US3705652A - Apparatus for sterile material exchange - Google Patents

Apparatus for sterile material exchange Download PDF

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Publication number
US3705652A
US3705652A US16331A US3705652DA US3705652A US 3705652 A US3705652 A US 3705652A US 16331 A US16331 A US 16331A US 3705652D A US3705652D A US 3705652DA US 3705652 A US3705652 A US 3705652A
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United States
Prior art keywords
hose
synthetic material
hoses
membrane
set forth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US16331A
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English (en)
Inventor
Horst Russmann
Helmut Determann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotest Serum Institut GmbH
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Biotest Serum Institut GmbH
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Filing date
Publication date
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/22—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by diffusion
    • B01D53/228—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by diffusion characterised by specific membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/22—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by diffusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/28—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/10—Spiral-wound membrane modules

Definitions

  • An apparatus for the sterile material exchange in solutions which comprises a conventional membrane in form of a hose, a grid of synthetic material, and a hollow empty hose of synthetic material.
  • the conventional membrane is disposed between the grid of synthetic material and is received in the hose of synthetic material.
  • Hose connections are carried by the hose of synthetic material and arecapable of being closed by a protection cap.
  • a sealing device closes jointly both the hoses, and both hoses permit an access capable of closing by another protection cap to the membrane connection.
  • the hoses are bent at substantially a right angle for insertion into the sealing or closing device.
  • the invention also includes the system of hoses being 11 Claims, 9 Drawing Figures PATENTED um 12 I972 SHEET 1 BF 2 ill:
  • FIG. IA is a diagrammatic representation of FIG. IA.
  • FIG. 2A is a diagrammatic representation of FIG. 2A.
  • the present invention relates to an apparatus for sterile material exchange, in general, and to such material exchange in solutions, in particular.
  • the apparatus designed in accordance with the present invention is suitable for the insulation of macro-molecular substances from solutions, in particular of biological material mixtures, for example, the dialysis in enzyme preparations, the hemo-dialysis, the laboratory-like technical dialysis in biology, biochemistry and medicine, for the concentration of solutions of any type by ultra-filtration, as oxygen generator and generally for the gas exchange in solutions.
  • the Kill-dialysis For the heme-dialysis at the present time two different forms of dialysis are provided: The Kill-dialysis and the Coildialysis. It is attempted in both embodiments, to distribute a smallest possible quantity of blood to a possible large face of an exchange membrane available on the market, and to permit rinsing of this membrane on the other side by a rinsing liquid, the so-called dialysis liquid.
  • the known oxygenerators are nearly always complicated combined devices, which are used many times merely for reason of costs.
  • the apparatus ready for use should be transparent, in order to make possible the observation of the exchange processes.
  • FIG. 1 is one embodiment of the apparatus, designed in accordance with the present invention, shown by example only;
  • FIG. 2 is a section of the sealing device through which the hose of synthetic material is closed.
  • FIG. 2A is a cross-section along section 2A of. FIG. 2B.
  • FIG. 2B is a cross-section along section 28 of FIG. 2A.
  • FIG. 3 is an elevation of another embodiment of the hose-system.
  • FIG. 4 is anelevation, partly in section, of another embodiment of the apparatus, designed in accordance with the present invention.
  • FIG. 4A is a cross-section along section 4A of FIG. 4.
  • FIG. 4B is a cross-section along section 4B of FIG.
  • the apparatus for the sterile material exchange in solutions of synthetic material is characterized by the feature, that a conventional membrane 1 in form of a hose is disposed between a grid 2 of synthetic material and is inserted into a hose 3 of synthetic material, which hose 3 has hose connections 4 closable with a conventional protection cap. Either both hoses are closed on both sides jointly by a sealing device 5, which permits an access 6 closable with.
  • a protective cap to the membrane hose or two accesses 6a and 6b are provided only at one side of the apparatus, which accesses make possible the approach to a hose.
  • the grid 2 of synthetic material can also be disposed between two foils 3a of synthetic material, which are then welded during the manufacture of the apparatus on both sides of the grid material to form a hose.
  • the membrane provided in accordance with the present invention, should permit for dialysis purposes the passage of small molecules from one solution into the other.” Thereby the macromolecules should be retained.
  • many membranes are available on the market, in particular products of celluloseregenerates or cellulose-derivates are suitable, for example, the product marketed by the firm Bemberg of Wuppertal, Germany, under the name Cuprophan.
  • any transparent material is suitable as a membrane, which retains liquids and dissolved material, preferably silicone rubber.
  • Suitable grid mate-rials have, for example, a waffle-like structure, as the produce marketed under the name of poly-net-grid material by the firm Norddeutsche 'Seectionwerke AG, Nordenham, Germany.
  • the task of the grid synthetic material to produce a rigid distance between the outer skin of the hose of synthetic material and the exchange membrane, so that a free flow cross-section for the rinsing liquid and the gas stream, respectively, is provided.
  • the unit it is in principle of no importance, whether the rinsing liquid and the gas, respectively, and the liquid to be treated flow in counter or parallel current. Since, however, due to the structure of the unit a very intensive contact of both media with the exchange membrane, and which is obtained in particular over its entirev length, due to the greater effectiveness by the larger concentration gradients, countercurrent operation is more advantageous.
  • the grid material and the exchange area are, as mentioned already, adjustable to a special exchange problem. This applies of course, also for the exchange membrane.
  • one has three values to be varied independently from each other, with which values possibly specific information can be given about a product to be I treated and specific exchange effects can be obtained, respectively.
  • the apparatus can be sterilized in the inner space andin the outer space and can therefore be applied for any type of the material exchange.
  • FIG. 1 shows an embodiment of the present apparatus by example only.
  • the rinsing liquid and the gas respectively, enters at one end of the hose 3 of synthetic material and emerges on the other end.
  • the hose 3 of synthetic material is compressed from the outside, simultaneously the membrane hose 1 is formed to a very flat, non-uniformly mounted flat-hose by the grid 2 of synthetic material engaging both sides. It is arranged, thereby, that the unit contains only a small quantity of liquid to be treated.
  • it is inserted advantageously with the hose 3 of synthetic material at a right angle into the closing device 5.
  • the unit is suspended perpendicularly and the liquid to be treated can escape nearly completely. With a rinsing media in addition a washing can be performed and this washing process can be observed by the totally transparent unit.
  • the pressure loss in the membrane hose 1 depends directly upon the length of the hose and its free cross-section. Since both values are variable, the pressure loss can be maintained extremely low. Since the liquid to be treated can be fed by its gravity force, as well as by means of a pump through the membrane hose 1, also a higher pressure loss in the unit can be overcome. If the unit is very long, the pressure loss caused thereby can be overcome by application of a pump.
  • the passage-quantity and-speed in the pressure ratio in the unit can be varied and be adjusted to the product.
  • sealing devices are disclosed, by which the hoses of synthetic material are closed. These sealing devices are advantageously machined of synthetic material or injection molded.
  • the screws, with which the sealing device can be compressed can be formed of any suitable material, in particular metal or synthetic material.
  • FIG. 4 of the drawings a selected possibility of an embodiment of the present invention is shown, as an apparatus which has at one side only two accesses 6a and 6b, which make possible the access to the individual hoses.
  • This embodiment has the advantage of greater handiness, in particular in longer units.
  • the apparatus designed in accordance with the present invention, fulfills the above-stated requirements in a satisfactory manner. It is to be understood, however, that the used materials is physiologically perfect, and that the apparatus is provided for a sterile use. With the apparatus, designed in accordance with the present invention, it is possible to maintain sterile also the used rinsing solution.
  • a dialysis apparatus for sterile material exchange using at least one solution comprising an inner permeable membrane in the form of a ho]- low empty hose,
  • said grid of synthetic material being interposed between said inner and outer hoses
  • hose connections carried by said hose of synthetic material and adapted to be closed by a protection cap
  • both said hoses permitting an access adapted to be closed by another protection cap to the membrane connection
  • said membrane comprises a material selected from the group consisting of a regenerated cellulose and a cellulose derivate.
  • the apparatus as set forth in claim 1, which includes a grid of synthetic material comprising poly-netgrid material.
  • one of said hose connections leads to said hose
  • a dialysis apparatus for sterile material exchange using at least one solution comprising an inner permeable membrane in the form of a hollow empty hose,
  • said grid of synthetic material being interposed between said inner and outer hoses
  • both said hoses permitting an access adapted to be closed by another protection cap to the membrane connection

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Water Supply & Treatment (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • External Artificial Organs (AREA)
US16331A 1969-03-06 1970-03-04 Apparatus for sterile material exchange Expired - Lifetime US3705652A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT224269A AT300734B (de) 1969-03-06 1969-03-06 Vorrichtung zum sterilen Stoff-Austausch in Lösungen

Publications (1)

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US3705652A true US3705652A (en) 1972-12-12

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US16331A Expired - Lifetime US3705652A (en) 1969-03-06 1970-03-04 Apparatus for sterile material exchange

Country Status (4)

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US (1) US3705652A (fr)
AT (1) AT300734B (fr)
BE (1) BE746841A (fr)
DE (1) DE2009155A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3851436A (en) * 1971-12-13 1974-12-03 Boeing Co Sterilizing and packaging process utilizing gas plasma
US4019988A (en) * 1975-08-28 1977-04-26 Extracorporeal Medical Specialities Inc. Dialyzer membrane seal and tubing connector
US4761229A (en) * 1987-06-22 1988-08-02 Thompson John A Multi-leaf membrane module
US5104532A (en) * 1989-09-15 1992-04-14 Exxon Research And Engineering Company Flat stack permeator

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT956374B (it) * 1972-06-08 1973-10-10 Dasco Spa Dispositivo per collegare tubi flessibili a membrana con condot ti di afflusso o di deflusso in dializzatori a rotolo
DE2843307A1 (de) * 1978-10-04 1980-04-10 Hoechst Ag Verfahren und anordnung zur abtrennung fester, schlammartiger und gegebenenfalls geloester anteile aus abwasser
DE3005408A1 (de) * 1979-02-15 1980-08-21 Daicel Chem Semipermeables membranelement
DE19724832C2 (de) * 1997-06-12 2000-07-06 Oxyphen Gmbh Dresden Querstromfilter
US6835314B2 (en) 2002-03-08 2004-12-28 Infrastructure Alternatives Method and apparatus for remediating wastewater holding areas and the like

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664395A (en) * 1949-08-24 1953-12-29 Marchand John Felix Dialyzer
FR1527944A (fr) * 1967-04-05 1968-06-07 Commissariat Energie Atomique Dispositif de dialyse, notamment pour rein artificiel
US3567028A (en) * 1968-12-26 1971-03-02 Research Corp Membrane envelope assembly

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664395A (en) * 1949-08-24 1953-12-29 Marchand John Felix Dialyzer
FR1527944A (fr) * 1967-04-05 1968-06-07 Commissariat Energie Atomique Dispositif de dialyse, notamment pour rein artificiel
US3567028A (en) * 1968-12-26 1971-03-02 Research Corp Membrane envelope assembly

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3851436A (en) * 1971-12-13 1974-12-03 Boeing Co Sterilizing and packaging process utilizing gas plasma
US4019988A (en) * 1975-08-28 1977-04-26 Extracorporeal Medical Specialities Inc. Dialyzer membrane seal and tubing connector
US4761229A (en) * 1987-06-22 1988-08-02 Thompson John A Multi-leaf membrane module
US5104532A (en) * 1989-09-15 1992-04-14 Exxon Research And Engineering Company Flat stack permeator

Also Published As

Publication number Publication date
BE746841A (fr) 1970-08-17
AT300734B (de) 1972-08-10
DE2009155A1 (de) 1970-09-24

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