WO1998024481A3 - Ligand radiomarque servant a introduire selectivement un radionucleide emetteur d'electrons auger dans le noyau d'une cellule cancereuse - Google Patents

Ligand radiomarque servant a introduire selectivement un radionucleide emetteur d'electrons auger dans le noyau d'une cellule cancereuse Download PDF

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Publication number
WO1998024481A3
WO1998024481A3 PCT/CA1997/000909 CA9700909W WO9824481A3 WO 1998024481 A3 WO1998024481 A3 WO 1998024481A3 CA 9700909 W CA9700909 W CA 9700909W WO 9824481 A3 WO9824481 A3 WO 9824481A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer cell
nucleus
ligand
radiolabelled ligand
selective introduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA1997/000909
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English (en)
Other versions
WO1998024481A2 (fr
Inventor
Raymond M Reilly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002273946A priority Critical patent/CA2273946A1/fr
Priority to AU51131/98A priority patent/AU5113198A/en
Publication of WO1998024481A2 publication Critical patent/WO1998024481A2/fr
Anticipated expiration legal-status Critical
Publication of WO1998024481A3 publication Critical patent/WO1998024481A3/fr
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention se rapporte à un ligand radiomarqué qui permet d'introduire un radionucléide émetteur d'électrons Auger dans le noyau d'une cellule cancéreuse. Ce ligand se lie spécifiquement à un récepteur de surface cellulaire qui est unique à une cellule cancéreuse ou qui est surexprimé sur une cellule cancéreuse. Un radionucléide émetteur d'électrons Auger se lie au ligand soit directement soit par l'intermédiaire d'un chélateur. Le ligand radiomarqué est internalisé par la cellule lors de la liaison au récepteur, et une partie suffisante des ligands ainsi internalisés est transportée jusqu'au noyau, afin d'appliquer sur celui-ci une dose de rayonnement l'étale.
PCT/CA1997/000909 1996-12-02 1997-12-01 Ligand radiomarque servant a introduire selectivement un radionucleide emetteur d'electrons auger dans le noyau d'une cellule cancereuse Ceased WO1998024481A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002273946A CA2273946A1 (fr) 1996-12-02 1997-12-01 Ligand radiomarque servant a introduire selectivement un radionucleide emetteur d'electrons auger dans le noyau d'une cellule cancereuse
AU51131/98A AU5113198A (en) 1996-12-02 1997-12-01 A radiolabelled ligand for selectively introducing an auger electron emitting radionuclide into the nucleus of a cancer cell

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75928296A 1996-12-02 1996-12-02
US08/759,282 1996-12-02

Publications (2)

Publication Number Publication Date
WO1998024481A2 WO1998024481A2 (fr) 1998-06-11
WO1998024481A3 true WO1998024481A3 (fr) 2001-12-20

Family

ID=25055081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1997/000909 Ceased WO1998024481A2 (fr) 1996-12-02 1997-12-01 Ligand radiomarque servant a introduire selectivement un radionucleide emetteur d'electrons auger dans le noyau d'une cellule cancereuse

Country Status (3)

Country Link
AU (1) AU5113198A (fr)
CA (1) CA2273946A1 (fr)
WO (1) WO1998024481A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001144A1 (fr) * 1989-07-20 1991-02-07 Sandoz Ltd Derives de polypeptide etiquetes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001144A1 (fr) * 1989-07-20 1991-02-07 Sandoz Ltd Derives de polypeptide etiquetes

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CAPALA J ET AL: "RADIOLABELING OF EPIDERMAL GROWTH FACTOR WITH 99MTC AND IN VIVO LOCALIZATION FOLLOWING INTRACEREBRAL INJECTION INTO NORMAL AND GLIOMA-BEARING RATS", BIOCONJUGATE CHEMISTRY, vol. 8, no. 3, May 1997 (1997-05-01), pages 289 - 295, XP000689386 *
DADPARVAR S ET AL: "Indium-111-labeled anti-EGFr-425 scintigraphy in the detection of malignant gliomas.", CANCER, 1-2-1994, VOL. 73, NO. 3 SUPPL, PAGE(S) 884-9, XP002068413 *
DE JONG M ET AL: "HANDLING OF IODINE-125 TYR-3-OCTREOTIDE INDIUM-111 DTPA -D-PHE-1-OCTREOTIDE AND IODINE-125 EPIDERMAL GROWTH FACTOR EGF BY THE ISOLATED PERFUSED RAT LIVER", 39TH ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE, LOS ANGELES, CALIFORNIA, USA, JUNE 9-12, 1992., XP002068414 *
DERUI L ET AL: "RADIOTOXICITY OF IODINE-125-LABELED MONOCLONAL ANTIBODY 425 AGAINST CANCER CELLS CONTAINING EPIDERMAL GROWTH FACTOR RECEPTOR", AM J CLIN ONCOL, 1992, VOL. 15, NO. 4, PAGE(S) 288-294., XP002068412 *
ENNIS B W ET AL: "THE EGF RECEPTOR SYSTEM AS A TARGET FOR ANTITUMOR THERAPY", CANCER INVESTIGATION, vol. 9, no. 5, 1991, pages 553 - 562, XP000619907 *
GOLDENBERG A ET AL: "Imaging of human tumor xenografts with an indium-111-labeled anti-epidermal growth factor receptor monoclonal antibody.", J NATL CANCER INST, NOV 1 1989, VOL. 81, NO. 21, PAGE(S) 1616-25, XP002068410 *
J NUCL MED, 1992, VOL. 33, NO. 5, SUPPL., PAGE(S) 955, ABSTRACT NO. 548 *
SAGA T ET AL: "SCINTIGRAPHIC DETECTION OF OVEREXPRESSED C-ERB-B-2 PROTOONCOGENE PRODUCTS BY A CLASS-SWITCHED MURINE ANTI-C-ERB-B-2 PROTEIN MONOCLONAL ANTIBODY", CANCER RES, 1991, VOL. 51, NO. 3, PAGE(S) 990-994., XP002068411 *
SANDRINE REMY ET AL: "A NEW RADIOLIGAND FOR THE EPIDERMAL GROWTH FACTOR RECEPTOR: 111IN LABELED HUMAN EPIDERMAL GROWTH FACTOR DERIVATIZED WITH A BIFUNCTIONAL METAL-CHELATING PEPTIDE", BIOCONJUGATE CHEMISTRY, vol. 6, no. 6, 1 November 1995 (1995-11-01), pages 683 - 690, XP000542534 *

Also Published As

Publication number Publication date
AU5113198A (en) 1998-06-29
WO1998024481A2 (fr) 1998-06-11
CA2273946A1 (fr) 1998-06-11

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