US3200037A - Topic angiotonic compositions - Google Patents

Topic angiotonic compositions Download PDF

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US3200037A
US3200037A US167659A US16765962A US3200037A US 3200037 A US3200037 A US 3200037A US 167659 A US167659 A US 167659A US 16765962 A US16765962 A US 16765962A US 3200037 A US3200037 A US 3200037A
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percent
weight
compositions
sheath
angiotonic
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US167659A
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Paul M Curtay
Adrienne M Curtay
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry

Definitions

  • TOPIC ANGIOTONIC COMPOSITIONS Filed Jan. 22. 1962 United States Patent 3,200,037 7 TOPIC ANGIIOTONIC CGMPOSITIONS Paul M. Curtay and Adrienne M. Curtay, born Boelens, both of 116 Blvd. Perch-e, Paris, France Filed Jan. 22, 1962, Ser. No. 167,659 Claims priority, application France, Feb. 10, 1961, 852,248; Sept. 30, 1961, 874,664
  • Another object is to provide compositions as aforesaid useful for prophylactic, therapeutic or cosmetic purposes.
  • Curative purposes treatment of disorders arising from the presence of more or less important varices, ulcers, recent or old phlebitis sclerous, hypodermites (lymphlegs); associated troubles such as edemas, varicose eczema and stiffness in joints, and lymphedemas in upper and lower limbs (in the latter case as a complementary treatment associated with intermittent compression treatment).
  • Prophylactic purposes patients about to be operated or as a pre-, peror post-operatory treatment in the case of admittedly thrombogenous operations, for pregnant women or after delivery, for patients having familial varicose records, for standing workers (e.g. shopmen and women, dental surgeons, mothers of family), for preventing lymphangitis rashes, for persons having varicosities.
  • Esthetic purposes cases of cellulitis, thinning of legs and ankles, heaviness feeling, tiredness in the evening or during hot periods, swelling Without apparent medical reason in the evening or during hot periods, red or purplish colour, feeling of burning or cold in feet.
  • Angiotonic agents of vegetable origin of the class of benzoin tincture and preparations containing vitamin P were found particularly effective for association with a volatile cooling agent or agents; for practical purposes we found by research and experiment that liquid extracts of hamamelis and benzoin extracts should be preferred although other preparations containing vitamin P such as horse-chestnut extracts and alcoholatures, and compositions containing rutoside may also be employed.
  • Suitable volatile cooling agents which may be employed singly or jointly are acetone, camphor, menthol, ethyl .ether and chloroform.
  • Preferable cooling agents are camphor and menthol which appear to produce a favorable angiotonic effect in addition to produce a mild hypothermia. It is well-known that applied on skin camphor and menthol determine a feeling of coolness. For example camphor which volatilizes at 15 C. causes a mild hypothermia if it is contacted with leg epidermis at a temperature of 28 C.
  • a further desirable ingredient of our compositions is ethyl alcohol which plays the roles of a carrier, of a penetrating agent, assisting the ingress of the angiotonic agent or agents into and through the epidermis and derm, and also of a cooling agent.
  • Alcohol is capable of dissolving fats and also produces a vasodilation facilitating penetration before cold has produced a vasoconstriction, the sequence of which is believed favorable as vasomotricity gymnastics.
  • a still further desirable ingredient of our compositions is glycerol which is useful as a carrier for the angiotonic and cooling agents. It is our feeling as a result of numerous experiments that glycerol has a favorable effect which is not simply that of a carrier, in the treatment of the disorders above referred to, but so far we are not in position to bring a scientifically satisfactory proof of that effect.
  • An alternative carrier for liquid compositions is propylene glycol.
  • composition (A) contains the above ingredients in the following proportions by weight:
  • composition (A) it is preferred to add crystalline camphor to menthol, to leave the mixture standing for say 24-48 hours, to add chloroform, then alcohol and afterwards benzoin tincture and hamamelis liquid extract while stirring, and to leave the mother mixture or master batch thus prepared standing for say 24 hours or more.
  • Glycerol may be added at the time or later, the composition being stirred at the time of use.
  • chloroform when used for cosmetic purposes, chloroform may be omitted, the ethyl alcohol and/or glycerol being increased correspondingly.
  • angiotonic agents shown as being hamamelis liquid extract and benzoin tincture may further be added azulene, alantoin or histamin by as small an amount as about 0.001 to about 0.1%; azulene and/ or histamin are desirable for patients liable to eczema.
  • a perfume may be added.
  • compositions also found to be effective particularly for cosmetic purposes are given below to illustrate possible modifications in the nature and proportions of the ingredients.
  • Azulene 0.3 Perfume 0.3 Glycerol 26 Distilled water 50 Percent Ethyl alcohol (90% by volume) 12 Menthol 2.25 Hamamelis liquid extract 6.75 Propylene glycol or glycerol 79 then one to three like bands may .be wound similarly, and
  • a dry band for example a cotton band.
  • J Such a bandage will be renewed as frequently as required, generally twice or three times a week;
  • the treatment is an ambulatory treatment, no rest being required.
  • a.thicker,-'slightly elastic band preserving its resiliency after impregnation with the pharmaceutical composition
  • a band being wound preferably from the toes to the top of the thigh with a view to compensating for the shorter period of application one hour for example, by means of a wider application area.
  • the sheath is made of an absorbing, resilient material adapted to be impregnated with the pharmaceutical composition; said sheath may have the shape of a complete hose, a sock, with or without toe end, or a thigh piece, to be placed on the leg or corresponding 'part of leg and retained thereon by its own elasticity; it may be made of woven or knitted fabric with or without ribs, resiliency being provided by the texture and/or the nature of the material, and/or by incorporating resilient, for example rubber threads in the fabric.
  • Such a sheath after it has been impregnated with the pharmaceutical composition and put on the leg is adapted to maintain a considerable amount of the active components of the composition in contact with the leg skin providing a kind of permanent bathing in the pharmaceutical composition.
  • the absorbing sheath may be combined with an impervious sheath having the same shape which may be made of any impervious, flexible material to be placed over the absorbing sheath.
  • the impervious sheath is made preferably of a plastic material, in particular from a polyvinyl chloride or other thermoplastic material sheet which is' cut to the suitable shape and welded, or of impervious textile material suitably sewn or Welded.
  • the imperviousisheath is effective to prevent the gar ments from being moistened or stained by the pharmaceutical composition.
  • the impervious sheath is preferably made with suitable resiliency to be maintained in positionon the absorbing sheath or as the case may be to maintain the absorbing sheath in position on the limb.
  • the irnpervious sheath may have ribbed edges or may be provided with separate resilient edgings, or arranged to be held with garters. 7 a
  • the absorbing sheath and the impervious sheath may be combined into a piece of garment, the absorbing sheath providing an inner lining for the impervious sheath.
  • the piece of garment is turned inside out to expose the absorbing face thereof which is impregnated with the pharmaceutical composition then the Whole is turnedagain and the leg introduced into the same.
  • FIG. 1 shows an absorbing sheath, i
  • FIG. 2 shows an impervious sheath
  • FIG. 3 shows the absorbing sheath only partly covered with the impervious sheath.
  • FIG. 4 is an exploded view of the top portion of an absorbing sheath and an impervious sheath placed .over the same. 4 p
  • an absorbing sheath 2 (FIG. 1), preferably made of cotton and adapted to be impregnated with a pharmaceutical composition is shaped as a hose to be placed as shown on FIG. 3.
  • An impervious sheath 3 (FIG. 2) made of plastic'material or rubbe'red textile fabric for example, is adapted to be placed over the absorbing sheath 2 and has the.
  • the impervious sheath 3 may be formed with a top, resilient, ribbed squeezing section 4 as shown or alternatively may be employed with garter.
  • the impervious sheath 3 is shown on FIG. 3 before it has been completely drawn over the absorbing sheath 2.
  • composition instead of impregnating a porous support with the pharmaceutical composition and placing the support on skin as described, it is possible to spray the composition, provided the composition is fluid enough, by means of an inert gaseous propellant such as nitrogen or a Freon either directly on the skin or on and through a porous support previously laid on skin.
  • an inert gaseous propellant such as nitrogen or a Freon either directly on the skin or on and through a porous support previously laid on skin.
  • the composition may be compounded to contain a propellant as employed for aerosols which is liquid under the pressure prevailing in the container provided with a spray nozzle.
  • Recent phlebitis can be healed by means of our pharmaceutical compositions without anticoagulating agents and without requirement for rest: post-phlebitic disorders such as edemas, pains, joint stiffness, indurated hypodermitis and various troubles with chronic varicose patents are improved to a wide extent.
  • compositions cause disappearance of the feeling of heaviness, tiredness and pains of standing workers and pregnant women; they also provide a useful assistance in the treatment of upper limb circulatory disorders, in particular lymphedemas following mastectomy, painful or painless lymphedemas of lower limbs, lymphangitis and cellulitis (in the latter case the improvement in blood circulation renders the tissues receptive to action of conventional treatments which have been so far ineffective), pre-, perand post-operation prevention in admittedly thrombogenous surgical operations or with predisposed varicose patients.
  • the compositions of this invention enable of preparing patients for sclerosis or surgery or varicose veins because they improve blood circulation in depth and impart increased vitality to tissues and vessels.
  • compositions are also of prophylactic interests for those who have familial varicose records or are predisposed by reason of their calling or a pregnancy condition, or for those who have small lesions such as varicosities, slight edema in the evening or like signs indicating a latent venous or venolymphatic insufiiciency.
  • the compositions according to this invention produce a quick lightening of legs, a removal of the permanent feeling of burn or cold, a steady thinning and a more natural color, which should be appreciated by women who take care of the esthetic appearance of their legs.
  • a composition for improving in depth predominantly venous or venoylmphatic circulatory troubles in limbs which comprises from 2.5 to 6 percent by weight of menthol, 2 to 4 percent by Weight of camphor, 20 to 30 percent by weight of percent by volume ethyl alcohol, 2 to 6 percent by weight of chloroform, 2 to 5 percent by weight of benzoin tincture, 10 to 15 percent by weight of hamamelis liquid extract and 61.5 to 34 percent by weight of glycerol.
  • a composition for improving in depth predominantly venous or venolymphatic circulatory troubles in limbs which comprises 4 percent by weight of menthol, 2.5 percent by weight of camphor, 23.5 percent by weight of 90 percent by volume ethyl alcohol, 4 percent by weight of chloroform, 3 percent by weight of benzoin tincture, 13 percent by weight of hamamelis liquid extract, and 50 percent by weight of glycerol.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US167659A 1961-02-10 1962-01-22 Topic angiotonic compositions Expired - Lifetime US3200037A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR852248A FR1056M (fr) 1961-02-10 1961-02-10 Produit pharmaceutiqué destine au traitement des affections circulatoires des membres supérieurs ou inférieurs.

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FR (1) FR1056M (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122487A (en) * 1982-05-25 1984-01-18 Alza Corp Elastomeric drug dermal delivery system
GB2249265B (en) * 1990-10-30 1993-04-28 George Garrett Shaving lotion
USD359843S (en) 1992-12-23 1995-07-04 Lazetta Jones Ankle cover
USD437479S1 (en) 1999-05-06 2001-02-13 Paul Lavitt Mills, Inc. Top band for an article of hosiery
USD437994S1 (en) 2000-05-04 2001-02-27 Adrea Ann Smith Ruffled sock
US20060235373A1 (en) * 2005-04-14 2006-10-19 Asah Medico A/S Intraluminal heat treatment of a lumen combined with cooling of tissue proximate the lumen
USD546003S1 (en) 2006-09-22 2007-07-03 United Exchange Corporation Stretchable sleeve
US7485111B1 (en) 2006-06-05 2009-02-03 Eugene Choi Medicated sleeve

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US74622A (en) * 1868-02-18 Joseph smith
US95771A (en) * 1869-10-12 Improved medicine for rheumatism
US1427199A (en) * 1919-07-14 1922-08-29 Isaac O Foote Lotion

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US74622A (en) * 1868-02-18 Joseph smith
US95771A (en) * 1869-10-12 Improved medicine for rheumatism
US1427199A (en) * 1919-07-14 1922-08-29 Isaac O Foote Lotion

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122487A (en) * 1982-05-25 1984-01-18 Alza Corp Elastomeric drug dermal delivery system
US4435180A (en) 1982-05-25 1984-03-06 Alza Corporation Elastomeric active agent delivery system and method of use
GB2249265B (en) * 1990-10-30 1993-04-28 George Garrett Shaving lotion
USD359843S (en) 1992-12-23 1995-07-04 Lazetta Jones Ankle cover
USD441949S1 (en) 1999-05-06 2001-05-15 Paul Lavitt Mills, Inc. Top band for an article of hosiery
USD437479S1 (en) 1999-05-06 2001-02-13 Paul Lavitt Mills, Inc. Top band for an article of hosiery
USD437994S1 (en) 2000-05-04 2001-02-27 Adrea Ann Smith Ruffled sock
US20060235373A1 (en) * 2005-04-14 2006-10-19 Asah Medico A/S Intraluminal heat treatment of a lumen combined with cooling of tissue proximate the lumen
EP1712208A3 (fr) * 2005-04-14 2007-11-21 Asah Medico A/S Traitement thermique intraluminal avec refroidissment du tissu près du lumen
US7485111B1 (en) 2006-06-05 2009-02-03 Eugene Choi Medicated sleeve
US20090118685A1 (en) * 2006-06-05 2009-05-07 United Exchange Corporation Medicated sleeve
US7959616B2 (en) 2006-06-05 2011-06-14 Eugene Choi Medicated sleeve
US20110208137A1 (en) * 2006-06-05 2011-08-25 United Exchange Corporation Medicated sleeve
USD546003S1 (en) 2006-09-22 2007-07-03 United Exchange Corporation Stretchable sleeve

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FR1056M (fr) 1962-02-16

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