US11607681B2 - Liquid handling device and a method for energizing a liquid handling device - Google Patents

Liquid handling device and a method for energizing a liquid handling device Download PDF

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US11607681B2
US11607681B2 US16/441,061 US201916441061A US11607681B2 US 11607681 B2 US11607681 B2 US 11607681B2 US 201916441061 A US201916441061 A US 201916441061A US 11607681 B2 US11607681 B2 US 11607681B2
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Prior art keywords
handling device
liquid handling
pipette
energy
harvested
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US20190381496A1 (en
Inventor
Sami ALT
Janne Leinonen
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Sartorius Biohit Liquid Handling Oy
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Sartorius Biohit Liquid Handling Oy
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Assigned to SARTORIUS BIOHIT LIQUID HANDLING OY reassignment SARTORIUS BIOHIT LIQUID HANDLING OY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LEINONEN, JANNE, ALT, SAMI
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—ELECTRIC POWER NETWORKS; CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or discharging batteries or for supplying loads from batteries
    • H02J7/34—Parallel operation in networks using both storage and other DC sources, e.g. providing buffering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/027—Digital display, e.g. LCD, LED
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0237—Details of electronic control, e.g. relating to user interface
    • H01L31/02—
    • H01L35/02—
    • H01L41/04—
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—ELECTRIC POWER NETWORKS; CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or discharging batteries or for supplying loads from batteries
    • H02J7/34—Parallel operation in networks using both storage and other DC sources, e.g. providing buffering
    • H02J7/345—Parallel operation in networks using both storage and other DC sources, e.g. providing buffering using capacitors as storage or buffering devices
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F77/00—Constructional details of devices covered by this subclass
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N10/00—Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects
    • H10N10/80—Constructional details

Definitions

  • the present invention relates generally to liquid handling devices, and more particularly to self-charging power systems for liquid handling devices.
  • a third category consists of so-called electromechanical or hybrid pipettes.
  • electromechanical pipettes part of functionalities is implemented by means of mechanical machinery, while another part is implemented by using electronic components.
  • a mechanical volume display or counter has typically been replaced by an electronic LCD display.
  • a segmented LCD display requires a low power, and therefore a button cell or a rechargeable battery can be used as a power source.
  • power sources require either frequent changing or regular recharging, which necessitates disassembling of the pipette, or a charging socket or a charging dock. Further, such power sources are self-discharging, implying that a new power source must always be charged before the first use.
  • a disadvantage of the known electromechanical or electronic pipettes is that in the event of battery discharge, the electronic components stop functioning completely. For example, an electronic display shuts off, which may lead to loss of information.
  • Electronic paper displays which are also called e-paper displays or E ink displays, have attracted a lot of interest in recent years and they have been applied to many consumer products.
  • Electronic paper displays mimic the appearance of ordinary ink on paper.
  • E-paper displays reflect light, whereas conventional flat panel displays are backlit and thus emit light.
  • the advantages of e-paper displays include their ability to display static text and images without any supply of power, and their flexibility: the substrate and the electronics of the backplane are made of plastic materials. In an e-paper display, the contrast is good and the viewing angle wide (170 degrees).
  • An E ink display can be a black-and-white display or a colour display.
  • electrophoretic displays electrowetting displays
  • electrofluidic displays electrofluidic displays
  • plasmonic electronic displays The electronic ink technology that has been commercialized by E Ink Corporation is based on small transparent microcapsules. Each microcapsule represents a pixel and contains a positively charged white pigment particle and a negatively charged black pigment particle. When a positive or negative electric field is applied, the charged pigment particles become rearranged within each capsule to change the color of the surface to either white or black. Even three-color versions have been developed.
  • WO 2014138530 A2 describes an automated clinical chemistry analyser comprising electronically rewriteable surfaces (e.g. E ink displays) configured to dynamically display optical marks, and independently movable carriers configured to move along the surfaces and to observe the marks to determine navigational information from the optical marks.
  • electronically rewriteable surfaces e.g. E ink displays
  • independently movable carriers configured to move along the surfaces and to observe the marks to determine navigational information from the optical marks.
  • the embodiments of the present invention are intended to overcome at least some of the above discussed disadvantages and restrictions of the known electromechanical pipettes.
  • a liquid handling device comprising: means for harvesting energy; energy storage arranged for storing the harvested energy in the liquid handling device; and an electronic component connected to the energy storage and configured to use the energy storage as a power source.
  • a method for energizing a liquid handling device comprising: harvesting energy; storing the harvested energy in an energy storage in the liquid handling device, and energizing an electronic component of the liquid handling device with the stored and harvested energy.
  • At least some embodiments of the present invention provide significant advantages in electronic pipettes.
  • the charging interval can be increased from days to several months or even dispensed with completely.
  • At least some embodiments of the present invention provide advantages in mechanical pipettes. It becomes possible to include electronic functionalities in a mechanical pipette. Simultaneously the pipette can be light-weight, as there is no need to include a heavy battery. Further, the manner of using and controlling the pipette need not be altered. Many users prefer the feel and touch of a mechanical pipette over an electronic pipette.
  • At least some embodiments of the present invention make it possible to use a pipette for long periods of time in locations in which charging of a traditional battery is not possible.
  • FIG. 1 illustrates an embodiment of the present invention in which energy is harvested from pushing and releasing movements of a button of a pipette.
  • FIG. 2 illustrates an embodiment of the present invention in which energy is harvested from rotation movements of a button of a pipette.
  • FIG. 3 illustrates an embodiment of the present invention in which solar energy is harvested.
  • FIG. 4 illustrates an embodiment of the present invention in which ambient heat is harvested.
  • liquid handling device comprises hand-held mechanical, electromechanical and electric pipettes, and automated liquid handling stations.
  • the term “electromechanical pipette” comprises a mechanical pipette with electronic functionalities.
  • the pipette is an air displacement micropipette that uses disposable tips.
  • energy harvesting can be applied successfully in a liquid handling device, such as a pipette, to energize low-power electronic components.
  • a liquid handling device such as a pipette
  • the principle of one form of energy harvesting is that ambient energy is harvested and stored to energize electronic devices that have relatively low power requirements.
  • Energy harvesting systems can be based on, for example, photovoltaics, thermovoltaics, piezoelectrics or electrodynamics. These systems can take advantage of various forms of ambient or environmental energy, for example movements, light, and vibrations.
  • a liquid handling device it is possible to harvest energy by various means.
  • the means for harvesting energy is integrated to the liquid handling device, such as a pipette.
  • the liquid handling device such as a pipette.
  • a magnetic induction system is utilized in the form of a magnet-through-coil system to harvest kinetic energy.
  • Power is generated through relative motion between a coil of wire and a magnet.
  • the magnetic flux through the coil changes and a voltage differential across the ends of the wire coil is generated.
  • the voltage difference can be used to charge a supercapacitor.
  • a magnet can be arranged to move downwards through a coil when a mechanical control button or a mechanical tip ejection button of the pipette is pushed down. When the button is released, the magnet moves in an opposite direction through the coil.
  • FIG. 1 illustrates an embodiment of the present invention in which energy is harvested from pushing and releasing movements of a control button 11 of a mechanical pipette 10 .
  • the pipette 10 uses disposable tips 12 .
  • FIG. 2 illustrates an embodiment of the present invention in which energy is harvested from rotation movements of a button 21 of a pipette 20 .
  • the button 21 is rotated in order to increase or decrease a counter.
  • solar energy is harvested by means of a solar cell.
  • the advantage is that continuous harvesting is possible as long as light is available.
  • the supply of energy is not limited to situations where the pipette is being used, moved or held in hand.
  • Solar energy harvesting is particularly advantageous in an electronic pipette.
  • an electronic pipette can be charged by an UV light source of a laminar hood.
  • the pipette can be stored and used in a laminar hood for long periods of time without charging it on a traditional charging stand.
  • FIG. 3 illustrates an embodiment of the present invention in which solar energy is harvested to a hand-held pipette 30 by a solar cell 33 located on the surface of the pipette body.
  • a pipette contains a thermoelectric generator (a TEG or a Seebeck generator) that is arranged to harvest body heat for example from a user's hand when the user holds the pipette.
  • a TEG is a solid state device that converts heat (temperature differences) directly into electrical energy through a phenomenon called the Seebeck effect.
  • the advantage is that continuous harvesting is possible when the user holds the pipette, and the user is not required to push any buttons to activate or energize the pipette or its display in the beginning of a pipetting task.
  • a TEG can be realized in the form of a Peltier module.
  • a pipette contains a thermoelectric generator that is arranged to harvest ambient heat, e.g. heat derived from the temperature difference between the pipette and the surrounding air or any surrounding or near-by located surface.
  • the surface of the liquid handling device is preferably made of a dark and rough (e.g. texturized) material to produce a difference in reflectivity.
  • the surface of the pipette can be smoother and shinier than the top surface of a laboratory bench.
  • a temperature difference of 0.5° C. is sufficient in the embodiment utilizing a thermoelectric generator.
  • body heat can provide enough harvested energy in a few seconds in order to energize electronic pipette components.
  • the temperature difference can be maintained for several minutes.
  • the liquid handling device comprises both a thermoelectric generator and a solar cell for harvesting energy. This embodiment ensures sufficient and continuous energy harvesting and power generation.
  • FIG. 4 illustrates an embodiment of the present invention in which ambient heat is harvested to a hand-held pipette 40 by a thermoelectric generator.
  • piezoelectric materials are utilized. When a piezoelectric material is subjected to mechanical movement, deformation or vibration, a voltage differential is built up across the ends of the material.
  • a layer of piezoelectric material can be arranged to any suitable location, for example in any of the buttons or a body or a handle or a finger hook or a tip cone of the pipette. Power can be generated when the user pushes the button and thus deforms the piezoelectric material. Alternatively, power can be generated when the user rotates a counter or moves the entire pipette.
  • a piezoelectric material can be configured to harvest energy derived from any movement, turning, rotation, grasping, pressing or deformation of a part of the pipette or the entire pipette by a user.
  • Another possible alternative is to use a system based on parallel-plate capacitors with movable plates.
  • the plates are charged to a certain voltage.
  • the distance between the plates increases, which results in energy being stored to the capacitor.
  • the energy is harvested when the plates return to their original position.
  • the harvested energy is preferably stored in an energy buffer or energy storage that is integrated to the liquid handling device.
  • the energy storage can be for example a lithium ion battery or a supercapacitor.
  • a supercapacitor is advantageous, as it has a better efficiency than a Li ion battery. It can accept and deliver charge much faster than batteries, and tolerate many more charge and discharge cycles.
  • the harvested and stored energy can be used for energizing various low power electronic components in a liquid handling device, such as a hand-held pipette.
  • a liquid handling device such as a hand-held pipette.
  • such an electronic component is integrated to the liquid handling device.
  • the energy is used for energizing an electronic paper display, e.g. a low power E ink display.
  • An E ink display is able to show static information to the user even in the absence of any power supply. When harvested energy is available, the display can be updated and new information displayed.
  • Use of an E ink display instead of an LCD display is advantageous, because it is easy to produce a curved E ink display that conforms to the shape of the pipette handle.
  • the radius of curvature of the E ink display may be approximately the same as that of the handle or the body of the pipette.
  • the radius of curvature of the E ink display differs from the radius of curvature of the handle or the body of the pipette by 10% at maximum.
  • the E ink display is integrated to a body of the pipette and has a shape with substantially the same curvature as the body of the pipette.
  • E ink display can be integrated to the body of the pipette seamlessly. Further, E ink displays can be produced as paper-thin components so that the space requirement is minimal in comparison to an LCD display or a mechanical volume counter.
  • a mechanical counter typically forms a significant portion of a mechanical pipette when considering the number of components and the amount of working hours. These components can be replaced with a single circuit board that provides an E ink display, a graphics card, position data and energy harvesting. Automated assembling of the pipette becomes possible as the number of small components is decreased. Also pad printing steps of the counter and the related costs are avoided.
  • the energy is used for energizing components for wireless communication, such as an active or passive RFID tag attached to the liquid handling device.
  • wireless communication such as an active or passive RFID tag attached to the liquid handling device.
  • Other possible low power wireless techniques that can be energized by means of the present method are Bluetooth low energy, ANT, ZigBee, and RF4CE.
  • the energy is used for energizing a sensor in a hand-held pipette.
  • An optical sensor or a photometric sensor configured to determine a liquid level or liquid volume inside a tip of a pipette.
  • An optical sensor can be used for monitoring various changes in a state of the tip or its contents, such as contact of the tip with external surfaces or with liquid, or orientation (straightness) of the tip.
  • multiple power sources can be utilized in parallel. For example, it is possible to supply power both from charging pins and from an energy storage containing harvested energy.
  • Some embodiments of the present invention are applicable even in automated liquid handling stations.
  • Harvested energy for example solar energy, can be used as a supplementary power source in liquid handling stations.
  • an electromechanical pipette comprising an E ink touch display which is powered by harvesting kinetic energy.
  • Kinetic energy can be harvested for example during the following actions: tip picking (linear movement and pressure); counter movement (rotation); tip ejection (linear movement derived from a tip ejection button or a tip ejection sleeve); dispensing (linear movement); blow-out of remaining liquid sample after dispensing (linear movement, pressure).
  • the battery of the pipette is empty and the display shows, for example, the text “Push eject to start” or “Push eject to unlock”.
  • the user is not explicitly prompted to charge the battery, and he does not even need to be aware of the charging requirements of the pipette.
  • no cords or chargers are needed.
  • the charging movements form the starting routine in order to begin dispensing.
  • Charging of the pipette is carried out by performing a few, for example 1 to 5, charging movements, which can be any of the above listed.
  • the pipette analyses the dispensing volume, and the display becomes activated and shows the volume and possibly graphic symbols.
  • the power requirements of the E ink display are very low, because the battery charge is only used for updating the display and for analysing the position of the plunger. Detection of plunger location is carried out electronically, for example by means of a position sensor, or by means of a resistor whose resistance varies as a function of the plunger's position. The latter alternative would enable a simple calibration or resetting of the counter to be carried out.
  • the user selects the volume for which calibration is to be performed, for example 1000 ⁇ l. Then the user presses “cal” on the display. The push button is rotated until the display shows the average of actual volume dispensed with this volume setting, for example 980 ⁇ l. The user presses “cal” again, after which the display shows 1000 ⁇ l.
  • harvested energy can be utilized in a mechanical pipette for incrementing an electronic usage counter that counts pushing actions of a control button and in this way records the usage (e.g. the number of dispensing events) of the pipette.
  • the pipette indicates to the user that the pipette should be calibrated or serviced.
  • the user may follow the counter value actively by himself and make a decision on the appropriate time for carrying out calibration and/or servicing.
  • the means for harvesting energy is a magnet moving back and forth inside a coil as a response to pushing and releasing of the control button or a tip ejection button.
  • At least some embodiments of the present invention find industrial application in electronic or electromechanical hand-held pipettes.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Human Computer Interaction (AREA)
  • Power Engineering (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
US16/441,061 2018-06-15 2019-06-14 Liquid handling device and a method for energizing a liquid handling device Active 2042-01-19 US11607681B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18178033.9 2018-06-15
EP18178033.9A EP3581274B1 (fr) 2018-06-15 2018-06-15 Dispositif de manipulation de liquide et procédé d'énergie d'un dispositif de manipulation de liquide
EP18178033 2018-06-15

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US20190381496A1 US20190381496A1 (en) 2019-12-19
US11607681B2 true US11607681B2 (en) 2023-03-21

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EP (1) EP3581274B1 (fr)
JP (1) JP7199309B2 (fr)
CN (1) CN110605149B (fr)

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USD982157S1 (en) * 2021-03-12 2023-03-28 Mettler-Toledo Rainin, LLC Pipette syringe

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US20190381496A1 (en) 2019-12-19
EP3581274B1 (fr) 2021-09-08
JP7199309B2 (ja) 2023-01-05
JP2019217495A (ja) 2019-12-26
CN110605149B (zh) 2022-08-19
EP3581274A1 (fr) 2019-12-18
CN110605149A (zh) 2019-12-24
RU2019115247A (ru) 2020-11-17

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