WO1992019572A3 - I-aza-2-phenylhydrorazino-heterocycles, leur procede de fabrication et produits pharmaceutiques les contenant - Google Patents

I-aza-2-phenylhydrorazino-heterocycles, leur procede de fabrication et produits pharmaceutiques les contenant Download PDF

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Publication number
WO1992019572A3
WO1992019572A3 PCT/DE1992/000349 DE9200349W WO9219572A3 WO 1992019572 A3 WO1992019572 A3 WO 1992019572A3 DE 9200349 W DE9200349 W DE 9200349W WO 9219572 A3 WO9219572 A3 WO 9219572A3
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WO
WIPO (PCT)
Prior art keywords
aza
heterocycles
producing
phenylhydrorazino
pharmaceuticals containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1992/000349
Other languages
German (de)
English (en)
Other versions
WO1992019572A2 (fr
Inventor
Rudolf Schneider
Thomas Koehler
Christian Locke
Peter Harenberg
Axel Buege
Rolf Hirschelmann
Michael Heinisch
Peter Nuhn
Peter Stenger
Sabine Gohlke
Herbert Dr Lettau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva GmbH
Original Assignee
Arzneimittelwerk Dresden GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden GmbH filed Critical Arzneimittelwerk Dresden GmbH
Publication of WO1992019572A2 publication Critical patent/WO1992019572A2/fr
Anticipated expiration legal-status Critical
Publication of WO1992019572A3 publication Critical patent/WO1992019572A3/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des 1-aza-2-phénylhydrazino-hétérocycles de la formule I, partiellement nouveaux, leur procédé de fabrication et leur utilisation dans des préparations pharmaceutiques. Leur fabrication s'effectue en faisant réagir des dérivés activés de lactame et de cyclo-imide avec des arylhydrazines ou avec des hydrochlorures d'arylhydrazines. Les composés selon l'invention sont des inhibiteurs de la lipoxygénase d'une grande efficacité et peuvent être utilisés dans des médicaments destinés à combattre toutes formes d'inflammation, des affections allergiques, l'asthme, la bronchite et le psoriasis.
PCT/DE1992/000349 1991-05-04 1992-04-29 I-aza-2-phenylhydrorazino-heterocycles, leur procede de fabrication et produits pharmaceutiques les contenant Ceased WO1992019572A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19914114542 DE4114542A1 (de) 1991-05-04 1991-05-04 3,4-cycloamidrazone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DEP4114542.9 1991-05-04

Publications (2)

Publication Number Publication Date
WO1992019572A2 WO1992019572A2 (fr) 1992-11-12
WO1992019572A3 true WO1992019572A3 (fr) 1996-09-19

Family

ID=6430948

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1992/000349 Ceased WO1992019572A2 (fr) 1991-05-04 1992-04-29 I-aza-2-phenylhydrorazino-heterocycles, leur procede de fabrication et produits pharmaceutiques les contenant

Country Status (2)

Country Link
DE (1) DE4114542A1 (fr)
WO (1) WO1992019572A2 (fr)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1957783A1 (de) * 1969-11-17 1971-05-19 Boehringer Sohn Ingelheim Neue substituierte Arylhydrazino-pyrroline,-tetrahydro-pyridine und -tetrahydro-7H-azepine sowie Verfahren zu deren Herstellung
DE2235113A1 (de) * 1972-07-18 1974-01-31 Bayer Ag Fungizides mittel
DE2235177A1 (de) * 1972-07-18 1974-02-07 Bayer Ag Verfahren zur herstellung von lactamhydrazonen aromatischer systeme
US4213773A (en) * 1977-11-17 1980-07-22 E. I. Du Pont De Nemours And Company Herbicidal substituted bicyclic triazoles
DE3035822A1 (de) * 1979-09-25 1981-04-09 Takeda Chemical Industries, Ltd., Osaka Akarizide mittel
EP0097614A2 (fr) * 1982-06-11 1984-01-04 Ciba-Geigy Ag Pesticides
EP0098204A1 (fr) * 1982-06-18 1984-01-11 LABORATOIRES CHAUVIN-BLACHE Société dite: Compositions thérapeutiques à base d'hydrazones N-substituées et nouvelles hydrazones N-substituées
EP0129829A1 (fr) * 1983-06-22 1985-01-02 Ciba-Geigy Ag Pesticides
EP0146711A2 (fr) * 1983-11-21 1985-07-03 American Cyanamid Company Hydrazino-2-imidazoles-1H
EP0158083A2 (fr) * 1984-04-12 1985-10-16 LUDWIG HEUMANN & CO GMBH Médicaments
US4567190A (en) * 1984-06-21 1986-01-28 Ciba-Geigy Corporation Pesticidal phenylhydrazonopyrrolidines

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1957783A1 (de) * 1969-11-17 1971-05-19 Boehringer Sohn Ingelheim Neue substituierte Arylhydrazino-pyrroline,-tetrahydro-pyridine und -tetrahydro-7H-azepine sowie Verfahren zu deren Herstellung
DE2235113A1 (de) * 1972-07-18 1974-01-31 Bayer Ag Fungizides mittel
DE2235177A1 (de) * 1972-07-18 1974-02-07 Bayer Ag Verfahren zur herstellung von lactamhydrazonen aromatischer systeme
US4213773A (en) * 1977-11-17 1980-07-22 E. I. Du Pont De Nemours And Company Herbicidal substituted bicyclic triazoles
DE3035822A1 (de) * 1979-09-25 1981-04-09 Takeda Chemical Industries, Ltd., Osaka Akarizide mittel
EP0097614A2 (fr) * 1982-06-11 1984-01-04 Ciba-Geigy Ag Pesticides
EP0098204A1 (fr) * 1982-06-18 1984-01-11 LABORATOIRES CHAUVIN-BLACHE Société dite: Compositions thérapeutiques à base d'hydrazones N-substituées et nouvelles hydrazones N-substituées
EP0129829A1 (fr) * 1983-06-22 1985-01-02 Ciba-Geigy Ag Pesticides
EP0146711A2 (fr) * 1983-11-21 1985-07-03 American Cyanamid Company Hydrazino-2-imidazoles-1H
EP0158083A2 (fr) * 1984-04-12 1985-10-16 LUDWIG HEUMANN & CO GMBH Médicaments
US4567190A (en) * 1984-06-21 1986-01-28 Ciba-Geigy Corporation Pesticidal phenylhydrazonopyrrolidines

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, Band 104, 1986, (Columbus, Ohio, US), S. HILBIG et al.: "Antibiotics from Basidiomycetes. 22. Chemistry and antiobiotic activity of the basidiomycete Agaricus xanthoderma", siehe Seite 416, Zusammenfassung Nr. 106184u, & ANGEW. CHEM. 1985, 97(12), 1063-4, siehe RN 99280-75-8 *
Chemical Abstracts, Band 71, 1969, (Columbus, Ohio, US), V.G. GRANIK et al.: "N-Methylsuccinimide acetal", siehe Seite 284, Zusammenfassung Nr. 101265m, & ZH. ORG. KHIM. 1969, 5(7), 1318-19, siehe RN 25291-51-4 *
Chemical Abstracts, Band 79, 1973, (Columbus, Ohio, US), V.G. GRANIK et al.: "Acetals of lactams. V. Synthesis and some chemical properties of N-methyl-2-piperidinone diethyl acetal", siehe Seite 387, Zuzammenfassung Nr. 126261k, & KHIM. GETEROTSIKL. SOEDIN. 1973, (7), 954-7, siehe RN 50362-01-1 *
Chemical Abstracts, Band 86, 1977, (Columbus, Ohio, US), T. YAMAZAKI et al.: "Studies on O-alkylated imides. II. Some reactions of O-ethyl succinimide and O-ethyl 4,4-dimethylglutarimide", siehe Seite 546, Zusammenfassung Nr. 171339x, & CHEM. PHARM. BULL. 1976, 24(12), 3011-18, siehe RN 62565-15-5 *
Chemical Abstracts, Band 97, 1982, (Columbus, Ohio, US), siehe Seite 811, Zusammenfassung Nr. 182233m, & CS,A,191584 (J. PROCHAZKA et al.) 15 Dezember 1981, siehe RN 52176-73-5 (in der Anmeldung erw{hnt) *
Chemical Abstracts, Band 98, 1983, (Columbus, Ohio, US), siehe Seite 653, Zusammenfassung Nr. 53683e, & CS,A,197975 (J. PROCHAZKA et al.) 1 Juni 1982, siehe RN 52176-97-3 (in der Anmeldung erw{hnt) *
Chemical Abstracts, Band 98, 1983, (Columbus, Ohio, US), siehe Seite 655, Zusammenfassung Nr. 53710m, & CS,A,197976 (J. PROCHAZKA et al.) 1 Juni 1982, siehe RN 84321-48-2 *
Chemical Abstracts, Band 99, 1983, (Columbus, Ohio, US), siehe Seite 607, Zusammenfassung Nr. 22343k, & CS,A,200428 (J. PROCHAZKA et al.) 30. November 1982, siehe zum Beispiel RN 86144-87-8 *
Die Pharmazie, Band 41, Nr. 1, 1986, R. GRUPE: "Lipoxygenasekatalysieter Arachidons{uremetabolismus und Auswirkungen seiner Inhibition auf anaphylaktische Reaktionen", Seiten 7-18, siehe Insgesamt *
Die Pharmazie, Band 46, Nr. 2, Februar 1991, P. NUHN et al.: "Trends bei der Entwicklung von Lipoxygenase-Hemmern", Seiten 81-88, siehe Insgesamt *
Pharmaceutical Research, Journal of the Pharmaceutical-Biomedical Sciences, Nr. 6, November 1985, J.R. CASHMAN et al.: "Leukotriene biosynthesis inhibitors", Seiten 253-261, siehe Insgesamt *

Also Published As

Publication number Publication date
WO1992019572A2 (fr) 1992-11-12
DE4114542A1 (de) 1992-11-05

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