US3118439A - Diagnostic and medicating capsule and the method of use - Google Patents

Diagnostic and medicating capsule and the method of use Download PDF

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Publication number
US3118439A
US3118439A US722514A US72251458A US3118439A US 3118439 A US3118439 A US 3118439A US 722514 A US722514 A US 722514A US 72251458 A US72251458 A US 72251458A US 3118439 A US3118439 A US 3118439A
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capsule
parts
chamber
high frequency
action
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US722514A
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English (en)
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Perrenoud Jean-Pierre
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0001—Means for transferring electromagnetic energy to implants

Definitions

  • the first problem consists in taking at a predetermined place of the alimentary canal a sample of liquid for purpose of analysis. Such an operation is useful, either for diagnosing a disease or, more generally, for better knowing the digestive process. Moreover, taking of samples may promote the scientific researches in parasitolog bacteriology and enzymology.
  • T he second problem consists in introducing a substance into a predetermined place of the alimentary canal.
  • This substance may be a medicament adapted to cure a given disease or any other substance the action of which at a predetermined level of the alimentary canal should be known.
  • the invention relates to a capsule consisting of two hollow parts provided with openings and susceptible of being moved with respect to each other, these openings being initially not in register, a block of metal, a spring tending to move the parts with respect to each other and a retaining means including a metallic element with a low melting point, neutralizing the action of the spring means, the whole being arranged in such a manner that when the capsule is placed into a high frequency electromagnetic field, the metallic block is heated and causes the said element with a low melting point to melt, so that the spring means is free to act for moving one of the parts of the capsule with respect to the other in order to bring, at least temporarily, the openings of both parts in register and thus to put in communication the interior of the capsule with the environment.
  • the invention also relates to the use of the said capsule,
  • the capsule in which the capsule is swallowed by a human being, the position of the capsule is ascertained in the alimentary canal by radioscopy, and a hi h frequency electromagnetic field is generated in the vicinity of the capsule when the latter is in the desired position, so as to cause the capsule to open and thus to put in communication, at least temporarily, the interior of the capsule with the environment.
  • FIG. 1 is an axial section of the first embodiment.
  • FIGS. 2 and 3 are similar sections of the same capsule, but in two different working positions.
  • PEG. 4 is a section taken along the line IVIV of FIG. 1.
  • PEG. 5 illustrates a detail of the pastille.
  • PEG. 6 is an elevation View, partially in section, of a fragment of a modified embodiment.
  • FIG. 7 is an axial section of another embodiment.
  • the capsule illustrated in FIGS. 1 to 5 consists of two hollow parts 1 and 2 capable of sliding on each other and enclosing the several members of the capsule,
  • the part ll will be called hereinafter the lower part and the part 2 the cap.
  • Both parts 1 and 2 are made of a material resisting the action of chemicals, for instance of a plastic material such as Teflon (registered trademark).
  • the lower part It has two lateral windows 3 of rectangular shape, and the cap 2 is provided with two windows 4-, which are also of rectangular shape.
  • a block 5 made of such a metal (for instance steel) that it is easily heated when it is placed in a high frequency electromagnetic field.
  • the block 5 has on its outer face ribs 6. It has in addition a conical bore 7 followed by a cylindrical bore 3, connected with the bore 7 by means of a shoulder 9.
  • a stop member ltl provided with a central hole lit and having on its upper face a plurality of ribs 12 on which rests a washer 13 of plastic material (for instance of Teflon).
  • a metal sleeve 24 On the washer l3 rests a metal sleeve 24 on the upper face of which bears one end of a coil spring 15 the other end of which bears against the bottom of the cap 2.
  • Cut-out portions 16 are provided in the sleeve 14, facing the windows 3 of the lower part 1.
  • the packing 29 is of the type commonly called O-ring and is intended to serve as a brake when it moves in the conical bore 7 of the block 5, as described later. It is made for instance of rubber or of plastic material.
  • Below the shoulder 19 the rod 17 has an annular groove 21 in which is accommodated a pastille 22 made of a metal or alloy with a low melting point.
  • the pastille 22 may be made, for instance, of so-called Woods metal, melting at about 70 C., or of another alloy.
  • a fixing member 24 which secures the cap 2 to the rod 17 by means of a lock nut 25.
  • the capsule When the capsule is assembl d as shown in PEG. 1, it is swallowed by the patient, for instance during a meal. its position in the alimentary canal is ascertained by radioscopy and thus the moment at which the capsule should be released can be chosen at will.
  • Releasing of the capsule is effected as follows: Th patient is isolated from earth by the fact that he is placed on a glass stool or the like, and is then surrounded by a copper cable with an insulating sheath. The ends of this cable and a point situated at about one third of its length are connected to a high frequency generator (about 2 megacycles) having a power of 1 kw.
  • the copper cable acts as a coil in which flows a very strong high frequency current, which results in heating the block 5 of the capsule by induction.
  • the temperature of the b cl reaches the melting point of the pastille 22, the later melts, which releases the longitudinal movement of the capsule parts. Indeed, as long as the pastille Z2 is intact (FIG.
  • the dimensions of the different parts of the capsule are chosen in such a manner that tie windows 3 and 4 of the lower part 1 and the cap 2 respectively are in register with one another at the moment when the expanding movement of the capsule is braked by the passage of the packing 20 in the upper portion of the conical bore 7 (FIG. 2). Due to this fact, the chamber of the capsule, situated above the washer 13, is put in communication with the environment during a time sufficient to allow the liquid situated in this environment (for instance the small intestine) to enter the said chamber. Upon expansion of the capsule, a vacuum takes place inside the capsule chamber, owing to the increase of volume. This vacuum can be increased by reducing the volume of the initial cavity of the cap 2, for instance by extending downwards the fixing member 24.
  • the capsule then acts as a means for transporting the liquid taken which is isolated from the environment by tight closing means.
  • the capsule is found again in the stools and is then opened for extracting therefrom the contents to be analysed.
  • the outer cylindrical surface of the lower part 1 may be smeared with a silicone-containing pomade.
  • the capsule may be entirely coated with a thin layer of a material easily soluble in the saliva or the (gastric juice, such as for instance gum-arabic.
  • the capsule has a very small volume (FIG. 1). It has for instance a length of 24 mm. and a diamthe eter of 3 mm. When the capsule is in the stomach or intestine, it can somewhat expand without incomthe patient.
  • the quantity of liquid taken by n. of this capsule is about (325-41030 cmfi, which is absolutely sutlicient for analysis purposes. l loreover, the test can be repeated at near intervals without any ditllulty.
  • the ribs 12 of the stop member 10 prevent, in connection with the washer 13 of plastic material, the heat transmission from the block 5 to the liquid contained in the capsule chamber.
  • the washer 13 also has the function of sealing the joint between the said chamber and the portion of the lower part 1 which contains the block 5.
  • additional windows are provided in the wall of the lower part l, in order to accelerate cooling of the block 5 after rele sing of the capsule.
  • the capsule initially closed, is temporarily opened for putting its interior in communication with the environment, and is then again closed hermetically.
  • the capsule is then opened and remains in this condition, in order to allow a substance contained in the capsule to flow out of the capsule and to act at the desired place of the alimentary canal.
  • the substance referred to may be a medicament or any other substance the specific action of which at a predetermined place of the alimentary canal should be known.
  • the capsule shown in FIG. 7 is similar to that of the first embodiment, except that the body 5 has a single cylindrical bore 29 in which is arranged a packing 30 of rectangular section. Therefore, when the pastille 22 melts, the rod 17 is no longer retained and the spring 15 moves upwards the cap 2 with respect to the lower part 1. This movement now takes place freely, without braking action, and is merely damped at its end when the shoulder 19 of the rod 17 strikes against the packing 30. At this moment, the windows 4 of the cap 2 are in register with the windows 3 of the lower part 1, and the substance contained in the capsule chamber can flow out of the capsule. This evacuation is facilitated by the stirring movement which normally takes place in the ambient liquid.
  • the capsule instead of being formed of two parts telescopically arranged on each other, the capsule might also include two arts susceptible of rotating with respect to each other. in this case, no variation of volume of the capsule would occur at the moment of releasing of the capsule.
  • a method of taking a sample of liquid from the alimentary canal comprising the steps of swallowing a cupsule provided with closing means which open temporarily when heated by a high frequency electromagnetic field, locating the desired position of the capsule in the alimentary canal by radioscopy, generating a high frequency electromagnetic field in the vicinity of the capsule when said capsule has reached the desired position, and using the high frequency field to produce heat to open said closing means and to put the interior of the capsule temporarily in communication with the environment so that liquid may be entrapped within the capsule thereafter the closing means being automatically actuated to retain said liquid Within the capsule.
  • a method of introducing substance into the alimentary canal comprising the steps of swallowing a capsule containing a substance therein, the capsule provided with closing means which open when heated by a high frequency electromagnetic field, locating the desired position of the capsule in the alimentary canal by radioscopy, generating a high frequency electromagnetic field in the vicinity of the capsule when said capsule has reached the desired position, and using the high frequency field to produce heat to open said closing means and to put the interior of the capsule in communication with the environment, so that said substance can fiow out of the capsule into the alimentary canal.
  • a swallowable capsule comprising a pair of hollow parts complementing each other to define a chamber, one of the parts slideable over the other part to vary the size of the chamber, at least one of the parts having an opening on the sidewall thereof so positioned that as the parts are separated the opening provides fiuid communication means between the interior and the exterior of the chamber, spring means tending to separate the parts, heat responsive means normally effective to render the spring means ineffective, and means adapted to be heated under the action of a high frequency field, said last-mentioned means positioned in juxtaposition to the heat responsive means so as to transfer heat thereto, whereby under the action of the high frequency field the Spring means is released to move the hollow parts so that the openings therein are in registration.
  • a capsule adapted to be swallowed comprising a pair of generally cup-shaped members adapted to be nested together with their closed ends defining a chamber which is expanded as the cup-shaped members are separated, both of the members having at least one opening on their sidewalls, the openings of the two members not in registration when the chamber is contracted, the openings in registration as the chamber is expanded and thereby providing an opening into the chamber, the openings again not in registration as the chamber is further expanded, spring means tending to separate the members and thereby expand the chamber, delay means effective to restrict the action of the spring means, heat responsive means operative normally to render the spring means ineifecti've, and means adapted to be heated responsive to the action of a high frequency field and positioned in heat exchange relationship with the heat responsive means whereby under the action of the high frequency field the spring means is operative to expand the members thereby at least temporarily providing an opening into the chamber, further movement of the members again closing the opening into the chamber, the expansion of the members tending to produce a suction into the chamber so that fluids
  • a capsule adapted to be swallowed comprising a pair of generally cup-shaped members adapted to be nested together with their closed end defining a chamber which is expanded as the cup-shaped members are separated, both of the members having at least one opening on their sidewalls, the openings of the two members not in registration when the chamber is contracted, the openings in registration as the chambers is expanded and thereby providing an opening into the chamber, spring means tending to separate the members and thereby expand the chamber, heat responsive means operative normally to render the spring means inetfective, and means adapted to be heated responsive to the action of a high frequency field and positioned in heat exchange relationship with the heat responsive means whereby under the action of the high frequency field the spring means is operative to expand the members thereby providing an opening into the chamber, so that substances within the chamber may be dispensed within the body of the swallower.
  • a swallowable hollow capsule means forming an opening into the capsule, closing means releasably closing the opening into the capsule, yieldable means tending at least temporarily to render ineffective said clos ing means, means adapted to be heated under the action of a high frequency field and thereby render ineffective the closing means and allowing the yieldable means to at least temporarily open the chamber, and delay means allowing the capsule to be opened for a predetermined time and thereafter closed.
  • a swallowable capsule comprising a pair of hollow parts complementing each other to define a chamber, one of the parts slideable over the other part to vary the size of the chamber, both of the hollow parts having openings therein so positioned that in a contracted position of the hollow parts the openings are not in registration but become in registration as the parts are expanded thereby providing fluid communication means between the interior and the exterior of the chamber, spring means tending to separate the parts, heat responsive means normally effective to render the spring means ineffective, and means adapted to be heated under the action of a high frequency field, said last mentioned means positioned in juxtaposition to the heat responsive means so as to transfer heat thereto, whereby under the action of the high frequency field the spring means is released to move the hollow parts so that the openings therein are in registration.
  • a capsule according to claim 7 in which the openings are so positioned that upon further expansion of the parts after the openings are in registration the openings are again not in registration.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
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  • Pathology (AREA)
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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
US722514A 1957-04-09 1958-03-19 Diagnostic and medicating capsule and the method of use Expired - Lifetime US3118439A (en)

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US3216411A (en) * 1962-05-16 1965-11-09 Nippon Electric Co Ingestible transmitter for the detection of bleeding in the gastrointestinal canal
US3315660A (en) * 1963-08-08 1967-04-25 Carlos A Abella Capsule for insertion in the digestive track
US3319622A (en) * 1963-01-04 1967-05-16 Nat Res Dev Device for gastro-intestinal fluids
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
US3608549A (en) * 1970-01-15 1971-09-28 Merrill Edward Wilson Method of administering drugs and capsule therefor
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs
US3688763A (en) * 1969-07-28 1972-09-05 Raymond Cromarty Diagnostic device and method
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US3732865A (en) * 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3844285A (en) * 1969-08-28 1974-10-29 Commw Scient Ind Res Org Device for administration to ruminants
WO1979000811A1 (fr) * 1978-03-22 1979-10-18 J Pawelec Dispositif d'etude du tube alimentaire
US4172446A (en) * 1974-12-20 1979-10-30 Louis Bucalo Apparatus for collecting body fluids
US4186730A (en) * 1974-08-23 1980-02-05 Louis Bucalo Methods for collecting body fluids
US4233992A (en) * 1977-07-19 1980-11-18 Bisping Hans Juergen Implantable electrode
US4239040A (en) * 1976-10-19 1980-12-16 Kabushiki Kaisha Daini Seikosha Capsule for medical use
US4257427A (en) * 1973-02-05 1981-03-24 Louis Bucalo Method for collecting body fluids
US4425117A (en) 1979-07-14 1984-01-10 Battelle-Institut E.V. Device for the release of substances at defined locations in the alimentary tract
US4481952A (en) * 1978-03-22 1984-11-13 Jerzy Pawelec Device for the study of the alimentary canal
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US5316015A (en) * 1992-07-30 1994-05-31 Sinaiko Robert J Externally controlled intestinal content sampler
US20040073018A1 (en) * 1996-11-27 2004-04-15 Gravel Roy A. Human methionine synthase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer
US20040253304A1 (en) * 2003-01-29 2004-12-16 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
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US20080188837A1 (en) * 2004-12-14 2008-08-07 Ziv Belsky Local Delivery of Drugs or Substances Using Electronic Permeability Increase
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US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
US20100286628A1 (en) * 2009-05-07 2010-11-11 Rainbow Medical Ltd Gastric anchor
US20100286660A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Gastroretentive duodenal pill
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US20120302916A1 (en) * 2009-10-20 2012-11-29 Ogeno Gmbh Biopsy instrument comprising a magnetic element
US8491495B1 (en) * 2012-11-16 2013-07-23 L. Zane Shuck Human intestinal tract research and diagnostic system to evaluate patients and advance medical science and bioengineering and to determine processes in the gut and causes of diseases
US20140162305A1 (en) * 2012-11-30 2014-06-12 L. Zane Shuck Patient In Vivo Gut Diagnostic and Treatment Tool
US20140163416A1 (en) * 2012-11-16 2014-06-12 L. Zane Shuck In Vivo Device and Method for Researching GI Tract Processes, Microbes, and Variables Associated with Illnesses and Diseases
WO2014140334A1 (fr) * 2013-03-15 2014-09-18 Mars, Incorporated Dispositif d'échantillonnage
US20150112166A1 (en) * 2012-11-16 2015-04-23 L. Zane Shuck In Vivo Technology System for Human Gut Research, Diagnostics and Treatment
US20150141967A1 (en) * 2010-10-06 2015-05-21 Medimetrics Personalized Drug Delivery Electronic Pill for Delivery of Powder Medication
US10172598B2 (en) 2012-02-17 2019-01-08 Progenity, Inc. Ingestible medical device
US20200146632A1 (en) * 2014-11-19 2020-05-14 Veloce Corporation Wireless communications system integrating electronics into orally ingestible products for controlled release of active ingredients
US10751033B2 (en) 2014-09-18 2020-08-25 Covidien Lp Use of expansion-force elements in a compressible cell collection device
US10792020B2 (en) 2014-09-18 2020-10-06 Covidien Lp Tapered geometry in a compressible cell collection device
US10835152B2 (en) 2014-09-25 2020-11-17 Progenity, Inc. Electromechanical pill device with localization capabilities
US11007356B2 (en) 2018-11-19 2021-05-18 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
US11096677B2 (en) 2014-09-18 2021-08-24 Covidien Lp Regions of varying physical properties in a compressible cell collection device
US11224383B2 (en) 2014-11-19 2022-01-18 Veloce Corporation Wireless communications system integrating electronics into orally ingestible products for controlled release of active ingredients
US11246536B2 (en) 2019-06-10 2022-02-15 Tim McCullough Gastroenterological diagnostic test for the determination of pH in the digestive tract for assessment of dysfunction
US11363964B2 (en) 2017-03-31 2022-06-21 Progenity Inc. Localization systems and methods for an ingestible device
US11413022B2 (en) 2014-09-17 2022-08-16 Mars, Incorporated Sampling device with ejectable compartment
US11419586B2 (en) 2014-09-17 2022-08-23 Mars, Incorporated Sampling device with ejectable compartment
US11547301B2 (en) 2016-12-07 2023-01-10 Biora Therapeutics, Inc. Methods for collecting and testing bacteria containing samples from within the gastrointestinal tract
US11707610B2 (en) 2019-12-13 2023-07-25 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
US11793420B2 (en) 2016-09-09 2023-10-24 Biora Therapeutics, Inc. Ingestible device for delivery of a dispensable substance

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DE69009045T2 (de) * 1990-07-06 1994-10-06 Miyarisan Pharma Kapsel für medizinische Zwecke und Vorrichtung zu deren Aktivierung.
US5279607A (en) * 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5247941A (en) * 1992-01-06 1993-09-28 Microbyx Corporation Multifunction collecting device for body fluids

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US2671451A (en) * 1952-06-16 1954-03-09 Stephen J Bolger Remedial pill
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US3732865A (en) * 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
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US4239040A (en) * 1976-10-19 1980-12-16 Kabushiki Kaisha Daini Seikosha Capsule for medical use
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US4481952A (en) * 1978-03-22 1984-11-13 Jerzy Pawelec Device for the study of the alimentary canal
WO1979000811A1 (fr) * 1978-03-22 1979-10-18 J Pawelec Dispositif d'etude du tube alimentaire
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WO2008110392A2 (fr) 2007-03-14 2008-09-18 Ogeno Gmbh Dispositif de biopsie pour l'enrichissement de tissus, de cellules ou d'analytes
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US20150141967A1 (en) * 2010-10-06 2015-05-21 Medimetrics Personalized Drug Delivery Electronic Pill for Delivery of Powder Medication
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CH337989A (fr) 1959-04-30
DE1076322B (de) 1960-02-25

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