138 extends through proximal plug 126 to provide access to interior chamber 108 .
  • receptacle 132 and access lumen 138 can be arranged to prevent improper installation of inflation stylus 130 .
  • a key 214 is provided to physically prevent improper installation of inflation stylus 130 .
  • Key 214 may be used to control the depth of insertion of inflation tip 130 .
  • positioning collar 190 may be used to control the depth of insertion of inflation tip 130 .
  • Access lumen 138 is configured to remain open after implantation to serve as a vent for internal chamber 108 .
  • a distal plug 140 is disposed in distal neck 120 to seal the distal neck.
  • Distal plug 140 may have a cylindrical recess 142 on the interior side for receiving a distal end 200 of a contrast lumen 188 of inflation stylus 130 .
  • Another cylindrical recess 146 may be provided on distal plug 140 .
  • Distal plug 140 may be made of silicone or another material which is compatible with enclosures 102 , 104 , and may be manufactured using conventional manufacturing techniques, such as injection molding.
  • annular reinforcing band 160 may be provided to reinforce implant 100 .
  • Annular reinforcing band 160 is useful when a patient's annulus fibrosus is damaged.
  • annular reinforcing band 160 comprises a tubular, woven textile material.
  • Annular reinforcing band 160 is disposed around the perimeter of the lateral edges of implant 100 to minimize or prevent over inflation of the outer and inner balloons 102 , 104 circumferentially. Controlling circumferential expansion also encourages vertical expansion of balloons 102 , 104 to distract the adjacent vertebra and widen the disc space.
  • the vertebral superior and inferior end plates constrain the vertical expansion of the implant 100 .
  • annular reinforcing band 160 is formed of a woven material. In one embodiment, annular reinforcing band 160 uses an axial weave which minimizes or substantially prevents shortening of the band when it is expanded.
  • U.S. Pat. No. 8,636,803 entitled Percutaneous Implantable Nuclear Implant discloses other suitable constructions of annular reinforcing band 160 , and is hereby incorporated by reference in its entirety for all purposes.
  • One suitable material for annular reinforcing brand 160 is ultra-high molecular weight polyethylene fiber, such as DYNEEMA® fiber available from Koninklijke DSM N.V., Heerleen, the Netherlands.
  • Annular reinforcement band 160 has a superior edge 162 , an inferior edge 164 , and a central zone 166 between superior and inferior edges 162 , 164 .
  • One or more pull strings and control elements are provided to help place annular reinforcement band during deployment of implant 100 .
  • an inferior pull string 168 , a superior pull string 170 , and a control element 172 are provided.
  • Superior pull string is placed in a pocket 176 or otherwise coupled to superior edge 162 of annular reinforcement band 160 .
  • inferior pull string 168 is placed in a pocket 176 or otherwise coupled to inferior edge 164 of annular reinforcement band 160 .
  • Inferior and superior pull strings can be used as a drawstring (i.e., pulled) during deployment to pull the edges of annular reinforcement band 160 inward, thereby helping to constrain and position implant 100 .
  • Control element 172 is disposed in central zone 166 of annular band 160 . If annular band 160 comprises a tubular material, then control element 172 is placed inside the tubular material. In other embodiments, control element 172 is placed in a pocket formed on annular reinforcing band 160 . Control element 172 may be a wire, such as a flat ribbon of nitinol, which runs around the perimeter of annular reinforcement band 160 . Control element 172 may be used to press annular reinforcement band 160 outward to an annulus fibrosus. Further details of the operation of control element 172 and pull strings 168 , 170 will be discussed below.
  • inflation stylus 130 may be used in conjunction with a delivery sheath to deliver implant 100 and annular reinforcement band 160 .
  • Inflation stylus 130 comprises a shaft 180 with a proximal end 182 and a distal end 184 .
  • a first lumen 186 and a second lumen 188 extend through shaft 180 .
  • a positioning collar 190 is provided to maintain first and second lumen 186 , 188 in a desired portion.
  • the distal ends of first and second lumens 186 , 188 form an inflation tip 192 which is configured to mate with proximal plug 126 .
  • First (or silicone) lumen 186 extends from proximal end 182 of inflation stylus 130 to distal end 184 of inflation stylus 130 .
  • an aperture 194 at the distal end of first lumen 186 is coincident with aperture 134 of proximal plug 126 to allow fluid communication between outer chamber 106 and first lumen 186 .
  • Proximal end of lumen 186 is provided with a connector 196 for connection to common inflation tools (such as syringes) known to those of skill in the art.
  • a vent 198 may be provided to allow air to exit silicone lumen 186 when silicone or another suitable material is delivered to outer chamber 106 .
  • Vent 198 may be large enough to allow air to freely move through it, while resisting more viscous fluids such as curable silicone.
  • silicone lumen means a lumen for delivery of any desired fluid to outer chamber 106 , and can encompass materials other than silicone.
  • Vent 198 preferably extends through shaft 180 to vent to atmosphere at the proximal end of inflation stylus 130 .
  • Second (or contrast) lumen 188 extends from proximal end 182 of inflation stylus 130 to distal end 184 of inflation stylus 130 . Contrast lumen 188 extends out the proximal end of inflation stylus 130 . Preferably, contrast lumen 188 is independently movable with respect to inflation stylus 130 so that the position of the distal end 200 of contrast lumen 188 may be extended and withdrawn with respect to the distal end 184 of inflation stylus 130 . For delivery prior to implantation, contrast lumen 188 can extend through access lumen 138 and the distal tip of contrast lumen 188 can be positioned within recess 142 of distal plug 140 to hold it into place.
  • Contrast lumen 188 can be used to both deliver and remove fluids from inner chamber 108 .
  • distal end 200 of contrast lumen 188 is preformed into a shape which allows easier removal of fluid from inner chamber 108 .
  • contrast lumen 188 is preformed into a curved shape which allows easier access to the bottom of inner chamber 108 .
  • the curved shape combined with the ability to extend and withdraw contrast lumen 188 allows it to be adjusted when used to withdraw fluid from inner chamber 108 .
  • contrast lumen should be understood to mean a lumen for delivery of any desired fluid to inner chamber 108 , and can encompass materials other than contrast medium. Contrast medium may be used to ensure visibility under imaging, such as fluoroscopy.
  • a delivery sheath 174 comprises a lumen sized to fit over shaft 180 of inflation stylus 130 .
  • implant 100 is placed onto inflation tip 192 , and the assembled bodies are withdrawn into the distal end of delivery sheath 174 . If pull wires 168 , 170 and control element 172 are used, they may be placed through the lumen of the delivery sheath.
  • implant 100 may be formed by forming an implant blank 150 , which comprises outer fillable enclosure 102 coupled to inner fillable enclosure 104 .
  • Implant blank 150 may be manufactured using conventional manufacturing techniques, such as injection molding or dip molding. After implant blank 150 is formed, implant blank 150 is partially inverted to place inner fillable enclosure 104 into the interior of outer fillable enclosure 102 .
  • Distal plug 140 is inserted into distal neck 120
  • proximal plug 126 is inserted into proximal neck 116 . Additional details regarding one suitable manufacturing technique are disclosed in application 62/074,295, entitled “Percutaneous Implantable Nuclear Prosthesis,” which was filed on Nov. 4, 2014 and is hereby incorporated by reference in its entirety.
  • fillable implant 100 is particularly well suited for deployment using minimally invasive or percutaneous surgical techniques.
  • the existing nucleus pulposus is removed by performing a discectomy while leaving annulus fibrosus 202 substantially intact.
  • the discectomy is performed using minimally invasive surgical techniques, such as percutaneous techniques, which uses a cannula 208 to access the disc cavity 206 through a small opening in annulus fibrosus 202 .
  • the disc cavity is accessed using a posterolateral approach through Kambin's triangle. An anterior approach may also be used.
  • the annulotomy in the annulus fibrosus may be created by penetrating the fibrosus annulus with a guide pin (e.g., a K-wire) and a series of increasing diameter dilators placed over the guide pin. Once the desired diameter is obtained, the access cannula 208 is placed over the largest diameter, and the dilator set is removed. This procedure spreads the fibrous bands of the annulus fibrosus to create an annulotomy without excising (i.e., removing) any tissue, which aids in the healing process.
  • the fibrosus may be stabbed with a scalpel to create vertical slit to gain access to the nucleus space.
  • the physician may remove the existing disc using any suitable instruments (such as rongeurs).
  • the physician should avoid violating the circumferential annulus or penetrating the superior and inferior vertebral end plates.
  • the physician may monitor the progress of the discectomy by inserting a compliant imaging balloon into the disc space and inflating the imaging balloon with a contrast agent.
  • the imaging balloon comprises a modified implant comprising outer inflatable enclosure 102 without an inner inflatable enclosure.
  • the imaging balloon also serves as a trial implant to predict the volume, shape and placement of the final implant.
  • annulus fibrosus 202 and vertebral end plates 204 form a substantially empty enucleated disc cavity 206 ( FIG. 18 ).
  • the implant 100 which is loaded into a delivery sheath 174 , is placed into enucleated disc cavity 206 through cannula 208 . Typically, the implant will be delivered to the far end of the disc cavity. The delivery sheath 174 is then withdrawn to expose the implant 100 inside the enucleated disc cavity.
  • control member 172 is manipulated to press central zone 166 of annular reinforcing band 160 substantially flush against the inner surface of annulus fibrosus 202 .
  • Pull strings 168 , 170 may be pulled to tighten edges 162 , 164 of annular reinforcing band 160 and form a pocket for receiving implant 100 .
  • Control member 172 and pull strings 168 , 170 may include radiopaque features (such as platinum or nitinol coating) to aid in visualization under fluoroscopy.
  • inner chamber 108 is first filled with a fluid to a desired size.
  • a substantially incompressible fluid 210 is used, such as a contrast medium. Prior to inflating the inner chamber, air should be purged from the system using, for example, a vacuum locking syringe. Fluid 210 is delivered using contrast lumen 188 of inflation stylus 130 . The inflation pressure of the inner chamber 108 is selected to fill inner fillable enclosure 104 to a desired size.
  • Inflation stylus 130 is used to deliver a curable material 212 to outer chamber 106 .
  • Curable material 212 is preferably an elastomeric material, such as silicone rubber containing a radiopaque material (such as barium sulfate). It is not necessary to evacuate air from the outer chamber prior to inflation because of the included vent. Curable material 212 may be chosen so that it polymerizes with the material of inner and outer fillable enclosures 102 , 104 to form a unitary member. The modulus of elasticity and other characteristics of curable material 212 can be selected based upon patient specific parameters. For instance, younger, more active patients may require a firmer material than less mobile geriatric patients.
  • curable material 212 is allowed to cure.
  • the curable material comprises curable silicone which cures in a short period of time, for example, less than 10 minutes, or less than 5 minutes.
  • the use of shorter curing periods may help prevent the dissolution of solvent from the curable medium to the fillable enclosures which may occur with longer curing mediums. Such leaching of solvents may adversely affect the structural integrity of the fillable enclosures.
  • substantially incompressible fluid 210 is removed using contrast lumen 188 .
  • contrast lumen 188 may be moved and manipulated to remove as much incompressible fluid 210 as is desired.
  • substantially all of fluid 210 is removed; however, some fluid is likely to remain and it is not necessary to remove all fluid.
  • inflation stylus 130 can all be withdrawn through cannula 208 , and cannula 208 can be removed. If the optional annular reinforcing band is used, pull strings 168 , 170 , control member 172 are also withdrawn through cannula 208 .
  • the implant 100 comprises an annular ring of cured material 212 surrounding hollow interior chamber 108 .
  • Interior chamber 108 remains open to allow fluids to enter and exit, thereby functioning as a shock absorber.
  • This structure allows for vertical and horizontal load stresses placed on the intervertebral disc space to be redirected inward, centrally toward interior chamber 108 (see direction arrows of FIG. 23 ) instead of outward.
  • annular reinforcing band 160 encourages tissue in-growth of native annulus fibrosus 202 , thereby providing reinforcement to native annulus fibrosus 202 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
US15/254,282 2015-09-01 2016-09-01 Implantable nuclear prosthesis Active 2037-07-22 US10575967B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US15/254,282 US10575967B2 (en) 2015-09-01 2016-09-01 Implantable nuclear prosthesis
US16/806,580 US11576793B2 (en) 2015-09-01 2020-03-02 Implantable nuclear prosthesis
US18/168,475 US12533245B2 (en) 2015-09-01 2023-02-13 Implantable nuclear prosthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562212950P 2015-09-01 2015-09-01
US15/254,282 US10575967B2 (en) 2015-09-01 2016-09-01 Implantable nuclear prosthesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/806,580 Division US11576793B2 (en) 2015-09-01 2020-03-02 Implantable nuclear prosthesis

Publications (2)

Publication Number Publication Date
US20170056195A1 US20170056195A1 (en) 2017-03-02
US10575967B2 true US10575967B2 (en) 2020-03-03

Family

ID=58097257

Family Applications (3)

Application Number Title Priority Date Filing Date
US15/254,282 Active 2037-07-22 US10575967B2 (en) 2015-09-01 2016-09-01 Implantable nuclear prosthesis
US16/806,580 Active 2037-11-28 US11576793B2 (en) 2015-09-01 2020-03-02 Implantable nuclear prosthesis
US18/168,475 Active 2036-11-14 US12533245B2 (en) 2015-09-01 2023-02-13 Implantable nuclear prosthesis

Family Applications After (2)

Application Number Title Priority Date Filing Date
US16/806,580 Active 2037-11-28 US11576793B2 (en) 2015-09-01 2020-03-02 Implantable nuclear prosthesis
US18/168,475 Active 2036-11-14 US12533245B2 (en) 2015-09-01 2023-02-13 Implantable nuclear prosthesis

Country Status (9)

Country Link
US (3) US10575967B2 (pl)
EP (1) EP3344156B1 (pl)
JP (1) JP6891176B2 (pl)
KR (1) KR102607758B1 (pl)
CN (1) CN108348227B (pl)
AU (1) AU2016315964B2 (pl)
ES (1) ES2774513T3 (pl)
PL (1) PL3344156T3 (pl)
WO (1) WO2017040734A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140277467A1 (en) 2013-03-14 2014-09-18 Spinal Stabilization Technologies, Llc Prosthetic Spinal Disk Nucleus
US10786360B2 (en) 2014-11-04 2020-09-29 Spinal Stabilization Technologies Llc Percutaneous implantable nuclear prosthesis
PL3215067T3 (pl) 2014-11-04 2020-11-02 Spinal Stabilization Technologies Llc Implantowana przezskórnie proteza jądra
JP6891176B2 (ja) 2015-09-01 2021-06-18 スパイナル スタビライゼーション テクノロジーズ リミテッド ライアビリティ カンパニー 埋込み可能な髄核プロテーゼ
US10285825B2 (en) 2016-04-07 2019-05-14 Howmedica Osteonics Corp. Surgical insertion instruments
EP3456297B1 (en) 2017-09-15 2023-10-04 Howmedica Osteonics Corp. Instruments for expandable interbody implants
WO2020106350A2 (en) 2018-09-04 2020-05-28 Spinal Stabilization Technologies, Llc Implantable nuclear prosthesis, kits, and related methods
US11129727B2 (en) 2019-03-29 2021-09-28 Medos International Sari Inflatable non-distracting intervertebral implants and related methods
US11376131B2 (en) * 2020-04-07 2022-07-05 Ethicon, Inc. Cortical rim-supporting interbody device and method
US20230285159A1 (en) * 2020-06-05 2023-09-14 Nuvasive, Inc. Dynamic interbody fusion devices
CN112535556B (zh) * 2020-11-02 2022-04-08 淮阴工学院 一种气囊式人工颈椎间盘假体
CN113855230B (zh) * 2021-09-26 2023-07-28 武汉大学中南医院 一种人体组织空腔建模装置及方法

Citations (232)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3875595A (en) 1974-04-15 1975-04-08 Edward C Froning Intervertebral disc prosthesis and instruments for locating same
US4187390A (en) 1970-05-21 1980-02-05 W. L. Gore & Associates, Inc. Porous products and process therefor
US4478898A (en) 1982-06-04 1984-10-23 Junkosha Co., Ltd. Laminated porous polytetrafluoroethylene tube and its process of manufacture
US4517979A (en) * 1983-07-14 1985-05-21 Cordis Corporation Detachable balloon catheter
US4619641A (en) 1984-11-13 1986-10-28 Mount Sinai School Of Medicine Of The City University Of New York Coaxial double lumen anteriovenous grafts
US4743480A (en) 1986-11-13 1988-05-10 W. L. Gore & Associates, Inc. Apparatus and method for extruding and expanding polytetrafluoroethylene tubing and the products produced thereby
US5123926A (en) 1991-02-22 1992-06-23 Madhavan Pisharodi Artificial spinal prosthesis
US5152782A (en) 1989-05-26 1992-10-06 Impra, Inc. Non-porous coated ptfe graft
US5181921A (en) 1990-05-25 1993-01-26 Kaken Co., Ltd. Detachable balloon with two self-sealing valves
US5192326A (en) 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5192310A (en) 1991-09-16 1993-03-09 Atrium Medical Corporation Self-sealing implantable vascular graft
US5437661A (en) 1994-03-23 1995-08-01 Rieser; Bernhard Method for removal of prolapsed nucleus pulposus material on an intervertebral disc using a laser
US5439464A (en) 1993-03-09 1995-08-08 Shapiro Partners Limited Method and instruments for performing arthroscopic spinal surgery
US5466509A (en) 1993-01-15 1995-11-14 Impra, Inc. Textured, porous, expanded PTFE
US5571189A (en) 1994-05-20 1996-11-05 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5628786A (en) 1995-05-12 1997-05-13 Impra, Inc. Radially expandable vascular graft with resistance to longitudinal compression and method of making same
US5645597A (en) 1995-12-29 1997-07-08 Krapiva; Pavel I. Disc replacement method and apparatus
US5674295A (en) 1994-10-17 1997-10-07 Raymedica, Inc. Prosthetic spinal disc nucleus
US5702449A (en) 1995-06-07 1997-12-30 Danek Medical, Inc. Reinforced porous spinal implants
US5752969A (en) 1993-06-17 1998-05-19 Sofamor S.N.C. Instrument for the surgical treatment of an intervertebral disc by the anterior route
US5827327A (en) 1994-09-23 1998-10-27 Impra, Inc. Carbon containing vascular graft and method of making same
US5860425A (en) 1991-12-03 1999-01-19 Boston Scientific Technology, Inc. Bladder neck suspension procedure
US5865845A (en) 1996-03-05 1999-02-02 Thalgott; John S. Prosthetic intervertebral disc
US5879366A (en) 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5888226A (en) 1997-11-12 1999-03-30 Rogozinski; Chaim Intervertebral prosthetic disc
US5888220A (en) 1994-05-06 1999-03-30 Advanced Bio Surfaces, Inc. Articulating joint repair
US5890268A (en) 1995-09-07 1999-04-06 Case Western Reserve University Method of forming closed cell metal composites
US5910277A (en) 1996-05-17 1999-06-08 Nitto Denko Corporation Process of making a porous PTFE membrane
US5928284A (en) 1998-07-09 1999-07-27 Mehdizadeh; Hamid M. Disc replacement prosthesis
US5935147A (en) 1991-11-08 1999-08-10 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5954767A (en) 1993-09-13 1999-09-21 C.R. Bard Inc. Curved prosthetic mesh and its method of manufacture
US5972022A (en) 1994-09-26 1999-10-26 Ethicon, Inc. Tissue attachment device having elastomeric section
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US5981826A (en) 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
US5990378A (en) 1995-05-25 1999-11-23 Bridport Gundry (Uk) Limited Textile surgical implants
US6001125A (en) 1996-01-22 1999-12-14 Meadox Medicals, Inc. PTFE vascular prosthesis and method of manufacture
US6001130A (en) 1994-11-14 1999-12-14 Bryan; Vincent Human spinal disc prosthesis with hinges
US6007570A (en) 1996-08-13 1999-12-28 Oratec Interventions, Inc. Apparatus with functional element for performing function upon intervertebral discs
US6007575A (en) 1997-06-06 1999-12-28 Samuels; Shaun Laurence Wilkie Inflatable intraluminal stent and method for affixing same within the human body
US6019793A (en) 1996-10-21 2000-02-01 Synthes Surgical prosthetic device
US6126682A (en) 1996-08-13 2000-10-03 Oratec Interventions, Inc. Method for treating annular fissures in intervertebral discs
US6127597A (en) 1997-03-07 2000-10-03 Discotech N.V. Systems for percutaneous bone and spinal stabilization, fixation and repair
US6140452A (en) 1994-05-06 2000-10-31 Advanced Bio Surfaces, Inc. Biomaterial for in situ tissue repair
US6146419A (en) 1999-05-13 2000-11-14 Board Of Trustees Of The University Method for forming a hollow prosthesis
US6180848B1 (en) 1997-08-27 2001-01-30 Ethicon, Inc. Prosthesis obturating device for the obturation of a hernial canal
US6183518B1 (en) 1999-02-22 2001-02-06 Anthony C. Ross Method of replacing nucleus pulposus and repairing the intervertebral disk
US6206921B1 (en) 1999-02-22 2001-03-27 Peter A. Guagliano Method of replacing nucleus pulposus and repairing the intervertebral disk
US6224630B1 (en) 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US6248131B1 (en) 1994-05-06 2001-06-19 Advanced Bio Surfaces, Inc. Articulating joint repair
US6264695B1 (en) 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
US6332894B1 (en) 2000-03-07 2001-12-25 Zimmer, Inc. Polymer filled spinal fusion cage
US6344054B1 (en) 1996-09-20 2002-02-05 Juan Carlos Parodi Endoluminal prosthesis comprising stent and overlying graft cover, and system and method for deployment thereof
US20020026244A1 (en) 2000-08-30 2002-02-28 Trieu Hai H. Intervertebral disc nucleus implants and methods
US6361637B2 (en) 1995-12-14 2002-03-26 Gore Enterprise Holdings, Inc. Method of making a kink resistant stent-graft
US6375682B1 (en) 2001-08-06 2002-04-23 Lewis W. Fleischmann Collapsible, rotatable and expandable spinal hydraulic prosthetic device
US6390992B1 (en) 1995-05-05 2002-05-21 Advanced Cardiovascular Systems, Inc. Intraluminal device with lubricious surface
US6395032B1 (en) 1998-12-11 2002-05-28 Dimso (Distribution Medicale Du Sud-Ouest) Intervertebral disc prosthesis with liquid chamber
US6398803B1 (en) 1999-02-02 2002-06-04 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Partial encapsulation of stents
US20020068975A1 (en) 2000-06-23 2002-06-06 Teitelbaum George P. Formable orthopedic fixation system with cross linking
US6402750B1 (en) 2000-04-04 2002-06-11 Spinlabs, Llc Devices and methods for the treatment of spinal disorders
US6419704B1 (en) 1999-10-08 2002-07-16 Bret Ferree Artificial intervertebral disc replacement methods and apparatus
US6428576B1 (en) 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6436143B1 (en) 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US6443988B2 (en) 1994-05-06 2002-09-03 Disc Dynamics, Inc. Mold apparatus and kit for in situ tissue repair
US20020147497A1 (en) 2001-04-06 2002-10-10 Integrated Vascular Systems, Inc. Methods for treating spinal discs
US20020151979A1 (en) 1999-08-18 2002-10-17 Lambrecht Greg H. Devices and method for nucleus pulposus augmentation and retention
US6482234B1 (en) 2000-04-26 2002-11-19 Pearl Technology Holdings, Llc Prosthetic spinal disc
US20020198588A1 (en) 1999-01-22 2002-12-26 Armstrong Joseph R. Covered endoprosthesis and delivery system
US20030028251A1 (en) 2001-07-30 2003-02-06 Mathews Hallett H. Methods and devices for interbody spinal stabilization
US20030040772A1 (en) 1999-02-01 2003-02-27 Hideki Hyodoh Delivery devices
US6527804B1 (en) 1998-12-11 2003-03-04 Dimso (Distribution Medicale Du Sud-Quest) Intervertebral disk prosthesis
US20030114917A1 (en) 2001-12-14 2003-06-19 Holloway Ken A. Layered stent-graft and methods of making the same
US6582466B1 (en) 1998-12-11 2003-06-24 Stryker Spine Intervertebral disc prosthesis with reduced friction
US6596008B1 (en) 1997-07-15 2003-07-22 Parviz Kambin Method and instruments for percutaneous arthroscopic disc removal, bone biopsy and fixation of the vertebral
US20030153976A1 (en) 1999-10-20 2003-08-14 Cauthen Joseph C. Spinal disc annulus reconstruction method and spinal disc annulus stent
US6632235B2 (en) * 2001-04-19 2003-10-14 Synthes (U.S.A.) Inflatable device and method for reducing fractures in bone and in treating the spine
US20030199979A1 (en) 2001-10-02 2003-10-23 Rex Medical Spinal implant and method of use
US6645248B2 (en) 2001-08-24 2003-11-11 Sulzer Orthopedics Ltd. Artificial intervertebral disc
US6673103B1 (en) 1999-05-20 2004-01-06 Scimed Life Systems, Inc. Mesh and stent for increased flexibility
US6689125B1 (en) 2000-04-04 2004-02-10 Spinalabs, Llc Devices and methods for the treatment of spinal disorders
US6712853B2 (en) 2000-12-15 2004-03-30 Spineology, Inc. Annulus-reinforcing band
US6733532B1 (en) 1998-12-11 2004-05-11 Stryker Spine Intervertebral disc prosthesis with improved mechanical behavior
US6733533B1 (en) 2002-11-19 2004-05-11 Zimmer Technology, Inc. Artificial spinal disc
US6780497B1 (en) 1999-08-05 2004-08-24 Gore Enterprise Holdings, Inc. Surface modified expanded polytetrafluoroethylene devices and methods of producing the same
US20040186471A1 (en) 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
US20040220672A1 (en) 2003-05-03 2004-11-04 Shadduck John H. Orthopedic implants, methods of use and methods of fabrication
US20040230309A1 (en) 2003-02-14 2004-11-18 Depuy Spine, Inc. In-situ formed intervertebral fusion device and method
US20050004578A1 (en) 1999-08-18 2005-01-06 Lambrecht Gregory H. Apparatus delivery in an intervertebral disc
US20050015150A1 (en) 2003-07-17 2005-01-20 Lee Casey K. Intervertebral disk and nucleus prosthesis
US6852095B1 (en) 1997-07-09 2005-02-08 Charles D. Ray Interbody device and method for treatment of osteoporotic vertebral collapse
US6852223B2 (en) 2001-10-31 2005-02-08 Yeu Ming Tai Chemical Industrial Co., Ltd. Asymmetric porous polytetrafluoroethylene membrane and process for preparing the same
US20050055099A1 (en) 2003-09-09 2005-03-10 Ku David N. Flexible spinal disc
US6866681B2 (en) 1996-11-20 2005-03-15 Jacques-Phillippe Laboureau Pre-adjusted prosthetic ligament and method of manufacture
US20050065609A1 (en) 2001-11-19 2005-03-24 Douglas Wardlaw Intervertebral disc prosthesis
US20050090901A1 (en) 2001-12-05 2005-04-28 Armin Studer Intervertebral disk prosthesis or nucleus replacement prosthesis
US6893465B2 (en) 2003-03-31 2005-05-17 Shi, Tain-Yew Vividly simulated prosthetic intervertebral disc
US6893466B2 (en) 2000-08-30 2005-05-17 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US20050119752A1 (en) 2003-11-19 2005-06-02 Synecor Llc Artificial intervertebral disc
US20050137675A1 (en) 2000-12-19 2005-06-23 Alexander Dubson Vascular prosthesis and method for production thereof
US6932843B2 (en) 2002-09-25 2005-08-23 Medicinelodge, Inc. Apparatus and method for the in-situ formation of a structural prosthesis
US6936070B1 (en) 2001-01-17 2005-08-30 Nabil L. Muhanna Intervertebral disc prosthesis and methods of implantation
US20050197702A1 (en) 2002-08-15 2005-09-08 Coppes Justin K. Intervertebral disc implant
US6958077B2 (en) 2003-07-29 2005-10-25 Loubert Suddaby Inflatable nuclear prosthesis
US6969405B2 (en) 2003-04-23 2005-11-29 Loubert Suddaby Inflatable intervertebral disc replacement prosthesis
US6969404B2 (en) 1999-10-08 2005-11-29 Ferree Bret A Annulus fibrosis augmentation methods and apparatus
US6984246B2 (en) 2003-06-06 2006-01-10 Tain-Yew Shi Artificial intervertebral disc flexibly oriented by spring-reinforced bellows
US7004971B2 (en) 2002-12-31 2006-02-28 Depuy Acromed, Inc. Annular nucleus pulposus replacement
US7008427B2 (en) 2000-05-25 2006-03-07 Orthoplex, Llc Inter-vertebral disc prosthesis for rachis through anterior surgery thereof
WO2006060482A2 (en) 2004-12-01 2006-06-08 The Regents Of The University Of California Systems, devices and methods of treatment of intervertebral disorders
US20060247780A1 (en) 2005-04-27 2006-11-02 Bert Jeffrey K Expandable artificial disc and associated methods and instrumentation
US7133001B2 (en) 2003-11-03 2006-11-07 Toyon Research Corporation Inflatable-collapsible transreflector antenna
US20060253132A1 (en) 2005-05-06 2006-11-09 International Business Machines Corporation System and devices for the repair of a vertebral disc defect
US20060265077A1 (en) * 2005-02-23 2006-11-23 Zwirkoski Paul A Spinal repair
US20060293749A1 (en) 2005-06-02 2006-12-28 Zimmer Spine, Inc. Interbody fusion ring and method of using the same
US7156877B2 (en) * 2001-06-29 2007-01-02 The Regents Of The University Of California Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs
US7156861B2 (en) 1997-08-15 2007-01-02 Kyphon Inc. Expandable structures for deployment in interior body regions
US7182783B2 (en) 2005-04-25 2007-02-27 Sdgi Holdings, Inc. Selectively expandable composite structures for spinal arthroplasty
US20070060924A1 (en) 2005-08-29 2007-03-15 Taeyon Medical Co., Ltd. Recovery device for balloon kyphoplasty
US20070073402A1 (en) 2005-08-26 2007-03-29 Edward Vresilovic Hydrogel balloon prosthesis for nucleus pulposus
US7201751B2 (en) 1997-01-02 2007-04-10 St. Francis Medical Technologies, Inc. Supplemental spine fixation device
US7201776B2 (en) 1999-10-08 2007-04-10 Ferree Bret A Artificial intervertebral disc replacements with endplates
US7204851B2 (en) 2000-08-30 2007-04-17 Sdgi Holdings, Inc. Method and apparatus for delivering an intervertebral disc implant
US20070093906A1 (en) 2005-10-26 2007-04-26 Zimmer Spine, Inc. Nucleus implant and method
US20070135921A1 (en) 2005-12-09 2007-06-14 Park Kee B Surgical implant
US20070150061A1 (en) 2005-12-27 2007-06-28 Sdgi Holdings, Inc. Intervertebral disc augmentation and rehydration with superabsorbent polymers
US20070162136A1 (en) 2005-12-22 2007-07-12 O'neil Michael Nucleus pulposus trial device and technique
US20070168042A1 (en) 2006-01-13 2007-07-19 Hudgins Robert G Devices and methods for disc replacement
US20070173935A1 (en) 2005-10-28 2007-07-26 O'neil Michael J Nucleus pulposus augmentation pretreatment technique
US20070173940A1 (en) 2006-01-18 2007-07-26 Zimmer Spine, Inc. Vertebral fusion device and method
WO2007087404A2 (en) 2006-01-24 2007-08-02 Hydrocision, Inc. Liquid jet surgical instrument having a distal end with a selectively controllable shape
US20070213732A1 (en) 2006-03-13 2007-09-13 The Johns Hopkins University Orthopedic Screw System
US7273497B2 (en) 1999-05-28 2007-09-25 Anova Corp. Methods for treating a defect in the annulus fibrosis
US20070255285A1 (en) 2006-04-27 2007-11-01 Warsaw Orthopedic, Inc. Devices, Apparatus, and Methods for Disc Augmentation
US20070255406A1 (en) 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for bilateral approach to disc augmentation
US7297158B2 (en) 2004-06-14 2007-11-20 Thoratec Corporation Multilayer composite vascular access graft
US20070270953A1 (en) 2006-03-29 2007-11-22 Sdgi Holdings, Inc. Transformable spinal implants and methods of use
US20070288095A1 (en) 2006-06-12 2007-12-13 Anthony Wirtel Inflatable multi-chambered devices and methods of treatment using the same
US7309359B2 (en) 2003-08-21 2007-12-18 Warsaw Orthopedic, Inc. Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs
US20080058932A1 (en) 2006-07-26 2008-03-06 Warsaw Orthopedic Inc. Rigidization-on-command orthopedic devices and methods
US20080119943A1 (en) 2006-11-16 2008-05-22 Armstrong Joseph R Stent having flexibly connected adjacent stent elements
US20080132934A1 (en) * 1994-01-26 2008-06-05 Kyphon, Inc. Systems and methods treating a vertebral body related applications
US20080154373A1 (en) 2006-12-21 2008-06-26 Warsaw Orthopedic, Inc. Curable orthopedic implant devices configured to be hardened after placement in vivo
US20080154367A1 (en) 2006-12-21 2008-06-26 Warsaw Orthopedic, Inc. Methods for positioning a load-bearing component of an orthopedic implant device by inserting a malleable device that hardens in vivo
US20080154368A1 (en) 2006-12-21 2008-06-26 Warsaw Orthopedic, Inc. Curable orthopedic implant devices configured to harden after placement in vivo by application of a cure-initiating energy before insertion
US20080195210A1 (en) 2005-03-01 2008-08-14 Columna Pty Ltd Intervertebral Disc Restoration
US20080288073A1 (en) 2007-05-17 2008-11-20 Depuy Spine, Inc. Self-Distracting Cage
US20080288074A1 (en) 2007-05-15 2008-11-20 O'neil Michael J Internally reinforced elastomeric intervertebral disc implants
US20090012618A1 (en) 2006-05-24 2009-01-08 Disc Dynamics, Inc. Retention structure for in situ formation of an intervertebral prosthesis
US20090030399A1 (en) * 2007-07-23 2009-01-29 Kamshad Raiszadeh Drug Delivery Device and Method
US20090076610A1 (en) 2007-03-31 2009-03-19 Spinal Kinetics, Inc. Prosthetic Intervertebral Discs Having Balloon-Based Fillable Cores That are Implantable By Minimally Invasive Surgical Techniques
US20090076609A1 (en) 2007-03-31 2009-03-19 Spinal Kinetics, Inc. Prosthetic Intervertebral Discs with Slotted End Plates That are Implantable By Minimally Invasive, Posterior Approach, Surgical Techniques
US20090082870A1 (en) 2007-09-20 2009-03-26 Osman Said G Transpedicular, extrapedicular and transcorporeal partial disc replacement
US20090105823A1 (en) 2004-09-30 2009-04-23 Synecor, Llc Artificial intervertebral disc nucleus
US20090112221A1 (en) 2007-10-25 2009-04-30 Disc Dynamics, Inc. System and method for measuring the shape of internal body cavities
US20090112323A1 (en) * 2007-10-29 2009-04-30 Zimmer Spine, Inc. Minimally invasive interbody device and method
US20090118833A1 (en) 2007-11-05 2009-05-07 Zimmer Spine, Inc. In-situ curable interspinous process spacer
US20090163994A1 (en) 2007-12-21 2009-06-25 Boston Scientific Scimed, Inc. Flexible Stent-Graft Device Having Patterned Polymeric Coverings
US7556650B2 (en) 2004-06-29 2009-07-07 Spine Wave, Inc. Methods for injecting a curable biomaterial into an intervertebral space
US20090222093A1 (en) * 2008-02-28 2009-09-03 Warsaw Orthopedic, Inc. Nucleus Implant and Method of Installing Same
US20090240341A1 (en) 2005-08-15 2009-09-24 Columna Pty Ltd Tissue prosthesis and a method of, and equipment for, forming a tissue prosthesis
US7618461B2 (en) 2000-08-30 2009-11-17 Warsaw Orthopedic, Inc. Composite intervertebral disc implants and methods for forming the same
US20090299476A1 (en) 2006-05-19 2009-12-03 Ashish Diwan Tissue prosthesis
US7632294B2 (en) 2003-09-29 2009-12-15 Promethean Surgical Devices, Llc Devices and methods for spine repair
US7632291B2 (en) 2003-06-13 2009-12-15 Trivascular2, Inc. Inflatable implant
US20100030216A1 (en) 2008-07-30 2010-02-04 Arcenio Gregory B Discectomy tool having counter-rotating nucleus disruptors
US7722612B2 (en) 2004-05-19 2010-05-25 Sintea Biotech S.P.A. Devices, kit and method for kyphoplasty
US7731753B2 (en) 2005-09-01 2010-06-08 Spinal Kinetics, Inc. Prosthetic intervertebral discs
US20100191335A1 (en) 2005-11-21 2010-07-29 Nicast Ltd. Spinal nucleus prosthesis device
US20100193999A1 (en) 2009-01-16 2010-08-05 Anneaux Bruce L Electrospinning of ptfe with high viscosity materials
US20100256766A1 (en) * 2009-04-07 2010-10-07 Hibri Nadi S Percutaneous Implantable Nuclear Prosthesis
US20100256619A1 (en) 2003-05-30 2010-10-07 Warsaw Orthopedic, Inc. Methods and Devices for Transpedicular Discectomy
US20100292798A1 (en) 2007-10-19 2010-11-18 Gianluca Maestretti Hemi-prosthesis
US7842055B2 (en) 1998-04-10 2010-11-30 Ev3 Endovascular, Inc. Neuro thrombectomy catheter
US7896920B2 (en) 2000-10-24 2011-03-01 Cryolife, Inc. In situ bioprosthetic filler and method, particularly for the in situ formation of vertebral disc bioprosthetics
US20110093076A1 (en) 2006-12-28 2011-04-21 Reo Michael L Prosthetic lumbar disc assembly having natural biomechanical movement
US7931689B2 (en) 2000-02-28 2011-04-26 Spineology Inc. Method and apparatus for treating a vertebral body
US7947079B2 (en) 1999-05-07 2011-05-24 University Of Virginia Patent Foundation Method and system for fusing a spinal region
US20110125158A1 (en) 2008-05-01 2011-05-26 Ashish Dhar Diwan Systems, methods and apparatuses for formation and insertion of tissue prostheses
US7972351B2 (en) 2004-07-13 2011-07-05 Boston Scientific Scimed, Inc. Balloon folding design and method and apparatus for making balloons
US20110190753A1 (en) 2004-04-23 2011-08-04 Leonard Edward Forrest Device and method treatment or evacuation of intervertebral disc
US7993351B2 (en) 2002-07-24 2011-08-09 Pressure Products Medical Supplies, Inc. Telescopic introducer with a compound curvature for inducing alignment and method of using the same
US20110196499A1 (en) 1998-08-14 2011-08-11 Kyphon Sarl Systems and methods for treating vertebral bodies
US7998210B2 (en) 2006-04-27 2011-08-16 Warsaw Orthopedic, Inc. Expandable intervertebral spacers and methods of use
US8012211B2 (en) 2002-11-05 2011-09-06 Spineology, Inc. Semi-biological intervertebral disc replacement system
US8012210B2 (en) 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
US20110264224A1 (en) 1999-05-28 2011-10-27 Anova Corporation Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft
US20110282418A1 (en) 2010-05-14 2011-11-17 Ameliomed, Llc Methods and devices for cooling spinal tissue
US8066758B2 (en) 2005-06-17 2011-11-29 C. R. Bard, Inc. Vascular graft with kink resistance after clamping
US8083800B2 (en) 2006-07-21 2011-12-27 Warsaw Orthopedic, Inc. Expandable vertebral implant and methods of use
US20110319996A1 (en) 2008-12-22 2011-12-29 Synthes Usa, Llc Expandable vertebral body replacement device and method
US8100978B2 (en) 2007-04-01 2012-01-24 Spinal Kinetics Inc. Prosthetic intervertebral discs having expandable cores that are implantable using minimally invasive surgical techniques
US8123808B2 (en) 2009-04-16 2012-02-28 Warsaw Orthopedic, Inc. Vertebral endplate connection implant and method
US8133250B2 (en) 2001-09-28 2012-03-13 Boston Scientific Scimed, Inc. Medical devices comprising nanocomposites
US8142489B2 (en) 1995-03-01 2012-03-27 Boston Scientific Scimed, Inc. Flexible and expandable stent
US20120089227A1 (en) 2009-06-18 2012-04-12 Peter Jarzem Hollow highly-expandable prosthetic vertebral body
US20120089229A1 (en) 2006-02-13 2012-04-12 Lanx, Inc. Method and apparatus for intervertebral disc support and repair
KR20120040309A (ko) 2010-10-19 2012-04-27 인하대학교 산학협력단 척추경 나사못 보강 풍선 앙카 볼트
US20120165941A1 (en) 2010-12-22 2012-06-28 Illuminoss Medical, Inc. Systems and methods for treating conditions and diseases of the spine
US8246682B2 (en) 2008-12-16 2012-08-21 Depuy Spine, Inc. Methods and devices for expanding a spinal canal using balloons
US8292961B2 (en) 2008-01-23 2012-10-23 Osman Said G Biologic vertebral reconstruction
US20120277862A1 (en) 2008-04-04 2012-11-01 Clariance Nuclear implant
US8317864B2 (en) 2004-10-20 2012-11-27 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US20120316648A1 (en) 1999-08-18 2012-12-13 Intrinsic Therapeutics, Inc. Intervertebral disc reinforcement systems
US8337556B2 (en) 2000-06-23 2012-12-25 Sdgi Holdings, Inc. Curable media for implantable medical device
US20130004586A1 (en) 2011-06-24 2013-01-03 Vachon David J Biologically Efficacious Compositions, Articles of Manufacture and Processes for Producing and/or Using Same
US8349013B2 (en) 1997-01-02 2013-01-08 Kyphon Sarl Spine distraction implant
US8377131B2 (en) 2007-06-06 2013-02-19 Spirit Spine Holdings Corporation, Inc. Medical implant
US8377136B2 (en) 2009-04-20 2013-02-19 Warsaw Orthopedic, Inc. Method for stabilizing an intervertebral disc device
US8382838B2 (en) 2003-04-14 2013-02-26 Synthes Usa, Llc Intervertebral implant
US8398511B2 (en) 2008-09-05 2013-03-19 Warrior Sports, Inc. Inflatable latex neoprene bladders
US8403987B2 (en) 2006-09-27 2013-03-26 Spinal Kinetics Inc. Prosthetic intervertebral discs having compressible core elements bounded by fiber-containing membranes
US8419839B2 (en) 2007-12-07 2013-04-16 Nitto Denko Corporation Porous polytetrafluoroethylene membrane, method for producing the same, and water-proof air permeable filter
US20130103155A1 (en) 2011-10-20 2013-04-25 Clariance (S.A.S.) Silicone nucleus implants
US20130131806A1 (en) 2010-11-04 2013-05-23 Clyde T. Carpenter Anatomic total disc replacement
US8449660B2 (en) 2008-11-04 2013-05-28 Nitto Denko Corporation Polytetrafluoroethylene porous membrane, method for producing same, and waterproof air-permeable filter
US8454612B2 (en) 2007-09-07 2013-06-04 Intrinsic Therapeutics, Inc. Method for vertebral endplate reconstruction
US8562634B2 (en) 2004-05-28 2013-10-22 Cavitech, Llc Instruments and methods for reducing and stabilizing bone fractures
US20130297026A1 (en) 2007-08-09 2013-11-07 Spinalmotion, Inc. Customized intervertebral prosthetic disc with shock absorption
US20130304212A1 (en) 2012-05-08 2013-11-14 Eric R. VonGunten Nucleus pulposus spinal implant and method of using the same
US8603171B2 (en) 2006-01-25 2013-12-10 Mimedx Group, Inc. Spinal disc implants with flexible keels and methods of fabricating implants
US8690919B2 (en) 2006-05-23 2014-04-08 Warsaw Orthopedic, Inc. Surgical spacer with shape control
US8734459B1 (en) 2013-01-17 2014-05-27 Abdulrazzaq Alobaid Device and method to prevent extravasation of bone cement used in balloon kyphoplasty
US8808381B2 (en) 2003-08-01 2014-08-19 Spinal Kinetics Inc. Prosthetic intervertebral discs having rigid end plates with depressions in their inner surfaces and fibers between those end plates
US20140277467A1 (en) 2013-03-14 2014-09-18 Spinal Stabilization Technologies, Llc Prosthetic Spinal Disk Nucleus
US20140276832A1 (en) 2013-03-14 2014-09-18 Nadi Salah Hibri Surgical Device
US8888850B2 (en) 2007-11-19 2014-11-18 Linares Medical Devices, Llc Combination spacer insert and support for providing inter-cervical vertebral support
US8894563B2 (en) 2012-08-10 2014-11-25 Attenuex Technologies, Inc. Methods and systems for performing a medical procedure
US8945223B2 (en) 2004-03-12 2015-02-03 Warsaw Orthopedic, Inc. In-situ formable nucleus pulposus implant with water absorption and swelling capability
US8979931B2 (en) 2006-12-08 2015-03-17 DePuy Synthes Products, LLC Nucleus replacement device and method
US20160120654A1 (en) 2014-11-04 2016-05-05 Spinal Stabilization Technologies Llc Percutaneous Implantable Nuclear Prosthesis
US20160120653A1 (en) 2014-11-04 2016-05-05 Spinal Stabilization Technologies Llc Percutaneous Implantable Nuclear Prosthesis
US9486323B1 (en) 2015-11-06 2016-11-08 Spinal Stabilization Technologies Llc Nuclear implant apparatus and method following partial nuclectomy

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338942A (en) 1980-10-20 1982-07-13 Fogarty Thomas J Dilatation catherter apparatus
US20030032963A1 (en) 2001-10-24 2003-02-13 Kyphon Inc. Devices and methods using an expandable body with internal restraint for compressing cancellous bone
US6079868A (en) 1997-12-18 2000-06-27 Advanced Bio Surfaces, Inc. Static mixer
AU2001253183B2 (en) * 2000-04-07 2006-07-27 Kyphon Sarl Insertion devices and method of use
US6898545B2 (en) 2002-06-28 2005-05-24 Agilent Technologies Inc Semiconductor test data analysis system
US7220252B2 (en) 2003-07-18 2007-05-22 Polyzen, Inc. Inflatable dual balloon catheter
WO2005041793A2 (en) 2003-10-23 2005-05-12 Trans1, Inc. Spinal mobility preservation apparatus and method
US20060014938A1 (en) * 2004-07-14 2006-01-19 Groman Ernest V Stable aqueous colloidal lanthanide oxides
EP1774478A1 (en) * 2004-07-27 2007-04-18 Hewlett-Packard Development Company, L.P. Document creation system and related methods
KR20070056079A (ko) * 2004-07-27 2007-05-31 신세스 게엠바하 추간판 내 수핵의 보충 또는 교체
US20060047296A1 (en) 2004-08-31 2006-03-02 Sdg Holdings, Inc. Annulus replacement system and technique
US20070162135A1 (en) 2005-06-15 2007-07-12 Jerome Segal Mechanical apparatus and method for artificial disc replacement
US20070021835A1 (en) 2005-07-11 2007-01-25 Edidin Avram A Systems and methods for providing prostheses
US8197505B2 (en) * 2005-10-14 2012-06-12 Endocross Ltd. Balloon catheter system for treating vascular occlusions
US8038920B2 (en) * 2006-01-25 2011-10-18 Carticept Medical, Inc. Methods of producing PVA hydrogel implants and related devices
US20070200271A1 (en) 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from melt processing
US20070265077A1 (en) 2006-04-27 2007-11-15 Microsoft Corporation Haptic feedback for peripheral devices
US20100145462A1 (en) 2006-10-24 2010-06-10 Trans1 Inc. Preformed membranes for use in intervertebral disc spaces
US7875079B2 (en) * 2006-12-14 2011-01-25 Warsaw Orthopedic, Inc. Vertebral implant containment device and methods of use
US8974904B2 (en) * 2007-07-05 2015-03-10 University Of Dayton Aligned carbon nanotubes for dry adhesives and methods for producing same
US8343189B2 (en) 2007-09-25 2013-01-01 Zyga Technology, Inc. Method and apparatus for facet joint stabilization
EP2387959B1 (en) 2008-04-21 2013-11-13 Covidien LP Braid-ball embolic devices and delivery systems
JP5616038B2 (ja) * 2008-07-31 2014-10-29 株式会社半導体エネルギー研究所 半導体装置の作製方法
US8394125B2 (en) 2009-07-24 2013-03-12 Zyga Technology, Inc. Systems and methods for facet joint treatment
US20140296831A1 (en) * 2011-08-20 2014-10-02 Fred Göbel Trans-anal inflow catheter and method for intermittently triggering a reflex-coordinated defecation
CN103099689B (zh) 2013-02-19 2015-08-26 哈尔滨朝阳滨辉实业发展集团有限公司 微创手术用盘旋状髓核假体的制备方法及应用
JP6891176B2 (ja) 2015-09-01 2021-06-18 スパイナル スタビライゼーション テクノロジーズ リミテッド ライアビリティ カンパニー 埋込み可能な髄核プロテーゼ
US10248349B2 (en) 2016-03-22 2019-04-02 Oracle International Corporation Efficient and thread-safe objects for dynamically-typed languages
US10881522B2 (en) 2017-02-09 2021-01-05 Nadi S Hibri Radially expandable annulus reinforcement prosthesis

Patent Citations (274)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4187390A (en) 1970-05-21 1980-02-05 W. L. Gore & Associates, Inc. Porous products and process therefor
US3875595A (en) 1974-04-15 1975-04-08 Edward C Froning Intervertebral disc prosthesis and instruments for locating same
US4478898A (en) 1982-06-04 1984-10-23 Junkosha Co., Ltd. Laminated porous polytetrafluoroethylene tube and its process of manufacture
US4517979A (en) * 1983-07-14 1985-05-21 Cordis Corporation Detachable balloon catheter
US4619641A (en) 1984-11-13 1986-10-28 Mount Sinai School Of Medicine Of The City University Of New York Coaxial double lumen anteriovenous grafts
US4743480A (en) 1986-11-13 1988-05-10 W. L. Gore & Associates, Inc. Apparatus and method for extruding and expanding polytetrafluoroethylene tubing and the products produced thereby
US5152782A (en) 1989-05-26 1992-10-06 Impra, Inc. Non-porous coated ptfe graft
US5181921A (en) 1990-05-25 1993-01-26 Kaken Co., Ltd. Detachable balloon with two self-sealing valves
US5192326A (en) 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5123926A (en) 1991-02-22 1992-06-23 Madhavan Pisharodi Artificial spinal prosthesis
US5192310A (en) 1991-09-16 1993-03-09 Atrium Medical Corporation Self-sealing implantable vascular graft
US5935147A (en) 1991-11-08 1999-08-10 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5860425A (en) 1991-12-03 1999-01-19 Boston Scientific Technology, Inc. Bladder neck suspension procedure
US5466509A (en) 1993-01-15 1995-11-14 Impra, Inc. Textured, porous, expanded PTFE
US5439464A (en) 1993-03-09 1995-08-08 Shapiro Partners Limited Method and instruments for performing arthroscopic spinal surgery
US5752969A (en) 1993-06-17 1998-05-19 Sofamor S.N.C. Instrument for the surgical treatment of an intervertebral disc by the anterior route
US5954767A (en) 1993-09-13 1999-09-21 C.R. Bard Inc. Curved prosthetic mesh and its method of manufacture
US20080132934A1 (en) * 1994-01-26 2008-06-05 Kyphon, Inc. Systems and methods treating a vertebral body related applications
US5437661A (en) 1994-03-23 1995-08-01 Rieser; Bernhard Method for removal of prolapsed nucleus pulposus material on an intervertebral disc using a laser
US6443988B2 (en) 1994-05-06 2002-09-03 Disc Dynamics, Inc. Mold apparatus and kit for in situ tissue repair
US7077865B2 (en) 1994-05-06 2006-07-18 Disc Dynamics, Inc. Method of making an intervertebral disc prosthesis
US6248131B1 (en) 1994-05-06 2001-06-19 Advanced Bio Surfaces, Inc. Articulating joint repair
US7713301B2 (en) 1994-05-06 2010-05-11 Disc Dynamics, Inc. Intervertebral disc prosthesis
US7001431B2 (en) 1994-05-06 2006-02-21 Disc Dynamics, Inc. Intervertebral disc prosthesis
US6140452A (en) 1994-05-06 2000-10-31 Advanced Bio Surfaces, Inc. Biomaterial for in situ tissue repair
US5888220A (en) 1994-05-06 1999-03-30 Advanced Bio Surfaces, Inc. Articulating joint repair
US7766965B2 (en) 1994-05-06 2010-08-03 Disc Dynamics, Inc. Method of making an intervertebral disc prosthesis
US5571189A (en) 1994-05-20 1996-11-05 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5827327A (en) 1994-09-23 1998-10-27 Impra, Inc. Carbon containing vascular graft and method of making same
US5972022A (en) 1994-09-26 1999-10-26 Ethicon, Inc. Tissue attachment device having elastomeric section
US5674295A (en) 1994-10-17 1997-10-07 Raymedica, Inc. Prosthetic spinal disc nucleus
US6001130A (en) 1994-11-14 1999-12-14 Bryan; Vincent Human spinal disc prosthesis with hinges
US8142489B2 (en) 1995-03-01 2012-03-27 Boston Scientific Scimed, Inc. Flexible and expandable stent
US6390992B1 (en) 1995-05-05 2002-05-21 Advanced Cardiovascular Systems, Inc. Intraluminal device with lubricious surface
US5628786A (en) 1995-05-12 1997-05-13 Impra, Inc. Radially expandable vascular graft with resistance to longitudinal compression and method of making same
US5990378A (en) 1995-05-25 1999-11-23 Bridport Gundry (Uk) Limited Textile surgical implants
US5702449A (en) 1995-06-07 1997-12-30 Danek Medical, Inc. Reinforced porous spinal implants
US5890268A (en) 1995-09-07 1999-04-06 Case Western Reserve University Method of forming closed cell metal composites
US6361637B2 (en) 1995-12-14 2002-03-26 Gore Enterprise Holdings, Inc. Method of making a kink resistant stent-graft
US5645597A (en) 1995-12-29 1997-07-08 Krapiva; Pavel I. Disc replacement method and apparatus
US6001125A (en) 1996-01-22 1999-12-14 Meadox Medicals, Inc. PTFE vascular prosthesis and method of manufacture
US6036724A (en) 1996-01-22 2000-03-14 Meadox Medicals, Inc. PTFE vascular graft and method of manufacture
US5865845A (en) 1996-03-05 1999-02-02 Thalgott; John S. Prosthetic intervertebral disc
US5910277A (en) 1996-05-17 1999-06-08 Nitto Denko Corporation Process of making a porous PTFE membrane
US6007570A (en) 1996-08-13 1999-12-28 Oratec Interventions, Inc. Apparatus with functional element for performing function upon intervertebral discs
US6126682A (en) 1996-08-13 2000-10-03 Oratec Interventions, Inc. Method for treating annular fissures in intervertebral discs
US6344054B1 (en) 1996-09-20 2002-02-05 Juan Carlos Parodi Endoluminal prosthesis comprising stent and overlying graft cover, and system and method for deployment thereof
US6019793A (en) 1996-10-21 2000-02-01 Synthes Surgical prosthetic device
US6866681B2 (en) 1996-11-20 2005-03-15 Jacques-Phillippe Laboureau Pre-adjusted prosthetic ligament and method of manufacture
US5879366A (en) 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US7201751B2 (en) 1997-01-02 2007-04-10 St. Francis Medical Technologies, Inc. Supplemental spine fixation device
US8349013B2 (en) 1997-01-02 2013-01-08 Kyphon Sarl Spine distraction implant
US6127597A (en) 1997-03-07 2000-10-03 Discotech N.V. Systems for percutaneous bone and spinal stabilization, fixation and repair
US5981826A (en) 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
US6007575A (en) 1997-06-06 1999-12-28 Samuels; Shaun Laurence Wilkie Inflatable intraluminal stent and method for affixing same within the human body
US6852095B1 (en) 1997-07-09 2005-02-08 Charles D. Ray Interbody device and method for treatment of osteoporotic vertebral collapse
US6596008B1 (en) 1997-07-15 2003-07-22 Parviz Kambin Method and instruments for percutaneous arthroscopic disc removal, bone biopsy and fixation of the vertebral
US7156861B2 (en) 1997-08-15 2007-01-02 Kyphon Inc. Expandable structures for deployment in interior body regions
US6180848B1 (en) 1997-08-27 2001-01-30 Ethicon, Inc. Prosthesis obturating device for the obturation of a hernial canal
US5888226A (en) 1997-11-12 1999-03-30 Rogozinski; Chaim Intervertebral prosthetic disc
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US7842055B2 (en) 1998-04-10 2010-11-30 Ev3 Endovascular, Inc. Neuro thrombectomy catheter
US6224630B1 (en) 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US5928284A (en) 1998-07-09 1999-07-27 Mehdizadeh; Hamid M. Disc replacement prosthesis
US20110196499A1 (en) 1998-08-14 2011-08-11 Kyphon Sarl Systems and methods for treating vertebral bodies
US6582466B1 (en) 1998-12-11 2003-06-24 Stryker Spine Intervertebral disc prosthesis with reduced friction
US6733532B1 (en) 1998-12-11 2004-05-11 Stryker Spine Intervertebral disc prosthesis with improved mechanical behavior
US6395032B1 (en) 1998-12-11 2002-05-28 Dimso (Distribution Medicale Du Sud-Ouest) Intervertebral disc prosthesis with liquid chamber
US6527804B1 (en) 1998-12-11 2003-03-04 Dimso (Distribution Medicale Du Sud-Quest) Intervertebral disk prosthesis
US20020198588A1 (en) 1999-01-22 2002-12-26 Armstrong Joseph R. Covered endoprosthesis and delivery system
US20030040772A1 (en) 1999-02-01 2003-02-27 Hideki Hyodoh Delivery devices
US6398803B1 (en) 1999-02-02 2002-06-04 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Partial encapsulation of stents
US6436143B1 (en) 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US6183518B1 (en) 1999-02-22 2001-02-06 Anthony C. Ross Method of replacing nucleus pulposus and repairing the intervertebral disk
US6206921B1 (en) 1999-02-22 2001-03-27 Peter A. Guagliano Method of replacing nucleus pulposus and repairing the intervertebral disk
US6428576B1 (en) 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US7947079B2 (en) 1999-05-07 2011-05-24 University Of Virginia Patent Foundation Method and system for fusing a spinal region
US6146419A (en) 1999-05-13 2000-11-14 Board Of Trustees Of The University Method for forming a hollow prosthesis
US6673103B1 (en) 1999-05-20 2004-01-06 Scimed Life Systems, Inc. Mesh and stent for increased flexibility
US7273497B2 (en) 1999-05-28 2007-09-25 Anova Corp. Methods for treating a defect in the annulus fibrosis
US20110264224A1 (en) 1999-05-28 2011-10-27 Anova Corporation Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft
US6780497B1 (en) 1999-08-05 2004-08-24 Gore Enterprise Holdings, Inc. Surface modified expanded polytetrafluoroethylene devices and methods of producing the same
US20020151979A1 (en) 1999-08-18 2002-10-17 Lambrecht Greg H. Devices and method for nucleus pulposus augmentation and retention
US20050004578A1 (en) 1999-08-18 2005-01-06 Lambrecht Gregory H. Apparatus delivery in an intervertebral disc
US20120316648A1 (en) 1999-08-18 2012-12-13 Intrinsic Therapeutics, Inc. Intervertebral disc reinforcement systems
US6264695B1 (en) 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
US6969404B2 (en) 1999-10-08 2005-11-29 Ferree Bret A Annulus fibrosis augmentation methods and apparatus
US7201776B2 (en) 1999-10-08 2007-04-10 Ferree Bret A Artificial intervertebral disc replacements with endplates
US6419704B1 (en) 1999-10-08 2002-07-16 Bret Ferree Artificial intervertebral disc replacement methods and apparatus
US20030153976A1 (en) 1999-10-20 2003-08-14 Cauthen Joseph C. Spinal disc annulus reconstruction method and spinal disc annulus stent
US7931689B2 (en) 2000-02-28 2011-04-26 Spineology Inc. Method and apparatus for treating a vertebral body
US6332894B1 (en) 2000-03-07 2001-12-25 Zimmer, Inc. Polymer filled spinal fusion cage
US6689125B1 (en) 2000-04-04 2004-02-10 Spinalabs, Llc Devices and methods for the treatment of spinal disorders
US6402750B1 (en) 2000-04-04 2002-06-11 Spinlabs, Llc Devices and methods for the treatment of spinal disorders
US6482234B1 (en) 2000-04-26 2002-11-19 Pearl Technology Holdings, Llc Prosthetic spinal disc
US6533818B1 (en) 2000-04-26 2003-03-18 Pearl Technology Holdings, Llc Artificial spinal disc
US7008427B2 (en) 2000-05-25 2006-03-07 Orthoplex, Llc Inter-vertebral disc prosthesis for rachis through anterior surgery thereof
US20020068975A1 (en) 2000-06-23 2002-06-06 Teitelbaum George P. Formable orthopedic fixation system with cross linking
US8337556B2 (en) 2000-06-23 2012-12-25 Sdgi Holdings, Inc. Curable media for implantable medical device
US7204851B2 (en) 2000-08-30 2007-04-17 Sdgi Holdings, Inc. Method and apparatus for delivering an intervertebral disc implant
US6893466B2 (en) 2000-08-30 2005-05-17 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US20020026244A1 (en) 2000-08-30 2002-02-28 Trieu Hai H. Intervertebral disc nucleus implants and methods
US7618461B2 (en) 2000-08-30 2009-11-17 Warsaw Orthopedic, Inc. Composite intervertebral disc implants and methods for forming the same
US20050278029A1 (en) 2000-08-30 2005-12-15 Trieu Hai H Intervertebral disc nucleus implants and methods
US7896920B2 (en) 2000-10-24 2011-03-01 Cryolife, Inc. In situ bioprosthetic filler and method, particularly for the in situ formation of vertebral disc bioprosthetics
US7220282B2 (en) 2000-12-15 2007-05-22 Spineology, Inc. Annulus-reinforcing band
US8747475B2 (en) 2000-12-15 2014-06-10 Spineology, Inc. Annulus-reinforcing band
US20140288656A1 (en) 2000-12-15 2014-09-25 Spineology, Inc. Annulus-reinforcing band
US7056345B2 (en) 2000-12-15 2006-06-06 Spineology, Inc. Annulus-reinforcing band
US6712853B2 (en) 2000-12-15 2004-03-30 Spineology, Inc. Annulus-reinforcing band
US20050137675A1 (en) 2000-12-19 2005-06-23 Alexander Dubson Vascular prosthesis and method for production thereof
US6936070B1 (en) 2001-01-17 2005-08-30 Nabil L. Muhanna Intervertebral disc prosthesis and methods of implantation
US20020147497A1 (en) 2001-04-06 2002-10-10 Integrated Vascular Systems, Inc. Methods for treating spinal discs
US6632235B2 (en) * 2001-04-19 2003-10-14 Synthes (U.S.A.) Inflatable device and method for reducing fractures in bone and in treating the spine
US7156877B2 (en) * 2001-06-29 2007-01-02 The Regents Of The University Of California Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs
US7641691B2 (en) * 2001-06-29 2010-01-05 The Regents Of The University Of California Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs
US20040106999A1 (en) 2001-07-30 2004-06-03 Mathews Hallett H. Methods and devices for interbody spinal stabilization
US20030028251A1 (en) 2001-07-30 2003-02-06 Mathews Hallett H. Methods and devices for interbody spinal stabilization
US6375682B1 (en) 2001-08-06 2002-04-23 Lewis W. Fleischmann Collapsible, rotatable and expandable spinal hydraulic prosthetic device
US6645248B2 (en) 2001-08-24 2003-11-11 Sulzer Orthopedics Ltd. Artificial intervertebral disc
US8133250B2 (en) 2001-09-28 2012-03-13 Boston Scientific Scimed, Inc. Medical devices comprising nanocomposites
US20030199979A1 (en) 2001-10-02 2003-10-23 Rex Medical Spinal implant and method of use
US6852223B2 (en) 2001-10-31 2005-02-08 Yeu Ming Tai Chemical Industrial Co., Ltd. Asymmetric porous polytetrafluoroethylene membrane and process for preparing the same
US20050065609A1 (en) 2001-11-19 2005-03-24 Douglas Wardlaw Intervertebral disc prosthesis
US20050090901A1 (en) 2001-12-05 2005-04-28 Armin Studer Intervertebral disk prosthesis or nucleus replacement prosthesis
US20030114917A1 (en) 2001-12-14 2003-06-19 Holloway Ken A. Layered stent-graft and methods of making the same
US7993351B2 (en) 2002-07-24 2011-08-09 Pressure Products Medical Supplies, Inc. Telescopic introducer with a compound curvature for inducing alignment and method of using the same
US20050197702A1 (en) 2002-08-15 2005-09-08 Coppes Justin K. Intervertebral disc implant
US7563284B2 (en) 2002-08-15 2009-07-21 Synthes Usa, Llc Intervertebral disc implant
US6932843B2 (en) 2002-09-25 2005-08-23 Medicinelodge, Inc. Apparatus and method for the in-situ formation of a structural prosthesis
US8012211B2 (en) 2002-11-05 2011-09-06 Spineology, Inc. Semi-biological intervertebral disc replacement system
US6733533B1 (en) 2002-11-19 2004-05-11 Zimmer Technology, Inc. Artificial spinal disc
US20040186471A1 (en) 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
US7004971B2 (en) 2002-12-31 2006-02-28 Depuy Acromed, Inc. Annular nucleus pulposus replacement
US20040230309A1 (en) 2003-02-14 2004-11-18 Depuy Spine, Inc. In-situ formed intervertebral fusion device and method
US20120310352A1 (en) 2003-02-14 2012-12-06 Depuy Spine, Inc. In-situ intervertebral fusion device and method
US6893465B2 (en) 2003-03-31 2005-05-17 Shi, Tain-Yew Vividly simulated prosthetic intervertebral disc
US8382838B2 (en) 2003-04-14 2013-02-26 Synthes Usa, Llc Intervertebral implant
US6969405B2 (en) 2003-04-23 2005-11-29 Loubert Suddaby Inflatable intervertebral disc replacement prosthesis
US20040220672A1 (en) 2003-05-03 2004-11-04 Shadduck John H. Orthopedic implants, methods of use and methods of fabrication
US20100256619A1 (en) 2003-05-30 2010-10-07 Warsaw Orthopedic, Inc. Methods and Devices for Transpedicular Discectomy
US6984246B2 (en) 2003-06-06 2006-01-10 Tain-Yew Shi Artificial intervertebral disc flexibly oriented by spring-reinforced bellows
US7632291B2 (en) 2003-06-13 2009-12-15 Trivascular2, Inc. Inflatable implant
US20080046082A1 (en) 2003-07-17 2008-02-21 Lee Casey K Intervertebral disc and nucleus prosthesis
US20050015150A1 (en) 2003-07-17 2005-01-20 Lee Casey K. Intervertebral disk and nucleus prosthesis
US20050251259A1 (en) 2003-07-29 2005-11-10 Loubert Suddaby Inflatable nuclear prosthesis
US6958077B2 (en) 2003-07-29 2005-10-25 Loubert Suddaby Inflatable nuclear prosthesis
US8808381B2 (en) 2003-08-01 2014-08-19 Spinal Kinetics Inc. Prosthetic intervertebral discs having rigid end plates with depressions in their inner surfaces and fibers between those end plates
US7309359B2 (en) 2003-08-21 2007-12-18 Warsaw Orthopedic, Inc. Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs
US20050055099A1 (en) 2003-09-09 2005-03-10 Ku David N. Flexible spinal disc
US7632294B2 (en) 2003-09-29 2009-12-15 Promethean Surgical Devices, Llc Devices and methods for spine repair
US7133001B2 (en) 2003-11-03 2006-11-07 Toyon Research Corporation Inflatable-collapsible transreflector antenna
US20050119752A1 (en) 2003-11-19 2005-06-02 Synecor Llc Artificial intervertebral disc
US8012210B2 (en) 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
US8945223B2 (en) 2004-03-12 2015-02-03 Warsaw Orthopedic, Inc. In-situ formable nucleus pulposus implant with water absorption and swelling capability
US20110190753A1 (en) 2004-04-23 2011-08-04 Leonard Edward Forrest Device and method treatment or evacuation of intervertebral disc
US7722612B2 (en) 2004-05-19 2010-05-25 Sintea Biotech S.P.A. Devices, kit and method for kyphoplasty
US8562634B2 (en) 2004-05-28 2013-10-22 Cavitech, Llc Instruments and methods for reducing and stabilizing bone fractures
US7297158B2 (en) 2004-06-14 2007-11-20 Thoratec Corporation Multilayer composite vascular access graft
US8337557B2 (en) 2004-06-29 2012-12-25 Spine Wave, Inc. Apparatus and kit for injecting a curable biomaterial into an intervertebral space
US7556650B2 (en) 2004-06-29 2009-07-07 Spine Wave, Inc. Methods for injecting a curable biomaterial into an intervertebral space
US8444694B2 (en) 2004-06-29 2013-05-21 Spine Wave, Inc. Methods for injecting a curable biomaterial into an intervertebral space
US7837733B2 (en) 2004-06-29 2010-11-23 Spine Wave, Inc. Percutaneous methods for injecting a curable biomaterial into an intervertebral space
US7789913B2 (en) 2004-06-29 2010-09-07 Spine Wave, Inc. Methods for injecting a curable biomaterial into an intervertebral space
US7972351B2 (en) 2004-07-13 2011-07-05 Boston Scientific Scimed, Inc. Balloon folding design and method and apparatus for making balloons
US20090105823A1 (en) 2004-09-30 2009-04-23 Synecor, Llc Artificial intervertebral disc nucleus
US8317864B2 (en) 2004-10-20 2012-11-27 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
WO2006060482A2 (en) 2004-12-01 2006-06-08 The Regents Of The University Of California Systems, devices and methods of treatment of intervertebral disorders
US20060149380A1 (en) * 2004-12-01 2006-07-06 Lotz Jeffrey C Systems, devices and methods for treatment of intervertebral disorders
US20060265077A1 (en) * 2005-02-23 2006-11-23 Zwirkoski Paul A Spinal repair
US20080195210A1 (en) 2005-03-01 2008-08-14 Columna Pty Ltd Intervertebral Disc Restoration
US7182783B2 (en) 2005-04-25 2007-02-27 Sdgi Holdings, Inc. Selectively expandable composite structures for spinal arthroplasty
US20060247780A1 (en) 2005-04-27 2006-11-02 Bert Jeffrey K Expandable artificial disc and associated methods and instrumentation
US20060253132A1 (en) 2005-05-06 2006-11-09 International Business Machines Corporation System and devices for the repair of a vertebral disc defect
US20060293749A1 (en) 2005-06-02 2006-12-28 Zimmer Spine, Inc. Interbody fusion ring and method of using the same
US8066758B2 (en) 2005-06-17 2011-11-29 C. R. Bard, Inc. Vascular graft with kink resistance after clamping
US20090240341A1 (en) 2005-08-15 2009-09-24 Columna Pty Ltd Tissue prosthesis and a method of, and equipment for, forming a tissue prosthesis
US20070073402A1 (en) 2005-08-26 2007-03-29 Edward Vresilovic Hydrogel balloon prosthesis for nucleus pulposus
US8287595B2 (en) 2005-08-26 2012-10-16 Synthes Usa, Llc Hydrogel balloon prosthesis for nucleus pulposus
US20070060924A1 (en) 2005-08-29 2007-03-15 Taeyon Medical Co., Ltd. Recovery device for balloon kyphoplasty
US7731753B2 (en) 2005-09-01 2010-06-08 Spinal Kinetics, Inc. Prosthetic intervertebral discs
US8377138B2 (en) 2005-09-01 2013-02-19 Spinal Kinetics Inc. Prosthetic intervertebral discs
US20070093906A1 (en) 2005-10-26 2007-04-26 Zimmer Spine, Inc. Nucleus implant and method
US20070173935A1 (en) 2005-10-28 2007-07-26 O'neil Michael J Nucleus pulposus augmentation pretreatment technique
US20100191335A1 (en) 2005-11-21 2010-07-29 Nicast Ltd. Spinal nucleus prosthesis device
US8551172B2 (en) 2005-12-09 2013-10-08 Kee B. Park Inflatable disk implant
US20070135921A1 (en) 2005-12-09 2007-06-14 Park Kee B Surgical implant
US20070162136A1 (en) 2005-12-22 2007-07-12 O'neil Michael Nucleus pulposus trial device and technique
US20070150061A1 (en) 2005-12-27 2007-06-28 Sdgi Holdings, Inc. Intervertebral disc augmentation and rehydration with superabsorbent polymers
US20070168042A1 (en) 2006-01-13 2007-07-19 Hudgins Robert G Devices and methods for disc replacement
US7645301B2 (en) 2006-01-13 2010-01-12 Zimmer Spine, Inc. Devices and methods for disc replacement
US20070168031A1 (en) 2006-01-13 2007-07-19 Zimmer Spine, Inc. Devices and methods for disc replacement
US7799079B2 (en) 2006-01-18 2010-09-21 Zimmer Spine, Inc. Vertebral fusion device and method
US20070173940A1 (en) 2006-01-18 2007-07-26 Zimmer Spine, Inc. Vertebral fusion device and method
WO2007087404A2 (en) 2006-01-24 2007-08-02 Hydrocision, Inc. Liquid jet surgical instrument having a distal end with a selectively controllable shape
US8603171B2 (en) 2006-01-25 2013-12-10 Mimedx Group, Inc. Spinal disc implants with flexible keels and methods of fabricating implants
US20120089229A1 (en) 2006-02-13 2012-04-12 Lanx, Inc. Method and apparatus for intervertebral disc support and repair
US20070213732A1 (en) 2006-03-13 2007-09-13 The Johns Hopkins University Orthopedic Screw System
US7993404B2 (en) 2006-03-29 2011-08-09 Warsaw Orthopedic, Inc. Transformable spinal implants and methods of use
US20070270953A1 (en) 2006-03-29 2007-11-22 Sdgi Holdings, Inc. Transformable spinal implants and methods of use
US20070255406A1 (en) 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for bilateral approach to disc augmentation
US7998210B2 (en) 2006-04-27 2011-08-16 Warsaw Orthopedic, Inc. Expandable intervertebral spacers and methods of use
US20070255285A1 (en) 2006-04-27 2007-11-01 Warsaw Orthopedic, Inc. Devices, Apparatus, and Methods for Disc Augmentation
US20090299476A1 (en) 2006-05-19 2009-12-03 Ashish Diwan Tissue prosthesis
US8690919B2 (en) 2006-05-23 2014-04-08 Warsaw Orthopedic, Inc. Surgical spacer with shape control
US8092536B2 (en) 2006-05-24 2012-01-10 Disc Dynamics, Inc. Retention structure for in situ formation of an intervertebral prosthesis
US20090012618A1 (en) 2006-05-24 2009-01-08 Disc Dynamics, Inc. Retention structure for in situ formation of an intervertebral prosthesis
US8236057B2 (en) 2006-06-12 2012-08-07 Globus Medical, Inc. Inflatable multi-chambered devices and methods of treatment using the same
US20070288095A1 (en) 2006-06-12 2007-12-13 Anthony Wirtel Inflatable multi-chambered devices and methods of treatment using the same
US8460383B2 (en) 2006-06-12 2013-06-11 Globus Medical, Inc. Inflatable multi-chambered devices and methods of treatment using the same
US20140052250A1 (en) 2006-06-12 2014-02-20 Anthony Wirtel, III Inflatable Multi-Chambered Devices and Methods of Treatment Using the Same
US8083800B2 (en) 2006-07-21 2011-12-27 Warsaw Orthopedic, Inc. Expandable vertebral implant and methods of use
US20080058932A1 (en) 2006-07-26 2008-03-06 Warsaw Orthopedic Inc. Rigidization-on-command orthopedic devices and methods
US8403987B2 (en) 2006-09-27 2013-03-26 Spinal Kinetics Inc. Prosthetic intervertebral discs having compressible core elements bounded by fiber-containing membranes
US20080119943A1 (en) 2006-11-16 2008-05-22 Armstrong Joseph R Stent having flexibly connected adjacent stent elements
US8979931B2 (en) 2006-12-08 2015-03-17 DePuy Synthes Products, LLC Nucleus replacement device and method
US20080154373A1 (en) 2006-12-21 2008-06-26 Warsaw Orthopedic, Inc. Curable orthopedic implant devices configured to be hardened after placement in vivo
US20080154367A1 (en) 2006-12-21 2008-06-26 Warsaw Orthopedic, Inc. Methods for positioning a load-bearing component of an orthopedic implant device by inserting a malleable device that hardens in vivo
US8663328B2 (en) 2006-12-21 2014-03-04 Warsaw Orthopedic, Inc. Methods for positioning a load-bearing component of an orthopedic implant device by inserting a malleable device that hardens in vivo
US8480718B2 (en) 2006-12-21 2013-07-09 Warsaw Orthopedic, Inc. Curable orthopedic implant devices configured to be hardened after placement in vivo
US20080154368A1 (en) 2006-12-21 2008-06-26 Warsaw Orthopedic, Inc. Curable orthopedic implant devices configured to harden after placement in vivo by application of a cure-initiating energy before insertion
US20110093076A1 (en) 2006-12-28 2011-04-21 Reo Michael L Prosthetic lumbar disc assembly having natural biomechanical movement
US20090076609A1 (en) 2007-03-31 2009-03-19 Spinal Kinetics, Inc. Prosthetic Intervertebral Discs with Slotted End Plates That are Implantable By Minimally Invasive, Posterior Approach, Surgical Techniques
US20090076610A1 (en) 2007-03-31 2009-03-19 Spinal Kinetics, Inc. Prosthetic Intervertebral Discs Having Balloon-Based Fillable Cores That are Implantable By Minimally Invasive Surgical Techniques
US8100978B2 (en) 2007-04-01 2012-01-24 Spinal Kinetics Inc. Prosthetic intervertebral discs having expandable cores that are implantable using minimally invasive surgical techniques
US20080288074A1 (en) 2007-05-15 2008-11-20 O'neil Michael J Internally reinforced elastomeric intervertebral disc implants
US20080288073A1 (en) 2007-05-17 2008-11-20 Depuy Spine, Inc. Self-Distracting Cage
US8377131B2 (en) 2007-06-06 2013-02-19 Spirit Spine Holdings Corporation, Inc. Medical implant
US20090030399A1 (en) * 2007-07-23 2009-01-29 Kamshad Raiszadeh Drug Delivery Device and Method
US20130297026A1 (en) 2007-08-09 2013-11-07 Spinalmotion, Inc. Customized intervertebral prosthetic disc with shock absorption
US8454612B2 (en) 2007-09-07 2013-06-04 Intrinsic Therapeutics, Inc. Method for vertebral endplate reconstruction
US20090082870A1 (en) 2007-09-20 2009-03-26 Osman Said G Transpedicular, extrapedicular and transcorporeal partial disc replacement
US8540772B2 (en) 2007-09-20 2013-09-24 Said G. Osman Transpedicular, extrapedicular and transcorporeal partial disc replacement
US20100292798A1 (en) 2007-10-19 2010-11-18 Gianluca Maestretti Hemi-prosthesis
US20090112221A1 (en) 2007-10-25 2009-04-30 Disc Dynamics, Inc. System and method for measuring the shape of internal body cavities
US20090112323A1 (en) * 2007-10-29 2009-04-30 Zimmer Spine, Inc. Minimally invasive interbody device and method
US8043381B2 (en) 2007-10-29 2011-10-25 Zimmer Spine, Inc. Minimally invasive interbody device and method
US20090118833A1 (en) 2007-11-05 2009-05-07 Zimmer Spine, Inc. In-situ curable interspinous process spacer
US8888850B2 (en) 2007-11-19 2014-11-18 Linares Medical Devices, Llc Combination spacer insert and support for providing inter-cervical vertebral support
US8419839B2 (en) 2007-12-07 2013-04-16 Nitto Denko Corporation Porous polytetrafluoroethylene membrane, method for producing the same, and water-proof air permeable filter
US20090163994A1 (en) 2007-12-21 2009-06-25 Boston Scientific Scimed, Inc. Flexible Stent-Graft Device Having Patterned Polymeric Coverings
US8292961B2 (en) 2008-01-23 2012-10-23 Osman Said G Biologic vertebral reconstruction
US20090222093A1 (en) * 2008-02-28 2009-09-03 Warsaw Orthopedic, Inc. Nucleus Implant and Method of Installing Same
US20120277862A1 (en) 2008-04-04 2012-11-01 Clariance Nuclear implant
US20110125158A1 (en) 2008-05-01 2011-05-26 Ashish Dhar Diwan Systems, methods and apparatuses for formation and insertion of tissue prostheses
US20100030216A1 (en) 2008-07-30 2010-02-04 Arcenio Gregory B Discectomy tool having counter-rotating nucleus disruptors
US8398511B2 (en) 2008-09-05 2013-03-19 Warrior Sports, Inc. Inflatable latex neoprene bladders
US8727920B2 (en) 2008-09-05 2014-05-20 Warrior Sports, Inc. Inflatable latex neoprene bladders
US8449660B2 (en) 2008-11-04 2013-05-28 Nitto Denko Corporation Polytetrafluoroethylene porous membrane, method for producing same, and waterproof air-permeable filter
US8246682B2 (en) 2008-12-16 2012-08-21 Depuy Spine, Inc. Methods and devices for expanding a spinal canal using balloons
US8632592B2 (en) 2008-12-22 2014-01-21 DePuy Synthes Products, LLC Expandable vertebral body replacement device and method
US20110319996A1 (en) 2008-12-22 2011-12-29 Synthes Usa, Llc Expandable vertebral body replacement device and method
US20100193999A1 (en) 2009-01-16 2010-08-05 Anneaux Bruce L Electrospinning of ptfe with high viscosity materials
US20140094914A1 (en) * 2009-04-07 2014-04-03 Spinal Stabilization Technologies, Llc Percutaneous Implantable Nuclear Prosthesis
US20100256766A1 (en) * 2009-04-07 2010-10-07 Hibri Nadi S Percutaneous Implantable Nuclear Prosthesis
US8636803B2 (en) * 2009-04-07 2014-01-28 Spinal Stabilization Technologies, Llc Percutaneous implantable nuclear prosthesis
US8123808B2 (en) 2009-04-16 2012-02-28 Warsaw Orthopedic, Inc. Vertebral endplate connection implant and method
US8377136B2 (en) 2009-04-20 2013-02-19 Warsaw Orthopedic, Inc. Method for stabilizing an intervertebral disc device
US20120089227A1 (en) 2009-06-18 2012-04-12 Peter Jarzem Hollow highly-expandable prosthetic vertebral body
US20110282418A1 (en) 2010-05-14 2011-11-17 Ameliomed, Llc Methods and devices for cooling spinal tissue
KR20120040309A (ko) 2010-10-19 2012-04-27 인하대학교 산학협력단 척추경 나사못 보강 풍선 앙카 볼트
US20130131806A1 (en) 2010-11-04 2013-05-23 Clyde T. Carpenter Anatomic total disc replacement
US20120165941A1 (en) 2010-12-22 2012-06-28 Illuminoss Medical, Inc. Systems and methods for treating conditions and diseases of the spine
US20130004586A1 (en) 2011-06-24 2013-01-03 Vachon David J Biologically Efficacious Compositions, Articles of Manufacture and Processes for Producing and/or Using Same
US20130103155A1 (en) 2011-10-20 2013-04-25 Clariance (S.A.S.) Silicone nucleus implants
US20130304212A1 (en) 2012-05-08 2013-11-14 Eric R. VonGunten Nucleus pulposus spinal implant and method of using the same
US8894563B2 (en) 2012-08-10 2014-11-25 Attenuex Technologies, Inc. Methods and systems for performing a medical procedure
US8734459B1 (en) 2013-01-17 2014-05-27 Abdulrazzaq Alobaid Device and method to prevent extravasation of bone cement used in balloon kyphoplasty
US20140276832A1 (en) 2013-03-14 2014-09-18 Nadi Salah Hibri Surgical Device
US20140277467A1 (en) 2013-03-14 2014-09-18 Spinal Stabilization Technologies, Llc Prosthetic Spinal Disk Nucleus
US20150057752A1 (en) 2013-03-14 2015-02-26 Spinal Stabilization Technologies, Llc Prosthetic Spinal Disk Nucleus
US20160120654A1 (en) 2014-11-04 2016-05-05 Spinal Stabilization Technologies Llc Percutaneous Implantable Nuclear Prosthesis
US20160120653A1 (en) 2014-11-04 2016-05-05 Spinal Stabilization Technologies Llc Percutaneous Implantable Nuclear Prosthesis
US9486323B1 (en) 2015-11-06 2016-11-08 Spinal Stabilization Technologies Llc Nuclear implant apparatus and method following partial nuclectomy

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
Birkenmaier et al. "Minimally Invasive Endoscopic Spinal Surgery" www.spineuniverse.com/displayarticle.pho/article2016.html [Jun. 15, 2009].
International Search Report and Written Opinion for PCT/US2015/058976 dated Jan. 25, 2016.
International Search Report and Written Opinion for PCT/US2015/059011, dated Feb. 15, 2016.
International Search Report and Written Opinion issued in PCT Application No. PCT/US2016/049816, dated Dec. 8, 2016.
International Search Report dated Jun. 17, 2014 for International Application No. PCT/US2014/019911 filed Mar. 3, 2014.
International Search Report dated Jun. 19, 2014 for International Application No. PCT/US2014/019887 filed Mar. 3, 2014.
International Search Report dated Jun. 25, 2014 for International Application No. PCT/US2014/019957 filed Mar. 3, 2014.
Sharma et al., "Manufacturing of Doubly Curved Tubular Composite Structures: Mapping and Weave Modifications," Thermoplastic Composite Materials, 15:209-225 (May 2002).
Supplementary European Search Report issued in European Patent Application No. 16842957.9, dated Jul. 26, 2018.
Viscocliosi et al. "Beyond Total Disc: The Future of Spine Surgery," Spine Non-Fusion Musculoskeletal Investment Research, pp. 1-289 (May 2004).
Wu et al., "The direct effect of graft compliance mismatch per se on development of host arterial intimal hyperplasia at the anastomotic interface," Annals of Vascular Surgery, 7(2): 156-168, (Mar. 1993).

Also Published As

Publication number Publication date
EP3344156A4 (en) 2018-08-08
EP3344156A1 (en) 2018-07-11
US20200229947A1 (en) 2020-07-23
ES2774513T3 (es) 2020-07-21
KR102607758B1 (ko) 2023-11-29
AU2016315964A1 (en) 2018-04-12
WO2017040734A1 (en) 2017-03-09
CN108348227B (zh) 2021-03-09
US11576793B2 (en) 2023-02-14
JP2018527145A (ja) 2018-09-20
EP3344156B1 (en) 2020-01-08
US12533245B2 (en) 2026-01-27
CN108348227A (zh) 2018-07-31
US20170056195A1 (en) 2017-03-02
JP6891176B2 (ja) 2021-06-18
PL3344156T3 (pl) 2020-07-27
AU2016315964B2 (en) 2021-05-13
CA2997117A1 (en) 2017-03-09
US20230218409A1 (en) 2023-07-13
KR20180051544A (ko) 2018-05-16

Similar Documents

Publication Publication Date Title
US12533245B2 (en) Implantable nuclear prosthesis
US12279963B2 (en) Percutaneous implantable nuclear prosthesis
JP2012513243A (ja) 拡張可能椎体置換デバイス及び方法
US12551352B2 (en) Implantable nuclear prosthesis, kits, and related methods
CA2997117C (en) Implantable nuclear prosthesis

Legal Events

Date Code Title Description
STPP Information on status: patent application and granting procedure in general

Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER

STPP Information on status: patent application and granting procedure in general

Free format text: NOTICE OF ALLOWANCE MAILED -- APPLICATION RECEIVED IN OFFICE OF PUBLICATIONS

AS Assignment

Owner name: SPINAL STABILIZATION TECHNOLOGIES LLC, TEXAS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FRANCIS, W. LOREN;REEL/FRAME:049726/0938

Effective date: 20151104

AS Assignment

Owner name: SPINAL STABILIZATION TECHNOLOGIES LLC, TEXAS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:NOVOTNY, MARK;REEL/FRAME:049751/0739

Effective date: 20151104

STCB Information on status: application discontinuation

Free format text: ABANDONMENT FOR FAILURE TO CORRECT DRAWINGS/OATH/NONPUB REQUEST

STPP Information on status: patent application and granting procedure in general

Free format text: PUBLICATIONS -- ISSUE FEE PAYMENT VERIFIED

STCF Information on status: patent grant

Free format text: PATENTED CASE

MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY

Year of fee payment: 4