WO1995013785A1 - Systeme de transvasement a usage medical ou pharmaceutique, par exemple pour transvaser une substance dans une solution - Google Patents

Systeme de transvasement a usage medical ou pharmaceutique, par exemple pour transvaser une substance dans une solution Download PDF

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Publication number
WO1995013785A1
WO1995013785A1 PCT/EP1994/003770 EP9403770W WO9513785A1 WO 1995013785 A1 WO1995013785 A1 WO 1995013785A1 EP 9403770 W EP9403770 W EP 9403770W WO 9513785 A1 WO9513785 A1 WO 9513785A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
transfer device
active substance
container
adapter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1994/003770
Other languages
German (de)
English (en)
Inventor
Christian Eichler
Claudio Enrique WOLFRING
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO1995013785A1 publication Critical patent/WO1995013785A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A61J1/2062—Connecting means having multiple connecting ports with directional valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents

Definitions

  • Transfer device for medicine and pharmacy e.g. of an active ingredient in a solution
  • the invention relates to a transfer device for medicine and pharmacy, e.g. of an active ingredient in a solution. It relates in particular to the transfer of cytostatics, for example into a NaCl solution. For this purpose, the invention relates to a device with the features of the preamble of claim 1.
  • transfer caps or mixing adapters are known, by means of which the entire amount of active substance is transferred into the carrier solution at once, but this is often regarded as undesirable or inadequate in practice with regard to the requirements.
  • the invention relates to the transfer of partial amounts and / or total amount of the active ingredient concentrate into the carrier solution, which is in particular injected into the carrier solution by cannula at a predetermined point (so-called "multi-step system").
  • multi-step system In everyday medical practice, when preparing mixed solutions, for example in the central pharmacy of the hospital, not only liquid but also powdered active ingredients are dissolved and removed with disposable syringes and transferred to the active ingredient solution by cannula.
  • the transfer device proposed according to the invention serves as a safety device for the transfer of aggressively toxic active substance concentrates and permits the preparation of mixed solutions, in particular in the case of cytostatic therapies (chemotherapy) in medicine and pharmacy. It ensures a hermetically closed system in which a dosed, safe and antiseptic transfer of active ingredient concentrates can take place. This solves the problems hitherto associated with "multi-step handling".
  • the housing is therefore used according to the invention and with the features of claim 2 preferably as a stationary part of a switching element which, for example, i.e. is rotatably arranged in this embodiment. This results in a rotationally symmetrical arrangement of a cock plug in the housing.
  • the angled bore provided therein forms the apex of the interconnected conveying paths. This creates a simple design of the decanting device. Among other things, influence their disposal favorably.
  • the adapters used in this and other embodiments of the invention permit different embodiments of filling devices, metering pumps and removal devices. In particular, the vials previously used as a filling device can be exchanged for containers with larger contents, which previously could not be handled due to this size and / or dimension.
  • the switching element used to transmit the kinetic energy to the movable part of the multi-way distributor can be used simultaneously as a pointer which is aligned with the respective adapter.
  • Such embodiments can also be made of plastic and can be provided as disposable fillers for hospitals at the bedside or in the hospital pharmacy.
  • the system of the mixer according to the invention can also be sealed off from the outside.
  • the features of claim 7 automatically prevent parts of the mixture or its components from becoming free even when the adapters are free.
  • the check valves used for this also automatically open the connection paths in the interior of the mixer in the predetermined working rhythm. Such a. Mixer can be operated safely and can be disposed of without hesitation.
  • Claim 10 describes a comparatively simple embodiment of the invention, which essentially comprises only the rotationally symmetrical housing described with the rotatable distributor and the adapters, the number and arrangement of which can also be expanded depending on the requirements of the individual case.
  • Such an embodiment of the invention permits a shape which, as described in claim 11, can be accommodated in a form-fitting manner in a holder, that is to say can be hung up in particular, in order to enable the Mi ⁇ to be operated ergonomically under unfavorable external conditions, for example on the patient's bed to reach schers.
  • Claim 12 thus describes an embodiment of the decanting device according to the invention, which provides for a translatory movement for this part instead of the rotary mobility of the multi-way distributor.
  • FIG. 1 shows a first embodiment of the invention in plan view
  • FIG. 3 shows the subject of FIGS. 1 and 2 in section along the line A-A 'of FIG. 2,
  • FIGS. 1 to 3 the object of FIGS. 1 to 3 on an enlarged scale, partly in section and in a side view,
  • Fig. 5 shows the cock chick, which in the embodiment is used according to Figures 1 to 4,
  • FIG. 6 is a plan view of the subject of FIG. 5,
  • FIG. 8 shows a modified embodiment of the invention essentially in a representation corresponding to FIG. 4,
  • FIG. 14 is a plan view of the subject of FIG. 12,
  • FIG. 16 shows a schematic illustration of the mixer in a top view, the adapters being shown partly in section,
  • FIGS. 19 and 20 are a side view of the object of FIGS. 19 and
  • Fig. 21 is a schematic representation of another embodiment.
  • FIG. 1 shows a decanting device which has a multi-way distributor 1 in a closed housing 13 and which produces flow paths and connections in predetermined rotational positions.
  • the interconnected flow paths can be seen externally by hatching in FIG. 1.
  • they open into a pipe socket 2 which, due to its shape at 3, forms an adapter for the tight connection of a metering pump, for example in the form of a disposable syringe 12.
  • a further pipe socket 4 communicates with the multi-way distributor 1 and, due to its shape at 5, an adapter for the liquid-tight aseptic one Connection of a removal container 32 is used, which, for example, as shown in Figure 17, can be designed as a liquid bag.
  • the disposable syringe 12 shown in FIG. 17 can be used to transfer a quantity of active substance determined by the piston position into the removal container 32.
  • the housing 13 carries a third pipe socket 8 which, due to its shape at 10, forms a liquid-tight adapter for a medicine bottle 31 (FIG. 17) which contains an active ingredient.
  • the adapters 2 and 5 and 10 are designed in such a way that they can accommodate certain and possibly also commercially available forms of removal containers 32, active substance concentrate containers 31 and metering pumps.
  • the multi-way distributor 1 consists of a cock plug 1 ', which is cylindrical and is arranged so that its axis of rotation in the illustration of Figure 3 is perpendicular to the plane of the drawing and to the horizontal plane of the housing 13, in which the flow paths 14 lead to the adapters described.
  • the cock plug 1 ' has an angled bore 14' (FIG. 7) which forms the apex of the paths 14 which are connected to one another in the respective rotational position of the cock plug 1 'in the cock housing.
  • the switch 20 has catches 19 on its levers, for example in the form of ball catches or plastic warts which, as can be seen, for example, from the top view in FIG. 6, cooperate with grids 19 'which are designed as depressions in the housing cover. In each of the predefined positions of the cock plug 1 ', these parts release the rotation of the cock plug when the lever's position is changed and the cock plug locks as soon as the bore 14' is aligned with the flow paths 14 .
  • the adapters 2, 3; 4.5; 8.10 shown in more detail.
  • the adapter 2, 3 is connected by the position of the valve housing 1 'to the angled bore 14' via the flow paths 14 in the housing with an insertion cannula 15 which projects into a cylindrical sleeve which has clamping webs 18.
  • the fact that the outer end face of the sleeve projects beyond the tip of the puncture cannula provides protection against contact with the puncture cannula.
  • the clamping webs 18 hold the neck of the bag 32, which is connected to the adapter 4, 5, in a form-fitting and / or force-fitting manner.
  • the pipe socket 8 carries a sleeve 10 which has in its axis a further puncture cannula 16 for the stopper of the active substance concentrate container 31 and which holds the neck with the aid of a wall thickening 17 which is designed as a press fit.
  • 16b are the. adapter shown there for active substance concentrate containers of various sizes give, with 9 the small size, 10 the medium size and 11 the adapter for the active ingredient concentrate container with maximum volume.
  • ventilation is provided for the cock plug designated 24 in the cock housing 13.
  • this ventilation in the cock plug fitting 39 in the housing 13 has a circumferential ventilation groove 28 in the cylinder jacket of the plug and, according to the exemplary embodiment, a plurality of connecting channels 26 leading from the latter.
  • Further channels 27 communicate with the groove 26 and open into air inlet openings 22 of the housing 13. These air inlet openings 22 are closed to the outside with air filters 23.
  • One of the air channels 27 opens into the annular groove 26 and into the cannula 25, which is introduced into the stopper of the active substance concentrate container 31. This creates an air pressure compensation to the outside and inside.
  • the pipe sockets 2, 4 and 8 are in one piece with adapters which carry internal threads 30 which are used as screw connections.
  • the various embodiments of the mixers have a lenticular housing 13, which adapters 2, 3; 4.5; 8, 10, which are offset by 120 ° on the circumference of the housing.
  • the disposable syringe 12 is a piston syringe with a connecting thread and volume division and is used as a metering pump, while the remaining adapters are provided for the active substance concentrate container 31 and the container 32 receiving the active substance.
  • the switch 24 is arranged on one of the curved housing covers, while the housing body is also cylindrical in accordance with the cylindrical shape of the valve plug 1 '.
  • FIG. 21 uses a cylindrical housing 38 in which the multi-way distributor 1 shown as a control piston runs.
  • the adapters are provided on the piston cylinder 38 at predetermined intervals, but are not shown in the illustration.
  • the control piston is connected to a multi-position switch 37 which adjusts the control piston in a predetermined rhythm and connects the various flow paths discussed in connection with the above-described embodiments of the invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un système de transvasement comprenant un dispositif de soutirage composé d'un réservoir de substance concentrée (31) et d'une pompe de dosage (12). Un volume prédéfini de substance concentrée est prélevée du réservoir (31) et est acheminé dans un réservoir de soutirage (32). Selon l'invention, il est prévu que le dispositif de soutirage et sa pompe de dosage (12) et les réservoirs (31, 32) soient raccordés à un boîtier (13) fermé et qu'ils soient reliés à un distributeur à plusieurs voies qui établit à tour de rôle la communication entre le réservoir de substance concentrée (31) et la pompe de dosage (12) et ensuite entre ladite pompe de dosage (12) et le réservoir de soutirage (32).
PCT/EP1994/003770 1993-11-16 1994-11-14 Systeme de transvasement a usage medical ou pharmaceutique, par exemple pour transvaser une substance dans une solution Ceased WO1995013785A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP4339140.0 1993-11-16
DE4339140 1993-11-16
DEP4408498.6 1994-03-14
DE19944408498 DE4408498C2 (de) 1993-11-16 1994-03-14 Umfülleinrichtung für die Medizin und die Pharmazie

Publications (1)

Publication Number Publication Date
WO1995013785A1 true WO1995013785A1 (fr) 1995-05-26

Family

ID=6502746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/003770 Ceased WO1995013785A1 (fr) 1993-11-16 1994-11-14 Systeme de transvasement a usage medical ou pharmaceutique, par exemple pour transvaser une substance dans une solution

Country Status (2)

Country Link
DE (1) DE4408498C2 (fr)
WO (1) WO1995013785A1 (fr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1894555A3 (fr) * 2006-08-30 2008-10-08 Transcoject GmbH & Co. KG. Dispositif pour l'extraction de liquides
US8962009B2 (en) 2004-04-30 2015-02-24 Allergan, Inc. Sustained release intraocular implants and related methods
US10245213B2 (en) 2014-01-29 2019-04-02 Eveon Device for reconstituting a pharmaceutical composition
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10772797B2 (en) 2016-12-06 2020-09-15 West Pharma. Services IL, Ltd. Liquid drug transfer devices for use with intact discrete injection vial release tool
US10806671B2 (en) 2016-08-21 2020-10-20 West Pharma. Services IL, Ltd. Syringe assembly
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
US10945921B2 (en) 2017-03-29 2021-03-16 West Pharma. Services IL, Ltd. User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
USD917693S1 (en) 2018-07-06 2021-04-27 West Pharma. Services IL, Ltd. Medication mixing apparatus
US11027062B2 (en) 2017-12-03 2021-06-08 West Pharma. Services IL, Ltd. Liquid transfer device with telescopic vial adapter for use with infusion liquid container and discrete injection vial
USD923782S1 (en) 2019-01-17 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD954253S1 (en) 2019-04-30 2022-06-07 West Pharma. Services IL, Ltd. Liquid transfer device
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
US11642285B2 (en) 2017-09-29 2023-05-09 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including twin vented female vial adapters
US11674614B2 (en) 2020-10-09 2023-06-13 Icu Medical, Inc. Fluid transfer device and method of use for same
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device
WO2024137497A1 (fr) * 2022-12-19 2024-06-27 Bayer Healthcare Llc Système de reconstitution et d'injection pour milieux de contraste à dose unique
US12274670B2 (en) 2019-04-09 2025-04-15 West Pharma. Services IL, Ltd. Liquid transfer device with integrated syringe
US12427091B2 (en) 2019-01-18 2025-09-30 West Pharma. Services IL, Ltd. Liquid transfer devices for use with intravenous (IV) bottles

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Publication number Priority date Publication date Assignee Title
US5893397A (en) * 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
WO2007101786A1 (fr) * 2006-03-06 2007-09-13 Novo Nordisk A/S Dispositif d'administration de medicaments muni d'une vanne
IT1400708B1 (it) * 2010-06-25 2013-06-28 Frattini Paolo Giuseppe Gobbi Dispositivo per la ricostituzione dosata e la somministrazione di soluzioni liquide contenenti sostanze attive disponibili in forma separata, in particolare in polvere o gel.
EP3427781B1 (fr) * 2017-07-11 2024-09-25 Pharma Resources GmbH Médicament et système de dispositif pour des thérapies d'aérosol sous pression dans un espace creux d'un mammifère

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WO1985004097A1 (fr) * 1984-03-13 1985-09-26 Christensen John F Equipement pour la preparation de medicaments administrables par injection
EP0225861A1 (fr) * 1985-12-12 1987-06-16 Mediplast AB Dispositif de transvasement
US5037390A (en) * 1989-12-28 1991-08-06 Kenneth Raines System and method for mixing parenteral nutrition solutions
EP0521460A1 (fr) * 1991-07-04 1993-01-07 Axel von Brand Pointe de transfert et prélèvement

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US4997430A (en) * 1989-09-06 1991-03-05 Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. Method of and apparatus for administering medicament to a patient

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Publication number Priority date Publication date Assignee Title
US4253501A (en) * 1979-11-09 1981-03-03 Ims Limited Transfer system
EP0085663A2 (fr) * 1982-01-29 1983-08-10 Göran SJÖNELL Appareil pour mélanger une substance avec une autre substance
WO1985004097A1 (fr) * 1984-03-13 1985-09-26 Christensen John F Equipement pour la preparation de medicaments administrables par injection
EP0225861A1 (fr) * 1985-12-12 1987-06-16 Mediplast AB Dispositif de transvasement
US5037390A (en) * 1989-12-28 1991-08-06 Kenneth Raines System and method for mixing parenteral nutrition solutions
EP0521460A1 (fr) * 1991-07-04 1993-01-07 Axel von Brand Pointe de transfert et prélèvement

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8962009B2 (en) 2004-04-30 2015-02-24 Allergan, Inc. Sustained release intraocular implants and related methods
EP1894555A3 (fr) * 2006-08-30 2008-10-08 Transcoject GmbH & Co. KG. Dispositif pour l'extraction de liquides
US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
US10245213B2 (en) 2014-01-29 2019-04-02 Eveon Device for reconstituting a pharmaceutical composition
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
US10806671B2 (en) 2016-08-21 2020-10-20 West Pharma. Services IL, Ltd. Syringe assembly
US10772798B2 (en) 2016-12-06 2020-09-15 West Pharma Services Il, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10772797B2 (en) 2016-12-06 2020-09-15 West Pharma. Services IL, Ltd. Liquid drug transfer devices for use with intact discrete injection vial release tool
US11786443B2 (en) 2016-12-06 2023-10-17 West Pharma. Services IL, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10945921B2 (en) 2017-03-29 2021-03-16 West Pharma. Services IL, Ltd. User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
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DE4408498A1 (de) 1995-05-18

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