US3114369A - Disposable ampul - Google Patents

Disposable ampul Download PDF

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Publication number
US3114369A
US3114369A US128645A US12864561A US3114369A US 3114369 A US3114369 A US 3114369A US 128645 A US128645 A US 128645A US 12864561 A US12864561 A US 12864561A US 3114369 A US3114369 A US 3114369A
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United States
Prior art keywords
container
needle
spout
base portion
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US128645A
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English (en)
Inventor
Victor C Hall
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Merck and Co Inc
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Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to US128645A priority Critical patent/US3114369A/en
Priority to GB33029/61A priority patent/GB990473A/en
Priority to AT704261A priority patent/AT246636B/de
Priority to ES271070A priority patent/ES271070A1/es
Priority to FR873846A priority patent/FR1301571A/fr
Priority to DK377361AA priority patent/DK103686C/da
Priority to BE608465A priority patent/BE608465A/fr
Priority to CH1109561A priority patent/CH396321A/de
Application granted granted Critical
Publication of US3114369A publication Critical patent/US3114369A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting

Definitions

  • VICTOR C HALL Z-ZJZ NEY 3 SheetsSheet 2 FIG.
  • FIG. 1 A first figure.
  • This invention relates to squeezable containers for liquids, and also for liquid-like materials such as creams and ointments; in other words, to containers which discharge their contents when the container is squeezed.
  • the invention is concerned with providing an improved squeezable container for a small volume of material that is simple and easy to pick up and hold without discharging the contents of the container, and yet is simple and inexpensive in construction.
  • FIGURE 1 is an isometric View of a container embodying this invention, with a removable cap in position on the spout of the container so that together they form a package and sales unit for the material within the container;
  • FIGURE 2 is a plan view of the container as made by an injection molding machine
  • FIGURE 3 is a side elevation of the container of FIGURE 1, with parts in section, and showing diagrammatically one manner of removing the molding core;
  • FIGURE 4 is a sectional view along the line 44 of FIGURE 3;
  • FIGURE 5 is a side elevation of the container, as in FIGURE 3, showing one manner of closing the end of the container through which the molding core was removed;
  • FIGURE 6 is a view similar to FIGURE 1 showing a modified construction for the container at the end opposite the spout;
  • FIGURE 7 is a plan view of a container having a modified construction at the spout end, and showing a hypodermic needle mounted in the spout to produce a combination container and needle unit;
  • FIGURE 8 is an isometric view similar to FIGURES 1 and 6 showing another modified construction for a container embodying this invention, with a portion broken away to show a detail or" construction;
  • FIGURE 9 is a sectional view along the line 9 of FIGURE 8.
  • FIGURE 10 is a view similar to FIGURE 9 showing the position of the parts when the container is squeezed to discharge the contents thereof;
  • FIGURE 11 is vertical section along the line 1111 of FIGURE 8;
  • FIGURE 12 is a view similar to FIGURE 11 showing the position of the parts when the container is squeezed to discharge the contents thereof;
  • FIGURE 13 is a view similar to FIGURE 11 showing a modified construction for a combination container and needle unit;
  • FIGURE 14 is a View similar to FIGURE 13 showing an improved needle cover for the needle, the cover being in position to be moved to protect the needle;
  • FIGURE 15 is a view similar to FIGURE 14 showing the needle cover after it has been depressed to cause the base of the needle to puncture the end wall at the bottom of the needle recess, and after the outer end of the needle cover is broken off at its weakened area and removed, as diagrammatically show by the arrows;
  • FIGURE 16 is a view similar to FIGURE 15, showing, in addition, the outer end of the needle inserted through the stopper of a vial so that the flange of the needle cover engages the outer surface of the vial stopper, in
  • FIGURE 17 is a view similar to FIGURES 14 and 15 showing a modified construction for the needle unit, for the passageway connecting the cointainer portion with the needle recess, and for the needle cover.
  • the container generally designated 10 has a rectangular piece or base 11 which is flat or substantially flat. Positioned on top of rectangular base 11 is a thin-wall 12 which joins the rectangular base along the lines 13 and 14, which are parallel to, but spaced inward from, the long edges of the rectangular base.
  • the thin-wall is spaced from the rectangular base in-between lines 13 and 14, so that the thin wall 12 and the enclosed portion of the rectangular base 11 form the side walls of the container 10, which is roughly tubular in shape.
  • the thickness of the rectangular base 11 is considerably greater than the thickness of wall 12, being at least two times thicker, so that, while wall 12 is thin and readily deformable by pressure upon it, the rectangular base 11 is much less readily deformable and, by comparison with wall 12, is relatively stiff.
  • Rectanguar base 11 preferably has portions 15 and 16 which do not serve as a side wall of container 10 but extend laterally beyond the thin side wall 12 of the container. These serve as a ready means for picking up the container Without squeezing the thin side wall 12.
  • the container 111 has a discharge spout 17 the base of which closes the space between the thin wall 12 and the rectangular base 11 at one end of the rectangular base.
  • the wall Spout is thicker than the thin Wall 12 in order to impart some rigidity to the spout, but need not be as thick as the rectangular base 11.
  • the spout 17 may be tapered, as shown in FIGURE 1, and a cap 18 with a tapered interior may be fitted over the end of the spout 17, and retained in place by frictional engagement.
  • the thin wall 12 engages the rectangular base 11 along the line 19, between the ends of the junction lines 13 and 14.
  • the material of which the container 10 is made is a plastic or other suitable material which may be used in standard injection molding, casting or forming equipment to produce a flexible container. This material at normal room temperature must be readily deformable when in the thickness used for the thin wall 12.
  • An example of such a plastic is polyethylene. Plastics of the polyethylene group or vinyl group are particularly suitable.
  • the size of the container 10 is variable, but this invention is of particular value when the container is small, for such a container may be picked up and handled by grasping the projections 15 and 16 between the thumb and forefinger without squeezing out the contents of the container.
  • Illustrative of what is meant by small is a container holding a medicament such as a liquid, cream or ointment which is to be applied in small quantities, such as drop by drop, and whose total capacity is 5 cc. or less.
  • the necessary labeling for the contents of the con tainer 161 may be readily applied to the rectangular base 11 on the side thereof opposite to that which cooperates with the thin wall 12 to form the container.
  • This flat rectangular surface greatly facilitates the labeling of the container, particularly for small containers.
  • FIGURES 2, 3, 4 and 5 A method of making this container 10 is shown in FIGURES 2, 3, 4 and 5.
  • the container is preferably formed in one piece at one time in an injection molding apparatus, the form of the container as produced by such apparatus being shown in FIGURES 2, 3 and 4.
  • FIGURES 2, 3 and 4 A method of making this container 10 is shown in FIGURES 2, 3, 4 and 5.
  • the container is open at the end opposite the spout I7, as indicated by the reference number 2% in FIGURE 3, and through this opennig 29 the interior die 21 may be withdrawn at the end of the molding operation.
  • the opening 26 is then closed by pressing the adjacent end of the thin wall 12 down against the rectangular base 11 and sealing the thin wall 12 to the rectangular base Ill along the line 19, by the application of heat and pressure, as indicated in FIGURE 5 by the Outline 22 of the end of a sealing iron.
  • the container may be filled in a variety of Ways.
  • One way is to place a number of these containers in a closed chamber with each container having its spout fitted over a hollow pin.
  • the base of these pins con1- municates with the medicament or other liquid or 11' uidlilre material to be put into the containers.
  • the entire assembly is placed under vacuum in the closed chamber, which thereupon removes the air from inside each container 16, by sucking it out through the spout 17 and through the medicament to the exhaust pump. When the air is removed, the vacuum is released, and the pressure difierential forces the medicament into the container 10.
  • Each container 10 is then removed from its pins and the tight fitting cap 18 placed over the end of the spout 17 of the container.
  • Another method of filling the containers 10 is to fill them through their openings 2%, preferably by automatic filling equipment, the spouts 1'7 having previously been fitted with their caps 18.
  • the filled containers then have their openings 29 closed and sealed, preferably by the application of heat and pressure, to seal the thin wall 12 of each container to its rectangular base 11.
  • the modified container 10a shown in FIGURE 6 is similar to container 10 shown in FIGURE 1, except that the base 111: is formed with its end area 31a (at its end opposite spout 17a) thinner than the thickness of base Ila throughout the remainder of its area. This is preferably achieved by maintaining the upper surface 321: of the area 31a flush with the upper surface 33a of the remainder of base Ila, and by displacing the undersurface 34a of the area 310 upwardly from the plane of the lower surface 35a of the remainder of the base 11a.
  • the thickness of the end area 31a is made less than that of the remainder of the base Illa to facilitate the sealing of the end of the thin wall 12a to the base Illa, along the line 19a, by automatic sealing apparatus that grips the parts between two heated members.
  • the flattened end of the thin wall 12a extends frontward of the line 13a (as the container is shown in FIGURE 6) so that the seal of the thin wall 12a to the sealing area 32a of base Ila along line 1% extends onto the projection 15a.
  • the seal also extends onto the projection 16a at the back of the container (as the container is shown in FIG- URE 6).
  • the body of the container 10b is similar to the body of container 10a of FIGURE 6, except that the spout 17b is not tapered, but is of uniform inside diameter along its axis, thus forming a cylindrical opening 36b.
  • the end wall 37b at the base of the spout (by which the spout connects with base 115 and thin wall 121)) also extends over the entire area of the spout opening 3dr). As a consequence, the contents of container 10b cannot pass out into spout 1% until the end wall 371) opposite spout opening 36b is punctured.
  • a hypodermic needle 38b Inserted in the cylindrical spout opening 36b is the base of a hypodermic needle 38b.
  • the base end of this needle extends through a metallic needle cylinder 40b to which the needle is secured, and this needle cylinder 40b fits snugly into the cylindrical opening 361; of container 19!).
  • a portion of the base end of the needle 38!) extends inwardly beyond the needle cylinder 4%, as shown at 41b in FIGURE 7, but this base end 41b of the needle does not extend through the end wall 377) at any time until the contents of the container unit 19/) are to be injected into a patient.
  • the doctor or nurse pushes the needle inwardly so that the base end 41b of the needle punctures the end wall 37b of the containcr 10b.
  • the container and needle unit may then be grasped by the projections 15b and 16b and the needle inserted into the patient without squeezing out the contents of the container, after which the thin wall portion 12b and the base ill! of the container are squeezed between the thumb and forefinger to eject the contents of the container 10!) through the needle 33! into the patient.
  • a suitable cylindrical protective cover (not shown) is applied over the needle and frictionally held in the open end of spout 17b. This is removed by the doctor or nurse at the time the unit is to be used, after it has been used to push this needle cylinder 4% inwardly and so puncture the end wall 371) of the container 10!).
  • Illustrative of the dimensions of a container embodying this invention is a container conforming to that shown in FIGURE 6 wholly made of polyethylene thermoplastic resin by injection molding equipment, where the thin wall 12:: is 0.015 inch thick, the base 10:: is 0.075 inch thick, l inch wide and 1 /2 inches long on its upper side, the sealing area 31a of the base 10a is 0.025 incn thick and recessed A inch from the end of the base, the exterior height of thin wall 12a above base 10a at the spout end is Mr inch, and the exterior width of thin wall 12!: at the spout end, next to base 10a, is /2 inch.
  • FIGURES 8l2 With the modified container shown in FIGURES 8l2, (in which parts corresponding to those described in FIGURES 1-7 bear the same numbers with the addition of one hundred thereto), a complete discharge of the contents of the container is obtained more readily than in the constructions shown in FIGURES 1-7.
  • the thin, deformable wall IE2 is flatter than a semi-circle, the arcuate portion 123 having a center well below the substantially rectangular, non-deformable base 111. This arcuate portion subtends less than 180 degrees of an arc and prefcrably subtcnds from 90 degrees to 150 degrees of an arc.
  • the ends of the arcuate portion are joined to the base 111 by substantially straight portions 124- and 125, each inwardly directed in relation to the arcuate portion 123 and of relatively short length in comparison to the length of the arcuate portion 123 (preferably less than one-fifth that length).
  • Straight portion 124 of wall 112 intersects the plane of base 111 to form an acute angle between the straight portion 124 and the outwardly projecting portion 115 of base 111, this angle preferably being from 30 degrees to 45 degrees.
  • straight portion of wall 112 intersects the plane of base 111 to form a similar acute angle between the straight portion 125 and the outwardly projecting portion 116 of base 111.
  • the arcuate portion 123 of the wall 112 collapses so that there is very little, if any, space left between the interior of the arcuate portion 123 and the opposite portion 133 of the base 111, as shown in FIGURE 10.
  • the discharge spout 117 of the modified container 110 has a substantially cylindrical exterior surface with a substantially cylindrical opening 136, as shown in FIGURE 11.
  • the thickness of the spout wall 126 is thinner than the deformable wall 112 but preferably not as thick as the major part of base 111, between surfaces 133 and 135.
  • the base of the cylindrical spout opening 136 is removed a substantial distance from the interior of the container 110, the distance therebetween being filled by a substantially solid piece of plastic 127 having an elongated passageway I28 therein, which provides the cornmunication from the container 110 to the opening 136 of the spout 117.
  • the container end 129 of the solid plastic portion 127 is slanted from the nozzle end of the container, at the point furthest from upper surface 133 of base 111, downwardly, and inwardly into the container, as shown in FIG- URE 11. Consequently, when the deformable thin wall 112 of the container is compressed, as shown in FIGURE 12, to discharge the contents of the container out of the spout 117, the part of this wall at the spout end of the container collapses against the wall end 129 of the plastic portion 127, so that there is very little, if any, open space at the spout end of the container.
  • the modified container 118 of FIGURES 8-l2 can be readily adapted for use with a hypodermic needle, in the manner shown in FIGURE 13.
  • the cylindrical spout opening 136 has inserted therein a needle unit consisting of a hypodermic needle 13% to which is tightly fitted a metallic needle cylinder 149.
  • the needle cylinder fits snugly into the spout opening 136, with a portion of the base end of the needle extending inwardly beyond the needle cylinder 140, as shown at 141 in FIGURE 13.
  • the passageway 128 between the interior of the container 111) and the base of the opening 136 has an end wall 137 closing this passageway at the base of the opening 136, so that the contents of the container are not dischargeable until that end wall 137 is punctured.
  • the base end 141 of the needle 138 punctures the end wall 137, thereby readying the combination container and hypodermic needle unit for use in discharging the contents of the container through the needle.
  • FIGURES 14, 15 and 16 show the combination container and hypodermic needle unit of FIGURE 13 in use with an improved needle cover, generally designated 145.
  • the cover consists of a long plastic tube 146 the outside diameter of which is such that it just fits inside the cylindrical opening 136 of spout 117.
  • the inside of the tube 146 is large enough to accommodate the needle 138 as the tube is slid down over the needle, as shown in FIG- URE 15.
  • the top end of the needle cover 145 is a solid plastic cylinder 147.
  • the needle cover 145 is inserted over the needle and slid into the opening 136 surhciently to secure the cover to the unit, but not so far as to cause the base of the needle to puncture the wall 137.
  • the tubular portion 146 of the needle cover 145 has a flange 148 positioned thereon a short distance 149 below the end of the needle 138 when the parts are in the position shown in FIGURE 15.
  • This tubular portion 146 is scored or otherwise weakened at the top surface or" the flange 148 (this scoring being depicted by the reduced diameter area 149 in FIGURE 14), so that the outer portion of the needle cover may readily be broken off at the top surface of flange 148 and removed (as shown in FIGURE 15). This will leave the end of needle 138 projecting above the top of flange 148, the amount of that projection being distance 149.
  • flange 145 The function of flange 145 is illustrated in FIGURE 16.
  • the end of needle 138 that projects above the top of flange 148 has been inserted through the center puncturable area 152 of stopper 15% which closes a vial 151 containing a medicament.
  • the contents of the container 110 are then discharged into the vial 151 by squeezing the wall 112 against the base 111, and the mixture shaken up 152 of the stopper.
  • FIGURE 17 shows a further modified construction for the combination container and needle unit, with a modified construction for the needle cover as well.
  • Parts which are the same as in the constructions shown in FIGURES 13, 14, 15 and 16 are designated with the same numbers; parts which are somewhat similar but not identical are designated with numbers which are onehundred larger than they are in FIGURES 13-16.
  • the solid plastic portion 227 positioned between the container 111 and the spout 117 has, instead of the relatively large diameter passageway 128 shown in FIG- URES 11, l2, 13, 14, 15 and 16, a passageway 228 of very small diameter, meaning a diameter about the diameter of the end 241 of the needle 238.
  • This passageway 228, being long, small, and capillary like, and eing in a transparent, or at least translucent, block of plastic, produces, when so filled by such withdrawn fluid, a readily visible indication to the doctor of the location of the end of the needle.
  • the base end 241 of the needle is accurately directed to puncture the wall 237 which closes the passageway 228 at the spout end of the passageway.
  • This supplemental needle cylinder 253 has a diameter smaller than that of cylinder 24%.
  • the inside diameter of the lower end of the tube portion 246 of. needle cap 2 .5 is about the same as the outside diameter of the supplemental needle cylinder 253, thereby providing a recess 254 in such needle cap that fits over this supplemental needle cylinder.
  • the needle cap 245 is similar to the needle cap 455 of FIGURES 14, 15 and 16.
  • the squeezable container of this invention is simple in construction, inexpensive to make, and effective in use, particularly when the container is small. It is also evident that the container is readily adaptable to serving as part of a container and needle unit, and that such a unit, as shown and described, has several valuable features.
  • a squeezable container of relatively small size for use between the thumb and forefinger of the hand having a relatively non-deformable base portion, a deformable wall portion and a relatively non-deformable spout portion, characterized by the fact that the design and construction of the parts are such as to enable the container to be made readily and inexpensively in an injection molding apparatus with all portions made of thermoplastic material and, excepting only the rear end area opposite the spout portion, made so that all portions are integral at their junctions with the adjacent portions of the container, the deformable wall portion and the nondeformable base portion at the rear end area being made with an opening therebetween for the withdrawal of the interior forming die, after which the opening is closed by thermoplastically sealing the rear end of the deformable wall portion to the rear end of the relatively nondeformable base portion, said design and construction including; a generally rectangular, substantially fiat shape for the base portion with one of the two short sides of the rectangle positioned at the spout end of the container and the other short side
  • a squcezable container as described in claim 1 in which the rear end of the base portion is substantially thinner, for a relatively short distance forwardly of the short side at that end, than the thickness of the remainder of the base portion, so as to facilitate the heat sealing of the rear end of the deformable wall portion with the rear end of the base portion.
  • a squcezable container as described in claim 1 in Which the bowed-out shape for the deformable Wall portion, in cross-section transverse to the long sides of the rectangular base pontion, is arcuate, with its center below the base portion, with the arc subtending an are be ween 180 degrees and degrees, and with the ends of the arcuate portion joined to the base portion by relatively short, substantially straight wall portions that intersect the plane of the upper surface of the base portion at acute angles, one on each of the long sides of the container with the open sides of these angles facing cxtel'iorly f the container, and with these angles being less than about 5 degrees, so that, when the deformable wall portion is squeezed toward the base portion to discharge the contents of the container, the deformable wall portion may readily be pushed into engagement with the surfaces beneath it through substantially the width of the container to minimize the amount of material left within the container.
  • a squeezable container as described in claim 3 in which the inner surface of the spout end of the container, starting at the junction of the spout portion with the deformable wall portion, is sloped at an angle downwardly and inwardly to the base portion so that the deformable wall portion, when squeezed to discharge the contents of the container, may readily be pushed substantially into engagement with this inclined inner stirface of the spout portion to minimize the amount of material left within the container, the communication between the interior of the container and the spout discharge opening being by way of a relatively long passageway within the resulting solid thermoplastic block between the interior of the container and the discharge opening of the spout.
  • the discharge spout portion includes a tube-like spout with a substantially uniform inside diameter to form a cylindrical. discharge spout opening the axis of which is parallel to the long sides of the b so portion of the container and also includes a puncturable wall at the base of such opening closing the passageway between the interior of the container and such spout opening, and in which a hypodermic needle is mounted in such spout opening so that the end of the needle for injection into the patient projects outwardly from the front end of the discharge spout portion, said needle having a metallic needle cylinder tightly fitted thereon around the exterior of the needle near the base end thereof, and the exterior of said needle cylinder fitting snugly into the cylindrical opening of the discharge spout portion, but eing movable axially toward the base of such opening by the application of force to the forwardly facing end of the needle cylinder, such movement causing the base end of the needle to puncture the puncturable wall at the base of the sp
  • a combination container and needle unit as described in claim 5 in which the inner surface of the spout end of the container, starting at the junction of the spout portion with the deformable wall portion, is sloped at an angle downwardly and inwardly to the base portion so that the deformable wall portion, when squeezed to discharge the contents of the container, may readily be pushed substantially into engagement with this inclined inner surface of the spout portion to minimize the amount aliases of material left Within the container, the combination between the interior of the container and the base of the nozzle discharge opening being by way of a relatively long passageway Within the resulting solid thermoplastic block between the interior of the container and the base of the cylindrical discharge spout opening of the spout portion, with the thermoplastic material of which the various parts of the squeezable container are made being.
  • the combination container and needle unit after injection of the needle into the patient to be treated with the contents of the container and before the contents are discharged into such person, may be used to withdraw a small amount of the body fluid of the patient, sufiicient to fill the needle and the long passageway, whereupon the character of the body fluid so withdrawn is readily visible in said long passageway without withdrawing a large amount of body fiuid.
  • a combination container and needle unit as described in claim 6 in which the hypodermic needle has a supplemental needle cylinder surrounding the needle at the front end of the primary needle cylinder and secured to said needle, with the diameter of said supplementary needle cylinder smaller than the diameter of the primary needle cylinder, and in which said unit includes a needle cover in the form of a cylinder having an axial recess the inside diameter of which is only slightly larger than the outside diameter of the needle, and having the outside diameter of the needle cover about equal to the inside diameter of the cylindrical opening of the spout portion of the container so that the container end of the needle cover slidably fits in said cylindrical opening, the needle cover also having an axial recess enlarged at its container end so that the inside diameter of the enlarged recess is about equal to the outside diameter of the supplemental needle cylinder, with the result that the needle cover prevents the needle from cocking as the needle cover is pushed axially toward the container to cause the base end of the needle to puncture the puncturable wall at the base of the cylindrical opening of the discharge
  • a combination container and needle unit as described in claim 5 in which said unit includes a needle cover in the form of a cylindrical tube with a closed outer end, the outside diameter of the cylindrical tube being about equal to the inside diameter of the cylindrical opening of the spout portion of the container so that the container end of the needle cover sliuably fits in said cylindrical opening, said needle cover having a flange thereon projecting radially outward from the cylindrical tube and forming, for the part of the flange furthest from the container end of the needle cover, a shoulder in a plane perpendicular to the axis of the cylindrical tube, such shoulder being at such a distance from the container end of the eedle cover that the plane of such shoulder intersects the needle a short distance below the outer end thereof when the container end of the needle cover abuts against the needle cylinder, said cylindrical tube having its area just above such shoulder scored circumferentially so that the portion of the cylindrical tube beyond the flange may be broken ofi and removed while the remainder of the needle cover is left in place, [

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Closures For Containers (AREA)
US128645A 1960-09-23 1961-08-10 Disposable ampul Expired - Lifetime US3114369A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US128645A US3114369A (en) 1961-08-10 1961-08-10 Disposable ampul
GB33029/61A GB990473A (en) 1960-09-23 1961-09-14 Squeezable containers
AT704261A AT246636B (de) 1961-08-10 1961-09-16 Quetschbarer Behälter
ES271070A ES271070A1 (es) 1960-09-23 1961-09-18 Perfeccionamientos en recipientes comprimibles
FR873846A FR1301571A (fr) 1960-09-23 1961-09-21 Récipients compressibles pour liquides, crèmes et pommades
DK377361AA DK103686C (da) 1960-09-23 1961-09-22 Sammentrykkelig beholder af forholdsvis ringe størrelse, især til indsprøjtning, dosering og lignende formål.
BE608465A BE608465A (fr) 1960-09-23 1961-09-22 Récipients
CH1109561A CH396321A (de) 1960-09-23 1961-09-25 Zwischen dem Daumen und einem anderen Finger zusammendrückbarer Kleinbehälter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US128645A US3114369A (en) 1961-08-10 1961-08-10 Disposable ampul

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368969A1 (fr) * 1972-09-29 1978-05-26 Eck William Van Seringue hypodermique
US4475906A (en) * 1982-09-13 1984-10-09 Holzner Guenter Partially flexible injection syringe device with pressure release valve or special breakable seal
US4581021A (en) * 1985-01-28 1986-04-08 Ergomed Squeeze-actuated syringe
US4692157A (en) * 1985-01-28 1987-09-08 Ergomed Squeeze-actuated syringe with position-selectable lock
US5035689A (en) * 1989-03-13 1991-07-30 Schroeder Thomas J Luer-loc-tipped vial--syringe combination
US5409125A (en) * 1989-12-11 1995-04-25 Aktiebolaget Astra Unit dose container
US5810783A (en) * 1993-11-17 1998-09-22 Claro; Jorge Antonio Rodrigues Medication injector
WO2001000134A1 (en) * 1999-06-23 2001-01-04 Eu Pharma Ltd. Oral medicine dispenser
US6605064B2 (en) 2000-09-15 2003-08-12 Thomas Hatch Single-use syringe
WO2006125747A1 (de) * 2005-05-24 2006-11-30 Vifor (International) Ag Behälter mit hohlnadel
US20120024905A1 (en) * 2010-07-31 2012-02-02 Roland Kneer Single-use applicator
EP2537772A1 (de) 2011-06-21 2012-12-26 Weibel CDS AG Vorrichtung zur Aufnahme und Abgabe eines Fluids
US20180312309A1 (en) * 2017-04-26 2018-11-01 The Hartz Mountain Corporation Applicator with Breakaway Cap
US20190117917A1 (en) * 2016-05-25 2019-04-25 Claudia Mattern Two-part plastic blank set

Citations (10)

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Publication number Priority date Publication date Assignee Title
US1065256A (en) * 1911-07-12 1913-06-17 Hattie Cheesman La Mar Fountain tooth-brush.
US2552100A (en) * 1948-04-06 1951-05-08 Leonetti Francois Combined ampoule and injection syringe
US2676591A (en) * 1951-03-27 1954-04-27 Fox Dorothy Brown Hypodermic unit
US2693183A (en) * 1951-10-10 1954-11-02 Compule Corp Hypodermic syringe blood telltale
US2724383A (en) * 1951-06-28 1955-11-22 Compule Corp Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations
US2771879A (en) * 1954-09-09 1956-11-27 Jr Alvin B Salisbury Disposable syringe
US2805662A (en) * 1955-02-16 1957-09-10 Becton Dickinson Co Syringe assembly
US2841143A (en) * 1956-01-17 1958-07-01 Penicillin Ges Dauelsberg & Co Injection device for liquids and ampoule therefor
FR1207205A (fr) * 1958-10-10 1960-02-15 Brosse à dents comportant un réservoir à pâte dentifrice
CA593504A (en) * 1960-03-01 H. Hassler Weddie Paste dispenser

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA593504A (en) * 1960-03-01 H. Hassler Weddie Paste dispenser
US1065256A (en) * 1911-07-12 1913-06-17 Hattie Cheesman La Mar Fountain tooth-brush.
US2552100A (en) * 1948-04-06 1951-05-08 Leonetti Francois Combined ampoule and injection syringe
US2676591A (en) * 1951-03-27 1954-04-27 Fox Dorothy Brown Hypodermic unit
US2724383A (en) * 1951-06-28 1955-11-22 Compule Corp Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations
US2693183A (en) * 1951-10-10 1954-11-02 Compule Corp Hypodermic syringe blood telltale
US2771879A (en) * 1954-09-09 1956-11-27 Jr Alvin B Salisbury Disposable syringe
US2805662A (en) * 1955-02-16 1957-09-10 Becton Dickinson Co Syringe assembly
US2841143A (en) * 1956-01-17 1958-07-01 Penicillin Ges Dauelsberg & Co Injection device for liquids and ampoule therefor
FR1207205A (fr) * 1958-10-10 1960-02-15 Brosse à dents comportant un réservoir à pâte dentifrice

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368969A1 (fr) * 1972-09-29 1978-05-26 Eck William Van Seringue hypodermique
US4475906A (en) * 1982-09-13 1984-10-09 Holzner Guenter Partially flexible injection syringe device with pressure release valve or special breakable seal
US4581021A (en) * 1985-01-28 1986-04-08 Ergomed Squeeze-actuated syringe
US4692157A (en) * 1985-01-28 1987-09-08 Ergomed Squeeze-actuated syringe with position-selectable lock
US5035689A (en) * 1989-03-13 1991-07-30 Schroeder Thomas J Luer-loc-tipped vial--syringe combination
US5409125A (en) * 1989-12-11 1995-04-25 Aktiebolaget Astra Unit dose container
US5810783A (en) * 1993-11-17 1998-09-22 Claro; Jorge Antonio Rodrigues Medication injector
WO2001000134A1 (en) * 1999-06-23 2001-01-04 Eu Pharma Ltd. Oral medicine dispenser
AU764881B2 (en) * 1999-06-23 2003-09-04 Eu Pharma Ltd. Oral medicine dispenser
US6605064B2 (en) 2000-09-15 2003-08-12 Thomas Hatch Single-use syringe
WO2002022191A3 (en) * 2000-09-15 2003-09-25 Thomas Hatch Single-use syringe
US6645180B1 (en) 2000-09-15 2003-11-11 Thomas Hatch Single-use syringe
RU2385707C2 (ru) * 2005-05-24 2010-04-10 Вифор (Интернациональ) Аг Контейнер с полой иглой
US20080200886A1 (en) * 2005-05-24 2008-08-21 Vifor (International) Ag Container with Hollow Needle
WO2006125747A1 (de) * 2005-05-24 2006-11-30 Vifor (International) Ag Behälter mit hohlnadel
AU2006251186B2 (en) * 2005-05-24 2012-01-19 Vifor (International) Ag Container with a hollow needle
US8721613B2 (en) 2005-05-24 2014-05-13 Vifor (International) Ag Container with hollow needle
RU2495681C2 (ru) * 2010-07-31 2013-10-20 Гапласт Гмбх Одноразовый аппликатор
CN103096863A (zh) * 2010-07-31 2013-05-08 盖普拉斯特有限公司 一次性敷料器
WO2012016553A3 (de) * 2010-07-31 2012-04-05 Gaplast Gmbh Einmal-applikator
US8690013B2 (en) * 2010-07-31 2014-04-08 Gaplast Gmbh Single-use applicator
US20120024905A1 (en) * 2010-07-31 2012-02-02 Roland Kneer Single-use applicator
CN103096863B (zh) * 2010-07-31 2015-01-21 盖普拉斯特有限公司 一次性敷料器
EP2537772A1 (de) 2011-06-21 2012-12-26 Weibel CDS AG Vorrichtung zur Aufnahme und Abgabe eines Fluids
WO2012175465A1 (de) 2011-06-21 2012-12-27 Weibel Cds Ag Vorrichtung zur aufnahme und abgabe eines fluids
US9650187B2 (en) 2011-06-21 2017-05-16 Weibel Cds Ag Device for receiving and dispensing a fluid
US20190117917A1 (en) * 2016-05-25 2019-04-25 Claudia Mattern Two-part plastic blank set
US20180312309A1 (en) * 2017-04-26 2018-11-01 The Hartz Mountain Corporation Applicator with Breakaway Cap
US10179678B2 (en) * 2017-04-26 2019-01-15 The Hartz Mountain Corporation Applicator with breakaway cap

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