Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K49/00—Preparations for testing in vivo
  • A61K49/04—X-ray contrast preparations
  • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent

Definitions

• Another object of the invention is the visualization of a wider area than hitherto rendered accessible. 4.
• Still a further objector the invention is to provide for visualizationf over an extended period to facilitate study of the function of the organs.
• Retrograding pyelography involves cystoscopy and catheterization, contrast substances such as lithium iodide or sodium iodide dissolved in water being introduced, through the catheter, into the bladder and the ureters. To the extent that the substances filled the organs, X-ray pictures showing in outline any irregularities were obtainable.
• the present invention is based on thev concept that all the drawbacks of the prior methods can be eliminated, and a procedure can be obtained which is generally applicable, i. e. which is operative also under conditions of obstructions or disorders in the anatomical channels, which is available to the general practitioner, which eliminates pain or discomfort on the part of the patient, which results in high" contrast visualization and pictures of the genito-urinary tract, and which increases both the area rendered visible and the period of time during which it is accessible to observation, if the methods of the prior art are critically departed from and a novel method is introduced which provides for the direct introduction of the contrast agent into the general circulation.
• the most obvious and most effective mode of directly introducing the contrast agent into the circulation is to administer'such substance by way of intravenous injection, and accordingly this is the method contemplated by the present invention.
• the class of substances thus established is distinguished by a combination of properties common to all its members, as follows: the substances are organic compounds containing iodine or bromine, have the halogen linked to carbon in a stable non-ionizing form, are highly soluble, and are substantially inert with respect to the human v body.
• the contrast substances employed according to the invention may be characterized as being salts of compounds having the general formula A-B-C, where A constitutes the shadow-forming part of the molecule and comprises an aliphatic or aromatic or pyridine ring substituted by halogen; B constitutes'a link connecting the groups A and C and comprising one or more carbon atoms in a chain, or an oxygen or an amino group, or a combination of several of these; and C constitutes the group responsible'for the high solubility of the compound, particularly in water, and comprises a carboxyl or sulfoxyl group. It is noted that while A and C must always be present, the intermediate link B may be non-existent, its part being taken by part of the group A.
• a solution of one of the novel contrast agents in water is prepared under sterile conditions, the concentration of the solution being preferably provided as between approximately 40 to
• the sterile solution is then preferably warmed to body temperature and intravenously injected into the cubital vein.
• the injection should proceed slow- 1y so as to avoid any discomfort on the part of the patient.
• After the injection is completed one has to wait for about from 5 to 10 minutes before the first screen observation may be made, or the first picture may be taken in the usual manner. Subsequently, a great number of pictures may be taken at intervals, the next following ones, e. g. after about 30 and '50 minutes.
• the method is generally applicable, even in cases of obstruction of the channels formerly utilized in retrograding pyelography.
• the method is available to the general practitioner. In years of experience, the method has been established to eliminate pain or discomfort on the part of the patient. High contrast visualization and pictures are readily obtainable.
• the area rendered visible is considerably increased when compared with that previously rendered accessible, owing to the utilisation of the entire tract as channel for the agents.
• the period of time over which visualization may be readily had is likewise considerably increased, the agent being kept in the tract for the length of time taken up by the physiological excretion processes.
• a contrast agent especially useful for rendering the urogenital system less pervious to X-rays comprising essentially a water-soluble pyridine which comprises rendering the urogenital system less pervious to X-rays, and thereby visible on the screen, by injecting into the blood stream of the patient, and thus conveying through the latter and'to the urogenital system, a solution of a soluble, stable, non-toxic pyridine c-arboxylie-acid salt containing as a further substituent in the nucleus a member of the group consisting of bromine and iodine joined directly to nuclear carlo bon in non-ionizing form.

Landscapes

• Health & Medical Sciences (AREA)
• Epidemiology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
• Radiation-Therapy Devices (AREA)

Applications Claiming Priority (1)

Publications (1)

Family

ID=7993153

Family Applications (1)

Country Status (6)

Cited By (1)

Families Citing this family (1)

• 1930
  • 1930-08-13 CH CH150122D patent/CH150122A/de unknown
  • 1930-08-13 AT AT129942D patent/AT129942B/de active
  • 1930-08-22 FR FR709790D patent/FR709790A/fr not_active Expired
  • 1930-08-26 GB GB25474/30A patent/GB361437A/en not_active Expired
  • 1930-09-03 ES ES0119679A patent/ES119679A1/es not_active Expired
• 1938
  • 1938-10-11 US US234403A patent/US2269489A/en not_active Expired - Lifetime

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