US3046997A - Selective alkaloid extraction - Google Patents

Selective alkaloid extraction Download PDF

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Publication number
US3046997A
US3046997A US58825A US5882560A US3046997A US 3046997 A US3046997 A US 3046997A US 58825 A US58825 A US 58825A US 5882560 A US5882560 A US 5882560A US 3046997 A US3046997 A US 3046997A
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US
United States
Prior art keywords
brine
solvent
tobacco
alkaloid
extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US58825A
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English (en)
Inventor
John D Hind
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philip Morris USA Inc
Original Assignee
Philip Morris USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philip Morris USA Inc filed Critical Philip Morris USA Inc
Priority to US58825A priority Critical patent/US3046997A/en
Priority to DE19611517299 priority patent/DE1517299A1/de
Priority to DK382861AA priority patent/DK112644B/da
Priority to CH1120561A priority patent/CH441091A/de
Priority to BR132953/61A priority patent/BR6132953D0/pt
Priority to GB34631/61A priority patent/GB934007A/en
Application granted granted Critical
Publication of US3046997A publication Critical patent/US3046997A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A24B15/243—Nicotine
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/26—Use of organic solvents for extraction

Definitions

  • FIGURE 1 is a schematic flow diagram of a process according to this invention.
  • Tobacco is placed in a leaf percolator 1, which is equipped with a solvent reservoir inlet 2, a recycle inlet 3 and an outlet 5.
  • fresh solvent or solvent which is saturated with Waxes and other non-alkaloid tobacco constituents is admitted to the percolator 1 through inlet 2.
  • the alkaloid-laden solvent is withdrawn through outlet 5 and trap 6 by means of pump 7 and is directed to liquidliquid extractor 10.
  • the rate of flow may be regulated by fiow meter 8, diverted extracting solvent passing by conduit 9 back to the leaf percolator 1, which it enters at inlet 4.
  • Example VII The effect of pH upon distribution coefl'icients for'nicotine salts in solvent-brine solutions is measured.
  • distribution coefficient is meant the concentration of solute in brine divided by the concentration of solute in solvent phase.
  • Nicotine is a valuable and expensive article of com merce and the foregoing procedure is particularly desirable since it provides a relatively inexpensive and efficient way of providing nicotine of substantial purity, largely free of fats and waxes.
  • the apparatus shown in FIG. 1 may readily be adapted to divert the alkaloid-enriched brine'to a second liquid-liquid extractor after, which the alkaloid-relieved brine maybe recycled to the extraction portion of the apparatus illustrated in the drawing. Provision may advantageously be made to a-lkalize the brine prior to reaching such second liquid-liquid extractor and to neutralize or acidify it before it returns to engage in countercurrent flow with the first solvent from the leaf percolator. In this manner a complete and self-contained process yielding vboth substantially alkaloid-free tobacco and valuable nicotine by product may be achieved.
  • a method for recovering alkaloid from tobacco, substantially free from fats and waxes naturally occurring in tobacco which comprises the steps of extracting tobacco with organic solvent, contacting the resultant solvent extract with brine, thereafter alkalizing the brine, contacting the alkalized brine with a second organic solvent, and recovering alkaloid from the second solvent.
  • a method for recovering nicotine from tobacco, substantially free from fats and waxes naturally occurring in tobacco which comprises the steps of extracting tobacco with organic solvent, contacting the resultant solvent extract with saturated aqueous brine, said brine having a pH below 7, thereafter alkalizing the brine, contacting the alkalized brine with a second organic solvent, and recovering nicotine from the second solvent.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Manufacture Of Tobacco Products (AREA)
US58825A 1960-09-27 1960-09-27 Selective alkaloid extraction Expired - Lifetime US3046997A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US58825A US3046997A (en) 1960-09-27 1960-09-27 Selective alkaloid extraction
DE19611517299 DE1517299A1 (de) 1960-09-27 1961-09-25 Verfahren zur selektiven Entfernung von Alkaloiden aus Tabak
DK382861AA DK112644B (da) 1960-09-27 1961-09-26 Fremgangsmåde til selektiv fjernelse af alkaloider, herunder nikotin fra tobak.
CH1120561A CH441091A (de) 1960-09-27 1961-09-27 Verfahren zur selektiven Entfernung von Alkaloiden aus Tabak
BR132953/61A BR6132953D0 (pt) 1960-09-27 1961-09-27 Processo quimico para a remocao de alcaloides do fumo
GB34631/61A GB934007A (en) 1960-09-27 1961-09-27 Tobacco extraction process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58825A US3046997A (en) 1960-09-27 1960-09-27 Selective alkaloid extraction

Publications (1)

Publication Number Publication Date
US3046997A true US3046997A (en) 1962-07-31

Family

ID=22019151

Family Applications (1)

Application Number Title Priority Date Filing Date
US58825A Expired - Lifetime US3046997A (en) 1960-09-27 1960-09-27 Selective alkaloid extraction

Country Status (6)

Country Link
US (1) US3046997A (da)
BR (1) BR6132953D0 (da)
CH (1) CH441091A (da)
DE (1) DE1517299A1 (da)
DK (1) DK112644B (da)
GB (1) GB934007A (da)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3139435A (en) * 1963-03-07 1964-06-30 Philip Morris Inc Process for selective extraction of alkaloid
US3390685A (en) * 1965-03-11 1968-07-02 Eresta Warenhandelsgmbh Process for extracting substances from plant particles
US3396735A (en) * 1965-04-15 1968-08-13 Eresta Warenhandelsgmbh Continuous process of removing nicotine from tobacco
US3404692A (en) * 1966-11-22 1968-10-08 Lampert Antal Cigarette substitute inhaler
US3612066A (en) * 1970-02-05 1971-10-12 Reynolds Tobacco Co R Denicotinizing process
US3880172A (en) * 1972-03-16 1975-04-29 Ici Ltd Smoking mixtures
US3894543A (en) * 1973-07-09 1975-07-15 Ici Ltd Smoking mixture
US4183364A (en) * 1976-12-07 1980-01-15 Gumushan Osman H Tobacco refining process
US4967771A (en) * 1988-12-07 1990-11-06 R. J. Reynolds Tobacco Company Process for extracting tobacco
US5005593A (en) * 1988-01-27 1991-04-09 R. J. Reynolds Tobacco Company Process for providing tobacco extracts
US5018540A (en) * 1986-12-29 1991-05-28 Philip Morris Incorporated Process for removal of basic materials
US5025812A (en) * 1989-08-10 1991-06-25 R. J. Reynolds Tobacco Company Tobacco processing
US5065775A (en) * 1990-02-23 1991-11-19 R. J. Reynolds Tobacco Company Tobacco processing
US5131414A (en) * 1990-02-23 1992-07-21 R. J. Reynolds Tobacco Company Tobacco processing
US5148819A (en) * 1991-08-15 1992-09-22 R. J. Reynolds Tobacco Company Process for extracting tobacco
US5234008A (en) * 1990-02-23 1993-08-10 R. J. Reynolds Tobacco Company Tobacco processing
US5497792A (en) * 1987-11-19 1996-03-12 Philip Morris Incorporated Process and apparatus for the semicontinuous extraction of nicotine from tobacco
US20080302377A1 (en) * 2007-06-05 2008-12-11 Michail Kassymovich Nauryzbaev Method for extraction of nicotine from tobacco raw material
US20120006341A1 (en) * 2008-10-22 2012-01-12 Gerald Schmekel Extractive Tobacco Material Extrusion
US10405571B2 (en) 2015-06-26 2019-09-10 Altria Client Services Llc Compositions and methods for producing tobacco plants and products having altered alkaloid levels

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US802487A (en) * 1903-12-28 1905-10-24 Karl Wimmer Treatment of tobacco for the removal of nicotin.
US1294310A (en) * 1918-05-16 1919-02-11 Ralph Sayre Method of removing nicotin from tobacco.
CH225351A (de) * 1942-01-07 1943-01-31 Bremer Cigarrenfabriken Vormal Verfahren zur Entnikotinierung von Tabak.
US2525785A (en) * 1949-12-05 1950-10-17 Feinstein Louis Process for extracting alkaloidals from plants with aqueous ammoniaethylene dichloride mixture
US2805667A (en) * 1953-09-17 1957-09-10 Martin Brinkmann K G Process for treating tobacco

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US802487A (en) * 1903-12-28 1905-10-24 Karl Wimmer Treatment of tobacco for the removal of nicotin.
US1294310A (en) * 1918-05-16 1919-02-11 Ralph Sayre Method of removing nicotin from tobacco.
CH225351A (de) * 1942-01-07 1943-01-31 Bremer Cigarrenfabriken Vormal Verfahren zur Entnikotinierung von Tabak.
US2525785A (en) * 1949-12-05 1950-10-17 Feinstein Louis Process for extracting alkaloidals from plants with aqueous ammoniaethylene dichloride mixture
US2805667A (en) * 1953-09-17 1957-09-10 Martin Brinkmann K G Process for treating tobacco

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3139435A (en) * 1963-03-07 1964-06-30 Philip Morris Inc Process for selective extraction of alkaloid
US3390685A (en) * 1965-03-11 1968-07-02 Eresta Warenhandelsgmbh Process for extracting substances from plant particles
US3396735A (en) * 1965-04-15 1968-08-13 Eresta Warenhandelsgmbh Continuous process of removing nicotine from tobacco
US3404692A (en) * 1966-11-22 1968-10-08 Lampert Antal Cigarette substitute inhaler
US3612066A (en) * 1970-02-05 1971-10-12 Reynolds Tobacco Co R Denicotinizing process
US3880172A (en) * 1972-03-16 1975-04-29 Ici Ltd Smoking mixtures
US3894543A (en) * 1973-07-09 1975-07-15 Ici Ltd Smoking mixture
US4183364A (en) * 1976-12-07 1980-01-15 Gumushan Osman H Tobacco refining process
US5018540A (en) * 1986-12-29 1991-05-28 Philip Morris Incorporated Process for removal of basic materials
US5497792A (en) * 1987-11-19 1996-03-12 Philip Morris Incorporated Process and apparatus for the semicontinuous extraction of nicotine from tobacco
US5005593A (en) * 1988-01-27 1991-04-09 R. J. Reynolds Tobacco Company Process for providing tobacco extracts
US4967771A (en) * 1988-12-07 1990-11-06 R. J. Reynolds Tobacco Company Process for extracting tobacco
US5025812A (en) * 1989-08-10 1991-06-25 R. J. Reynolds Tobacco Company Tobacco processing
US5065775A (en) * 1990-02-23 1991-11-19 R. J. Reynolds Tobacco Company Tobacco processing
US5234008A (en) * 1990-02-23 1993-08-10 R. J. Reynolds Tobacco Company Tobacco processing
US5131414A (en) * 1990-02-23 1992-07-21 R. J. Reynolds Tobacco Company Tobacco processing
US5148819A (en) * 1991-08-15 1992-09-22 R. J. Reynolds Tobacco Company Process for extracting tobacco
US20080302377A1 (en) * 2007-06-05 2008-12-11 Michail Kassymovich Nauryzbaev Method for extraction of nicotine from tobacco raw material
US9004074B2 (en) * 2007-06-05 2015-04-14 Al-Farabi Kazakh National University Method for extraction of nicotine from tobacco raw material
US20120006341A1 (en) * 2008-10-22 2012-01-12 Gerald Schmekel Extractive Tobacco Material Extrusion
US8931491B2 (en) * 2008-10-22 2015-01-13 British American Tobacco (Germany) Gmbh Extractive tobacco material extrusion
US9101164B2 (en) 2008-10-22 2015-08-11 British American Tobacco (Germany) Gmbh Extractive tobacco material extrusion
US10405571B2 (en) 2015-06-26 2019-09-10 Altria Client Services Llc Compositions and methods for producing tobacco plants and products having altered alkaloid levels
US12553058B2 (en) 2015-06-26 2026-02-17 Altria Client Services Llc Compositions and methods for producing tobacco plants and products having altered alkaloid levels

Also Published As

Publication number Publication date
DE1517299A1 (de) 1969-09-25
CH441091A (de) 1967-07-31
GB934007A (en) 1963-08-14
DK112644B (da) 1968-12-30
BR6132953D0 (pt) 1973-09-06

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