WO1987003479A3 - Medicament pour combattre les troubles de l'irrigation sanguine - Google Patents

Medicament pour combattre les troubles de l'irrigation sanguine

Info

Publication number
WO1987003479A3
WO1987003479A3 PCT/EP1986/000695 EP8600695W WO8703479A3 WO 1987003479 A3 WO1987003479 A3 WO 1987003479A3 EP 8600695 W EP8600695 W EP 8600695W WO 8703479 A3 WO8703479 A3 WO 8703479A3
Authority
WO
WIPO (PCT)
Prior art keywords
medicament
use against
circulatory disorders
against circulatory
phisiological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1986/000695
Other languages
German (de)
English (en)
Other versions
WO1987003479A2 (fr
Inventor
Elfriede Leniger-Follert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
Original Assignee
Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV filed Critical Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
Publication of WO1987003479A2 publication Critical patent/WO1987003479A2/fr
Anticipated expiration legal-status Critical
Publication of WO1987003479A3 publication Critical patent/WO1987003479A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)

Abstract

Le médicament ci-décrit contient comme substance active au moins une substance captant des ions de potassium à des valeurs pH physiologiques, comme par ex. un composé de formule générale (I) dans laquelle R1, R2 et R3 représentent chacun un groupe alkyle comprenant de 1 à 4 atomes de carbone, et n, p et q représentent indépendamment les uns des autres un nombre entier de 1 à 5, ou un éther en couronne, éventuellement avec des additifs, solvants et/ou diluants physiologiques usuels.
PCT/EP1986/000695 1985-12-12 1986-12-02 Medicament pour combattre les troubles de l'irrigation sanguine Ceased WO1987003479A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3543974.2 1985-12-12
DE19853543974 DE3543974A1 (de) 1985-12-12 1985-12-12 Arzneimittel zur bekaempfung von durchblutungsstoerungen

Publications (2)

Publication Number Publication Date
WO1987003479A2 WO1987003479A2 (fr) 1987-06-18
WO1987003479A3 true WO1987003479A3 (fr) 1988-07-28

Family

ID=6288296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000695 Ceased WO1987003479A2 (fr) 1985-12-12 1986-12-02 Medicament pour combattre les troubles de l'irrigation sanguine

Country Status (5)

Country Link
US (1) US5008269A (fr)
EP (1) EP0248046A1 (fr)
JP (1) JPH01500175A (fr)
DE (1) DE3543974A1 (fr)
WO (1) WO1987003479A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4116889A1 (de) * 1991-05-23 1992-11-26 Leniger Follert Elfriede Prof Arzneimittel zur bekaempfung von durchblutungsstoerungen

Non-Patent Citations (18)

* Cited by examiner, † Cited by third party
Title
Acta Physiol. Scand., Band 114, Nr. 4, 1982, P. ARHEM et al.: "Inactivation of the Potassium Transport System of Myelinated Nerve in the Presence of a Cyclic Ionophore", seiten 593-600, siehe den ganzen artikel *
Acta Physiol. Scand., Band 123, Nr. 3, 1985, H. KRISTBJARNARSON et al.: "The Effect of Crown Ethers on Ionic Currents in Myolinated Nerve Fibres from Xenopus Laevis", seiten 261-268, siehe den ganzen artikel *
Annual Review of Biochemistry, Band 45, 1976, E.E. Snell, Editor, Annual Reviews Inc. (Palo Alto, Ca., US) B.C. PRESSMAN: "Biological Applications of Ionophores", seiten 501-530, siehe seite 502, zeilen 36-40; seite 505, zeilen 4-7; seite 521, die letzten 5 zeilen; seite 522, zeilen 1-30; seiten 524-525 *
Arch. Toxicol., Band 7, Suppl. 7, 1984, Springer Verlag, M. BAUMANN et al.: "Short Term Studies with the Cryptating Agent Hexaoxa-Diaza-Bicyclo-Hexacosane in Rats", seiten 427-429 siehe zusammenfassung *
Biochimica et Biophysica Acta, Band 508, NR. 1, 1978, Elsevier/North-Holland Biomedical Press, B. TUMMLER et al.: "Open Chain Crown-Type Poly-Ethers and Pyridinophane Cryptands Act as Ionophores upon Frog Motor Nerve and Isolated Rat Heart Cells", seiten 122-129 siehe Zusammenfassung; seite 128, sie letzten 5 zeilen *
Byull. Eksp. Biol. Med., Band 98, Nr. 8, 1984, seiten 165-168 siehe Zusammenfassung *
Catalog/Handbook of Fine Chemicals, 1983-1984, Janssen Chimica, (Beerse, BE), seite 325 siehe Nummer 18,883-2 *
CHEMICAL ABSTRACTS, Band 102, 1985 (Columbus, Ohio, US), A.V. BOGATSKII et al.: "Study of the Effect of 15-Crown-5 on Smooth Muscle Cell Membranes", siehe seite 55, Zusammenfassung 56021z, & Fiziol. Zh. (Kiev) 1984, 30(6), 727-30 *
Drug and Chemical Toxicology, Band 8, Nr. 6, 1985, Marcel Dekker, Inc., S.C. GAD et al.: "Thirteen Cationic Ionophores: their Acute Toxicity, Neurobehavioral and Membrane Effects", seiten 451-468, siehe den ganzen artikel *
Experientia, Band 40, Nr. 7, 1984, R.C. KOLBECK et al.: "Crown Ethers which Influence Cardiac and Respiratory Muscle Contractility", seiten 727-731 siehe den ganzen artikel *
Farmakol. Toksikol., Band 47, Nr. 5, 1984, N.G. LUKYANENKO et al.: "Search for and Study of Antiarrhytmic Drugs in a Series of MAC Rocyclic Polyesters", seiten 29-32, siehe seite 32, Zusammenfassung *
Life Sci., Band 17, Nr. 12, 1975, W.H. MULLER et al.: "Distribution of a Cryptating Agent in Excreta and its Influence on Urinary Elimination of Na, K, Mg, Ca and Zn in the Rat", seiten 1815-1820 siehe Zusammenfassung *
Life Sciences, Band 35, Nr. 4, 1984, Pergamon Press (US), P. BOUSQUET et al.: "The Effects of Ouabain in the Medullary Site of the Hypotensive Action of Clonidine", seiten 373-380, siehe zusammenfassung *
Magnesium, Band 3, Nr. 4-6, 1984, S. Karger AG, (Basel, CH), B.M. ALTURA et al.: "Interactions of Mg and K on Blood Vessels - Aspects in view of Hypertension", seiten 175-194 siehe Zusammenfassung *
Naunyn-Schmiedeberg's Arch. Pharmacol., Band 310, Nr. 1, 1979, Springer-Verlag, R. GUNTHER et al.: "Effect of Cryptands on Cardiac Purkinje Fibres", seiten 79-85, siehe seite 79, seiten 83-84, "Discussion" *
Pfluegers Arch. Eur. J. Physiol., Band 373, Suppl. 1978 C. ACHENBACH et al.: "Electrophysiological Effects of Various Cryptates on Cardiac Purkinje Fibres", seite R 49, Zusammenfassung Nr. 166 siehe Zusammenfassung *
Physiol. Chem. & Physics, Band 12, Nr. 3, 1980 C. ACHENBACH et al.: "Effects of Cryptand 2.2.1py on the Fast Sodium Current in Cardiac Purkinje Fibers", seiten 277-288, siehe Zusammenfassung *
Studia Biophysica, Band 74, 1978, (Berlin, DE), A.K. TASHMUKHAMEDOVA et al.: "Effect of Macrocyclic Polyethers on the Properties of Biological and Artificial Membranes", seiten 53-54 siehe den ganzen artikel *

Also Published As

Publication number Publication date
WO1987003479A2 (fr) 1987-06-18
DE3543974A1 (de) 1987-06-19
JPH0223162B2 (fr) 1990-05-23
EP0248046A1 (fr) 1987-12-09
JPH01500175A (ja) 1989-01-26
US5008269A (en) 1991-04-16

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