WO1987003596A3 - Nouveaux composes phosphores et medicaments les contenant - Google Patents

Nouveaux composes phosphores et medicaments les contenant Download PDF

Info

Publication number
WO1987003596A3
WO1987003596A3 PCT/EP1986/000707 EP8600707W WO8703596A3 WO 1987003596 A3 WO1987003596 A3 WO 1987003596A3 EP 8600707 W EP8600707 W EP 8600707W WO 8703596 A3 WO8703596 A3 WO 8703596A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkylamino
propyl
alkyl group
halogen
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1986/000707
Other languages
German (de)
English (en)
Other versions
WO1987003596A2 (fr
Inventor
Hansjoerg Eibl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863606633 external-priority patent/DE3606633A1/de
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to AT87900102T priority Critical patent/ATE50581T1/de
Priority to DE8787900102T priority patent/DE3669161D1/de
Publication of WO1987003596A2 publication Critical patent/WO1987003596A2/fr
Priority to DK398387A priority patent/DK398387A/da
Priority to NO873245A priority patent/NO873245L/no
Priority to FI873365A priority patent/FI84832C/fi
Publication of WO1987003596A3 publication Critical patent/WO1987003596A3/fr
Anticipated expiration legal-status Critical
Priority to GR90400093T priority patent/GR3000363T3/el
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Composés cytostatiquement actifs de formule (I) dans laquelle R est un résidu de carbone saturé ou insaturé contenant de 12 à 24 atomes de carbone, qui peut également être substitué par un halogène, X est un atome d'oxygène, NH ou NR2, n est un nombre entier compris entre 0 et 10, R1 est un groupe alkyle C1-C8, ou bien dans laquelle R1 est un groupe alkyle C2-C8 qui est insaturé et/ou est substitué par un halogène, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, tri-C1-C6-alkylamino, hydroxy, carboxy, C3-C8-cycloalkyle ou phényle, et dans laquelle R1, en outre, peut également être 2-tert.-butyloxycarbonylaminoéthyle, 2-tert.-butyloxycarbonyléthyle, 2,3-isopropylidènedioxy-propyle-(1), 2,3-dibenzyloxy-propyle-(1), 1,3-dibenzyloxy-propyle-(2) ou N-C1-C6-alkylamino-C2-C6-alkyle, si X est un atome d'oxygène, et dans laquelle R1 peut, en outre, également être 2,3-dihydroxypropyle-(1), si X est le groupe NH et R2 est un groupe de 2,3 dihydroxy-propyle-(1), un groupe alkyle C1-C8 ou un groupe alkyle C2-C8, qui est insaturé et/ou substitué par un halogène, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, tri-C1-C6-alkylamino, hydroxy, carboxy, C3-C8-cycloalkyle ou phényle. Sont également décrits leurs sels physiologiquement compatibles et leurs procédés de fabrication.
PCT/EP1986/000707 1985-12-04 1986-12-04 Nouveaux composes phosphores et medicaments les contenant Ceased WO1987003596A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT87900102T ATE50581T1 (de) 1985-12-04 1986-12-04 Neue phosphorverbindungen und diese enthaltende arzneimittel.
DE8787900102T DE3669161D1 (de) 1985-12-04 1986-12-04 Neue phosphorverbindungen und diese enthaltende arzneimittel.
DK398387A DK398387A (da) 1985-12-04 1987-07-30 Hidtil ukendte phosphoforbindelser og laegemiddel indeholdende disse
NO873245A NO873245L (no) 1985-12-04 1987-08-03 Nye fosforbindelser og legemiddel inneholdende disse.
FI873365A FI84832C (fi) 1985-12-04 1987-08-03 Foerfarande foer framstaellning av nya fosfo-foereningar.
GR90400093T GR3000363T3 (en) 1985-12-04 1990-03-01 Novel phospho-compounds and medicaments containing these

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP3542894.5 1985-12-04
DE3542894 1985-12-04
DE19863606633 DE3606633A1 (de) 1986-02-28 1986-02-28 Neue phosphoverbindungen und diese enthaltende arzneimittel
DEP3606633.8 1986-02-28

Publications (2)

Publication Number Publication Date
WO1987003596A2 WO1987003596A2 (fr) 1987-06-18
WO1987003596A3 true WO1987003596A3 (fr) 1987-09-24

Family

ID=25838511

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000707 Ceased WO1987003596A2 (fr) 1985-12-04 1986-12-04 Nouveaux composes phosphores et medicaments les contenant

Country Status (9)

Country Link
EP (2) EP0248858B1 (fr)
JP (1) JPS63502824A (fr)
DE (1) DE3669161D1 (fr)
ES (1) ES2018578B3 (fr)
FI (1) FI84832C (fr)
HU (1) HU203359B (fr)
IE (1) IE59664B1 (fr)
PT (1) PT83874B (fr)
WO (1) WO1987003596A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061872A1 (fr) * 1981-03-30 1982-10-06 Takeda Chemical Industries, Ltd. Dérivés de l'éthylèneglycol, leur production et utilisation
EP0121088A1 (fr) * 1983-03-05 1984-10-10 A. Nattermann & Cie. GmbH O-Acyl-alcanediol-phospholipides, procédé pour les préparer et compositions pharmaceutiques les contenant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061872A1 (fr) * 1981-03-30 1982-10-06 Takeda Chemical Industries, Ltd. Dérivés de l'éthylèneglycol, leur production et utilisation
EP0121088A1 (fr) * 1983-03-05 1984-10-10 A. Nattermann & Cie. GmbH O-Acyl-alcanediol-phospholipides, procédé pour les préparer et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
IE863175L (en) 1987-06-04
EP0248858A1 (fr) 1987-12-16
FI873365A0 (fi) 1987-08-03
DE3669161D1 (de) 1990-04-05
JPS63502824A (ja) 1988-10-20
EP0224925A3 (fr) 1987-10-21
FI873365A7 (fi) 1987-08-03
PT83874A (de) 1987-01-01
ES2018578B3 (es) 1991-04-16
HU203359B (en) 1991-07-29
FI84832C (fi) 1992-01-27
EP0248858B1 (fr) 1990-02-28
FI84832B (fi) 1991-10-15
EP0224925A2 (fr) 1987-06-10
WO1987003596A2 (fr) 1987-06-18
HUT47298A (en) 1989-02-28
PT83874B (pt) 1989-01-17
IE59664B1 (en) 1994-03-09

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