US3696155A - Production of 2-methyl-3-buten-2-ol - Google Patents

Production of 2-methyl-3-buten-2-ol Download PDF

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Publication number
US3696155A
US3696155A US37061A US3696155DA US3696155A US 3696155 A US3696155 A US 3696155A US 37061 A US37061 A US 37061A US 3696155D A US3696155D A US 3696155DA US 3696155 A US3696155 A US 3696155A
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Prior art keywords
methyl
buten
percent
acid
parts
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US37061A
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English (en)
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Herbert Mueller
Dietrich Mangold
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S585/00—Chemistry of hydrocarbon compounds
    • Y10S585/929—Special chemical considerations
    • Y10S585/947—Terpene manufacture or recovery

Definitions

  • 2-methyl-3-buten-2-ol can be prepared by reaction of acetone with acetylene followed by partial hydrogenation of the resultant 2- methyl-3-buten-1-ol (cf. for example Liebigs Annalen der Chemie, 596, 37( 1955).
  • the process is very expensive however because in the first stage special precautionary measures are necessary because acetylene is being used and in the second stage the partial hydrogenation using poisoned catalysts requires very exact maintenance of the reaction conditions.
  • the production of 2-methyl-3-buten-2-ol by adding isopropanol radicals to acetylone at superatmospheric pressure is furthermore described in French Pat. No. 1,301,882. This process however gives only unsatisfactory yields.
  • the object of the invention is a process for the production of 2-methyl-3-buten-2-ol according to which 2-methyl-3-buten-2-ol is obtained by a simpler method and in better yields than in.the prior art methods.
  • 2-methyl-3-buten-2-ol is obtained in one stage in good yields/
  • the starting material (3-methyl-3-buten-l-ol) can be prepared in a simple manner by the method of German Printed application No. 1,275,049 by reaction of isobutylene with formaldehyde.
  • the reaction may be carried out in he presence of a monobasic or polybasic, preferably up to dibasic, organic or inorganic acid.
  • the aqueous acid generally has a dissociation constant of at least 1 X l' Naturally compounds which are converted in aqueous medium into acids such as aluminum chloride may also be used.
  • suitable acids are hydrogen chloride, hydrogen bromide, hydrogen iodide, hydrogen fluoride, sulfuric acid, phosphoric acid, p-toluenesulfonic acid, trichloroacetic acid, dichloroacetic acid, chloroacetic acid, formic acid, oxalic acid, and ion exchange resins which contain sulfonic acid groups or carboxyl groups.
  • the concentration of the aqueous acid is generally from 0.01 to 35 percent by weight.
  • Very strong acids i.e., acids having a dissociation constant of more than about are advantageously used in a concentration of 0.01 to 10 percent by weight, particularly from 0.05 to 2 percent by weight.
  • Acids having a dissociation constant of less than about 10 are preferably used in amounts of from 0.5 to 25 percent by weight, particularly 1 to 10 percent, by weight. It is generally advantageous to use lower concentrations of acid when using higher temperatures and to use higher acid concentrations at lower temperatures. Thus it may for example be advantageous to decrease the acid concentration by about the factor 0.2 to 0.1 upon an increase in temperature of for example 30C.
  • Atmospheric pressure is generally used. It is also possible however to use superatmospheric pressure, for example 5 atmospheres, or subatmospheric pressure, for example 100 mm Hg.
  • the ratio by weight of starting material to aqueous acid is generally from 1:5 to 5:1, preferably from 1:2 to 3: 1. It may be advantageous additionally to use inert organic solvents in the isomerization.
  • suitable solvents are aromatic or aliphatic hydrocarbons which may be nitrated or halogenated such as benzene,
  • fonic acids trichloroacetic acid and particularly oxalic acid or maleic acid.
  • the inert solvents are advantageously used in amounts of 10 to 200 percent by weight, preferably 30 to. percent by weight, with reference to the mixture of starting material and aqueous acid. When using an inert solvent it is advantageous to provide for vigorous mixing of the reaction mixture.
  • the isomerization may be carried out-continuously or batchwise. Batchwise operation may be carried out for example by heating a mixture of starting material and aqueous acid in the specified amounts in a reactor having a superimposed packed column at atmospheric pressure at the reaction temperature, the 2-methyl-3- buten-2-ol formed being taken overhead. Water generally is distilled off from the reaction mixture together with the end product. Water is advantageously added to the reaction mixture at the rate at which it is distilled off. It is preferred to carry out the reaction continuously.
  • 2-methyl-3-buten-2-ol is a valuable intermediate for example for the production of terpenes.
  • EXAMPLE 1 Six hundred and seventy parts of 3fmethyl-3-butenl-ol, 535 parts of water and 1.67 parts of concentrated sulfuric acid are heated at boiling temperature for 10 hours in a 2-liter stirred flask having a superposed column having a height of 1 meter which is packed with glass Raschig rings and provided with a distilling head. During this period, at a distillation temperature of 94 to 95C, water (which is continuously returned to the still) and 660 parts of an organic distillate are taken off; the latter has the following composition according to gas chromatographic analysis: 6 percent isoprene, 31.8 percent 2-methyl-3-buten-2-ol and 57.6 percent 3- methyl-3-buten-1-ol. At a conversion of 43 percent, the yield of 2-methyl-3-buten-2-ol is 72 percent of the theory.
  • EXAMPLE 2 One thousand parts of 3-methyl-3-buten-l-ol, 400 parts of water and 2.5 parts of concentrated phosphoric EXAMPLE 3 Fifteen hundred parts of 3-methyl-3-buten-1-ol, 300 parts of water, 2.5 parts of concentrated sulfuric acid and 500 parts of ethylbenzene are heated at boiling temperature for 20 hours with vigorous stirring in the apparatus described in Example 1 and by an analogous method to that described in Example 1.
  • the 999 parts of distillate obtained contains the following substances according to gas chromatographic analysis: 7.2 percent isoprene, 14.4 percent 2-methyl-3-buten-2-ol and 27 percent 3-methyl-3-buten-lol. Ata conversion of 46 percent, the yield of 2-methyl-3-buten-2-ol is 63 percent of the theory.
  • EXAMPLE 4 One thousand parts of 3-methyl-3-buten-l-ol, 400 parts of water and 80 parts of oxalic acid are kept at boiling temperature for 18 hours in a manner analogous to that described in Example 1. During the said period, 912 parts of an organic distillate is obtained which according to gas chromatographic analysis has the following composition: 10.5 percent isoprene, 65 percent 2-methyl-3-buten-2-ol and 23 percent 3-methyl-3-buten-l-ol. At a conversion of 79 percent, the yield of 2-methyl-3-buten-2-ol is 75 percent of the theory.
  • 3-methyl-3-buten-lol 45.5 parts water 54.5 parts oxalic acid. 4.5 parts
  • the feed temperature is 100C.
  • a mixture of water and pentenols boiling at 92C is taken overhead. While the aqueous phase is returned to the evaporator of the column, the organic phase is supplied in the middle of a second column having eight theoretical trays. 0.8 part of isoprene (boiling point 34C) is taken off at the top of this column.
  • the bottoms of the column is introduced into the lower third of a third column having about 15 theoretical trays.
  • the overhead product obtained here is a 2-methyl-3-buten-2-ol/water azeotrope having a boiling point of 86C. The bottoms of this column are returned to column 1.
  • EXAMPLE 6 The procedure of Example 5 is followed but a pressure of 2 atmospheres gauge is used in the first column and a 0.5 percent by weiglrilt aqueous oxalic acid is used. The top temperature of e first column is 127 C. The

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
US37061A 1969-05-17 1970-05-13 Production of 2-methyl-3-buten-2-ol Expired - Lifetime US3696155A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691925197 DE1925197C3 (de) 1969-05-17 Verfahren zur Herstellung von 2-Methyl-3-buten-2-ol

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US3696155A true US3696155A (en) 1972-10-03

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US (1) US3696155A (de)
JP (1) JPS4817247B1 (de)
BE (1) BE750481A (de)
CH (1) CH524555A (de)
FR (1) FR2047710A5 (de)
GB (1) GB1299615A (de)
NL (1) NL159947C (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993702A (en) * 1975-09-29 1976-11-23 Phillips Petroleum Company Production of unsaturated alcohols
US4219683A (en) * 1978-09-25 1980-08-26 Phillips Petroleum Company Isomerization of unsaturated alcohols
US5349097A (en) * 1992-08-29 1994-09-20 Basf Aktiengesellschaft Catalytic isomerization of α-alkenols
US5998680A (en) * 1997-02-25 1999-12-07 Basf Aktiengesellschaft Isomerization of allyl alcohols
US6180839B1 (en) * 1998-03-12 2001-01-30 Basf Aktiengesellschaft Continuous preparation of dimethylvinylcarbinol by isomerizing prenol

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2373956A (en) * 1940-08-29 1945-04-17 Shell Dev Rearrangement of unsaturated aliphatic alcohols
US2435078A (en) * 1945-02-12 1948-01-27 Shell Dev Rearrangement of unsaturated aliphatic alcohols
US3344191A (en) * 1963-12-03 1967-09-26 Columbian Carbon Process for isomerizing unsaturated alcohols

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2373956A (en) * 1940-08-29 1945-04-17 Shell Dev Rearrangement of unsaturated aliphatic alcohols
US2435078A (en) * 1945-02-12 1948-01-27 Shell Dev Rearrangement of unsaturated aliphatic alcohols
US3344191A (en) * 1963-12-03 1967-09-26 Columbian Carbon Process for isomerizing unsaturated alcohols

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Nazarov et al., Akad Nask 555R Seris Khim, (1946) pages 4-19-26, Library Congress No. AS262. A 62425. *
Nazarov et al., Chem. Abstracts , Vol. 42, (1948), pages 7730 to 7739, QDIA5/. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993702A (en) * 1975-09-29 1976-11-23 Phillips Petroleum Company Production of unsaturated alcohols
US4219683A (en) * 1978-09-25 1980-08-26 Phillips Petroleum Company Isomerization of unsaturated alcohols
US5349097A (en) * 1992-08-29 1994-09-20 Basf Aktiengesellschaft Catalytic isomerization of α-alkenols
US5998680A (en) * 1997-02-25 1999-12-07 Basf Aktiengesellschaft Isomerization of allyl alcohols
US6180839B1 (en) * 1998-03-12 2001-01-30 Basf Aktiengesellschaft Continuous preparation of dimethylvinylcarbinol by isomerizing prenol

Also Published As

Publication number Publication date
GB1299615A (en) 1972-12-13
NL159947C (nl) 1979-09-17
FR2047710A5 (de) 1971-03-12
DE1925197A1 (de) 1970-11-26
DE1925197B2 (de) 1975-07-10
CH524555A (de) 1972-06-30
BE750481A (fr) 1970-11-16
JPS4817247B1 (de) 1973-05-28
NL7007145A (de) 1970-11-19
NL159947B (nl) 1979-04-17

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