US7236814B2 - Optical member for biological information measurement, biological information calculation apparatus, biological information calculation method, computer-executable program, and recording medium - Google Patents

Optical member for biological information measurement, biological information calculation apparatus, biological information calculation method, computer-executable program, and recording medium Download PDF

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Publication number
US7236814B2
US7236814B2 US11/200,461 US20046105A US7236814B2 US 7236814 B2 US7236814 B2 US 7236814B2 US 20046105 A US20046105 A US 20046105A US 7236814 B2 US7236814 B2 US 7236814B2
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Prior art keywords
living body
body tissue
biological information
light
optical member
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US11/200,461
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US20060041195A1 (en
Inventor
Masahiko Shioi
Shinji Uchida
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Panasonic Holdings Corp
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Matsushita Electric Industrial Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6834—Means for maintaining contact with the body using vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G01N2201/021—Special mounting in general

Definitions

  • the present invention relates to an optical member for biological information measurement, a biological information calculation apparatus, a biological information calculation method, a computer-executable program, and a recording medium for calculating noninvasively glucose, cholesterol, urea, triglyceride, protein, and the like in body fluid by measuring a living body tissue optically.
  • a conventional optical measuring instrument for measuring a specific component in a living body or a solution will be described.
  • an optical measuring instrument for measuring a blood glucose level with making upper and lower lips adhere to a transparent attenuated total reflection element having a pair of reflecting surfaces facing each other in parallel hereafter, referred to as an ATR prism
  • ATR prism transparent attenuated total reflection element having a pair of reflecting surfaces facing each other in parallel
  • FIG. 12 which is a view of a conventional optical member for biological information measurement
  • light is injected in an ATR prism 1201 from an optical fiber 1202 in the state of holding the ATR prism 1201 , which is constituted of selenium zinc, silicon, germanium or the like, in a mouth to press down the ATR prism 1201 by the lips 1203 .
  • an optical measuring instrument for measuring a blood glucose level and a blood ethanol concentration by injecting a laser beam with a wavelength of 9 to 11 ⁇ m is into this ATR prism after making the ATR prism, which is constituted of ZnSe crystal, or the like, adhere to mucosae of lips, performing multipath reflection inside the ATR prism, and analyzing attenuated total reflection light, scatter reflection light, and the like (i.e., refer to Hideo Fukushima, et al., “Non-invasive mensuration technique—development of optical glucose sensor of blood glucose level—”, BME, Japan Society of Medical Electronics and Biological Engineering, 1991, vol. 5(8), p. 16-21). It is assumed that this conventional optical measuring instrument is called second conventional art.
  • the light which proceeds to the inside of the ATR prism is reflected after infiltrating into lips slightly.
  • the reflected light receives the influence of each component in body fluid which exists in lips, and decreases more than before infiltrating into lips.
  • the first and a second conventional art apply an evanescent wave (being the so-called seeping light) to a quantitative analysis.
  • a contact for biological information detection including abutting means of having a concave portion abutting against the living body tissue, detected-light emission means of emitting detected light from a part of the concave portion, and detected-light incident means which is provided in another part of the concave portion and is injected with the detected light, wherein the abutting means is constituted of a material which has a refractive index higher than a refractive index of a living body tissue, and wherein the detected light is injected into the detected-light incident means in the state that the abutting means and living body tissue abut each other after passing the living body tissue which is wrapped up in the concave portion (e.g., refer to National Publication of International Patent Application No. 2001-058355). It is assumed that this conventional contact for biological information detection is called third conventional art.
  • the seeping depth d of an evanescent wave filtrating into a living body can be obtained as follows:
  • n 1 Refractive index of first medium
  • an electric field of the evanescent wave exponentially decreases according to the depth.
  • the ATR prism is just held or is just pressed in lips.
  • the adhesion of the living body tissue and living body tissue measuring section is very important.
  • the present invention aims at providing an optical member for biological information measurement, a biological information calculation apparatus, a biological information calculation method, a computer-executable program, and a recording medium which can suppress the adverse effect to biological information measurement by disturbance light.
  • the 1 st aspect of the present invention is an optical member for biological information measurement, comprising:
  • an optical element having an incident surface which is injected with emitted light, a contact surface which a living body tissue contacts, and an emitting surface which emits the light that has been reflected by the contact surface in contact with the living body tissue, or the light that has passed the living body tissue via the contact surface in contact with the living body tissue;
  • an optical element cover provided so as to expose the contact surface and to surround all or a part of an outer circumferential portion of the optical element.
  • the 2 nd aspect of the present invention is the optical member for biological information measurement according to the 1 st aspect of the present invention, wherein a space, which a part of the living body tissue can enter, is formed between the optical element and the optical element cover.
  • the 3 rd aspect of the present invention is the optical member for biological information measurement according to the 2 nd aspect of the present invention, wherein the contact surface projects outside of the space.
  • the 4 th aspect of the present invention is the optical member for biological information measurement according to the 2 nd aspect of the present invention, further comprising:
  • a movable space cover provided so as to cover the space
  • space cover moves into the space when being pressed by the living body tissue in contact with the contact surface.
  • the 5 th aspect of the present invention is the optical member for biological information measurement according to the 4 th aspect of the present invention, wherein the space cover is held by an elastic material.
  • the 6 th aspect of the present invention is the optical member for biological information measurement according to the 2 nd aspect of the present invention, further comprising:
  • a decompressing unit of decompressing the space when the living body tissue contacts the contact surface a decompressing unit of decompressing the space when the living body tissue contacts the contact surface.
  • the 7 th aspect of the present invention is the optical member for biological information measurement according to the 6 th aspect of the present invention, further comprising:
  • a movable space cover having a window provided so as to cover the space
  • the decompressing unit decompresses the space by performing evacuation through the window.
  • the 8 th aspect of the present invention is the optical member for biological information measurement according to the 1 st aspect of the present invention, further comprising:
  • a light attenuating portion provided in all or a part of an outside of the optical element cover.
  • the 9 th aspect of the present invention is the optical member for biological information measurement according to the 8 th aspect of the present invention, wherein the light attenuating portion is at least one of a light reflecting element which reflects light, a light absorbing element which absorbs light, and a light scattering element which scatters light.
  • the 10 th aspect of the present invention is the optical member for biological information measurement according to the 1 st aspect of the present invention, wherein the contact surface has a groove.
  • the 11 th aspect of the present invention is the optical member for biological information measurement according to the 10 th aspect of the present invention, wherein a refractive index of the optical element is 1.55 or more.
  • the 12 th aspect of the present invention is the optical member for biological information measurement according to the 1 st aspect of the present invention, wherein the contact surface has a curved surface.
  • the 13 th aspect of the present invention is the optical member for biological information measurement according to the 1 st aspect of the present invention, wherein a portion of an end face of the optical element cover, which contacts the living body tissue, has a curved surface.
  • the 14 th aspect of the present invention is a biological information calculation apparatus, comprising:
  • optical member for biological information measurement according to the 1 st aspect of the present invention
  • an arithmetic section calculating biological information with regard to a living body, which has the living body tissue, on the basis of a result of the detection.
  • the 15 th aspect of the present invention is the biological information calculation apparatus according to the 14 th aspect of the present invention, wherein the biological information to be calculated is information with regard to a concentration of a material included in the living body tissue.
  • the 16 th aspect of the present invention is a biological information calculation method using an optical member for biological information measurement comprising an optical element having an incident surface which is injected with emitted light, a contact surface which a living body tissue contacts, and an emitting surface which emits the light that has been reflected by the contact surface in contact with the living body tissue, or the light that has passed the living body tissue via the contact surface in contact with the living body tissue, and an optical element cover provided so as to expose the contact surface and to surround all or a part of an outer circumferential portion of the optical element, comprising the steps of:
  • the 17 th aspect of the present invention is a computer-executable program comprising computer-executable program code operable to cause a computer to execute the step of calculating biological information with regard to a living body, which has the living body tissue, on the basis of a result of the detection, in the biological information calculation method according to the 16 th aspect of the present invention.
  • the 18 th aspect of the present invention is a recording medium carrying the program according to the 17 th aspect of the present invention, which can be processed by a computer.
  • the present invention has an advantage that it is possible to suppress the adverse effect to biological information measurement by disturbance light.
  • FIG. 1( a ) is a top view of an optical member for biological information measurement according to a first embodiment of the present invention
  • FIG. 1( b ) is a side view of the optical member for biological information measurement according to the first embodiment of the present invention
  • FIG. 1( c ) is a perspective view of the optical member for biological information measurement according to the first embodiment of the present invention.
  • FIG. 2 is a perspective view of an optical member for biological information measurement, where a living body tissue measuring section 213 and a prism cover 214 are separated, according to an embodiment of the present invention.
  • FIG. 3( a ) is a perspective view of an optical member for biological information measurement before operation according to a second embodiment of the present invention
  • FIG. 3( b ) is a perspective view of the optical member for biological information measurement after the operation, that is, in a state that a living body tissue is contacted to a living body tissue measuring section 313 , according to the second embodiment of the present invention
  • FIG. 3( c ) is a sectional view, taken on line A-A′, of the optical member for biological information measurement before the operation according to the second embodiment of the present invention.
  • FIG. 4 is a perspective view of an optical member for biological information measurement according to a third embodiment of the present invention.
  • FIG. 5( a ) is a perspective view of an optical member for biological information measurement, where a living body tissue measuring section 513 has grooves 551 , according to an embodiment of the present invention
  • FIG. 5( b ) is a schematic diagram of the grooves 551 according to an embodiment of the present invention, at the time when a living body tissue 599 adheres thereto and light 552 is transmitting the inside of the living body tissue 599 adhered.
  • FIG. 6 is a perspective view of an optical member for biological information measurement, which has a living body tissue measuring section 613 with a round portion contacting to a living body tissue, according to an embodiment of the present invention.
  • FIG. 7 is a perspective view of an optical member for biological information measurement, which has a prism cover 714 with a round portion contacting to a living body tissue, according to an embodiment of the present invention.
  • FIG. 8 is a schematic diagram of a biological information calculation apparatus according to a fourth embodiment of the present invention.
  • FIG. 9 is a perspective view of an optical member for biological information measurement, where a one-way valve 911 is provided in a vacuum port 441 , according to an embodiment of the present invention.
  • FIG. 10( a ) is a perspective view of an optical member for biological information measurement, where a living body tissue measuring section 1013 has a groove 1051 , according to an embodiment of the present invention
  • FIG. 10( b ) is a schematic diagram of an embodiment of the present invention, at the time when a living body tissue 1099 adheres to the groove 1051 and light 1052 is transmitting the inside of the living body tissue 1099 adhered.
  • FIG. 11( a ) is a perspective view of an optical member for biological information measurement, which has optical fiber bundles 1100 and 1101 having living body tissue measuring sections 1113 as end portions of the optical fiber, according to an embodiment of the present invention
  • FIG. 11( b ) is a schematic diagram of an embodiment of the present invention, at the time when a living body tissue 1199 adheres to a gap 1151 and light 1152 is transmitting the inside of the living body tissue 1199 adhered.
  • FIG. 12 is a view of a conventional optical member for biological information measurement.
  • FIG. 1( a ) is a top view of the optical member for biological information measurement according to a first embodiment of the present invention
  • FIG. 1( b ) is a side view of the optical member for biological information measurement of the first embodiment of the present invention
  • FIG. 1( c ) is a perspective view of the optical member for biological information measurement according to the first embodiment of the present invention.
  • the optical member for biological information measurement is constituted of a light incident surface 11 , a light emitting surface 12 , a living body tissue measuring section 13 , a prism cover 14 , and a living body tissue containing section 15 .
  • the optical member for biological information measurement comprises a prism 100 , which has a light incident surface 11 receiving emitted light, a living body tissue measuring section 13 which is a contact surface which contacts a living body tissue such as lips (not shown), and a light emitting surface 12 which emits the light reflected by the living body tissue measuring section 13 which the living body tissue contacts, and a prism cover 14 which is provided so as to expose the living body tissue measuring section 13 and to surround an outer circumferential portion of the prism 100 .
  • the material with a high transmittance in the wave number region of approx 1000 to 1100 cm ⁇ 1 in the mid-infrared region is preferable.
  • the material of the prism 100 is silicon or germanium with small content of impurities, such as boron and phosphorus which become a cause of decrease of the above-mentioned transmittance.
  • the resistivity of silicon or germanium becomes high as the content of impurities such as boron and phosphorus is small. For this reason, it is preferable when the resistivity is 100 ⁇ cm or more, and it is further preferable when the resistivity is more than 1500 ⁇ cm.
  • the material of the prism 100 is silicon or a plastic with a high refractive index. In the case of silicon, what has 100 ⁇ cm or more of resistivity is preferable by the same reason, and what has 1500 ⁇ cm or more of resistivity is further preferable. In addition, the material of the prism 100 may be calcium fluoride, fused quartz, or the like.
  • the living body tissue measuring section 13 projects outside of the living body tissue containing section 15 rather than an end face of the prism cover 14 in a side where a part of the living body tissue enters.
  • the prism cover 14 is provided so as to surround the living body tissue measuring section 13 as an outer circumferential portion of the optical member for biological information measurement.
  • a light attenuating portion 16 is provided in this prism cover 14 .
  • the light attenuating portion 16 may be something to reduce a probability that light enters into a photodetector, and hence, may be constituted of any of a light absorbing element, a light scattering element, and a light reflecting element.
  • An optical thin film which absorbs light at various wavelengths which is regarded as disturbance light or the like is cited as a specific example of a light absorbing element.
  • an optical thin film with a monolayer or a multilayer film at suitable thickness so as to be able to absorb unnecessary light efficiently by performing multiplex interference of the light within the film.
  • the material of such an optical thin film are Cu, Cr, Mo, Fe, Ni, amorphous Si, SiC, Ge, WSi 2 , Ti, TiN, Ta, TiW, Co, SiGe, TiSi 2 , CrSi 2 , MoSi 2 , FeSi 2 , NiSi 2 , CrN, MoN 2 , SiO 2 , Al 2 O 3 , TiO 2 , and the like.
  • the prism cover 14 whose surface is roughened by blast processing or the like so as to scatter light.
  • the light reflecting element such as an optical thin film formed of aluminum or the like is cited.
  • the living body tissue containing section 15 is provided between the living body tissue contact section 13 and prism cover 14 , and is a concave portion.
  • the prism 100 corresponds to the optical element of the present invention
  • the prism cover 14 corresponds to the optical element cover of the present invention
  • the light attenuating portion 16 corresponds to the light attenuating portion of the present invention.
  • a living body tissue is contacted to the living body tissue measuring section 13 .
  • the living body tissue enters the concave portion of the living body tissue containing section 15 .
  • the prism cover 14 Since being provided in the outer circumferential portion of the living body tissue measuring section 13 , the prism cover 14 forms the living body tissue containing section 15 , and prevents the illumination light of a room, sunlight, radiation from a human body, and other disturbance light adversely affecting measurement from being injected into the living body tissue measuring section 13 .
  • FIG. 2 is a perspective view of an optical member for biological information measurement, where a living body tissue measuring section 213 and a prism cover 214 are separated
  • a portion where a light attenuating portion 216 is provided in the prism cover 214 may be produced separately, and a portion which has a light incident surface 211 , the living body tissue measuring section 213 , and the like may be also incorporated after that.
  • a portion excluding the light incident surface 211 and a light emitting surface, and being given hatching in FIG.
  • a light attenuating portion of preventing disturbance light from being injected into the living body tissue measuring section 213 may be provided.
  • FIG. 3( a ) is a perspective view of the optical member for biological information measurement before operation according to a second embodiment of the present invention
  • FIG. 3( b ) is a perspective view of the optical member for biological information measurement after the operation, that is, in a state that a living body tissue is contacted to a living body tissue measuring section 313 , according to the second embodiment of the present invention
  • FIG. 3( c ) is a sectional view, taken on line A-A′, of the optical member for biological information measurement before the operation according to the second embodiment of the present invention.
  • a living body tissue containing section cover 331 is provided.
  • a notched portion 334 which has size and shape substantially equal to the living body tissue measuring section 313
  • a notch 332 (shown by a dotted line in FIG. 3( a )) provided in a direction parallel to line A-A′ from four corners of the notched portion 334 are provided.
  • the living body tissue containing section cover 331 can move with contacting the prism 300 as shown in FIG. 3( b ).
  • a material of the living body tissue containing section cover 331 it is preferable to be rubber, which has moderate elasticity, such as silicone rubber, natural rubber, or the like.
  • the living body tissue-containing section cover 331 moves when the living body tissue is pressed toward the living body tissue measuring section 313 , and it returns to an original state when the living body tissue measuring section 313 is removed from the living body tissue.
  • the provision of the spring 333 makes it possible to design a force necessary for sinking the living body tissue containing section cover 331 by appropriately selecting a spring constant of the spring 333 , it is possible to perform an optimal design for the improvement of adhesion.
  • the living body tissue containing section cover 331 corresponds to the space cover of the present invention.
  • the living body tissue containing section 315 is shut with the living body tissue containing section cover 331 .
  • the living body tissue containing section cover 331 sinks as shown in FIG. 3( b ) by the pressure with which the living body tissue is pressed to the living body tissue measuring section 313 .
  • the living body tissue containing section cover 331 can sink as shown in FIG. 3( b ).
  • the living body tissue containing section cover 331 sinks when a living body tissue is pressed to the living body tissue measuring section 313 , and it returns to an original state when the living body tissue is removed from the living body tissue measuring section 313 .
  • an elastic material such as rubber may be used instead of the spring 333 .
  • a light attenuating portion like a light attenuating portion 316 , provided in the prism cover 314 , in the living body tissue containing section cover 331 since it is possible to prevent radiation from the living body tissue, such a light attenuating portion may be provided.
  • FIG. 4 is a bird's eye view of the optical member for biological information measurement according to the third embodiment of the present invention.
  • round windows are provided also in the living body tissue containing section cover 431 in positions of overlapping with the vacuum ports 441 .
  • a pump 499 can decompress the interior of a living body tissue containing section 415 by performing evacuation through such windows when the living body tissue containing section cover 431 is pressed with the living body tissue in contact with the prism 400 and sinks into the interior of the living body tissue containing section 415 .
  • the pump 499 corresponds to the decompressing unit of the present invention.
  • exhaust is performed by sucking air from the vacuum ports 441 using the pump 499 .
  • adhesion is increased by making the inside of the living body tissue containing section 415 negative pressure.
  • a hole for suction may be provided so as to penetrate a side face portion of the prism cover 414 .
  • a window does not need to be provided in the living body tissue containing section cover 431 .
  • FIG. 9 is a bird's eye view of the optical member for biological information measurement in which a one-way valve 911 is provided in the vacuum ports 441
  • the one-way valve 911 which has a check valve may be provided in the vacuum ports 441 .
  • what may be used is such configuration of a sucker that, when a living body tissue fulfills the living body tissue containing section 415 when the living body tissue is pressed by the living body tissue measuring section 413 , air in the living body tissue containing section 415 is evacuated through the one-way valve 911 from the vacuum ports 441 and the living body tissue adheres to the living body tissue measuring section 413 .
  • FIG. 5( a ) which is a perspective view of the optical member for biological information measurement, where the living body tissue measuring section 513 has grooves 551 , according to the embodiment of the present invention
  • FIG. 5( b ) which is a schematic diagram at the time when a living body tissue 599 adheres the grooves 551 and light 552 is transmitting the inside of the living body tissue 599 adhered, according to the embodiment of the present invention.
  • measurement is performed by making the living body tissue 599 adhere to a plurality of grooves 551 , which are provided in the living body tissue measuring section 513 , and making light 552 transmit the living body tissue 599 .
  • the optical path length of the light 552 having passed the living body tissue 599 through the living body tissue measuring section 513 which the living body tissue 599 has contacted is determined by a dimension of one groove of the plurality of grooves 551 .
  • the optical path length is determined mechanically by a dimension of the grooves 551 , and hence, it is possible to perform measurement with sufficient accuracy:
  • a refractive index of the prism 500 is 1.55 or more which is higher than a living body's refractive index of 1.3 to 1.5.
  • FIG. 10( a ) which is a perspective view of an optical member for biological information measurement, where the living body tissue measuring section 1013 has the groove 1051 , according to an embodiment of the present invention
  • FIG. 10( b ) which is a schematic diagram according to an embodiment of the present invention at the time when a living body tissue 1099 adheres to the groove 1051 and light 1052 is transmitting the inside of the living body tissue 1099 adhered.
  • FIG. 6 is a perspective view of an optical member for biological information measurement, which has a living body tissue measuring section 613 with a round portion contacting to a living body tissue, according to an embodiment of the present invention, it is also good to make an outer circumferential portion of the living body tissue measuring section 613 a curved surface.
  • the curved surface of the outer circumferential portion of the living body tissue measuring section 613 is roundish in any direction, it is possible to reduce the pain securely.
  • FIG. 7 is a bird's eye view of the optical member for biological information measurement having the prism cover 714 whose portion in contact with the living body tissue is round, according to an embodiment of the present invention.
  • FIG. 11( a ) which is a bird's eye view of an optical member for biological information measurement, which has the optical fiber bundles 1100 and 1101 having living body tissue measuring sections 1113 as end portions, according to an embodiment of the present invention
  • FIG. 11( b ) which is a schematic diagram of an embodiment of the present invention, at the time when a living body tissue 1199 adheres to a gap 1151 and light 1152 is transmitting the inside of the living body tissue 1199 adhered.
  • the light 1152 enters into the optical fiber bundle 1100 from a light incident surface 1111 , passes the optical fiber bundle 1100 and enters into the living body tissue 1199 from an end portion of the optical fiber in a side of the gap 1151 . Then, the light 1152 is emitted from the living body tissue 1199 , enters into the optical fiber bundle 1101 from an end portion of the optical fiber in a side of the gap 1151 of the optical fiber bundles 1101 , passes the optical fiber bundle 1101 , and is emitted from a light emitting surface 1112 .
  • FIG. 8 is a schematic diagram of the biological information calculation apparatus according to a fourth embodiment of the present invention.
  • the biological information calculation apparatus of this embodiment is constituted of a light source 881 which emits light, the optical member 1 for biological information measurement described in the first embodiment mentioned above, a photodetector 882 which detects the light emitted from the prism 100 , and a data processing apparatus 883 which calculates biological information with regard to a living body, which has a living body tissue, on the basis of a result of the detection.
  • a spectroscope such as a spectroscopic instrument using a grating, a Fourier transform spectroscopic instrument, or the like, between the light source 881 and optical member 1 for biological information measurement.
  • the light source 881 is means of emitting light at an absorption wavelength of a measurement component which is a measuring object, such as an LD, an LED, a halogen light source, a semiconductor laser, a Glover light source formed by sintering SiC cylindrically, a CO 2 laser, a tungsten lamp, or the like.
  • a measurement component which is a measuring object, such as an LD, an LED, a halogen light source, a semiconductor laser, a Glover light source formed by sintering SiC cylindrically, a CO 2 laser, a tungsten lamp, or the like.
  • the case that the light source 881 is an LD is shown.
  • the Glover light source is preferable from the viewpoint of being able to cover a comparatively wide wave range and emitting light favorably also in a long wavelength region which is about 10 ⁇ m, when measuring infra-red light.
  • the halogen light source is preferable as the light source 881 .
  • the light which has a wavelength between 1000 nm and 10000 nm is desirable to include the light which has a wavelength between 1000 nm and 10000 nm as the emitted light.
  • the photodetector 882 is means of an MCT detector using mixed crystal of mercury, tellurium and cadmium, a pyroelectric sensor, a DTGS detector, a thermistor, a thermopile, a Golay cell, or the like in the case of amid-infrared region, and a PbS detector, an InSb detector, a PbSe detector, an InGaAs detector, a Si detector, or the like in the case of a near-infrared region.
  • the data processing apparatus 883 is a computer.
  • biological information to be calculated is information or the like with regard to a concentration of glucose, triglyceride, urea, cholesterol (total cholesterol), protein, or the like.
  • the light source 881 corresponds to the light source of the present invention
  • the photodetector 882 corresponds to the photodetector of the present invention
  • the data processing apparatus 883 corresponds to the arithmetic section of the present invention.
  • Light 852 emitted from the light source 881 enters into the optical member 1 for biological information measurement.
  • the light 852 entering into the optical member 1 for biological information measurement is transmitted, scattered, and absorbed with a living body tissue in contact with the living body tissue measuring section 13 , and is emitted from the light emitting surface 12 of the optical member 1 for biological information measurement.
  • the light 852 emitted from the optical member 1 for biological information measurement is detected by the photodetector 882 .
  • the data processing apparatus 883 calculates biological information using the result of detection by the photodetector 882 .
  • the optical member 1 for biological information measurement described in the first embodiment mentioned above since the optical member 1 for biological information measurement described in the first embodiment mentioned above is used, it is possible to reduce the influence of stray light which enters from faces other than a living body tissue measuring section, to increase the adhesion of a living body tissue and an optical element, and to calculate the concentration of a target component in a device under test stably and easily, and hence, this is useful for measurement of, for example, a body fluid component in a medical application.
  • the program of the present invention is a program for making a computer execute the operation of all or a part of steps of the biological information calculation method of the present invention mentioned above, and is a program which operates with collaborating with a computer.
  • the recording medium of the present invention is a recording medium which holds a program for executing the operation of all or a part of steps of the biological information calculation method of the present invention mentioned above by a computer, the program which can be read by a computer and executes the above-mentioned operation with collaborating with the above-mentioned computer.
  • a part of steps of the present invention means one or some steps of a plurality of those steps.
  • operation of a step means the operation of all or a part of the above-mentioned step.
  • one utilizing form of the program of the present invention may be an aspect of being recorded in a recording medium which a computer can read, and operating with collaborating with the computer.
  • another utilizing form of the program of the present invention may be an aspect which is transmitted inside a transmission medium, is read by a computer, and operates with collaborating with the computer.
  • recording media ROM and the like are included, and as transmission media, transmission media such as the Internet, light, electric waves, acoustic waves, and the like are included.
  • the computer of the present invention mentioned above may be not only pure hardware such as a CPU, but also firmware, OS, and further, what includes a peripheral device.
  • the configuration of the present invention may be achieved in software or hardware.
  • An optical member for biological information measurement, a biological information calculation apparatus, a biological information calculation method, a computer-executable program, and a recording medium according to the present invention can suppress an adverse effect to biological information measurement by disturbance light, and hence, are useful.

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US20060041195A1 (en) 2006-02-23
CN1736331A (zh) 2006-02-22
CN100450438C (zh) 2009-01-14
EP1627596B1 (de) 2008-05-21
EP1627596A1 (de) 2006-02-22

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