US3645142A - Pipette system - Google Patents

Pipette system Download PDF

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Publication number
US3645142A
US3645142A US85056A US3645142DA US3645142A US 3645142 A US3645142 A US 3645142A US 85056 A US85056 A US 85056A US 3645142D A US3645142D A US 3645142DA US 3645142 A US3645142 A US 3645142A
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United States
Prior art keywords
openings
opening
liquid
distribution means
container
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Expired - Lifetime
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US85056A
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English (en)
Inventor
Pierre Turpin
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F Hoffmann La Roche AG
Hoffmann La Roche Inc
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples

Definitions

  • the device is designed to transfer samples taken from human sub- [56] References Cited jects, which samples are to be tested for diagnostically signifi- UNITED STATES PATENTS Cam featuresl,204,368 11/1916 Lowy ..73/425.6 13 Claims, 7 Drawing Figures mcmgumza I912 SHEET 2 [IF 4 FIG. 117
  • the present invention relates to an apparatus for transferring a predetermined amount of a liquid sample from a sample container into a receiving receptacle.
  • the liquid transferred to the last-mentioned receptacle is destined to be fed into a machine which analyses such liquids for significant features.
  • sample fluids which are to be analyzed are of human origin such as blood, urine and the like.
  • samples are to be analyzed for diagnostically significant features.
  • the present invention concerns an automated precision pipette system so constructed and arranged as to effect the transfer of a calibrated volume of a liquid from a first receptacle to a second.
  • the present invention has for its object the provision of a pipette system, which permits the transfer of predetermined small quantities of liquids, for example, a few microliters, from one receptacle or container to another.
  • Another object of the present invention is the provision of an automatic pipette system, which permits a rapid sequence of functions whereby the pipette system performs at a high rate of speed in a precise consistent manner, e.g., withdraws rapidly from a multitude of samples, a constant measured volume thereof at the rate of one withdrawal per second.
  • Another aim of the invention is the provision of a pipette which permits the transfer of a sample from one container to another without being contaminated by residue from previously transferred liquids. Particularly, with human samples destined for human analysis, the necessity of avoiding cross contamination between samples should be evident.
  • the present invention includes a pipette system adapted to transfer a calibrated or measured volume of a liquid substance from a first container in which it is stored into a second receptacle.
  • the liquid contained in the second receptacle is to be fed into an automatic analyzing machine.
  • the pipette system is characterized by the fact that it comprises an internal distribution means comprising a first member transversed by two separated noncommunication canals and a second member movable with respect to the said first member, said second member being provided with four openings traversing the second member. Each of the two canals in the first member in operative position is in communication with corresponding pairs of the openings in the second member.
  • the internal distribution means preferably comprises an outer hollow cylindrical stator member (the second member) and an inner rotatable rotor core (the first member).
  • the outer hollow cylindrical member is provided with four transfer openings or passages extending from its inner surface to its outer surface.
  • the inner rotor core is provided as is noted above with two independent noncommunicating canals which traverse the inner core member. The two ends of each canal are opened at the exterior of the rotor core. The open ends of the two canals, when in operative condition, are adapted to communicate with adjacent openings in the outer cylindrical member, thereby permitting a flow of liquid through the passageway, so obtained.
  • FIGS. la and lb represent schematically a first embodiment of the pipette system respectively showing the positioning of the various members of the pipette system at the start and about the finish of the transfer operation.
  • FIG. 2 represents schematically a pipette system in accordance with that in FIG. 1 and provided with a cleaning and drying means.
  • FIG. 3 is a schematic view illustrating another embodiment of the present invention.
  • FIGS. 4a, 4b and 5 represent schematically still other embodiments of the pipette system in accordance with the present invention.
  • FIGS. la and 1b represent schematically one preferred embodiment of the invention.
  • FIG. la illustrates the said embodiment during the starting phase of the transfer operation.
  • FIG. 1b shows the device at about the completion of the transfer operation.
  • the pipette system is designed to extract a measured quantity of a liquid 10 contained in a container 11 and to inject the measured amount into a receptacle 12.
  • the pipette system of the present invention includes in combination a hollow needle 1, for example, of the hypodermic type.
  • the hollow needle 1 is fixedly joined to a distribution means 7 (rotary valve or sluice 7).
  • a reservoir 3 is fixedly secured to the valve 7.
  • Valve 7 is also connected to an evacuating container 4; the interior of which is under reduced pressure. That is to say, the container is maintained below atmospheric pressure.
  • a stop valve 5 and a liquid detector 8 are disposed between the depressurized container 4 and valve 7.
  • the container 4 may be replaced by any suitable pumping mechanism.
  • the internal volume of the hollow needle is equal in volume to the volume of that portion of the sample required for precision analysis.
  • the needle 1 is advantageously coated all along its internal surface and at least partially along a portion of its external surface extending from the free end thereof, with a layer of a water-repellent material such as a silicon.
  • a hydrophobic material By the utilization of a hydrophobic material, it is assured that no substantial portion of the sample liquid will adhere to the needle after the transferring operation is completed.
  • Valve 7 is presented in the Figures as having a rotatable inner core. It should be evident, however, that without departing from the scope of the invention, there could be utilized any equivalent distribution valve of a difierent type provided that it functions in the same manner as the rotary form of valve 7 described herein.
  • the needle 1 is fixedly secured at its upper end to valve 7 by any appropriate means, i.e., a force-fit or the like.
  • the valve 7, as is indicated above, in the preferred aspect comprises a rotatable inner member, namely, rotor 70.
  • Rotor 70 has formed therein two internal noncommunication independent canals 71 and 72. Canals 71 and 72 extend through the rotor 70 to the periphery thereof. In the embodiment illustrated in FIGS. 1a and lb, the entrances to the canals are spaced one from the other.
  • the outer member 73 contains four openings 7111, 712, 721 and 722. The four openings are disposed about the stator 73 at an angle of 90, one from the other.
  • the needle 1 is disposed below the opening 721, while the opening 722 is connected to the evacuating means 4 by a conduit 40.
  • a valve 5 Disposed in the path of the internal passage in conduit 40 is a valve 5.
  • Adjacent valve 5 and operatively connected thereto is a liquid passage detector 8.
  • Detector 8 is positioned in the pipette system between stop valve 5 and opening 722 as shown in FIG. la. Detector 8 controls the opening and closing of valve 5.
  • the opening 7 11 in the outer member 73 is connected to a source of coml0l025 Ol 39 pressed gas 2 (for example, atmospheric air under pressure or a bottle of nitrogen) by a flexible conduit 20.
  • the opening 712 as seen in FIG. 1 is connected to a small expansion reservoir or tank 3 via conduit 30.
  • the apparatus performs its designated function in the following manner.
  • valve 7 occupies the position indicated in FIG. 1a and the valve is opened.
  • the needle 1 is immersed into the liquid to a predetermined, calibrated depth.
  • the valve 7 is in a position whereat the opening in conduit 40 communicates with canal 72 which in turn is in communication with the opening in hollow needle 1.
  • a passageway extending from vessel 4 to container 11 is therefore provided.
  • the liquid 10 passes through needle 1 under the influence of the vessel 4, and then through canal 72 into conduit 40.
  • detector 8 gives a command directing that valve 5 be closed.
  • the liquid 10 rests in suspension in the needle 1, the canal 72 and the portion of the conduit 40 extending from valve 7 to stop valve 5.
  • the detector 8 need not necessarily be precisely positioned in the system since it is only the liquid contained in the needle which is to be transferred. Also, the valve 5 need not be of a precision type for the same reason. The detector also commands the mechanism which effects movement of the rotor 70 and the pipette system per se.
  • the reservoir 3 which is in communication with the gaseous source 2 adjusts to the pressure of this source via the canal 71 and conduits and 30.
  • the pipette system is transported as a whole to a position whereat needle 1 is above the receptacle 12 by any suitable means.
  • the receptacle 12 is closed, (e.g., if a closed pouch is used) the needle can be conveniently adapted either by designing it to be able to partake of a supplementary translational movement in order to pierce the receptacle wall.
  • the rotor 70 is then turned a quarter of a turn clockwise, i.e., through an angle of 90.
  • the movements of the rotor 70 can be effected by a motor of the step-by-step type.
  • rotor 70 can move through a smaller angle, namely one-eighth one-sixteenth or smaller increments of a complete 360 turn.
  • the motor 70 can have an intermediate position between that shown in FIGS. 10 and 1b at which the canals or channels 71 and 72 are not in communication with the openings 711, 712, 721 and 722.
  • the passage from the first position (FIG. 1a) into the second position (FIG. lb) will be accomplished by several successive movements of the step-by-step motor.
  • the volume of the liquid transferred from the container 11 into the receptacle 12 is precisely determined by the volume of the needle (including, of course, the amount contained in the opening 721 in the outer cylindrical member 73). In any event, the volume transferred from opening 721 and the needle 1 is easily calculated and can be kept constant and ascertainable with accuracy. Taking into account the slight volume found in opening 721, the precise amount of liquid is obtained by the fact that canal 72 is cut off from communication with opening 721 as the device moves from the position shown in FIG. 1a to that shown in FIG. 1b.
  • the pressure in the reservoir 3 decreases exponentially.
  • the force exerted on the liquid is maximal at the beginning of the decantation and weak at the end of the opera- 10 justed by regulating the amount of compressed air 2 entering the system with the volume of container 3 in view.
  • a pressure reducer such as a relief valve associated with conduit 20 placed in series in the system.
  • reservoir 3 In an alternate embodiment and to obtain a force of ejection of liquid adapted specifically to a need, several reservoirs of the type illustrated by reservoir 3 can be disposed in the system in series separated by valves with controllable delivery provided by diaphragms or lost-load devices. There is illustrated in FIG. 3 such an embodiment. In the embodiment shown in FIG. 3, several reservoirs 3, 31 and 32 are disposed in series and are separated by the valves 35 and 36 so arranged as to provide a controllable delivery.
  • the number of reservoirs, the volume and the number of valves are chosen by taking into account the volume of the sample to be transferred, the viscosity thereof, its specific gravity, its propensity for turbity and the like during the opera tion and at the finish thereof. It should be evident that these characteristics are well within the skill of the artisan to recognize and then to adapt the device to compensate for the influence thereof.
  • FIG. 2 represents schematically a pipette system identical to that illustrated in FIGS. 10 and lb but which includes additionally a supplementary means for permitting a sequential cleaning and drying of the canals between each transferring operation.
  • the reservoir 3 is placed in communication with a cleaning conduit 37 closed by a valve 38.
  • Conduit 20 also communicates with an additional conduit 21.
  • a cleaning liquid is adapted to enter the system via conduit 21.
  • the entry of the cleaning liquid into the system is controlled by valve 22.
  • the compressed gas is prevented from entering the valve during the cleaning operation.
  • in order to permit conduit 40 to be cleaned one could dispose between the opening 722 and the valve 5, an inlet 25 for a cleaning liquid, which inlet is closed by a valve 26.
  • the drying of conduit 30 and reservoir 3 is effected by the compressed gas 2.
  • Conduit 40 is dried by connecting to it an inlet which permits entry of a compressed gas 27. The last-mentioned inlet is closed by valve 28.
  • valves 7 and 107 are connected thusly.
  • Valve 7 is connected to the needle 1.
  • the receptacle 4 has disposed between it and valve 7, the stop valve 5 and the detector 8.
  • Valve 7 is connected to the valve 107 by a conduit 200 having a calibrated internal volume.
  • Valve 7 is also connected to a depressurized draining vat 9. Between the two is a liquid detector 90.
  • Valve 107 is connected to a reservoir containing a dilution liquid 110. In the path of movement of the dilution liquid, there is disposed a valve 50 controlled by liquid detector 90.
  • This embodiment functions as follows:
  • the rotor of the valve 7 and 107 take the position represented in FIG. 4a.
  • the valves 5 and 50 are open. Because of the vacuum created in the receptacle 4, the liquid to be transferred or decanted rises into needle 1. Concurrently, the reservoir 3 fills with compressed gas.
  • the conduit 200 fills with the dilution liquid under the influence of evacuating vat 9.
  • the valve 5 closes as a result of command given by the detector.
  • the valve 50 is commanded to close and the aspiration of liquid 110 ceases.
  • valves 7 and 1107 are displaced a quarter of a turn from the position shown in FIG. 4a to the position shown in H6. 4b.
  • communication is established between the needle 11 and the reservoir 3 via the conduit 200.
  • the pressure exerted by the gas contained in reservoir 3 causes a predetermined measured amount of the liquid sample contained in needle 1 and the diluting liquid contained in conduit 200 to enter the receptacle 12.
  • the tube 200 being calibrated and the volume of the internal canals in valves 7 and 107 being previously measured, one can obtain an extremely precise dilution of the sample in a relatively rapid and feasible manner.
  • conduit 40 and one of the internal canals of valve 7 are in communication with the evacuating container 9 and the residual liquids contained therein are emptied into container 9.
  • the apparatus is now ready to recommence the novel sequence of operation in order to provide another sample of the product after a rotation of a quarter of a turn of the rotors of the valves 7 and 107 back to the position thereof shown in H6. 4a.
  • FIG. 5 represents another embodiment of the pipette system of the present invention. it comprises a distribution valve having four canals in the rotor and eight corresponding openings in the stator. More generally, it should be recognized that one could utilize a distribution sluice having n canals in the rotor and Zn openings in the stator. The four canals are spaced equidistant from each other about the axis of the rotor. Openings 801i, 802, 003 and 804 are respectively connected to a source of gas 2, to an expansion reservoir 3, a hollow needle 1 and a depressurized trough 4 separated from the valve 7 by a stop valve 5 and a liquid detector 8. The four other outlets are connected in the following manner:
  • Outlet 005 is connected to an inlet for a cleaning liquid, outlet 807 to an inlet for clean and dry air and outlets 806 and 000 are for evacuation and thus are connected to an exhaust.
  • canal 8111 is in a position for being cleaned
  • canal 8113 is in a position for being dried
  • canal 012 serves for pressurizing the reservoir 3
  • canal 8110 connects hollow needle 1 to trough 4 for the next sample aspiration.
  • a pipette system for transferring a desired volume of a liquid sample from a sample container in which it is stored into a receiving receptacle which comprises a distribution means including a first member having formed therein at least two independent, noncommunicating canals, the ends of which open at the periphery of the first member and a second member movable with respect to the first member, said second member being traversed by at least four noncommunicating openings, each canal when in operative condition being in communication with two of said openings, a sampling means adapted to be immersed into the container and joined to said distribution means, said sampling means having an opening therein in communication with a first of said openings, a depressurized evacuating container connected to a second of said openings, a reservoir connected to a third of said openings, a source of compressed gaseous material connected to a fourth of said openings, one of the canals in the first member in a first operative position being in communication with a first and a second of said openings
  • a pipette system in accordance with claim 1 characterized by the fact that the said means for moving the first member of the distribution system relative to the second member includes a motor means of the step-by-step type thereby permitting incremental movements, said motor means being energized in response to commands given by a liquid detector, said liquid detector being positioned in the system between the depressurized container and the said second of the openings and being responsive to passage of the liquid sample through the said passageway into which it is withdrawn.
  • a pipette system in accordance with claim l characterized by the fact that the two members of the distribution means are movable rotatively relative to each other, and the said at least four openings are spaced equidistant one from another.
  • a pipette system in accordance with claim 1 characterized by the fact that it comprises a cleaning liquid conduit for entry of a cleaning liquid operatively connected to the said fourth of said openings between the latter and said source of gaseous material, said cleaning liquid conduit having a valve disposed in the path of the passageway provided by the interior of the cleaning liquid conduit, and an inlet conduit and outlet conduit operatively connected to the said second of said openings between the said second opening and the depressurized evacuating container, a source of drying gas connected to the inlet conduit, said outlet conduit being adapted to permit the escape of the drying gas and first and second valve means on said inlet and outlet conduits and disposed in the entering and escape path, respectively, of the drying gas and adapted to control die entry and escape of the drying gas.
  • a pipette system in accordance with claim 1 characterized by the fact that the second member of the distribution means includes a fifth and sixth opening, said fifth and sixth openings adapted to communicate with a third canal in the first member in the said first operative positions, one of said last-mentioned fifth and sixth openings being connected to a source of cleaning liquid and the other being connected to an evacuating depressurized vessel.
  • sampling means includes a hollow needle coated all along its internal surface and at least partially along its external surface with a water-repellent coating.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
US85056A 1969-11-03 1970-10-29 Pipette system Expired - Lifetime US3645142A (en)

Applications Claiming Priority (1)

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FR6937726A FR2067416A5 (de) 1969-11-03 1969-11-03

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AU (1) AU2105470A (de)
BE (1) BE758245A (de)
CH (1) CH517526A (de)
DE (1) DE2051707A1 (de)
FR (1) FR2067416A5 (de)
IL (1) IL35476A0 (de)
NL (1) NL7015798A (de)
ZA (1) ZA707061B (de)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929413A (en) * 1974-03-04 1975-12-30 Anatronics Corp Fluid transport and metering system
US3999945A (en) * 1974-08-30 1976-12-28 Delta Scientific Corporation Liquid analysis system
US4059408A (en) * 1976-03-12 1977-11-22 Commissariat A L'energie Atomique Automatic liquid-liquid extraction device
US4163392A (en) * 1978-10-02 1979-08-07 Manning Environmental Corp. Sampler purge system
US20010000723A1 (en) * 1998-06-16 2001-05-03 Mcluen Gary R. Multi-well rotary synthesizer
US20010038071A1 (en) * 2000-04-26 2001-11-08 Nichols Jon A. Mass rate attenuator
WO2001079422A3 (en) * 2000-04-18 2002-05-16 Amersham Biosciences Ab Improved spot picker head
US20030072679A1 (en) * 2000-10-11 2003-04-17 Innovadyne Technologies, Inc. Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device
US20030162304A1 (en) * 2002-02-25 2003-08-28 Cepheid Fluid processing and control
US20030170903A1 (en) * 2002-01-25 2003-09-11 Innovadyne Technologies, Inc. High performance, low volume, non-contact liquid dispensing apparatus and method
US6852291B1 (en) * 2000-10-11 2005-02-08 Innovadyne Technologies, Inc. Hybrid valve apparatus and method for fluid handling
US7032605B1 (en) 2003-10-15 2006-04-25 Douglas B. Dority Dual piston rotary valve
EP2807410A4 (de) * 2012-07-17 2015-03-04 Idex Health & Science Llc Ventil zur probenahme einer flüssigkeit
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
US9683975B2 (en) 2014-02-12 2017-06-20 Idex Health & Science Llc Volumetric flow regulation in multi-dimensional liquid analysis systems
US10240182B2 (en) * 2013-08-25 2019-03-26 Lishtot Detection, Ltd. Devices and methods for identifying a biological or chemical residue in an aqueous sample
US20210072121A1 (en) * 2019-09-06 2021-03-11 Elemental Scientific, Inc. System and method for trapping fluid at a valve
US20220276133A1 (en) * 2016-04-28 2022-09-01 Shanghai Kohler Electronics, Ltd. Device for collecting liquid and smart toilet comprising the same
US11598696B2 (en) * 2019-06-14 2023-03-07 Emerald Coast Manufacturing, LLC Method and apparatus for sampling liquid
US11927508B1 (en) * 2020-01-21 2024-03-12 Elemental Scientific, Inc. System and method for handling small samples with multiple vacuum configurations

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548781B1 (fr) * 1983-07-05 1986-02-14 Rhone Poulenc Chim Base Dispositif de prelevement d'echantillons de liquide
DE19742005A1 (de) * 1997-09-24 1999-04-01 Microdrop Ges Fuer Mikrodosier Vorrichtung und Verfahren zum genauen Dosieren und Umsetzen von kleinen Flüssigkeitsmengen
DE19841782A1 (de) * 1998-09-12 2000-08-31 Walz Karl Heinz Automatische Probenahmeeinrichtung für die Entnahme von Flüssigproben aus geschlossenen Leitungen oder Behältern, auch wenn diese unter Druck stehen (Inline-Probenahme)
DE10236160B4 (de) * 2002-08-07 2004-12-02 Dr.Ing.H.C. F. Porsche Ag Vorrichtung zur selektiven Zuleitung von Medien, insbesondere bei Emissionsmessungen von Abgasen in Brennkraftmaschinen
DE10249771A1 (de) * 2002-10-24 2004-05-13 AMTEC-Anwendungszentrum für Mikrotechnologien Chemnitz GmbH Verfahren und Vorrichtung zur Entnahme von flüssigen Proben aus einem oder mehreren Druckbehältern
DE102004039378A1 (de) * 2004-08-13 2006-02-23 Hte Ag The High Throughput Experimentation Company Vorrichtung zur kontrollierten Entnahme von Fluidproben aus Druckbehältern

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1204368A (en) * 1916-03-27 1916-11-07 Alexander Lowy Analytical pipette.
GB109753A (en) * 1917-04-30 1917-09-27 Percy Edwin Spielmann Improvements in Analytical Pipettes.
US3119524A (en) * 1961-06-02 1964-01-28 Arthur H Thomas Company Automatic controlled volume liquid delivery assembly
US3137172A (en) * 1960-09-08 1964-06-16 Fisher Scientific Co Automatic pipet

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1204368A (en) * 1916-03-27 1916-11-07 Alexander Lowy Analytical pipette.
GB109753A (en) * 1917-04-30 1917-09-27 Percy Edwin Spielmann Improvements in Analytical Pipettes.
US3137172A (en) * 1960-09-08 1964-06-16 Fisher Scientific Co Automatic pipet
US3119524A (en) * 1961-06-02 1964-01-28 Arthur H Thomas Company Automatic controlled volume liquid delivery assembly

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929413A (en) * 1974-03-04 1975-12-30 Anatronics Corp Fluid transport and metering system
US3999945A (en) * 1974-08-30 1976-12-28 Delta Scientific Corporation Liquid analysis system
US4059408A (en) * 1976-03-12 1977-11-22 Commissariat A L'energie Atomique Automatic liquid-liquid extraction device
US4163392A (en) * 1978-10-02 1979-08-07 Manning Environmental Corp. Sampler purge system
US20010007644A1 (en) * 1998-06-16 2001-07-12 Mcluen Gary R. Multi-well rotary synthesizer
US20010001035A1 (en) * 1998-06-16 2001-05-10 Northwest Engineering Inc. Multi-well rotary synthesizer
US7150998B2 (en) * 1998-06-16 2006-12-19 Mcluen Design, Inc. Multi-well rotary synthesizer
US7192558B2 (en) 1998-06-16 2007-03-20 Mcluen Design, Inc. Multi-well rotary synthesizer
US8147776B2 (en) 1998-06-16 2012-04-03 Mcluen Design, Inc. Multi-well rotary synthesizer
US8158085B2 (en) 1998-06-16 2012-04-17 Mcluen Design, Inc. Multi-well rotary synthesizer
US8747780B2 (en) 1998-06-16 2014-06-10 Mcluen Design, Inc. Multi-well rotary synthesizer
US8404196B2 (en) 1998-06-16 2013-03-26 Mcluen Design, Inc. Multi-well rotary synthesizer
US20010000723A1 (en) * 1998-06-16 2001-05-03 Mcluen Gary R. Multi-well rotary synthesizer
WO2001079422A3 (en) * 2000-04-18 2002-05-16 Amersham Biosciences Ab Improved spot picker head
US20050118075A1 (en) * 2000-04-26 2005-06-02 Nichols Jon A. Mass rate attenuator
US6890489B2 (en) * 2000-04-26 2005-05-10 Rheodyne, L.P. Mass rate attenuator
US7575723B2 (en) 2000-04-26 2009-08-18 Idex Health & Science Llc Mass rate attenuator
US20010038071A1 (en) * 2000-04-26 2001-11-08 Nichols Jon A. Mass rate attenuator
US9212980B2 (en) 2000-08-25 2015-12-15 Cepheid Fluid processing and control
US9669409B2 (en) 2000-08-25 2017-06-06 Cepheid Fluid processing and control
US6852291B1 (en) * 2000-10-11 2005-02-08 Innovadyne Technologies, Inc. Hybrid valve apparatus and method for fluid handling
US20070053798A1 (en) * 2000-10-11 2007-03-08 Innovadyne Technologies, Inc. Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device
US7135146B2 (en) 2000-10-11 2006-11-14 Innovadyne Technologies, Inc. Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device
US7497995B2 (en) 2000-10-11 2009-03-03 Innovadyne Technologies, Inc. Hybrid valve apparatus and method for fluid handling
US20090074625A1 (en) * 2000-10-11 2009-03-19 Innovadyne Technologies, Inc. Micro fluidics manifold apparatus
US20030072679A1 (en) * 2000-10-11 2003-04-17 Innovadyne Technologies, Inc. Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device
US20050129584A1 (en) * 2000-10-11 2005-06-16 Innovadyne Technologies, Inc. Hybrid valve apparatus and method for fluid handling
US20030170903A1 (en) * 2002-01-25 2003-09-11 Innovadyne Technologies, Inc. High performance, low volume, non-contact liquid dispensing apparatus and method
US20070155019A1 (en) * 2002-01-25 2007-07-05 Innovadyne Technologies, Inc. System and method for repetitive, high performance, low volume, non-contact liquid dispensing
US7169616B2 (en) 2002-01-25 2007-01-30 Innovadyne Technologies, Inc. Method of purging trapped gas from a system fluid contained in an actuation valve
US6983636B2 (en) 2002-01-25 2006-01-10 Innovadyne Technologies, Inc. Apparatus and method for assessing the liquid flow performances through a small dispensing orifice
US10906039B2 (en) 2002-02-25 2021-02-02 Cepheid Fluid processing and control
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US8673238B2 (en) 2002-02-25 2014-03-18 Cepheid Fluid processing and control
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US20030162304A1 (en) * 2002-02-25 2003-08-28 Cepheid Fluid processing and control
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US8431413B2 (en) 2002-02-25 2013-04-30 Cepheid Fluid processing and control
US7032605B1 (en) 2003-10-15 2006-04-25 Douglas B. Dority Dual piston rotary valve
EP2807410A4 (de) * 2012-07-17 2015-03-04 Idex Health & Science Llc Ventil zur probenahme einer flüssigkeit
US9032819B2 (en) 2012-07-17 2015-05-19 Idex Health & Science Llc Liquid sampling valve
US10036736B2 (en) 2012-07-17 2018-07-31 Idex Health & Science Llc Liquid sampling valve
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
US10240182B2 (en) * 2013-08-25 2019-03-26 Lishtot Detection, Ltd. Devices and methods for identifying a biological or chemical residue in an aqueous sample
US10677766B2 (en) 2014-02-12 2020-06-09 Idex Health & Science Llc Volumetric flow regulation in multi-dimensional liquid analysis systems
US9683975B2 (en) 2014-02-12 2017-06-20 Idex Health & Science Llc Volumetric flow regulation in multi-dimensional liquid analysis systems
US20220276133A1 (en) * 2016-04-28 2022-09-01 Shanghai Kohler Electronics, Ltd. Device for collecting liquid and smart toilet comprising the same
US11686654B2 (en) * 2016-04-28 2023-06-27 Shanghai Kohler Electronics, Ltd. Device for collecting liquid and smart toilet comprising the same
US11971335B2 (en) 2016-04-28 2024-04-30 Shanghai Kohler Electronics, Ltd. Device for collecting liquid and smart toilet comprising the same
US11598696B2 (en) * 2019-06-14 2023-03-07 Emerald Coast Manufacturing, LLC Method and apparatus for sampling liquid
US20210072121A1 (en) * 2019-09-06 2021-03-11 Elemental Scientific, Inc. System and method for trapping fluid at a valve
US11692912B2 (en) * 2019-09-06 2023-07-04 Elemental Scientific Inc. System and method for trapping fluid at a valve
US12078579B2 (en) 2019-09-06 2024-09-03 Elemental Scientific, Inc. System and method for trapping fluid at a valve
US11927508B1 (en) * 2020-01-21 2024-03-12 Elemental Scientific, Inc. System and method for handling small samples with multiple vacuum configurations

Also Published As

Publication number Publication date
AU2105470A (en) 1972-04-20
CH517526A (de) 1972-01-15
FR2067416A5 (de) 1971-08-20
BE758245A (fr) 1971-04-30
ZA707061B (en) 1971-10-27
IL35476A0 (en) 1970-12-24
DE2051707A1 (de) 1971-05-19
NL7015798A (de) 1971-05-05

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