US3898982A - Capillary tube for blood examination - Google Patents
Capillary tube for blood examination Download PDFInfo
- Publication number
- US3898982A US3898982A US401175A US40117573A US3898982A US 3898982 A US3898982 A US 3898982A US 401175 A US401175 A US 401175A US 40117573 A US40117573 A US 40117573A US 3898982 A US3898982 A US 3898982A
- Authority
- US
- United States
- Prior art keywords
- tube
- blood
- reagent
- capillary tube
- staining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004159 blood analysis Methods 0.000 title claims description 16
- 210000004369 blood Anatomy 0.000 claims abstract description 37
- 239000008280 blood Substances 0.000 claims abstract description 37
- 238000010186 staining Methods 0.000 claims abstract description 34
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 32
- 210000000601 blood cell Anatomy 0.000 claims abstract description 12
- 239000011248 coating agent Substances 0.000 claims abstract description 10
- 238000000576 coating method Methods 0.000 claims abstract description 10
- 239000000126 substance Substances 0.000 claims abstract description 10
- 206010057249 Phagocytosis Diseases 0.000 claims abstract description 8
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 8
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 8
- 230000008782 phagocytosis Effects 0.000 claims abstract description 8
- 230000000242 pagocytic effect Effects 0.000 claims abstract description 6
- 239000003086 colorant Substances 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 26
- 239000012530 fluid Substances 0.000 claims description 13
- 239000001963 growth medium Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 239000011247 coating layer Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 6
- 239000010410 layer Substances 0.000 claims description 6
- 238000007664 blowing Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 238000010241 blood sampling Methods 0.000 abstract description 2
- 239000000975 dye Substances 0.000 description 18
- 239000000243 solution Substances 0.000 description 15
- 210000001995 reticulocyte Anatomy 0.000 description 7
- 125000000853 cresyl group Chemical group C1(=CC=C(C=C1)C)* 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 238000007447 staining method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000006059 cover glass Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000002738 Giemsa staining Methods 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- VZCCTDLWCKUBGD-UHFFFAOYSA-N 8-[[4-(dimethylamino)phenyl]diazenyl]-10-phenylphenazin-10-ium-2-amine;chloride Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1N=NC1=CC=C(N=C2C(C=C(N)C=C2)=[N+]2C=3C=CC=CC=3)C2=C1 VZCCTDLWCKUBGD-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 206010019372 Heinz bodies Diseases 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 210000000624 ear auricle Anatomy 0.000 description 2
- 210000001907 heinz body Anatomy 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 2
- NZYCYASKVWSANA-UHFFFAOYSA-M new methylene blue Chemical compound [Cl-].CCNC1=C(C)C=C2N=C(C=C(C(NCC)=C3)C)C3=[S+]C2=C1 NZYCYASKVWSANA-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 235000015250 liver sausages Nutrition 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- QWYZFXLSWMXLDM-UHFFFAOYSA-M pinacyanol iodide Chemical compound [I-].C1=CC2=CC=CC=C2N(CC)C1=CC=CC1=CC=C(C=CC=C2)C2=[N+]1CC QWYZFXLSWMXLDM-UHFFFAOYSA-M 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- XYSQXZCMOLNHOI-UHFFFAOYSA-N s-[2-[[4-(acetylsulfamoyl)phenyl]carbamoyl]phenyl] 5-pyridin-1-ium-1-ylpentanethioate;bromide Chemical compound [Br-].C1=CC(S(=O)(=O)NC(=O)C)=CC=C1NC(=O)C1=CC=CC=C1SC(=O)CCCC[N+]1=CC=CC=C1 XYSQXZCMOLNHOI-UHFFFAOYSA-N 0.000 description 1
- 239000012192 staining solution Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/56—Labware specially adapted for transferring fluids
- B01L3/561—Tubes; Conduits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
Definitions
- ABSTRACT Capillary tubes of the double open-ended type used for blood collection and examination are provided over a portion of their internal surfaces with a dry coating of a reagent, e.g., a colorant for staining blood cells, a phagocytic substance for examining phagocytosis of leucocyte, etc.
- a reagent e.g., a colorant for staining blood cells, a phagocytic substance for examining phagocytosis of leucocyte, etc.
- the blood introduction end of the tube is left uncoated to promote capillary action in blood sampling.
- the coating may include an anticoagulant and several different reagents may be mixed in the coating or coated at intervals longitudinally of the tube.
- FIG. 1c FIG. 2B g 3 FIG. 20
- This invention relates to a capillary tube for use in staining cells and bacteria for observation and in a phagocytosis test of blood corpuscles or leucocyte.
- the staining of a blood smear preparation is effected using generally a May-Giemsa staining method. This method is" important in the diagnosis of blood disease staining method, it is conventional to also stain reticulocytes, mitochondria and intracellar granula.
- a. general staining b. reticulocyte staining c. Heinz bodies staining d. nuclear bodies staining e. mitchondria staining f; Golgi body staining g. oxidase i h. peroxidasei. PAS staining Astainin'gcapillary tube is designed to simplify these methods and one or all of these methods are intended to be effected within the capillary tube.
- the general staining includes a May-Giemsa staining; Giemsa staining; Wrightstaining; and a method using a fluorescent dye.
- the fluorescent dye is subject to an ultraviolet ray to produce a varying color tone dependent upon the kind of cells.
- Staining dyes used are asjfollowsz a. general staining Wright solution, Giemsa solution, May-Gruenwald solution, acridine orange (fluorescent dye) b. reticulocyte staining new methylene blue, brilliant cresyl blue c. Heinz bodies staining methyl, violet d. nuclear bodies staining brilliant cresyl blue e. mitochondria'fstaining janus green 1+; neutral red pinacyanol+ neutral red Various methods for staining cells such as blood corpuscles etc. have been known.
- a brilliantcresyl blue pure ethanol solution (dye solution) is dropped onto a glass plate 1 which is carefully cleaned and somewhat warmed, and is spread thin, if possible, for drying. Then, a droplet of blood is dropped at the'center of a cover glass and the cover glass is placed on the glass plate.
- the resultant sample is sealed by petroleum jelly or fluid paraffin and is allowed to stand for to minutes to obtain a complete sample as shown in FIG. 1C.
- a dye solution is sucked into a capillary tube to an extent that it reaches about one third of a length of the tube (FIG. 2A). Then, about the same amount of blood is sucked into the tube (FIG. 2B). The resultant solutuion is blow spattered on a slide 4 and intimately mixed (FIG. 2C). Then it is sucked back into the capillary tube (FIG. 2D) andallowed to standfor- 10 minutes (FIG. 2E). The solution is again blow spattered on a slide 5 and intimately mixed (FIG. 2F). A part of the solution is taken out and smeared thin on a spreader slider and air dryed. Thus a larger number of steps than those of the pappenheim method are required.
- the object of this invention is to provide a capillary tube for staining treatment or phagocytosis test which is capable of effecting a staining treatment or performing phagocytosis test with ease and with rapidity.
- a capillary tube whose inner wall surface is coated with a dry substance consisting primarily of a dye or a phagocytic foreign matter.
- FIG. 1 is an explanatory view of a pappenheim method, one of staining methods conventionally practised
- FIG. 2 is an explanatory view of a Brecker staining method
- FIG. 3 is a perspective view of a capillary tube according to this invention.
- FIG. 4 is a cross-sectional view of the capillary tube
- FIGS. 5 and 6 are explanatory views of the capillary tube.
- a reference numeral 11 is a transparent glass capillary tube.
- a dry material including a dye as a primary component is coated to provide a coating layer 12.
- the dry material differs in its components dependent upon the object to be stained.
- a fluorescent substance may be used.
- an observation can be made by exciting the substance by subjection to an ultraviolet ray etc. and when use is made of a blood from a vacuum fluid container containing an anticoagulant, no particular addition of an anti-coagulant is necessary, i.e., only a dye is required.
- a plurality of dyes may be contained simultaneously.
- Deposition of the dry material on the inner wall of the capillary tube 11 is effected, for example, in the following way.
- a solution is prepared by dissolving into a solvent such as water, or suspending in a solvent, a dye, phagocytizing foreign matter and anti-coagulant. Then, one end of the capillary tube is inserted into the solution to permit a proper amount of the solution to be .introduced, under a capillary action, into the interior of the capillary tube. A hot air is blown into that end of the capillary tube from which the solution is introduced and the solution so introduced into the capillary tube is blown out towards the other end of the tube, i.e., an excessive amount of the solution is blown out towards the other end of the tube. The solution deposited on the inner wall of the tube 11 is immediately evaporated to form a coating layer 12. Graduations 13 are marked on the peripheral wall of the capillary tube.
- a capillary tube 11 When a desired amount of blood is collected, a capillary tube 11 is withdrawn from the wound. Then, the capillary tube is, for example, shaked to cause the dye etc. deposited on the inner wall of the capillary tube 11 to be dissolved into the blood to permit them to be sufficiently mixed as shown in FIG. 5B.
- a smear preparation is obtained by blow spattering the blood within the capillary tube 11 onto glass plate as shown in FIG. 5C. The smear preparation can be permanently preserved.
- a vital staining sample is prepared, the same process as shown in FIGS. 5A and 5B is effected. Then, the blood within the capillary tube 11 is dropped onto a cover glass 15 as shown in FIG. 6C and the cover glass is inverted and put on a glass plate 16 as shown in FIG. 6D.
- the vital staining sample so obtained can not be preserved.
- a capillary tube whose inner surface is coated with a reagent coating layer, for example, a dry material including as a primary component a colorant or dye or a phagocytizing foreign substance, for example, carbon, starch or polystyrene.
- a reagent coating layer for example, a dry material including as a primary component a colorant or dye or a phagocytizing foreign substance, for example, carbon, starch or polystyrene.
- a blood corpuscle when a blood corpuscle is stain-treated, one end of the capillary tube is contacted with the human blood to cause the latter to be naturally sucked into the interior of the capillary tube under capillary action to permit the dye coated on the inner wall of the tube to be dissolved into the blood. That is, the collection of blood and the staining of blood corpuscle or cells can be simultaneously effected. Therefore it is not necessary to adjust a staining fluid, as encountered in the prior art, in an attempt to stain cells. Furthermore, there is saved the trouble of forming a dye film on the slide as in the case of the pappenheim method.
- a transparent capillary tube it is possible to observe the amount of blood sucked into the capillary tube.
- the amount of blood can be freely selected if the capillary tube is withdrawn when a predetermined amount of blood is reached. The operation is further facilitated when a graduation is marked on the outer wall of the capillary tube. Since the amount of blood can be freely selected, the mixing ratio between the dye and the blood can be easily adjusted.
- a dye or phagocytic foreign matter is coated on the whole inner wall surface of the capillary tube.
- a part of the inner wall of the capillary tube for example one third of a length of the tube, may be free from any reagent coating layer.
- blood etc. can be quickly sucked into the capillary tube without being obstructed by a coated layer.
- Two or more reagents may be coated at intervals in a lengthwise direction of the tube in a manner that the layer is divided into sections of individual reagents.
- the inner wall of one end portion of the tube is coated with a culture medium and the inner wall of the other end' portion of the tube is coated with a dye with an intermediate portion of the tube left uncoated.
- a lymphocyte suspension is sucked from the culture medium side and cultured for a predetermined time period in a humid room and then mixed with the dye.
- the capillary tube according to this invention can of course be applied to not only a lympphocyte suspension, or whole blood, but also other blood cells.
- a tube for blood examination which comprises a double open-ended capillary tube having an inner diameter which allows the introduction of blood by capillary action through the inlet end of the tube, at least one reagent coating layer coated on a portion of the inner wall surface thereof and spaced apart from said inlet end, and an uncoated inner wall area for the introduction of blood, which runs from said inlet end to an edge of the reagent coating layer.
- the tube for blood examination according to claim two kinds of reagent and each reagent is coated at intervals longitudinally of the tube.
- a blood examining method comprising the steps of drawing by capillary action a prescribed amount of fluid containing blood cells, from one end portion of a double open ended capillary tube where no reagent is coated to an extent corresponding to the prescribed amount of the fluid to be introduced, into said capillary tube having a portion where at least one blood examination reagent-containing layer is coated on the inner wall surface thereof, shaking the capillary tube to permit the reagent to be dissolved into the fluid, and blowing the fluid from the tube onto a substrate whereby an examination sample is prepared.
- said layer coating portion of said inner wall surface consists of two separate parts, one part being a culture medium and the other part being a staining material, and said shaking step comprises first mixing the fluid with the culture medium and then mixing the fluid-culture medium mixture with the staining material.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP47113033A JPS4858403A (fr) | 1971-11-13 | 1972-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3898982A true US3898982A (en) | 1975-08-12 |
Family
ID=14601758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US401175A Expired - Lifetime US3898982A (en) | 1972-11-13 | 1973-09-27 | Capillary tube for blood examination |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US3898982A (fr) |
| BE (1) | BE805489A (fr) |
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4027660A (en) * | 1976-04-02 | 1977-06-07 | Wardlaw Stephen C | Material layer volume determination |
| US4045175A (en) * | 1975-12-10 | 1977-08-30 | Ragnar Weber | Micro-method of erythrocyte sedimentation |
| US4137755A (en) * | 1976-09-20 | 1979-02-06 | Wardlaw Stephen C | Material layer volume determination |
| EP0005979A1 (fr) * | 1978-05-25 | 1979-12-12 | Dynatech Ag | Récipient de réaction miniature et méthode et appareil pour l'introduction d'un microvolume de liquide dans un tel récipient |
| US4190328A (en) * | 1978-12-01 | 1980-02-26 | Levine Robert A | Process for detection of blood-borne parasites |
| US4295857A (en) * | 1979-04-06 | 1981-10-20 | Peter Schuler | Process for the crystalline precipitation of chromogens |
| US4308029A (en) * | 1976-10-18 | 1981-12-29 | Radiometer A/S | Method and capillary tube for treating blood sample |
| US4314030A (en) * | 1979-02-27 | 1982-02-02 | C. A. Greiner & Sohne GmbH | Test tube for the examination of urine samples |
| US4576185A (en) * | 1983-12-05 | 1986-03-18 | Terumo Medical Corporation | Collection device for capillary blood |
| USD285115S (en) | 1983-12-05 | 1986-08-12 | Terumo Medical Corporation | Collector for capillary blood |
| US4634679A (en) * | 1982-11-10 | 1987-01-06 | Becton Dickinson And Company | Method of determining adhesion of a liquid sample |
| US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
| DE3833408C1 (en) * | 1988-10-01 | 1990-01-04 | Juergen 5223 Nuembrecht De Bethkenhagen | Capillary tube |
| US4949728A (en) * | 1988-11-30 | 1990-08-21 | Derek Brook | Method for performing in vitro diagnostic test on horses utilizing a blood sample |
| US4963498A (en) * | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
| US5300779A (en) * | 1985-08-05 | 1994-04-05 | Biotrack, Inc. | Capillary flow device |
| US5605838A (en) * | 1993-09-17 | 1997-02-25 | Boehringer Mannheim Gmbh | Method for the quantitative analysis of sample liquid |
| EP0826955A3 (fr) * | 1993-02-03 | 1999-03-03 | HISTAGGEN Incorporated | Procédé de stockage d'un ligand dans un récipient séparable et procédé de libération d'un ligand à partir de celui-ci |
| US6218193B1 (en) * | 1995-09-19 | 2001-04-17 | University Of Washington | Precision small volume fluid processing apparatus and method |
| WO2001073396A1 (fr) * | 2000-03-28 | 2001-10-04 | Caliper Technologies, Corp. | Procedes permettant de reduire un report fluidique dans des dispositifs microfluidiques |
| US6555386B1 (en) * | 1999-07-23 | 2003-04-29 | Clinical Diagnostic Chemicals Limited | Apparatus for collecting a liquid sample |
| US20040156746A1 (en) * | 2001-05-10 | 2004-08-12 | Larsen Ulrik Darling | Device for sampling small and precise volumes of liquid |
| US20050287674A1 (en) * | 2000-08-24 | 2005-12-29 | Bio-Rad Laboratories, Inc | Labeling proteins with dyes that are insoluble or only sparingly soluble in water |
| EP1055112B1 (fr) * | 1998-01-14 | 2008-02-20 | Hemocue AB | Procede de melange |
| US11278225B2 (en) * | 2015-08-12 | 2022-03-22 | University Of Tasmania | Liquid collection device |
| WO2023056103A1 (fr) * | 2021-10-01 | 2023-04-06 | Essenlix Corporation | Préparation d'essai d'échantillon pour uniformité de réactif, en particulier de sang |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2487077A (en) * | 1943-12-28 | 1949-11-08 | Us Commerce | Colorimetric gas detection |
| US2940448A (en) * | 1957-04-29 | 1960-06-14 | Jr Norman B Furlong | Disposable blood-gas analyzer |
| US3146163A (en) * | 1962-01-23 | 1964-08-25 | John H Brewer | Apparatus for separating certain components from blood |
| US3518804A (en) * | 1966-10-27 | 1970-07-07 | Horace W Gerarde | Pipette assembly having precise quantity stabilized reagent in liquid form and method of preparing same |
| US3579303A (en) * | 1968-03-06 | 1971-05-18 | Donald E Pickering | System for handling specimens and other substances in medicine and physical sciences |
| US3620676A (en) * | 1969-02-20 | 1971-11-16 | Sterilizer Control Royalties A | Disposable colorimetric indicator and sampling device for liquids |
| US3732079A (en) * | 1969-02-20 | 1973-05-08 | Sterilizer Control Royalties | Disposable plastic syringe for use in colorimetry |
| US3768978A (en) * | 1971-03-01 | 1973-10-30 | Hamilton Co | Disposable pipette |
-
1973
- 1973-09-27 US US401175A patent/US3898982A/en not_active Expired - Lifetime
- 1973-09-28 BE BE136196A patent/BE805489A/fr not_active IP Right Cessation
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2487077A (en) * | 1943-12-28 | 1949-11-08 | Us Commerce | Colorimetric gas detection |
| US2940448A (en) * | 1957-04-29 | 1960-06-14 | Jr Norman B Furlong | Disposable blood-gas analyzer |
| US3146163A (en) * | 1962-01-23 | 1964-08-25 | John H Brewer | Apparatus for separating certain components from blood |
| US3518804A (en) * | 1966-10-27 | 1970-07-07 | Horace W Gerarde | Pipette assembly having precise quantity stabilized reagent in liquid form and method of preparing same |
| US3579303A (en) * | 1968-03-06 | 1971-05-18 | Donald E Pickering | System for handling specimens and other substances in medicine and physical sciences |
| US3620676A (en) * | 1969-02-20 | 1971-11-16 | Sterilizer Control Royalties A | Disposable colorimetric indicator and sampling device for liquids |
| US3732079A (en) * | 1969-02-20 | 1973-05-08 | Sterilizer Control Royalties | Disposable plastic syringe for use in colorimetry |
| US3768978A (en) * | 1971-03-01 | 1973-10-30 | Hamilton Co | Disposable pipette |
Cited By (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4045175A (en) * | 1975-12-10 | 1977-08-30 | Ragnar Weber | Micro-method of erythrocyte sedimentation |
| US4027660A (en) * | 1976-04-02 | 1977-06-07 | Wardlaw Stephen C | Material layer volume determination |
| US4077396A (en) * | 1976-04-02 | 1978-03-07 | Wardlaw Stephen C | Material layer volume determination |
| US4137755A (en) * | 1976-09-20 | 1979-02-06 | Wardlaw Stephen C | Material layer volume determination |
| US4308029A (en) * | 1976-10-18 | 1981-12-29 | Radiometer A/S | Method and capillary tube for treating blood sample |
| EP0005979A1 (fr) * | 1978-05-25 | 1979-12-12 | Dynatech Ag | Récipient de réaction miniature et méthode et appareil pour l'introduction d'un microvolume de liquide dans un tel récipient |
| US4190328A (en) * | 1978-12-01 | 1980-02-26 | Levine Robert A | Process for detection of blood-borne parasites |
| US4314030A (en) * | 1979-02-27 | 1982-02-02 | C. A. Greiner & Sohne GmbH | Test tube for the examination of urine samples |
| US4295857A (en) * | 1979-04-06 | 1981-10-20 | Peter Schuler | Process for the crystalline precipitation of chromogens |
| US4634679A (en) * | 1982-11-10 | 1987-01-06 | Becton Dickinson And Company | Method of determining adhesion of a liquid sample |
| US4576185A (en) * | 1983-12-05 | 1986-03-18 | Terumo Medical Corporation | Collection device for capillary blood |
| USD285115S (en) | 1983-12-05 | 1986-08-12 | Terumo Medical Corporation | Collector for capillary blood |
| AU593001B2 (en) * | 1985-08-05 | 1990-02-01 | Biotrack, Inc. | Capillary flow device |
| US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
| US4963498A (en) * | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
| US5300779A (en) * | 1985-08-05 | 1994-04-05 | Biotrack, Inc. | Capillary flow device |
| DE3833408C1 (en) * | 1988-10-01 | 1990-01-04 | Juergen 5223 Nuembrecht De Bethkenhagen | Capillary tube |
| US4949728A (en) * | 1988-11-30 | 1990-08-21 | Derek Brook | Method for performing in vitro diagnostic test on horses utilizing a blood sample |
| EP0826955A3 (fr) * | 1993-02-03 | 1999-03-03 | HISTAGGEN Incorporated | Procédé de stockage d'un ligand dans un récipient séparable et procédé de libération d'un ligand à partir de celui-ci |
| US5605838A (en) * | 1993-09-17 | 1997-02-25 | Boehringer Mannheim Gmbh | Method for the quantitative analysis of sample liquid |
| US6218193B1 (en) * | 1995-09-19 | 2001-04-17 | University Of Washington | Precision small volume fluid processing apparatus and method |
| EP1055112B1 (fr) * | 1998-01-14 | 2008-02-20 | Hemocue AB | Procede de melange |
| JP2009053201A (ja) * | 1998-01-14 | 2009-03-12 | Hemocue Ab | 混合方法 |
| US6555386B1 (en) * | 1999-07-23 | 2003-04-29 | Clinical Diagnostic Chemicals Limited | Apparatus for collecting a liquid sample |
| WO2001073396A1 (fr) * | 2000-03-28 | 2001-10-04 | Caliper Technologies, Corp. | Procedes permettant de reduire un report fluidique dans des dispositifs microfluidiques |
| US20050287674A1 (en) * | 2000-08-24 | 2005-12-29 | Bio-Rad Laboratories, Inc | Labeling proteins with dyes that are insoluble or only sparingly soluble in water |
| US20040156746A1 (en) * | 2001-05-10 | 2004-08-12 | Larsen Ulrik Darling | Device for sampling small and precise volumes of liquid |
| US11278225B2 (en) * | 2015-08-12 | 2022-03-22 | University Of Tasmania | Liquid collection device |
| US12588845B2 (en) | 2015-08-12 | 2026-03-31 | University Of Tasmania | Liquid collection device |
| WO2023056103A1 (fr) * | 2021-10-01 | 2023-04-06 | Essenlix Corporation | Préparation d'essai d'échantillon pour uniformité de réactif, en particulier de sang |
Also Published As
| Publication number | Publication date |
|---|---|
| BE805489A (fr) | 1974-01-16 |
| AU6090573A (en) | 1975-04-10 |
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