WO1998024896A3 - Muteins of obese protein - Google Patents

Muteins of obese protein Download PDF

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Publication number
WO1998024896A3
WO1998024896A3 PCT/EP1997/006541 EP9706541W WO9824896A3 WO 1998024896 A3 WO1998024896 A3 WO 1998024896A3 EP 9706541 W EP9706541 W EP 9706541W WO 9824896 A3 WO9824896 A3 WO 9824896A3
Authority
WO
WIPO (PCT)
Prior art keywords
muteins
obese protein
obese
protein
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1997/006541
Other languages
French (fr)
Other versions
WO1998024896A2 (en
Inventor
Rene Devos
Yves Guisez
Geert Plaetinck
Der Heyden Jose Van
Sandra Verploegen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to AU56549/98A priority Critical patent/AU5654998A/en
Publication of WO1998024896A2 publication Critical patent/WO1998024896A2/en
Publication of WO1998024896A3 publication Critical patent/WO1998024896A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to ob muteins, to DNA sequences coding for these ob muteins and methods for making these.
PCT/EP1997/006541 1996-12-06 1997-11-22 Muteins of obese protein Ceased WO1998024896A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56549/98A AU5654998A (en) 1996-12-06 1997-11-22 Muteins of obese protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96119606 1996-12-06
EP96119606.0 1996-12-06

Publications (2)

Publication Number Publication Date
WO1998024896A2 WO1998024896A2 (en) 1998-06-11
WO1998024896A3 true WO1998024896A3 (en) 1998-10-01

Family

ID=8223476

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/006541 Ceased WO1998024896A2 (en) 1996-12-06 1997-11-22 Muteins of obese protein

Country Status (8)

Country Link
AR (1) AR010333A1 (en)
AU (1) AU5654998A (en)
CO (1) CO4930295A1 (en)
HR (1) HRP970654A2 (en)
MA (1) MA24411A1 (en)
PE (1) PE20399A1 (en)
WO (1) WO1998024896A2 (en)
ZA (1) ZA9710832B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208572B2 (en) 1998-08-21 2007-04-24 Albany Medical College Leptin-related peptides
US6777388B1 (en) 1998-08-21 2004-08-17 Clf Medical Technology Acceleration Program, Inc. Leptin-related peptides
US6420339B1 (en) * 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
US8227408B2 (en) 2005-09-07 2012-07-24 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
KR20110028457A (en) 2008-05-21 2011-03-18 뉴로테즈 인코포레이티드 How to treat neurodegenerative disorders associated with nerve fiber knots
CA2742600A1 (en) 2008-11-04 2010-05-14 Nikolaos Tezapsidis Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta
MX349054B (en) 2010-09-28 2017-07-07 Aegerion Pharmaceuticals Inc Highly soluble leptins.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137234A2 (en) * 1983-08-17 1985-04-17 The Wellcome Foundation Limited Physiologically active compositions
GB2292382A (en) * 1994-08-17 1996-02-21 Univ Rockefeller Obesity(OB) polypeptides
EP0725078A1 (en) * 1995-01-31 1996-08-07 Eli Lilly And Company Anti-obesity proteins
WO1996034885A2 (en) * 1995-05-05 1996-11-07 Smithkline Beecham Plc Biologically active peptide fragments of ob protein

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137234A2 (en) * 1983-08-17 1985-04-17 The Wellcome Foundation Limited Physiologically active compositions
GB2292382A (en) * 1994-08-17 1996-02-21 Univ Rockefeller Obesity(OB) polypeptides
EP0725078A1 (en) * 1995-01-31 1996-08-07 Eli Lilly And Company Anti-obesity proteins
WO1996034885A2 (en) * 1995-05-05 1996-11-07 Smithkline Beecham Plc Biologically active peptide fragments of ob protein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VERPLOEGEN, S.A.B.W. ET AL.: "A human leptin mutant induces weight gain in normal mice.", FEBS LETTERS, vol. 405, no. 2, 24 March 1997 (1997-03-24), pages 237 - 240, XP002062174 *

Also Published As

Publication number Publication date
CO4930295A1 (en) 2000-06-27
WO1998024896A2 (en) 1998-06-11
MA24411A1 (en) 1998-07-01
ZA9710832B (en) 1998-06-08
HRP970654A2 (en) 1998-10-31
PE20399A1 (en) 1999-03-05
AU5654998A (en) 1998-06-29
AR010333A1 (en) 2000-06-07

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