UY38657A - Derivados de carbamoil-ciclohexano para tratar el trastorno del espectro del autismo - Google Patents
Derivados de carbamoil-ciclohexano para tratar el trastorno del espectro del autismoInfo
- Publication number
- UY38657A UY38657A UY0001038657A UY38657A UY38657A UY 38657 A UY38657 A UY 38657A UY 0001038657 A UY0001038657 A UY 0001038657A UY 38657 A UY38657 A UY 38657A UY 38657 A UY38657 A UY 38657A
- Authority
- UY
- Uruguay
- Prior art keywords
- disorder
- autism spectrum
- carbamoil
- derivatives
- autism
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se refiere al compuesto de trans-N-[4-[2-[4-(2,3-diclorofenil)piperazin-1-il]etil]ciclohexil]-N’,N’-dimetilurea (cariprazina), sus sales, análogos cercanos, derivados, composiciones farmacéuticas, metabolitos y combinaciones para su uso en el tratamiento de los síntomas del trastorno del espectro autista en general, y preferentemente el objeto de la presente invención es tratar uno o más síntomas del autismo. Además, se determi nó también que la cariprazina, sus sales, análogos cercanos, derivados, composiciones farmacéuticas, metabolitos y combinaciones son adecuadas para el tratamiento de afecciones tales como el síndrome de Asperger, autismo atípico (también conocido como trastorno generalizado del desarrollo no especificado de otra manera, TGD NE), el síndrome de Rett, el trastorno desintegrativo de la infancia, el trastorno por el déficit de atención e hiperactividad (TDAH) y la disfunción de integración sensorial
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP1900121A HU231500B1 (hu) | 2019-04-10 | 2019-04-10 | Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY38657A true UY38657A (es) | 2020-10-30 |
Family
ID=89992883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001038657A UY38657A (es) | 2019-04-10 | 2020-04-13 | Derivados de carbamoil-ciclohexano para tratar el trastorno del espectro del autismo |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP3952872B1 (es) |
| JP (2) | JP2022527386A (es) |
| KR (1) | KR20210151162A (es) |
| CN (1) | CN113677345A (es) |
| AR (1) | AR118634A1 (es) |
| AU (2) | AU2020271363B2 (es) |
| BR (1) | BR112021019367A2 (es) |
| CL (1) | CL2021002632A1 (es) |
| DK (1) | DK3952872T3 (es) |
| EA (1) | EA202192717A1 (es) |
| ES (1) | ES2980780T3 (es) |
| FI (1) | FI3952872T3 (es) |
| GE (2) | GEAP202315793A (es) |
| HR (1) | HRP20240772T1 (es) |
| HU (2) | HU231500B1 (es) |
| IL (1) | IL287076A (es) |
| LT (1) | LT3952872T (es) |
| MX (1) | MX2021012321A (es) |
| MY (1) | MY209375A (es) |
| PH (1) | PH12021552324A1 (es) |
| PL (1) | PL3952872T3 (es) |
| PT (1) | PT3952872T (es) |
| RS (1) | RS65530B1 (es) |
| SG (1) | SG11202110421YA (es) |
| SI (1) | SI3952872T1 (es) |
| TW (1) | TW202103701A (es) |
| UA (1) | UA130037C2 (es) |
| UY (1) | UY38657A (es) |
| WO (1) | WO2020208564A1 (es) |
| ZA (1) | ZA202108429B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114588162B (zh) * | 2022-03-30 | 2023-10-27 | 中国人民解放军空军军医大学 | 拉莫三嗪治疗孤独症触觉异常的应用 |
| US11980603B2 (en) | 2022-06-11 | 2024-05-14 | AMS Therapeutics, LLC | Method of treating expressive language deficit in autistic humans |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227534B1 (en) * | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| HU230748B1 (hu) | 2007-05-11 | 2018-02-28 | Richter Gedeon Nyrt | Új piperazin só és előállítási eljárása |
| AU2008251520B2 (en) | 2007-05-11 | 2014-03-06 | Richter Gedeon Nyrt. | Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives |
| HUP0700353A2 (en) | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| HUE036004T2 (hu) * | 2007-08-03 | 2018-06-28 | Richter Gedeon Nyrt | Dopamin receptor ligandumokat tartalmazó gyógyszerkészítmények és kezelési eljárások dopamin receptor ligandumok alkalmazásával |
| AP2975A (en) | 2008-07-16 | 2014-09-30 | Richter Gedeon Nyrt | Pharmaceutical formulations containing dopamine receptor ligands |
| WO2011060363A2 (en) * | 2009-11-16 | 2011-05-19 | Auspex Pharmaceuticals, Inc. | Cyclohexyl urea modulators of d2 receptors and/or d3 receptors |
| EP3079688B1 (en) | 2013-12-13 | 2017-11-22 | Pierre Fabre Médicament | A chromone derivative as a dopamine d3 receptor antagonist for its use in the treatment of autism spectrum disorder |
-
2019
- 2019-04-10 HU HUP1900121A patent/HU231500B1/hu unknown
-
2020
- 2020-03-11 TW TW109108018A patent/TW202103701A/zh unknown
- 2020-04-08 AR ARP200101001A patent/AR118634A1/es not_active Application Discontinuation
- 2020-04-09 ES ES20719737T patent/ES2980780T3/es active Active
- 2020-04-09 KR KR1020217036553A patent/KR20210151162A/ko active Pending
- 2020-04-09 FI FIEP20719737.7T patent/FI3952872T3/fi active
- 2020-04-09 SI SI202030436T patent/SI3952872T1/sl unknown
- 2020-04-09 DK DK20719737.7T patent/DK3952872T3/da active
- 2020-04-09 EA EA202192717A patent/EA202192717A1/ru unknown
- 2020-04-09 BR BR112021019367A patent/BR112021019367A2/pt unknown
- 2020-04-09 PT PT207197377T patent/PT3952872T/pt unknown
- 2020-04-09 LT LTEPPCT/IB2020/053382T patent/LT3952872T/lt unknown
- 2020-04-09 JP JP2021559605A patent/JP2022527386A/ja active Pending
- 2020-04-09 GE GEAP202315793A patent/GEAP202315793A/en unknown
- 2020-04-09 PH PH1/2021/552324A patent/PH12021552324A1/en unknown
- 2020-04-09 MY MYPI2021005916A patent/MY209375A/en unknown
- 2020-04-09 MX MX2021012321A patent/MX2021012321A/es unknown
- 2020-04-09 HU HUE20719737A patent/HUE066941T2/hu unknown
- 2020-04-09 UA UAA202106383A patent/UA130037C2/uk unknown
- 2020-04-09 SG SG11202110421YA patent/SG11202110421YA/en unknown
- 2020-04-09 RS RS20240573A patent/RS65530B1/sr unknown
- 2020-04-09 AU AU2020271363A patent/AU2020271363B2/en active Active
- 2020-04-09 HR HRP20240772TT patent/HRP20240772T1/hr unknown
- 2020-04-09 EP EP20719737.7A patent/EP3952872B1/en active Active
- 2020-04-09 CN CN202080027793.XA patent/CN113677345A/zh active Pending
- 2020-04-09 PL PL20719737.7T patent/PL3952872T3/pl unknown
- 2020-04-09 GE GEAP202015793A patent/GEP20237554B/en unknown
- 2020-04-09 WO PCT/IB2020/053382 patent/WO2020208564A1/en not_active Ceased
- 2020-04-13 UY UY0001038657A patent/UY38657A/es not_active Application Discontinuation
-
2021
- 2021-10-07 IL IL287076A patent/IL287076A/en unknown
- 2021-10-08 CL CL2021002632A patent/CL2021002632A1/es unknown
- 2021-10-29 ZA ZA2021/08429A patent/ZA202108429B/en unknown
-
2025
- 2025-07-03 JP JP2025112954A patent/JP2025143406A/ja active Pending
- 2025-12-12 AU AU2025279746A patent/AU2025279746A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2022003510A1 (es) | Inhibidores de cisteína proteasas y sus métodos de uso | |
| CL2024003450A1 (es) | Compuestos y usos de estos | |
| BR112014000792A2 (pt) | compostos de piperidinila para uso como inibidores da tanquirase | |
| CL2025000629A1 (es) | Inhibidores de parp1 de azetidina y pirrolidina y usos de estos | |
| CL2019001264A1 (es) | Ácidos propiónicos 3-sustituidos como inhibidores de la integrina alfa v. | |
| JOP20240165A1 (ar) | مشتقات بيبريدينيل سبيرو سيكليك كمثبطات عامل مكمل b واستخداماتها | |
| CL2023000921A1 (es) | Derivados de 1,2,3,4-tetrahidroquinolina como inhibidores de la activacion de yap/taz-tead | |
| CU20110168A7 (es) | Derivados de benzofuranilo | |
| CO6400220A2 (es) | Derivados de sulfonamida | |
| BR112015028879A8 (pt) | compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos | |
| AR058338A1 (es) | Derivados de pirrol fusionado, composiciones farmaceuticas que los contienen y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la quinasa. | |
| CL2021002632A1 (es) | Derivados del carbamoil-ciclohexano para tratar el trastorno del espectro autista | |
| DOP2019000076A (es) | DERIVADOS DE CROMANO, ISOCROMANO Y DIHIDROISOBENZOFURANOS COMO MODULADORES ALOSTÉRICOS NEGATIVOS DE mGluR2, COMPOSICIONES Y SU USO | |
| UY32744A (es) | Derivados de 2-carboxamida-7-piperazinil-benzofurano 774 | |
| CL2012000013A1 (es) | Compuestos derivados de 4-{3-[3-(4-trifluorometil-fenil)ureido]-5-fluoro-bencilamino}-1h-pirazol-3-carboxamida; procedimiento de preparacion; composicion farmaceutica que los comprende; compuestos intermediarios; y su uso como moduladores de la actividad de las proteinas quinasa para el tratamiento del cancer. | |
| CO2025004988A2 (es) | Enlazadores-cargas útiles de adc derivados de exatecán, composiciones farmacéuticas, y usos de los mismos | |
| CL2021000424A1 (es) | Uso de roluperidona para tratar síntomas y trastornos negativos, aumentar la neuroplasticidad y promover la neuroprotección | |
| MX2025009815A (es) | Inhibidores de la integrina alfa4beta7 macrociclica | |
| CL2009000637A1 (es) | Compuestos derivados sulfonamida sustituido, antagonista b1r; composición farmacéutica que los comprende; proceso de preparación de los compuestos, y uso en el tratamiento del dolor causado por inflamación, dolor agudo, neuropático, visceral, también en diabetes, migraña, entre otras. | |
| CL2021000282A1 (es) | Inhibidores de ckd8/19 | |
| BR112015000392A2 (pt) | novos indazóis para o tratamento e profilaxia da infecção por vírus sincicial respiratório | |
| BR112018004719A2 (pt) | composto de fluoroindola, composição farmacêutica, método para o tratamento de uma desordem relacionada a receptor muscarínico m1 e uso do composto | |
| CL2025003313A1 (es) | Compuestos derivados de feniloxazolona sustituida. | |
| MX2025013985A (es) | Inhibidores de prmt5 | |
| CL2017002605A1 (es) | Derivados de indol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RDES | Application refused |
Effective date: 20250911 |