US5079010A - Pharmaceutical preparation for the treatment of wounds, damaged tissue and inflammation in animals - Google Patents

Pharmaceutical preparation for the treatment of wounds, damaged tissue and inflammation in animals Download PDF

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Publication number
US5079010A
US5079010A US07/410,984 US41098489A US5079010A US 5079010 A US5079010 A US 5079010A US 41098489 A US41098489 A US 41098489A US 5079010 A US5079010 A US 5079010A
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United States
Prior art keywords
solution
pharmaceutical preparation
acid
wounds
inflammation
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Expired - Lifetime
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US07/410,984
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English (en)
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Siegfreid Natterer
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
    • C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
    • C02F1/46104—Devices therefor; Their operating or servicing
    • C02F1/4618—Devices therefor; Their operating or servicing for producing "ionised" acidic or basic water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
    • C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
    • C02F1/46104—Devices therefor; Their operating or servicing
    • C02F1/46109—Electrodes
    • C02F2001/46123—Movable electrodes
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
    • C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
    • C02F1/46104—Devices therefor; Their operating or servicing
    • C02F1/46109—Electrodes
    • C02F2001/46133—Electrodes characterised by the material
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
    • C02F2103/02—Non-contaminated water, e.g. for industrial water supply
    • C02F2103/026—Treating water for medical or cosmetic purposes
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2201/00—Apparatus for treatment of water, waste water or sewage
    • C02F2201/46—Apparatus for electrochemical processes
    • C02F2201/461—Electrolysis apparatus
    • C02F2201/46105—Details relating to the electrolytic devices
    • C02F2201/46115—Electrolytic cell with membranes or diaphragms
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2209/00—Controlling or monitoring parameters in water treatment
    • C02F2209/06—Controlling or monitoring parameters in water treatment pH

Definitions

  • the object of the present invention is to provide a pharmaceutical preparation and a method for the production of such a preparation which assure increased bio-availability, upon both transdermal and oral use.
  • a pharmaceutical preparation corresponding to the body of claim 1 and a method of producing said preparation corresponding to the body of claim 8 are carried out.
  • Preferred embodiments form the object of the subordinate claims.
  • the preparation of the invention which is suitable for both oral administration (for instance in order to substitute for a lack of trace elements) and transdermal use assures, in each case, a high bio-availability of the metallic trace elements present, so that the desired therapeutic effect is obtained even in small doses.
  • the preparation of the invention which is also characterized by good compatibility with the mucous membranes, has the following pharmacological properties, in particular upon transdermal use:
  • the invention is based in this connection on, among other things, the discovery that damaged tissue has an increased need for different trace elements and, in this connection, in particular also for zinc and iron. In addition, however, there is also an increased need for other trace elements, particularly metals, in tissue regions of increased activity (defense processes and/or cell proliferation). Since, in accordance with the discovery which forms the basis of the invention, altered tissue, depending on the degree of the damage, increasingly loses the ability, for instance, to reduce zinc this means, in the case of the customary treatment with zinc oxide ointments, that zinc does not pass into solution and therefore also not into action in the corresponding wound, or does so only to a very unsatisfactory extent.
  • dilute solutions of acids particularly also of physiological acids, i.e. acids which are endogenous in the human body or related thereto such as, for instance, sulfuric acid, hydrochloric acid, silicic acid, acetic acid and ascorbic acid or citric acid have substantially no pharmacological effect and, in particular, also no detumescent effect aside from a certain anti-bacterial action, and although furthermore metal or metal compounds also have only an extremely limited pharmacological effect, it has been found that the combination of metallic trace elements and acid in aqueous solution which characterizes the invention leads to very surprising, unexpected effects, i.e.
  • the pharmaceutical preparation of the invention in which the essential metallic trace elements are present in ions exerts, even in extremely small concentration, a strongly detumescent, anti-bacterial and wound-healing action.
  • synergistic effect which can be further increased by the use of various physiological acids and/or various essential metallic trace elements, it is possible to prepare very effective pharmaceutical preparations having a low total concentration of the active substances.
  • the preparations prepared in this manner are not only highly effective, but as already mentioned, also very well tolerated.
  • the form of administration of the preparation of the invention can be optimally adapted to the specific indication or use.
  • the preparation of the invention is suitable, among other things, also for oral administration, in particular in order to eliminate deficiencies of trace elements or to substitute for metallic trace elements in the human or animal body, the above-mentioned synergistic effect between acid and metal and the improved bio-availability obtained thereby leading in this case also to a high rate of absorption.
  • the water used can, for instance, be distilled water.
  • electrolytically demineralized water is used since it has other favorable biological properties.
  • concentration of the metallic trace elements dissolved as salts or other water-soluble compounds in the water, as well as the ratio of the trace elements to each other preferably corresponds to the physiological quantity or concentration, i.e. the concentration or quantity in the natural serum or a multiple thereof.
  • the quantity of these metal salts or compounds, which are toxic in large amounts, lies thus within the range of milligrams per liter of solution and, in the same way as the ratio of the metal salts or compounds to each other, is based approximately on the physiological amounts, the latter being possibly also exceeded by a multiple, for instance 2-20 times. Very good results have been obtained, for example, with concentrations of 3 mg of zinc chloride and 6 mg of iron chloride per liter.
  • An increase in the concentration can in certain cases increase the efficacy of the preparation, the tolerance of the preparation being impaired with increased concentration of metallic trace elements.
  • one essential factor for the efficacy of the preparation of the invention is its pH.
  • pH values within the range of between about 4.0 and 1.0, the pH, to be sure, being preferably less than 3.5.
  • the pH can be adjusted by the addition of a corresponding amount of physiological acid (for instance hydrochloric acid, sulfuric acid, silicic acid, acetic acid, and/or ascorbic acid).
  • One preparation in accordance with the invention which is suitable, in particular, for the treatment of inflammations by external or internal (oral) use contains, in solution, zinc and iron as metallic trace elements and sulfuric acid as physiological acid in such amount that the solution has a pH within the range of between about 2.0 and 3.0.
  • the proportion of zinc, iron and sulfuric acid is in this connection preferably such that one liter of solution contains about 5 to 30 mg of zinc, about 10 to 50 mg of iron and about 100 to 160 mg of sulfuric acid.
  • detoxication takes place via sulfates, i.e. the toxic protein compounds present or produced upon inflammations are bound to sulfates and thus neutralized.
  • this preparation forms, for instance, the active principal of an ointment.
  • This preparation can also serve, however, as active principal for a pharmaceutical preparation intended for oral ingestion.
  • the most varied methods can, in principle, be used.
  • it can be produced in the manner that at least one metal forming an essential metallic trace element, in particular from the group consisting of iron, zinc, manganese, chromium, copper, cobalt, molybdenum, tin, vanadium, nickel and selenium, is brought, preferably in comminuted or powdered form, with acid and water into solution, the pH of the solution then being adjusted, for instance, by the amount of water added and/or by the amount of acid added.
  • an essential metallic trace element in particular from the group consisting of iron, zinc, manganese, chromium, copper, cobalt, molybdenum, tin, vanadium, nickel and selenium
  • the preparation of the invention in the manner that at least one water-soluble metal compound of an essential metallic trace element, for instance zinc chloride, iron chloride or chromium oxide, is dissolved in water with the addition of the physiological acid, the necessary pH being established in this case also by the amount of water and/or of acid added.
  • an essential metallic trace element for instance zinc chloride, iron chloride or chromium oxide
  • the preparation of the invention contains, in addition to the essential metallic trace elements, preferably also essential nonmetallic trace elements, selected, for instance, from the group consisting of silicon, iodine and fluorine, which are also contained in the preparation in a physiological quantity or a multiple thereof.
  • FIG. 1 is a container of electrically non-conductive material, for instance glass or plastic.
  • a substantially neutral aqueous starting solution which contains chlorides and/or sulfates dissolved in water is introduced into the container 1.
  • Two electrodes 3 and 4 extend into this starting solution 2 in such a manner that these electrodes 3 and 4 are arranged at a predetermined distance from each other within the container.
  • the two electrodes 3 and 4 are so connected to a source of direct voltage, not shown in detail, that the electrode 3 acts as cathode and the electrode 4 as anode.
  • the inside of the container 1 is divided substantially into three zones by these membranes 5 and 6, namely into the zone 7 lying in the region of the electrode 3 or cathode, the zone 8 lying in the region of the electrode 4 or anode, and the zone 9 lying between the zones 8 and 7.
  • the membranes 5 and 6 are made of a suitable material, for instance clay, fabric or felted material, and have such a density that ionization of the starting solution 2 is possible by the electrodes 3 and 4 which are connected to the source of direct voltage; however, at the same time, the membranes 5 and 6 assure a concentrating of the acid portion (H + ) obtained upon the ionization of the electrolysis in the region of the zone 7 and a concentrating of the basic portion (OH - ) obtained upon the electrolysis in the region of the zone 8, and the separation of the two zones 7 and 8 by the central zone 9 prevents possible precipitation.
  • a suitable material for instance clay, fabric or felted material
  • the electrode 3 which forms the cathode consists of at least one metal suitable for the formation of an essential metallic trace element or an alloy of such metals.
  • the at least one metal forming the electrode 3 or the metal alloy forming the electrode 3 is dissolved in the zone 7 so that an acid solution of increasing concentration of essential metallic trace elements is obtained there.
  • At least the electrode or electrodes 3 present there are held in an adjustable mount which permits a decrease or increase of the depth of immersion of the electrodes, as required.
  • At least one membrane developed as a tube can also be used, preferably such a membrane which is made of water-pervious fired clay.
  • the electrodes used are then so arranged within said at least one membrane that, depending on the arrangement, either the acid or the alkaline portion is concentrated by the electrolysis within the corresponding tubular membrane.
  • the pharmaceutical preparation of the invention may also be to treat animals including humans, suffering from a virus, comprising administering to the sufferer an anti-viral effective amount of the preparation to obtain an anti-viral effect.
  • the pharmaceutical preparation of the invention may further be used as a suntan composition, such as a suntan lotion, cream and the like, since the metal trace elements promote the formation of melanin in the human body upon exposure of the human body to UV radiation after topical application to the skin of the pharmaceutical composition of the invention in an amount effective to promote tanning of the skin.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hydrology & Water Resources (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental & Geological Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US07/410,984 1988-09-22 1989-09-22 Pharmaceutical preparation for the treatment of wounds, damaged tissue and inflammation in animals Expired - Lifetime US5079010A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3832211 1988-09-22
DE3832211 1988-09-22
DE3929411 1989-09-05
DE3929411A DE3929411A1 (de) 1988-09-22 1989-09-05 Pharmazeutische zubereitung sowie verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
US5079010A true US5079010A (en) 1992-01-07

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US07/410,984 Expired - Lifetime US5079010A (en) 1988-09-22 1989-09-22 Pharmaceutical preparation for the treatment of wounds, damaged tissue and inflammation in animals

Country Status (4)

Country Link
US (1) US5079010A (fr)
EP (1) EP0363696B1 (fr)
CA (1) CA1330419C (fr)
DE (2) DE3929411A1 (fr)

Cited By (56)

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WO1996019183A1 (fr) * 1994-12-21 1996-06-27 Cosmederm Technologies Formulations et procedes pour diminuer l'irritation de la peau
WO1996019181A1 (fr) * 1994-12-21 1996-06-27 Cosmederm Technologies Formulations et procedes pour diminuer l'irritation de la peau
WO1996019182A1 (fr) * 1994-12-21 1996-06-27 Cosmederm Technologies Formulations et procedes pour diminuer l'irritation de la peau
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US5658946A (en) * 1996-05-29 1997-08-19 The Procter & Gamble Company Methods for the treatment of herpes virus infections
AU681416B2 (en) * 1993-08-31 1997-08-28 Miura, Toshiyuki Treating water for dermatoses in domestic animals
US5679360A (en) * 1994-12-19 1997-10-21 L'oreal Substance P antagonist for the treatment of lichens, prurigo, pruritus
US5824650A (en) * 1994-12-19 1998-10-20 L'oreal Topical composition containing a substance P antagoinst
US5851556A (en) * 1995-04-10 1998-12-22 Societe L'oreal S.A. Use of a salt of an alkaline-earth metal as TNF-A or substance P inhibitor in a topical composition and composition obtained
US5858024A (en) * 1995-09-19 1999-01-12 Societe L'oreal S.A. Composition for dyeing keratin fibres containing a substance P antagonist
US5866168A (en) * 1995-10-26 1999-02-02 Societe L'oreal S.A. Dermatological/pharmaceutical compositions comprising lanthanide, manganese, tin, zinc, yttrium, cobalt, barium and/or strontium salts as substance P antagonists
US5900257A (en) * 1995-10-26 1999-05-04 Societe L'oreal S.A. Cosmetic/pharmaceutical compositions comprising lanthanide manganese, tin and/or yttrium salts as substance P antagonists
WO1999037312A1 (fr) * 1998-01-27 1999-07-29 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Preparation pharmaceutique a base de vanadium ou de l'un de ses sels pour le traitement des brulures
US6060079A (en) * 1998-09-09 2000-05-09 Freeman; Frank Device for topical localized administration of zinc to tissue
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WO2001028339A3 (fr) * 1999-10-19 2001-09-13 Procter & Gamble Composition antimicrobienne comprenant un acide organique biologiquement actif
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US20040131702A1 (en) * 2001-02-13 2004-07-08 Jaroslaw Lampe Use of selenite or preparation containing selenite for treating wounds
US20050121334A1 (en) * 2001-12-05 2005-06-09 Osao Sumita Method and apparatus for producting negative and positive oxidative reductive potential (orp) water
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US7867522B2 (en) 2006-09-28 2011-01-11 Jr Chem, Llc Method of wound/burn healing using copper-zinc compositions
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US8952057B2 (en) 2011-01-11 2015-02-10 Jr Chem, Llc Compositions for anorectal use and methods for treating anorectal disorders
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DE102005025156A1 (de) * 2005-06-01 2006-12-07 Siegfried Natterer Polares Unterstützungs- und Breitbandresonatorpräparat
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EP0363696A1 (fr) 1990-04-18

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