US8414293B2 - Carrier strip for application to oral surfaces and related methods - Google Patents

Carrier strip for application to oral surfaces and related methods Download PDF

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Publication number
US8414293B2
US8414293B2 US11/168,680 US16868005A US8414293B2 US 8414293 B2 US8414293 B2 US 8414293B2 US 16868005 A US16868005 A US 16868005A US 8414293 B2 US8414293 B2 US 8414293B2
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US
United States
Prior art keywords
carrier strip
oral
oral carrier
strip according
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime, expires
Application number
US11/168,680
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English (en)
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US20060292520A1 (en
Inventor
Rensl Dillon
Mahmoud Hassan
David B. Viscio
Abdul Gaffar
Lisa Christina Beck
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Colgate Palmolive Co
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Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Priority to US11/168,680 priority Critical patent/US8414293B2/en
Assigned to COLGATE-PALMOLIVE COMPANY reassignment COLGATE-PALMOLIVE COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BECK, LISA CHRISTINA, DILLON, RENSL, GAFFAR, ABDUL, HASSAN, MAHMOUD, VISCIO, DAVID B.
Priority to MYPI20062965A priority patent/MY145562A/en
Priority to TW095123053A priority patent/TWI426892B/zh
Priority to ARP060102765A priority patent/AR056398A1/es
Priority to MX2008000105A priority patent/MX2008000105A/es
Priority to RU2008102969/14A priority patent/RU2373898C2/ru
Priority to CA2613509A priority patent/CA2613509C/en
Priority to CN2006800310853A priority patent/CN101247771B/zh
Priority to BRPI0612839-4A priority patent/BRPI0612839A2/pt
Priority to JP2008519531A priority patent/JP4987865B2/ja
Priority to PCT/US2006/025232 priority patent/WO2007002776A1/en
Priority to EP06774224A priority patent/EP1895932A1/en
Priority to AU2006263679A priority patent/AU2006263679C1/en
Publication of US20060292520A1 publication Critical patent/US20060292520A1/en
Priority to ZA2008/00124A priority patent/ZA200800124B/en
Priority to US29/375,874 priority patent/USD655007S1/en
Priority to US29/408,651 priority patent/USD671215S1/en
Publication of US8414293B2 publication Critical patent/US8414293B2/en
Application granted granted Critical
Adjusted expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00Dental auxiliary appliances
    • A61C19/06Implements for therapeutic treatment
    • A61C19/063Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00Dental auxiliary appliances
    • A61C19/06Implements for therapeutic treatment
    • A61C19/063Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A61C19/066Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips

Definitions

  • Oral carrier strips are commonly used to provide an oral care composition to the teeth or other surface in the oral cavity. These oral compositions are used for a wide variety of purposes, including the enhancement of hygiene and appearance, and the prevention or treatment of a variety of diseases and other oral cavity conditions in humans and in animals by delivering systemic or localized active agents.
  • the conventional strips typically comprise a plastic film with an oral composition applied to the surface.
  • Carrier strips must be sized to accommodate a large variation of the dimensions of the teeth and oral cavity of the human and animal subject populations.
  • Conventional carrier strips have several disadvantages: some may be too loose when applied to the dental surfaces, or may bunch up when folded and applied to the front and back portions of the teeth. Carriers having slits to prevent bunching have been known to rip and tear, which adversely affects the delivery function and usefulness of the strip.
  • the invention provides an oral carrier strip including (i) a first portion having a proximal longitudinal perimeter and (ii) a second portion having a distal longitudinal perimeter.
  • the distal longitudinal perimeter defines a rounded notch.
  • oral carrier strips including a first portion adapted to contact a front facing side of a plurality of teeth and having a first perimeter patterned to substantially match a shape of an outer gingival tissue; and a second portion adapted to be folded around the teeth so as to contact a back facing side of the teeth, the second portion having a second perimeter opposite the first perimeter and patterned to match a shape of an inner gingival tissue.
  • the second portion has a rounded notch positioned in a center portion of the strip.
  • the invention provides an oral carrier strip including a first portion having a proximal longitudinal perimeter, and a second portion having a distal longitudinal perimeter.
  • the distal longitudinal perimeter contains a notch that is adapted to inhibit tearing of the strip upon application.
  • FIG. 1A is a plan view illustrating an oral carrier strip configured for the upper teeth of a subject according to the principles of the present invention
  • FIG. 1B is a plan view illustrating an oral carrier strip configured for the lower teeth of a subject according to the principles of the present invention
  • FIG. 1C is a magnified view illustrating an aperture and rounded notch of FIG. 1A ;
  • FIG. 2A is a perspective view illustrating the oral carrier strips being applied to the upper and lower teeth of a human subject
  • FIG. 2B is a partial perspective view of FIG. 2A illustrating the oral carrier strip in the process of being folded over the upper teeth and adjusted for treatment;
  • FIG. 2C is a partial perspective view of FIG. 2A illustrating the oral carrier strip being fully folded over the upper teeth and adjusted for treatment;
  • FIG. 3 is a magnified cross-sectional view of FIG. 2C taken through line 3 - 3 illustrating the oral carrier strip folded over a tooth and adjacent the gingival surfaces.
  • the present invention provides shaped oral carrier strips that are useful for delivery of active agents to the oral surfaces, such as the teeth and gums, and to the oral cavity.
  • the invention also relates to methods of administration of active agents or oral care compositions to the dental surfaces using the oral carrier strips of the invention. It has been discovered that the oral carrier strips of this invention afford advantages over the carrier strips among those known in the art. Such advantages include providing a carrier strip that is resistant to tearing when folded from the front to the back portion of the teeth surfaces. Further uses, benefits, and embodiments of the present invention are apparent from the description set forth herein.
  • oral cavity refers to the cavity bounded by the lips and the epiglottis in vertebrates.
  • the oral cavity includes “hard tissues,” such as the teeth and periodontal support, and “soft tissues,” such as the gums and gingiva, the tongue, and the surfaces of the buccal cavity.
  • hard tissues such as the teeth and periodontal support
  • soft tissues such as the gums and gingiva, the tongue, and the surfaces of the buccal cavity.
  • an “oral surface” includes the hard and soft tissues of the oral cavity.
  • the carrier strips of the invention may be fabricated of rigid or flexible materials, comprising any of a variety of orally or cosmetically acceptable materials, i.e., materials that are suitable for use with humans and/or animals to provide the desired benefit without undue adverse effects (such as toxicity, irritation, and allergic response) commensurate with a reasonable benefit/risk ratio.
  • exemplary materials may include polymer/copolymer films (thermoset polymers, thermoplastic polymers), papers, waxes, textiles (non-woven and woven), clays, foils, gels and wood composites and combinations of the same.
  • a strip can comprise a first layer comprising a polymer and/or an adhesive, a second layer that comprises an oral care active or functional composition, and one or more additional layers that provide additional ingredients or a coating.
  • the coating can be, for example, a shellac coating.
  • a coating can comprise a layer on either or both sides of a polymer or intermediate layer.
  • Specific polymers suitable for use as the strip material include cellulose ethers, methacrylates, polyvinylpyrollidone, hydroxyalkyl cellulose polymers, such as hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose; polyvinylpyrrolidone, cross-linked polyvinyl pyrrolidone, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl alcohol, polyacrylic acid, poly acrylate polymer, cross-linked polyacrylate polymer, cross-linked polyacrylic acid (e.g., CARBOPOL® available from Noveon, Inc., Cleveland, Ohio, United States of America), polyethylene oxide, polyethylene glycol, poly vinylalkyl ether-maleic acid copolymer (such as GANTREZ® available from ISP Corporation, Wayne N.J., United States of America) and carboxy vinyl polymers; marine colloids and natural gum
  • suitable polymers may include modified starches, cellulose acetate, cellulose nitrate, ethylene-vinyl acetate copolymers, vinyl acetate homopolymer, ethyl cellulose, butyl cellulose, isopropyl cellulose, shellac, silicone polymer (e.g., dimethylsilicone), PMMA (poly methyl methacrylate), cellulose acetate phthalate and natural or synthetic rubber; polymers insoluble in organic solvents, such as cellulose, polyethylene, polypropylene, polyesters, polyurethane and nylon.
  • the carrier strips of the invention may contain various inorganic materials, such as mica, mica coated with titanium dioxide, clay, and mother-of-pearl.
  • the film forming material comprises graphite.
  • a film forming material may include a hydrophobic organic non-polymeric material such as a wax, for example, beeswax or paraffin.
  • the carrier strips of the invention can be formulated of materials such that they disintegrate within a time period after placement on an oral surface.
  • the strips may release an active agent into the oral cavity prior to disintegrating and/or the release of the active agents may occur subsequent to the disintegration.
  • the disintegration of the carrier strip may be through any means, such as mechanical, chemical (dissolution or as a result of a chemical reaction occurring upon placement on an oral surface), or physical-chemical means.
  • the disintegration can result, for example, from shearing, grinding, or exposure to elevated temperatures during use.
  • Carrier strips of the invention may disintegrate into small pieces that are not visually discernable or disintegrate to collectively form a colloid or gel.
  • the polymer of the carrier is a breakable water soluble polymer that dissolves during use. The dissolution can occur as a result of, for example, mechanical means, and/or exposure to a solvent comprising a high concentration of water, such as saliva.
  • the polymer is insoluble but breakable in water by being dispersible, i.e., the polymer breaks down into small fragments, or the polymer is insoluble but is water swellable.
  • the polymer can be a water-repellant polymer or an aqueous-stable hydrophilic polymer such as certain types of cellulose, for example paper.
  • the strip can comprise a mixture of film forming materials.
  • the carrier strips of the present invention optionally comprise materials that affect the physical or functional characteristics of the strip.
  • additional substances can be, for example, surfactants, emulsifiers, plasticizers, fillers, or thickeners or other texture modifiers.
  • Fillers among those useful herein include inert starch particles and cellulose.
  • Texture modifiers include water swellable, physically modified and pregelatinized starches, to increase the stiffness of polymeric films, such as those comprising hydroxyalkyl methyl cellulose.
  • the granular starch is preferably cooked in the presence of water and, optionally, an organic solvent at a temperature not higher than 10° C. higher than the gelatinization temperature. The obtained starch is then dried.
  • Pregelatinized corn starch useful herein is available commercially.
  • Embodiments of this invention comprise one or more oral carrier strips.
  • a “strip” is a material having a substantially lamellar structure.
  • a “lamellar” structure has, or is capable of having, a size in one or two dimensions (e.g., the x- or y-dimensions) that is substantially greater than the thickness of the structure in a third dimension (e.g., the z-direction).
  • Lamellar structures among those useful herein include those that are substantially planar, layered, or lamelliform.
  • the lamellar structure is substantially planar, having a size in both the x- and y-dimensions that is substantially greater than the z-direction.
  • the lamellar structure is non-planar.
  • the strips of this invention comprise a substantially continuous surface that can appear as a substantially flat surface, although in some embodiments the strip is slightly deformed or curved. In such embodiments, the strip can have any of a number of shapes, including having a smooth curved surface.
  • the strips have a lamellar structure (further described below), but such structure may be composed of a single layer of material or multiple layers of material. If more than one layer of materials is present in the strip, the layers may be affixed to one another by any means, including lamination, application of an intervening adhesive layer(s), or application of the additional layer by coating, such that the layers are bonded to one another.
  • FIGS. 1A and 1B are plan views illustrating an oral carrier strip configured for the upper and lower teeth of a subject, respectively designated with reference numerals 10 and 12 , according to the principles of the present invention.
  • certain features that are common to, or shared by, the carrier strips 10 , 12 or their environment in the oral cavity are generally referred to by the same reference numbers.
  • the discussion may be specifically directed to the upper 10 or lower 12 carrier strip, the overall design may be applicable to both carrier strips 10 , 12 .
  • specific reference may be made explicitly to certain figures throughout the specification, attention should be made to all of the figures, as certain figures may depict or illustrate certain features or aspects of the present invention while not specifically being referred to.
  • the upper oral carrier strip 10 has a first portion 14 a adapted to contact a front facing side 16 of a plurality of upper teeth 18 a , and a second portion 20 a adapted to be folded so as to contact a back facing side 22 of the plurality of teeth 18 a .
  • the upper strip 10 has a first, or proximal, perimeter 24 a patterned to substantially match a shape of an outer gingival tissue 26, and a second, or distal, perimeter 28 a patterned to substantially match a shape of an inner gingival tissue 30.
  • the second perimeter 28 a is shaped to define an aperture 32 a disposed in the second portion 20 a of the strip 10 having a rounded notch 34 a positioned in a center location or portion of the strip 10 .
  • the rounded notch 34 a is located at a medial location between the first 24 a and second 28 a perimeters.
  • the lower oral carrier strip 12 has a first portion 14 b adapted to contact a front facing side 16 of a plurality of lower teeth 18 b , and a second portion 20 b adapted to be folded so as to contact a back facing side 22 of the plurality of teeth 18 b .
  • the lower strip 12 has a first, or proximal perimeter 24 b patterned to substantially match a shape of an outer gingival tissue 26, and a second or distal perimeter 28 b patterned to substantially match a shape of an inner gingival tissue 30.
  • the second perimeter 28 b is shaped to define an aperture 32 b disposed in the second portion 20 b of the strip 12 having a rounded notch 34 b positioned in a center portion of the strip 12 .
  • the rounded notch 34 b is located at a midpoint area, or medial location between the first 24 b and second 28 b perimeters.
  • FIG. 1C is a magnified view illustrating the aperture 32 a of FIG. 1A .
  • the aperture 32 a is defined by the second perimeter 28 a and includes two rounded corners 35 adjacent substantially linear wall regions 38 that preferably taper slightly inward towards a rounded notch 34 a .
  • the notch is configured so as to prevent the strip from tearing when folded around the teeth; i.e., to substantially minimize or eliminate the incidence of tearing during typical conditions of use.
  • the notch 34 a is configured to be substantially rounded, for example, semi-circular or oval shaped, thereby minimizing or preventing the strip 10 from tearing when folded around the teeth 18 a .
  • the notch does not have straight angle cuts.
  • One function of the aperture 32 a is to allow the second portion 20 a to be folded around to the back side 22 of the teeth 18 a with minimal bunching or folding of material. Another advantage is that the aperture 32 a can be used by the user to align the strip with the center of the teeth without other graphical indicia such as lines or arrows, thus allowing proper alignment within the oral cavity.
  • the aperture 32 a has a width 40 from about 1.5 to about 3 mm in length, and a height 42 from about 3 to about 8 mm in length.
  • the rounded notch 34 a preferably has a radius of curvature 34 r from about 0.5 to about 2 mm, preferably from about 0.75 to about 1.5 mm.
  • the corners 35 preferably have a radius of curvature 35 r from about 0.5 to about 2.5 mm and will depend upon the specific design.
  • the height 42 of the aperture 32 a is about 6 mm, and the radius of curvature 34 r of the rounded notch 34 a is about 0.8 mm.
  • the specific dimensions will vary slightly depending upon desired application, along with the mean tooth sizes of the populations the strips are designed for use with.
  • FIG. 1C specifically depicts the aperture 32 a and rounded notch 34 a of the upper carrier strip 10 , the dimensions and discussion are equally applicable to the aperture 32 b and rounded notch 34 b of the lower carrier strip 12 .
  • the oral carrier strips 10 , 12 have a substantially horizontal, or longitudinal, fold 36 a , 36 b separating the respective first 14 a , 14 b and second 20 a , 20 b portions.
  • the fold 36 a , 36 b may be perforated to assist a user in folding the second portion 20 a , 20 b around to the back facing side 22 of the teeth 18 a , 18 b .
  • the fold may be a graphical indicia of a different color, for example, a red or black line, arrow, or the like.
  • the rounded notch 34 a , 34 b is co-joined with, the fold 36 a , 36 b.
  • FIG. 2A is a perspective view illustrating the oral carrier strips 10 , 12 being applied to the upper 18 a and lower teeth 18 b , respectively, of a human subject.
  • the carrier strips 10 , 12 extend a length operable to contact at least 6 to 8 teeth, preferably including the upper and lower incisors 44 a , 44 b and canine 46 a , 46 b teeth, respectively.
  • the upper strips 10 can range in length from about 60 mm up to about 75 mm in the longest dimension.
  • the lower strips 12 can range in length from about 40 mm up to about 65 mm in the longest dimension.
  • a “long dimension” is the dimension of the strip in length or width (i.e., in the x- and y-dimensions, as the strip is, or is deformed to be, in a planar shape) in a dimension substantially perpendicular to the “thickness” or shortest dimension of the strip (i.e., the z-dimension). It should be understood that in certain instances, it may be desirable to have shorter or longer strips 10 , 12 depending upon use and the subject population.
  • FIG. 2B is a partial perspective view of FIG. 2A illustrating the oral carrier strip 10 in the process of being folded over the upper teeth 18 a .
  • the aperture 32 a is aligned between the central incisor teeth 44 a .
  • the first portion 14 a is pressed upon the front facing side 16 of the teeth 118 a and light pressure is applied.
  • a first half 48 of the second portion 20 a is folded over and pressed onto the back facing side 22 of the teeth 18 a and adjusted as necessary for form and comfort during treatment.
  • a second half 50 of the oral carrier strip 10 is folded over the remaining upper teeth 18 a and adjusted for treatment.
  • both halves 48 , 50 may be folded over at the same time, if so desired.
  • the first 24 a , 24 b and second 28 a , 28 b perimeters are substantially linear. In other embodiments, at least one of the perimeters 24 a , 24 b , 28 a , 28 b is non-linear, for example, angled or substantially arcuate in shape, and better configured to be applied to the upper 18 a or lower 18 b teeth and matched to the gingival areas 26 , 30 .
  • the carrier strips 10 , 12 have a first portion 14 a , 14 b with first and second opposite rounded corners 52 a , 52 b having a radius of curvature 52 r from about 1.5 to about 2.5 mm.
  • the carrier strips 10 , 12 have a second portion 20 a , 20 b with first and second opposite rounded corners 54 a , 54 b having a radius of curvature 54 r from about 4 to about 5 mm.
  • the first perimeter 24 b of the lower strip 12 is provided with three areas slightly angled from one another wherein angle ⁇ is from about 5 to about 15 degrees.
  • the carrier strip 10 , 12 side regions 56 a , 56 b are also substantially rounded in shape, having a radius of curvature 56 r from about 5 to about 15 mm, preferably from about 8 to about 12 mm.
  • FIG. 3 is a magnified cross-sectional view of FIG. 2C illustrating the upper carrier strip 10 folded over a tooth 44 a .
  • the strips are sized having a width that will accommodate twice the mean height of the canine and incisor tooth lengths for a given subject population. In certain embodiments, for example, the width is from about 10 to about 20 mm in length, preferably, the width is about 15 mm.
  • the first perimeter 24 a is patterned to be adjacent to, or conjoins the outer gingiva 26 tissue
  • the second perimeter 28 a is patterned to be adjacent to, or conjoins the inner gingiva tissue 30.
  • the first 24 a and second 28 a perimeters overlap a portion of the respective outer 26 and inner 30 gingiva tissues (not shown).
  • the carrier strips 10 , 12 of the present invention have a thickness of from about 20 microns to about 750 microns. In certain preferred embodiments, the strips 10 , 12 have a thickness of from about 20 microns up to about 250 microns, or from about 100 microns up to about 200 microns, preferably from about 150 microns up to about 175 microns.
  • Kits according to various embodiments of the present invention comprise both an upper 10 and a lower 12 carrier strip as described herein, each having an oral composition thereon.
  • the oral compositions may be the same on both strips, or they may be different.
  • the kits may contain a single strip 10 , 12 for the upper 18 a and lower 18 b teeth, or they may also include various combinations of the strips 10 , 12 in the same or different quantities. Instructions for using the kit and optimizing the use of the carriers may also be provided.
  • the carrier strip as described above may “carrie” an oral care composition for delivery of such agent/compositions to the dental surface(s) upon contact or it may be impregnated with such compositions(s).
  • Contact of the strip to the dental surfaces is meant to include those situations where the strip is coated with the composition and the composition contacts the dental surface.
  • An “oral care active agent” is a material having a desired utility for oral care.
  • the agent may have one or more of a therapeutic, cosmetic, aesthetic, decorative, sensory, prophylactic, or diagnostic utility.
  • Active agents can include sulfur precipitating agents, pharmaceuticals cosmetic actives, natural extracts and essential oils, sensory agents, stain prevention actives, conditioning agents, moisturizers, and combinations thereof. Such active agents may be included or impregnated in the strip, or may be a coating or layer on the strip.
  • Cosmetic and pharmaceuticals active agents include those which act either systemically and/or locally to provide a therapeutic, diagnostic and/or prophylactic effect or act to enhance the appearance of the oral surface or to reduce or eliminate breath or mouth odor. Active agents are disclosed in, e.g., U.S. Patent Publication 2003/0206874, Doyle et al., published Nov. 6, 2003; U.S. Pat. No. 6,290,933, Durga et al., issued Sep. 18, 2001; and U.S. Pat. No. 6,685,921, Lawlor, issued Feb. 3, 2004, the contents of each of which are incorporated herein by reference.
  • the oral compositions of the present invention comprise a whitening agent.
  • a “whitening agent” is a material which is effective to effect whitening of a tooth surface to which it is applied.
  • the compositions of this invention comprise a peroxide whitening agent, comprising a peroxide compound.
  • a “peroxide compound” is an oxidizing compound comprising a bivalent oxygen-oxygen group.
  • Peroxide compounds include peroxides and hydroperoxides, such as hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, pharmaceutically-acceptable salts thereof, and mixtures thereof.
  • Peroxides of alkali and alkaline earth metals include lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof.
  • Organic peroxy compounds include carbamide peroxide, glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, hydrogen peroxide, and monoperoxyphthalate, and mixtures thereof.
  • Peroxy acids and their salts include organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as persulfate, dipersulfate, percarbonate, perphosphate, perborate and persilicate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof.
  • An antibacterial agent may be included. Any orally acceptable antimicrobial agent can be used, including triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol); 8-hydroxyquinoline and salts thereof; zinc and stannous ion sources such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate; copper (II) compounds such as copper (II) chloride, fluoride, sulfate and hydroxide; phthalic acid and salts thereof such as magnesium monopotassium phthalate; sanguinarine; quaternary ammonium compounds, such as alkylpyridinium chlorides (e.g., cetylpyridinium chloride (CPC), combinations of CPC with zinc and/or enzymes, tetradecylpyridinium chloride, and N-tetradecyl-4-ethylpyridinium chloride); bisguanides, such as chlorhexidine digluconate,
  • the carrier strip comprises a backing layer and an oral composition.
  • the components of a film forming oral composition slurry are mixed to form a slurry composition, cast or applied to the backing layer, and subsequently dried. Drying of the slurry can be carried out at high temperature with the aid of a drying oven, a drying terminal, a vacuum drier, or any other suitable drying equipment known in the art. Once dry, the carrier strips are stamped or cut to size using dies or the like.
  • the slurry is cast on a releasable substrate and dried to form a sheet of film material.
  • the substrate material has a surface tension that allows the film slurry to spread substantially uniformly across the substrate surface, thereby avoiding formation of a destructive bond between the film and the substrate.
  • suitable substrates include glass, stainless steel, Polytetrafluoroethylene, and polyethylene- or silicone-impregnated paper.
  • the film is then dried as previously detailed.
  • the film is made by extrusion of the film composition through a die, followed by cutting to a desired pattern, and drying.
  • the film is made by solvent casting.

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
US11/168,680 2005-06-28 2005-06-28 Carrier strip for application to oral surfaces and related methods Expired - Lifetime US8414293B2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
US11/168,680 US8414293B2 (en) 2005-06-28 2005-06-28 Carrier strip for application to oral surfaces and related methods
MYPI20062965A MY145562A (en) 2005-06-28 2006-06-22 Carrier strip for application to oral surfaces and related methods
TW095123053A TWI426892B (zh) 2005-06-28 2006-06-27 施用於口表面之載體條
ARP060102765A AR056398A1 (es) 2005-06-28 2006-06-27 Banda portadora para la aplicacion de superficies orales y metodos relacionados
CN2006800310853A CN101247771B (zh) 2005-06-28 2006-06-28 用于口腔表面的托架条
AU2006263679A AU2006263679C1 (en) 2005-06-28 2006-06-28 Carrier strip for application to oral surfaces and related methods
RU2008102969/14A RU2373898C2 (ru) 2005-06-28 2006-06-28 Лента-носитель для применения на поверхностях рта и относящиеся к ней способы
CA2613509A CA2613509C (en) 2005-06-28 2006-06-28 Carrier strip for application to oral surfaces and related methods
MX2008000105A MX2008000105A (es) 2005-06-28 2006-06-28 Tira transportadora para aplicacion a superficies orales y metodos relacionados.
BRPI0612839-4A BRPI0612839A2 (pt) 2005-06-28 2006-06-28 tira de suporte oral, kit para a aplicação de uma composição para o cuidado oral, e, método para dispensar uma composição oral a uma superfìcie oral
JP2008519531A JP4987865B2 (ja) 2005-06-28 2006-06-28 口内表面に施すための基材ストリップ及び関連する方法
PCT/US2006/025232 WO2007002776A1 (en) 2005-06-28 2006-06-28 Carrier strip for application to oral surfaces and related methods
EP06774224A EP1895932A1 (en) 2005-06-28 2006-06-28 Carrier strip for application to oral surfaces and related methods
ZA2008/00124A ZA200800124B (en) 2005-06-28 2008-01-04 Carrier strip for application to oral surface and related methods
US29/375,874 USD655007S1 (en) 2005-06-28 2010-09-29 Oral care strip
US29/408,651 USD671215S1 (en) 2005-06-28 2011-12-15 Oral care strip

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/168,680 US8414293B2 (en) 2005-06-28 2005-06-28 Carrier strip for application to oral surfaces and related methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US29/375,874 Continuation USD655007S1 (en) 2005-06-28 2010-09-29 Oral care strip

Publications (2)

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US20060292520A1 US20060292520A1 (en) 2006-12-28
US8414293B2 true US8414293B2 (en) 2013-04-09

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US11/168,680 Expired - Lifetime US8414293B2 (en) 2005-06-28 2005-06-28 Carrier strip for application to oral surfaces and related methods
US29/375,874 Expired - Lifetime USD655007S1 (en) 2005-06-28 2010-09-29 Oral care strip
US29/408,651 Active USD671215S1 (en) 2005-06-28 2011-12-15 Oral care strip

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US20170119643A1 (en) * 2015-05-06 2017-05-04 The Procter & Gamble Company Detoxification of microbial virulence factors in oral cavity
US10156566B2 (en) * 2015-05-06 2018-12-18 The Procter & Gamble Company Detoxification of microbial virulence factors in oral cavity
US11826437B2 (en) 2020-10-19 2023-11-28 The Procter & Gamble Company Oral care article comprising a hydrophobic delivery carrier and solid hydrophilic particle comprising a bleaching agent
US11833231B2 (en) 2020-10-19 2023-12-05 The Procter & Gamble Company Oral care article comprising a delivery carrier and solid hydrophilic particles comprising a bleaching agent
US11839667B2 (en) 2020-10-19 2023-12-12 The Procter & Gamble Company Oral care article comprising a delivery carrier and solid hydrophilic particles comprising an active agent
US11839666B2 (en) 2020-10-19 2023-12-12 The Procter & Gamble Company Oral care article comprising a hydrophobic delivery carrier and solid hydrophilic particles comprising an agent
US11904033B2 (en) 2020-10-19 2024-02-20 The Procter & Gamble Company Oral care article comprising a hydrophobic delivery carrier and solid hydrophilic particles comprising a bleaching agent
US12133904B2 (en) 2020-10-19 2024-11-05 The Procter & Gamble Company Oral care article comprising a hydrophobic delivery carrier and solid hydrophilic particles comprising an active agent
US12133903B2 (en) 2020-10-19 2024-11-05 The Procter & Gamble Company Oral care article comprising a delivery carrier and solid hydrophilic particles comprising a bleaching agent
US12201705B2 (en) 2020-10-19 2025-01-21 The Procter And Gamble Company Oral care article comprising a delivery carrier and solid hydrophilic particles comprising a bleaching agent
US12208149B2 (en) 2020-10-19 2025-01-28 The Procter & Gamble Company Oral care article comprising a hydrophobic delivery carrier and solid hydrophilic particles comprising a bleaching agent

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US20060292520A1 (en) 2006-12-28
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