WO1987000751A3 - Utilisation d'acides carboxyliques d'oxirane pour le traitement de l'hyperlipemie - Google Patents

Utilisation d'acides carboxyliques d'oxirane pour le traitement de l'hyperlipemie

Info

Publication number
WO1987000751A3
WO1987000751A3 PCT/EP1986/000450 EP8600450W WO8700751A3 WO 1987000751 A3 WO1987000751 A3 WO 1987000751A3 EP 8600450 W EP8600450 W EP 8600450W WO 8700751 A3 WO8700751 A3 WO 8700751A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
hyperlipemia
oxirancarboxylic
acids
oxirancarboxylic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1986/000450
Other languages
German (de)
English (en)
Other versions
WO1987000751A2 (fr
Inventor
Horst Wolf
Klaus Eistetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Priority to DE8686905250T priority Critical patent/DE3680507D1/de
Priority to AT86905250T priority patent/ATE65398T1/de
Publication of WO1987000751A2 publication Critical patent/WO1987000751A2/fr
Publication of WO1987000751A3 publication Critical patent/WO1987000751A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

Utilisation d'acides carboxyliques d'oxirane de formule (I), dans laquelle R1, R2, R3, Y et n ont les significations indiquées dans les revendications, pour la prévention et/ou le traitement d'infections associées à une concentration accrue de cholesterol et/ou de triglyceride.
PCT/EP1986/000450 1985-08-02 1986-07-29 Utilisation d'acides carboxyliques d'oxirane pour le traitement de l'hyperlipemie Ceased WO1987000751A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE8686905250T DE3680507D1 (de) 1985-08-02 1986-07-29 Verwendung von oxirancarbonsaeuren zur behandlung der hyperlipaemie.
AT86905250T ATE65398T1 (de) 1985-08-02 1986-07-29 Verwendung von oxirancarbonsaeuren zur behandlung der hyperlipaemie.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3527800.5 1985-08-02
DE3527800 1985-08-02

Publications (2)

Publication Number Publication Date
WO1987000751A2 WO1987000751A2 (fr) 1987-02-12
WO1987000751A3 true WO1987000751A3 (fr) 1987-04-23

Family

ID=6277544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000450 Ceased WO1987000751A2 (fr) 1985-08-02 1986-07-29 Utilisation d'acides carboxyliques d'oxirane pour le traitement de l'hyperlipemie

Country Status (5)

Country Link
US (1) US4946866A (fr)
EP (1) EP0231367B1 (fr)
JP (1) JP2556496B2 (fr)
DE (1) DE3680507D1 (fr)
WO (1) WO1987000751A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4340879A1 (de) * 1993-12-01 1995-06-08 Horst P O Dr Wolf Arzneimittel zur Behandlung der Herzinsuffizienz
US6013666A (en) * 1996-07-02 2000-01-11 Sang Sup Jew Oxirane carboxylic acid derivative and its manufacturing method
DE19705718A1 (de) * 1997-02-14 1998-08-20 Horst P O Dr Wolf Neue Oxirancarbonsäuren zur Behandlung des Diabetes Typ 2 und anderer insulinresistenter Zustände
US7381413B1 (en) * 1998-04-17 2008-06-03 University Of Vermont And State Agricultural College Methods and products related to metabolic interactions in disease
MXPA01009840A (es) * 1999-03-31 2002-06-21 Abbott Lab Nuevas formulaciones que comprenden agentes reguladores de lipido.
CN1964630A (zh) * 2003-02-13 2007-05-16 耶希瓦大学艾伯塔·爱恩斯坦医学院 通过控制下丘脑的长链脂肪酰基－辅酶A(LC－CoA)的水平来调控食物摄取和葡萄糖产生
CA2534816A1 (fr) 2003-06-12 2004-12-23 Evan Newell Systemes et procedes de traitement de maladies inflammatoires et proliferatives humaines et de lesions au moyen d'inhibiteurs du metabolisme des acides gras et/ou d'inhibiteurs glycolytiques
WO2005070126A2 (fr) 2004-01-08 2005-08-04 The Regents Of The University Of Colorado Systemes et procedes pour le traitement de maladies inflammatoires et proliferantes humaines, et des plaies avec le gene ucp et/ou l'anticorps anti-fas ou autre inhibiteur, eventuellement avec un inhibiteur du metabolisme d'acide gras et/ou un inhibiteur du metabolisme de glucose et applications associees
WO2006041922A2 (fr) * 2004-10-08 2006-04-20 Dara Biosciences, Inc. Agents, et procedes d'administration au systeme nerveux central
US20070026079A1 (en) * 2005-02-14 2007-02-01 Louis Herlands Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels
WO2010008554A2 (fr) 2008-07-14 2010-01-21 The Regents Of The University Of Colorado Procédés et produits pour traiter des maladies prolifératives
US8450090B2 (en) 2009-10-06 2013-05-28 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for promoting fatty acid production in plants

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025192A2 (fr) * 1979-09-07 1981-03-18 Byk Gulden Lomberg Chemische Fabrik GmbH Acides oxiranne-carboxyliques substitués, procédé pour leur préparation, leur utilisation et médicaments les contenant
EP0046590A2 (fr) * 1980-08-25 1982-03-03 Byk Gulden Lomberg Chemische Fabrik GmbH Acides oxirannecarboxyliques substitués par des groupes phén(alk)oxy, procédé pour leur préparation, leur application et médicaments les contenant
EP0046961A1 (fr) * 1980-08-29 1982-03-10 Byk Gulden Lomberg Chemische Fabrik GmbH Acides époxy-cycloalcoylalcanoiques, procédé pour les préparer, leur utilisation et médicaments les contenant
EP0071175A2 (fr) * 1981-07-24 1983-02-09 Byk Gulden Lomberg Chemische Fabrik GmbH Acides phénylalkyloxiranecarboxyliques, procédé pour leur préparation, leur utilisation et médicaments les renfermant

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235923A (en) * 1979-05-04 1980-11-25 Shell Oil Company Esters of 3-substituted-2-(aminocarbonyl)oxiranecarboxylic acids as lipogenesis inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025192A2 (fr) * 1979-09-07 1981-03-18 Byk Gulden Lomberg Chemische Fabrik GmbH Acides oxiranne-carboxyliques substitués, procédé pour leur préparation, leur utilisation et médicaments les contenant
US4324796A (en) * 1979-09-07 1982-04-13 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung Substituted oxiranecarboxylic acids, their use and medicaments containing them
EP0046590A2 (fr) * 1980-08-25 1982-03-03 Byk Gulden Lomberg Chemische Fabrik GmbH Acides oxirannecarboxyliques substitués par des groupes phén(alk)oxy, procédé pour leur préparation, leur application et médicaments les contenant
EP0046961A1 (fr) * 1980-08-29 1982-03-10 Byk Gulden Lomberg Chemische Fabrik GmbH Acides époxy-cycloalcoylalcanoiques, procédé pour les préparer, leur utilisation et médicaments les contenant
EP0071175A2 (fr) * 1981-07-24 1983-02-09 Byk Gulden Lomberg Chemische Fabrik GmbH Acides phénylalkyloxiranecarboxyliques, procédé pour leur préparation, leur utilisation et médicaments les renfermant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biochemical Pharmacology, Vol. 33, No. 3, 1984, (Pergamon Press Ltd, GB) P.P. KOUNDAKJIAN et al.: "Metabolic Changes in fed rats Caused by Chronic Administration of Ethyl 2( 5(4-Chlorophenyl) Pentyl) Oxirane-2-Carboxylate, a new Hypoglycaemic Compound, pages 465-473, see page 465 cited in the application *
Biochemical Society Transactions, Vol. 14, No. 4, August 1986, Y.T. KRUSZYNSKA et al.: "The Effects of 2 ( - 6(4-Clorophenoxy) Hexyl) Oxirane-2-Carboxylate (Extomir) on Glucose Turnover in Fasted rats", pages 699-700 see the whole article *
Diabetologia, Vol. 29, No. 8 August 1986 H. BLIESATH et al.: "First Administration of Etomoxir in man", page 519 A see Abstract No. 49 *

Also Published As

Publication number Publication date
EP0231367A1 (fr) 1987-08-12
US4946866A (en) 1990-08-07
WO1987000751A2 (fr) 1987-02-12
JPS63500380A (ja) 1988-02-12
JP2556496B2 (ja) 1996-11-20
EP0231367B1 (fr) 1991-07-24
DE3680507D1 (de) 1991-08-29

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