WO1999007738A3 - Human orphan receptor ntr-1 - Google Patents

Human orphan receptor ntr-1 Download PDF

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Publication number
WO1999007738A3
WO1999007738A3 PCT/US1998/016202 US9816202W WO9907738A3 WO 1999007738 A3 WO1999007738 A3 WO 1999007738A3 US 9816202 W US9816202 W US 9816202W WO 9907738 A3 WO9907738 A3 WO 9907738A3
Authority
WO
WIPO (PCT)
Prior art keywords
ntr
orphan receptor
provides
human
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/016202
Other languages
French (fr)
Other versions
WO1999007738A2 (en
Inventor
Piotr J Masiakowski
Jodi Morris
David M Valenzuela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Procter and Gamble Co
Original Assignee
Regeneron Pharmaceuticals Inc
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc, Procter and Gamble Co filed Critical Regeneron Pharmaceuticals Inc
Priority to JP2000506239A priority Critical patent/JP2001512667A/en
Priority to AU87676/98A priority patent/AU8767698A/en
Priority to CA002299619A priority patent/CA2299619A1/en
Priority to EP98939199A priority patent/EP1019502A2/en
Publication of WO1999007738A2 publication Critical patent/WO1999007738A2/en
Publication of WO1999007738A3 publication Critical patent/WO1999007738A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides for a nucleic acid sequence, designated as HUMAN NTR-1, that encodes a novel orphan receptor expressed in pancreas and fetal heart. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the HUMAN NTR-1 gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between NTR-1 and agents that initiate signal transduction through binding to NTR-1.
PCT/US1998/016202 1997-08-06 1998-08-04 Human orphan receptor ntr-1 Ceased WO1999007738A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000506239A JP2001512667A (en) 1997-08-06 1998-08-04 Human orphan receptor NTR-1
AU87676/98A AU8767698A (en) 1997-08-06 1998-08-04 Novel orphan receptor
CA002299619A CA2299619A1 (en) 1997-08-06 1998-08-04 Human orphan receptor ntr-1
EP98939199A EP1019502A2 (en) 1997-08-06 1998-08-04 Human orphan receptor ntr-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5486997P 1997-08-06 1997-08-06
US60/054,869 1997-08-06

Publications (2)

Publication Number Publication Date
WO1999007738A2 WO1999007738A2 (en) 1999-02-18
WO1999007738A3 true WO1999007738A3 (en) 1999-04-15

Family

ID=21994032

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/016202 Ceased WO1999007738A2 (en) 1997-08-06 1998-08-04 Human orphan receptor ntr-1

Country Status (5)

Country Link
EP (1) EP1019502A2 (en)
JP (1) JP2001512667A (en)
AU (1) AU8767698A (en)
CA (1) CA2299619A1 (en)
WO (1) WO1999007738A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
KR20000070174A (en) 1997-01-14 2000-11-25 벤슨 로버트 에이치. Tumor necrosis factor receptors 6α and 6β
WO1999014330A1 (en) 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG
WO1999026977A1 (en) * 1997-11-24 1999-06-03 Biogen, Inc. Novel receptors opg-2
WO1999031128A2 (en) * 1997-12-16 1999-06-24 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins
DE19809978A1 (en) * 1998-03-09 1999-09-16 Basf Ag New soluble member of tumor necrosis factor receptor family, useful for identification specific modulators and for treating disease e.g. tumors
TR200002824T2 (en) * 1998-03-30 2000-12-21 Eli Lilly And Company Therapeutic applications of advanced FLINT (mFLINT) polypeptides or OPG3, an element of the TNF receptor superfamily.
AU2211100A (en) * 1998-12-22 2000-07-12 Eli Lilly And Company Therapeutic applications of flint polypeptides
DE60041912D1 (en) 1999-02-10 2009-05-14 Serono Genetics Inst Sa POLYMORPHE MARKERS OF THE LSR GENE
CA2362929A1 (en) * 1999-03-04 2000-09-08 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US6965012B1 (en) * 1999-03-30 2005-11-15 Eli Lilly And Company Flint polypeptide analogs
US6627199B1 (en) 1999-07-09 2003-09-30 Amgen Inc Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
AU783682B2 (en) 1999-08-04 2005-11-24 Amgen, Inc. Fhm, a novel member of the TNF ligand supergene family
AU6517800A (en) * 1999-08-04 2001-03-05 Amgen, Inc. Ntr3, a member of the tnf-receptor supergene family
US7338787B2 (en) 2000-01-14 2008-03-04 Serono Genetics Institute S.A. Nucleic acids encoding OBG3 globular head and uses thereof
CA2396793A1 (en) 2000-02-16 2001-08-23 Genentech, Inc. Uses of agonists and antagonists to modulate activity of tnf-related molecules
CN101289511A (en) 2000-04-11 2008-10-22 杰南技术公司 Multivalent antibodies and uses therefore
PT1303293E (en) 2000-07-27 2009-03-11 Genentech Inc Sequential administration of cpt-11 and apo-2l polypeptide
WO2003066661A2 (en) 2001-07-03 2003-08-14 Genentech, Inc. Human dr4 antibodies and uses thereof
WO2007062090A2 (en) 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851A (en) * 1992-04-02 1995-09-05 Board Of Regents, The University Of Texas System DNA encoding a chimeric polypeptide comprising the extracellular domain of TNF receptor fused to IgG, vectors, and host cells
DE19654610A1 (en) * 1995-12-22 1997-06-26 Amgen Inc Osteoproteger
WO1998030694A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
EP0861850A1 (en) * 1997-02-04 1998-09-02 Smithkline Beecham Corporation Tumor necrosis related receptor, TR4

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851A (en) * 1992-04-02 1995-09-05 Board Of Regents, The University Of Texas System DNA encoding a chimeric polypeptide comprising the extracellular domain of TNF receptor fused to IgG, vectors, and host cells
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
DE19654610A1 (en) * 1995-12-22 1997-06-26 Amgen Inc Osteoproteger
WO1998030694A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
EP0861850A1 (en) * 1997-02-04 1998-09-02 Smithkline Beecham Corporation Tumor necrosis related receptor, TR4

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HILLIER L ET AL: "Human cDNA clone 366305", EMBL SEQUENCE DATABASE, 16 August 1996 (1996-08-16), HEIDELBERG DE, XP002091562 *
HILLIER L ET AL: "Human cDNA clone 592256", EMBL SEQUENCE DATABASE, 18 January 1997 (1997-01-18), HEIDELBERG DE, XP002091560 *

Also Published As

Publication number Publication date
WO1999007738A2 (en) 1999-02-18
AU8767698A (en) 1999-03-01
CA2299619A1 (en) 1999-02-18
EP1019502A2 (en) 2000-07-19
JP2001512667A (en) 2001-08-28

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