US3533408A - Extra-corporeal blood circulation - Google Patents

Extra-corporeal blood circulation Download PDF

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Publication number
US3533408A
US3533408A US539261A US3533408DA US3533408A US 3533408 A US3533408 A US 3533408A US 539261 A US539261 A US 539261A US 3533408D A US3533408D A US 3533408DA US 3533408 A US3533408 A US 3533408A
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Prior art keywords
shunt
valve
arterial
signal
pipe
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US539261A
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English (en)
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Jean-Marc Paoli
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JEAN MARC PAOLI
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JEAN MARC PAOLI
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/247—Positive displacement blood pumps
    • A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
    • A61M60/258—Piston pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/38—Blood oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/515—Regulation using real-time patient data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/851—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3303—Using a biosensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/247—Positive displacement blood pumps
    • A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
    • A61M60/268—Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
    • A61M60/279—Peristaltic pumps, e.g. roller pumps

Definitions

  • an electronic unit including a multitrack electrocardiograph receiving an R wave from a patient and converting said wave into a QRS output signal; an arterial line and a venous line, a return reservoir connected to said lines; a continuous delivery pump con nected in said arterial line; a shunt connecting said arterial line to said reservoir for branching off said pump at the moment of cardiac systole, a valve for opening and closing said shunt; a control system for governing said valve, said control system including a piston means responsive to said output signal to pinch or release said shunt in synchronism therewith.
  • E.C.C. extra-corporeal circulation of the blood
  • E.C.C. any extra-corporeal circulation of the blood (hereinafter abbreviated to E.C.C.), carried out, for example, before or during or after a surgical operation, comprises an apparatus which includes:
  • Arterial injection is generally carried out in a continuous manner. When such injection is used it may add its pressure to that of the blood pumped by the heart, and may thereby cause such discomfort to the patient that it cannot be endured very long.
  • the object of the present invention is to provide a continuous-flow blood pump which is only branched off, at the moment of the cardiac systole (cardiac contraction) by a shunt connecting the arterial line to the intermediatecircuit, e.g. to the return reservoir;
  • this shunt includes a valve the opening and closing of which is controlled, at suitable moments and after predetermined durations, by an electric unit which utilizes the QRS signal of an electrocardiograph apparatus, thus itself regulating the moments and durations'of arterial pipe 16 connecting the patients artery to the pipes 13 the opening and closing actions, or enabling them-to be regulated, in accordance with the desired result.
  • the device can be connected to any surgical E.C.C. as a preoperatory measure, or at the end of the operation, or to afford medical treatment.
  • FIG. I is a graph showing relative time periods and durations
  • FIG. 2 is a graph showing a modification of the time periods and durations
  • FIG. 3 is a diagram which shows the apparatus in actual use connected to a patient
  • FIGS. 4 and 5 show two different modes of use of a shunt system in the device
  • FIG. 6 shows schematically a preferred construction of shunt valve
  • FIG 7 is a block diagram of an electronic control device
  • FIG. 8 is a block diagram showing a monitoring system for the control device.
  • FIG. 3 shows the device of the invention, as applied to a patient prepared for a surgical operation such as open heart surgery, or during or after the latter.
  • An electronic synchronizing unit 10 receives the R wave of the patient from an ECG or pace maker" (not shown) and converts it into a signal of which the duration is regulated as desired.
  • This output signal is received by an electromechanical bypass control 11 for controlling the closing and opening of a valve 12 in a shunt pipe 13.
  • the shunt 13 which short circuits the pump, thus rendering possible an arterial return", which is facilitated by gravity, towards the intermediate circuit, and hence towards a return reservoir; this shunt can be a tube of elastic material such as Tygon.
  • the valve 12 is mounted on said shunt pipe 13 and can be rapidly actuated for example by an electric solenoid valve as described in relation to FIG. 6, to compress the pipe I3.
  • FIG. 3 the valve 12 is shown open.
  • the shunt pipe I3' leads to an oxygenating apparatus 14, which forms a return reservoir.
  • In parallel with the shunt pipe 13 there is a continuousdelivery pump-l5 connected to the reservoir 14.
  • the valve 12' is mounted on the arterial pipe I6 before its confluence with the shunt pipe I3 in order to enable its return delivery to be reduced, if necessary, in synchronism with the shunt valve I2, during the shunting process; similarly, 1
  • a venous pipe 17 connects the apparatus 14 to a vein
  • FIG. 3 is shown without any valve in it.
  • FIG. 4 there is shown diastolic transfusion.
  • the shunt 13 is closed by closing the valve I2, and the arterial pipe 16 isleft open at valve 12' (that part of the shunt 13 which follows the closure at 12 being shown in broken line).
  • FIG. 5 there is shown systolic by-passing by the shunt pipe 13, and the two valves 12 and 12' are left open; it is thus possible to permit an arterial return to take place, through the pipe line 16, or to interrupt it, by operating the valve I2.
  • FIG. 6 shows, schematically, a form of control valve for the shunt'pipe 13 or for any other flexible pipe.
  • the pipe l3 is clamped diametrically between a fixed part 18 and a movable part 19, the latter being controlled by a piston 20 connected to a solenoid valve 21 which in its turn is controlled by an electric line 21 "from the control unit 11.
  • FIG. 7 shows the structure of the electronic synchronizing unit 10, which includes an ECG unit 22, and its connection to the control device I l for the valve 12 of the shunt pipe 13 and this diagram provides an explanation of the application of the systole-diastole selection circuit, and of the regulating system.
  • the electronic unit I0 which enables the opening otlthe shunt pipe 13 to be regulated at the exact moment when the systole of cardiac contraction takes place, also enables the satisfactory operation of the assembly used to be verified; this electronic unit analyses the electrocardiographic complex and enables pressure control to be effected, for the purpose of the aforementioned regulation.
  • This electronic unit includes Y a.
  • the cardiotachymeter 23 imparting a brief impulse at the moment when the QRS signal of the ECG occurs, upon reception of R waves from the patient;
  • the relay 25 supplying a required advance in relation to the original QRS wave, at the moment when the shunt pipe valve opens, and capable of being coordinated with the frequency of the heart beats.
  • the pace maker 27 which takes over when no waves are received from the patient, and the relay 26 for actuating f.
  • a filtering relay' (not shown).
  • the ECG track retained the signal of each relay; an arterial pressure track; a venous pressure track; and the signal relating to the opening or the closingof .the shunt tap; 1
  • FIG. 8 provides an explanation of the visual monitoring system.
  • a cardiotachymeter 23 takes the instantaneous impulses from the positive ECG deflections on this selected track; a relay 24 receiving the output of the cardiotachymeter 23 then effects a filtering operation, so that only a QRS impulse 11 remains and this is fed to a relay 25 which converts it into a rectangular impulse of duration 12". This is fed to a relay 26 of a pace maker 27 and simultaneously to the bypass control device ii' 'iiWlfic nBp'eE'sYhE s'h'um i3 au'rirgtra'szaba 12'.
  • Signals from the ECG 22 are fed to a sorting oscilloscope 29 receiving all the tracks, and from there any selected signal can be transferred to a monitor tube 30 showing for example one ECG track, one track for relay 24, one arterial pressure track, one track for relay 25, one venous pressure track, opening or closing signal of electromechanical selector 11-12.
  • a monitor tube 30 showing for example one ECG track, one track for relay 24, one arterial pressure track, one track for relay 25, one venous pressure track, opening or closing signal of electromechanical selector 11-12.
  • At the relay stage 24 there is regulation of the duration :1; at the relay stage 25, there is regulation of the duration 12 (time for which the shunt pipe 13 is open, and duration of systole), starting of the electromechanical control lIl2, regulation of venous return delivery" and of arterial return and regulation of the pump.
  • An audio signal is obtained from an audio unit 28; control oscilloscope 30: unit 31 is a multitrack magnetic recording system.
  • FIG. I it is shown how, staning from a QRS signaL'there is obtained a long impulse 4 for the control of the shunt valve 12.
  • the point PS indicates theclosing of the aortic sigmoid valvulae.
  • point P indicates the contraction of the auricles of the heart
  • QRS indicates the wave marking the commencement of the contraction of the ventricles
  • T indicates the depolarization wave.
  • the original impulse I which is short, and synchronous with QRS, is taken up by the the cardiotachymeter 23. If it is accompanied by a parasitic impulse 2 caused, for example, by T, filtering is applied during the period 4 and interrupts this parasitic impulse.
  • the signal of the opening and closing relay occurs, the shunt pipe I3 being open during the hatched period 6, which can be increased in accordance with the arterial pressure curve PA.
  • the arrow 7 indicates the instant of opening and the arrow 8 the instant of closing.
  • FIG. 2 shows an alternative version of part 5 of FIG. 1, the opening taking place with a certain advance (the arrow 9 indicating the opening, advanced in respect of the arrow 7 or the arrow QRS shown afterwards, with the hatched opening period 6
  • the apparatus is utilized as follows:
  • the signals of the ECG unit 22 are transmitted to its sorting oscilloscope 29, on which they can be compared in order to select the best track or signal.
  • the QRS signal retained is analysed by the cardiotachymeter 23, after the regulation of the threshold in accordance with its amplitude. We thus obtain an impulse on the QRS signal.
  • the first signal actuates the electronic relay 24 which interrupts the cardiotachymeter circuit for a period corresponding to the duration of the electrocardiographic complex following the original signal. It is thus the first signal that is transmitted (and not the subsequent signal, e.g. that emanating from T). At the end of this period, the relay 24 returns the cardiotachymeter 23 to the circuit, and the first signal of the following complex may set up an original impulse and block the cardiotachymeter. The satisfactory operation of this filtering system is verified on the screen on the monitoring oscilloscope 30. A synchronous visual signal is recorded below the electrocardiographic track and enables this period to be prolonged or shortened at any moment.
  • This original impulse thus filtered, sets up an audiosignal, in unit 28, which enables the electrocardiographic rhythm to beconstantly monitored by ear and makes it possible to take immediate action in the event ofdisturbance.
  • the original impulse is transmitted tothe electronic relay 25 which converts it into an impulse whose duration can be regulated as desired; this duration must correspond to the time for which the valve 12 of the shunt pipe 13 is open, which time is steplessly variable, e.g. between zero and a quarter of a second or more.
  • This impulse is verified on the monitoring oscilloscope 30 by a synchronous visual signal in the vicinity of the arterial pressure track". It is thus known at any moment whether the opening of the shunt valve 12 is being correctly controlled. In this case, the final order can be transmitted to the said shunt valve 12 and to the valve 12', if provided on the arterial line. It also causes a signal to be conveyed to the screen of the monitoring oscilloscope 30, so that the periods during which the valve has been actually operated can be accurately differentiated in the recordings.
  • the final regulating operations are carried out in accordance with the haemodynamic effects desired. They necessitate control of the commencement of the venous return (the degree of shutting of the valve being variable by an electrical or manual control means), of the systolic arterial return, and of the real injection delivery which depends on the output of the injection pump (ascertainable from the revolution-counter on its control panel), and of the through flow in the shunt pipe as determined by the frequency and duration of opening of valve control, and the flow cross section of the pipe.
  • the shunt valve 12 is actuated, the relay 25 being closed and then progressively opened for oscilloscopic verification of the pressure curves so as to obtain the value which is desired from the haemodynamic point of view.
  • the apparatus enables the arterial and venous outputs to be distributed in such a way as to enable any one of the following to be obtained, according to the type of return selected:
  • a veno-arterial ECC with diastolic injection the artery being closed during the systole, and the injection continuing to be branched by the shunt pipe (treatment of righthand cavities of heart, necessitating the use of a blood oxygenating apparatus);
  • the invention offers a further advantage in that the opening of the shunt pipe enables ventricular ejections to be facilitated, this being partly effected in an open system at a low pressure since it is in communication with the return reservoir of the ECC. It thus provides a true cardiac treatment combining the advantages of a reduction of the work having to be performed by the heart, and administration of a diastolic transfusion.
  • an electronic unit including a multi-track electrocardiograph receiving an R wave from a patient and converting said wave into a QRS output signal; an arterial line and a venous line, a return reservoir connected to said lines: a continuous delivery pump connected in said arterial line; a shunt connecting said arterial line to said reservoir for branching off said pump at the moment of cardiac systole, a valve for opening and closing said shunt; a control system for governing said valve said control system including a piston means responsive to said output signal to control said shunt in synchronism therewith.
  • System according to claim 1 having a second similar valve controlling said arterial line and means for controlling said second valve in synchronism or alternation with said first valve.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
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  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)
US539261A 1965-03-31 1966-03-30 Extra-corporeal blood circulation Expired - Lifetime US3533408A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR20948A FR1451277A (fr) 1965-03-31 1965-03-31 Procédé et appareils pour établir les circulations extra-corporelles, en phase avec la révolution cardiaque, par dérivation systolique de la pompe

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907504A (en) * 1973-04-06 1975-09-23 Gen Electric Blood oxygenation system including automatic means for stabilizing the flow rate of blood therethrough
US3946731A (en) * 1971-01-20 1976-03-30 Lichtenstein Eric Stefan Apparatus for extracorporeal treatment of blood
US4192302A (en) * 1978-09-12 1980-03-11 Boddie Arthur W Hepatic isolation and perfusion circuit assembly
US4416280A (en) * 1980-04-07 1983-11-22 Minnesota Mining And Manufacturing Company Cardioplegia delivery system
US4427470A (en) 1981-09-01 1984-01-24 University Of Utah Vacuum molding technique for manufacturing a ventricular assist device
US4473423A (en) * 1982-05-03 1984-09-25 University Of Utah Artificial heart valve made by vacuum forming technique
US4838889A (en) * 1981-09-01 1989-06-13 University Of Utah Research Foundation Ventricular assist device and method of manufacture
US5158534A (en) * 1990-07-03 1992-10-27 Cardiopulmonics, Inc. Automated gas delivery system for blood gas exchange devices
US20040243051A1 (en) * 2001-08-01 2004-12-02 Monzyk Bruce F Artificial pulmonary capillary
US20050029121A1 (en) * 2001-08-01 2005-02-10 Battelle Memorial Institute And Pharos, Llc Photolytic artificial lung
US20050265894A1 (en) * 2004-05-14 2005-12-01 Monzyk Bruce F Oxygen generation in whole blood by photolytic activation
US20090017128A1 (en) * 2001-08-01 2009-01-15 Battelle Memorial Institute Carbon dioxide removal from whole blood by photolytic activation
RU2665179C1 (ru) * 2018-02-06 2018-08-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Искусственное сердце
RU2665178C1 (ru) * 2018-02-06 2018-08-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Устройство и способ управления потоком крови роторных насосов
RU2665180C1 (ru) * 2018-02-06 2018-08-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Устройство и способ управления потоком крови в аппаратах сердечно-легочного обхода
WO2019156589A1 (fr) * 2018-02-06 2019-08-15 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Dispositif et procédé de commande de flux sanguin de pompes à rotor dans des dispositifs extracorporels et implantés pour l'assistance mécanique à la circulation sanguine

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150314A3 (fr) * 1981-09-25 1985-08-21 Tsunekazu Hino Système de circulation sanguine extracorporelle
EP0246302A1 (fr) * 1985-11-12 1987-11-25 Electro-Catheter Corporation Dispositif externe d'assistance cardiaque pulsatile
US5820579A (en) * 1996-04-30 1998-10-13 Medtronic, Inc. Method and apparatus for creating pulsatile flow in a cardiopulmonary bypass circuit

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946731A (en) * 1971-01-20 1976-03-30 Lichtenstein Eric Stefan Apparatus for extracorporeal treatment of blood
US3907504A (en) * 1973-04-06 1975-09-23 Gen Electric Blood oxygenation system including automatic means for stabilizing the flow rate of blood therethrough
US4192302A (en) * 1978-09-12 1980-03-11 Boddie Arthur W Hepatic isolation and perfusion circuit assembly
US4416280A (en) * 1980-04-07 1983-11-22 Minnesota Mining And Manufacturing Company Cardioplegia delivery system
US4427470A (en) 1981-09-01 1984-01-24 University Of Utah Vacuum molding technique for manufacturing a ventricular assist device
US4838889A (en) * 1981-09-01 1989-06-13 University Of Utah Research Foundation Ventricular assist device and method of manufacture
US4473423A (en) * 1982-05-03 1984-09-25 University Of Utah Artificial heart valve made by vacuum forming technique
US5158534A (en) * 1990-07-03 1992-10-27 Cardiopulmonics, Inc. Automated gas delivery system for blood gas exchange devices
US20110027380A9 (en) * 2001-08-01 2011-02-03 Battelle Memorial Institute Carbon dioxide removal from whole blood by photolytic activation
US7498275B2 (en) * 2001-08-01 2009-03-03 Battelle Memorial Institute Artificial pulmonary capillary
US20050040029A1 (en) * 2001-08-01 2005-02-24 Battelle Memorial Institute And Pharos, Llc Photolytic artificial lung
US6866755B2 (en) 2001-08-01 2005-03-15 Battelle Memorial Institute Photolytic artificial lung
US7914479B2 (en) 2001-08-01 2011-03-29 Battelle Memorial Institute Photolytic artificial lung
US20080017037A1 (en) * 2001-08-01 2008-01-24 Battelle Memorial Institute Photolytic artificial lung
US7909788B2 (en) 2001-08-01 2011-03-22 Battelle Memorial Institute Carbon dioxide removal from whole blood by photolytic activation
US20090017128A1 (en) * 2001-08-01 2009-01-15 Battelle Memorial Institute Carbon dioxide removal from whole blood by photolytic activation
US7485261B2 (en) 2001-08-01 2009-02-03 Battelle Memorial Institute Photolytic artificial lung
US20050029121A1 (en) * 2001-08-01 2005-02-10 Battelle Memorial Institute And Pharos, Llc Photolytic artificial lung
US20040243051A1 (en) * 2001-08-01 2004-12-02 Monzyk Bruce F Artificial pulmonary capillary
US20110038760A1 (en) * 2001-08-01 2011-02-17 Pharos, Llc Photolytic artificial lung
US7399717B2 (en) 2004-05-14 2008-07-15 Battelle Memorial Institute Oxygen generation in whole blood by photolytic activation
US20050265894A1 (en) * 2004-05-14 2005-12-01 Monzyk Bruce F Oxygen generation in whole blood by photolytic activation
RU2665179C1 (ru) * 2018-02-06 2018-08-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Искусственное сердце
RU2665178C1 (ru) * 2018-02-06 2018-08-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Устройство и способ управления потоком крови роторных насосов
RU2665180C1 (ru) * 2018-02-06 2018-08-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Устройство и способ управления потоком крови в аппаратах сердечно-легочного обхода
WO2019156589A1 (fr) * 2018-02-06 2019-08-15 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) Dispositif et procédé de commande de flux sanguin de pompes à rotor dans des dispositifs extracorporels et implantés pour l'assistance mécanique à la circulation sanguine

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